James Garnett

2024

N4BP1 functions as a dimerization-dependent linear ubiquitin reader which regulates TNF signalling

Kliza, K. W., Song, W., Pinzuti, I., Schaubeck, S., Kunzelmann, S., Kuntin, D., Fornili, A., Pandini, A., Hofmann, K., Garnett, J. A., Stieglitz, B. & Husnjak, K., 20 Apr 2024, In: Cell Death Discovery. 10, 1, 183.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

The Legionella collagen-like protein employs a distinct binding mechanism for the recognition of host glycosaminoglycans

Rehman, S., Antonovic, A. K., McIntire, I. E., Zheng, H., Cleaver, L., Baczynska, M., Adams, C. O., Portlock, T., Richardson, K., Shaw, R., Oregioni, A., Mastroianni, G., Whittaker, S. B. M., Kelly, G., Lorenz, C. D., Fornili, A., Cianciotto, N. P. & Garnett, J. A., Dec 2024, In: Nat Commun. 15, 1, 4912.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

2023

Autoantibody and T cell responses to oxidative post-translationally modified insulin neoantigenic peptides in type 1 diabetes

Strollo, R., Vinci, C., Man, Y. K. S., Bruzzaniti, S., Piemonte, E., Alhamar, G., Briganti, S. I., Malandrucco, I., Tramontana, F., Fanali, C., Garnett, J., Buccafusca, R., Guyer, P., Mamula, M., James, E. A., Pozzilli, P., Ludvigsson, J., Winyard, P. G., Galgani, M. & Nissim, A., Jan 2023, In: Diabetologia. 66, 1, p. 132-146 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Citations (Scopus)

The influence of ions on the lubricative abilities of mucin and the role of sialic acids

Weston, A., Vladescu, S.-C., Reddyhoff, T., Griffiths, A., Crouzier, T., Fielden, M., Garnett, J. A. & Carpenter, G. H., Jul 2023, In: Colloids and Surfaces B: Biointerfaces. 227, 113327.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Citations (Scopus)

2022

Molecular and cellular insight into Escherichia coli SslE and its role during biofilm maturation

Corsini Madeira, P., Wang, S., Rehman, S., Fenn, K., Sagar, A., Sirovica, S., Cleaver, L., Edwards-Gayle, C., Mastroianni, G., Dorgan, B. J., Sewell, L., Lynham, S., Iuga, D., Franks, W. T., Jarvis, J., Carpenter, G., Curtis, M., Bernado, P., Darbari, V. & Garnett, J., Dec 2022, In: npj Biofilms and Microbiomes. 8, 1, 9.

Research output: Contribution to journal › Article › peer-review

Open Access

File

10 Citations (Scopus)

132 Downloads (Pure)

Structural Model of a Porphyromonas gingivalis type IX Secretion System Shuttle Complex

Dorgan, B., Liu, Y., Wang, S., Aduse-Opoku, J., Whittaker, S. B. M., Roberts, M. A. J., Lorenz, C. D., Curtis, M. A. & Garnett, J. A., 15 Dec 2022, In: Journal of Molecular Biology. 434, 23, 167871.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

2021

Assay for Assessing Mucin Binding to Bacteria and Bacterial Proteins

Grigoryeva, L. S., Rehman, S., White, R. C., Garnett, J. A. & Cianciotto, N. P., 5 Mar 2021, In: Bio-protocol LLC. 11, 5, p. e3933 e3933.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Comparative Microbial Profiles of Caries and Black Extrinsic Tooth Stain in Primary Dentition

Chen, Y., Dou, G., Wang, D., Yang, J., Zhang, Y., Garnett, J. A., Chen, Y., Wang, Y. & Xia, B., 1 Aug 2021, In: Caries research. 55, 4, p. 310-321 12 p.

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

2020

Discovery of a new neisseria gonorrhoeae type iv pilus assembly factor, tfpc

Hu, L. I., Yin, S., Ozer, E. A., Sewell, L., Rehman, S., Garnett, J. A. & Seifert, H. S., 1 Sept 2020, In: Mbio. 11, 5, p. 1-14 14 p., e02528-20.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Citations (Scopus)

GloBody Technology: Detecting Anti-Drug Antibody against VH/VL domains

Saxena, G. K., Theocharopoulos, I., Aziz, N. T., Jones, M., Gnanapavan, S., Giovannoni, G., Schmierer, K., Garnett, J. A., Baker, D. & Kang, A. S., 5 Feb 2020, (E-pub ahead of print) In: Scientific Reports. 10, 1, 1860.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Citations (Scopus)

Structure, dynamics and cellular insight into novel substrates of the Legionella pneumophila type II secretion system

Portlock, T. J., Tyson, J., Dantu, S., Rehman, S., White, R. C., McIntire, I., Sewell, L., Richardson, K. H., Shaw, R., Pandini, A., Cianciotto, N. P. & Garnett, J., 12 May 2020, (Accepted/In press) In: Frontiers in Molecular Biosciences.

Research output: Contribution to journal › Article › peer-review

Open Access

File

124 Downloads (Pure)

Structure and functional analysis of the Legionella pneumophila chitinase ChiA reveals a novel mechanism of metal-dependent mucin degradation

Rehman, S., Grigoryeva, L., Richardson, K. H., Corsini Madeira, P., White, R. C., Shaw, R., Portlock, T. J., Dorgan, B., Zanjani, Z., Fornili, A., Cianciotto, N. P. & Garnett, J., 22 Jan 2020, (Accepted/In press) In: Plos pathogens.

Research output: Contribution to journal › Article › peer-review

Open Access

File

94 Downloads (Pure)

The biofilm-associated surface protein Esp of Enterococcus faecalis forms amyloid-like fibers

Taglialegna, A., Matilla-Cuenca, L., Dorado-Morales, P., Navarro, S., Ventura, S., Garnett, J. A., Lasa, I. & Valle, J., 1 Dec 2020, In: npj Biofilms and Microbiomes. 6, 1, 15.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Citations (Scopus)

2019

Scalable Geometrically Designed Protein Cages Assembled via Genetically Encoded Split Inteins

Wright, J. N., Wong, W. L., Harvey, J. A., Garnett, J. A., Itzhaki, L. S. & Main, E. R. G., 7 May 2019, In: Structure. 27, 5, p. 776-784.e4

Research output: Contribution to journal › Article › peer-review

Open Access

9 Citations (Scopus)

The fungal ribonuclease-like effector protein CSEP0064/BEC1054 represses plant immunity and interferes with degradation of host ribosomal RNA

Pennington, H. G., Jones, R., Kwon, S., Bonciani, G., Thieron, H., Chandler, T., Luong, P., Morgan, S. N., Przydacz, M., Bozkurt, T., Bowden, S., Craze, M., Wallington, E. J., Garnett, J., Kwaaitaal, M., Panstruga, R., Cota, E. & Spanu, P. D., 1 Mar 2019, In: PLoS Pathogens. 15, 3, e1007620.

Research output: Contribution to journal › Article › peer-review

Open Access

98 Citations (Scopus)

2018

Type II secretion-dependent aminopeptidase lapa and acyltransferase plac are redundant for nutrient acquisition during Legionella pneumophila intracellular infection of amoebas

White, R. C., Gunderson, F. F., Tyson, J. Y., Richardson, K. H., Portlock, T. J., Garnett, J. A. & Cianciotto, N. P., 17 Apr 2018, In: Mbio. 9, 2, e00528-18.

Research output: Contribution to journal › Article › peer-review

Open Access

File

25 Citations (Scopus)

125 Downloads (Pure)

2016

Crystal structure and analysis of HdaB: The enteroaggregative Escherichia coli AAF/IV pilus tip protein

Lee, W. C., Matthews, S. & Garnett, J. A., 1 Oct 2016, In: Protein science. p. 1898-1905 8 p.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Crystal structure of the CupB6 adhesive tip from the chaperone-usher family of pili from Pseudomonas aeruginosa

Rasheed, M., Garnett, J., Pérez-Dorado, I., Muhl, D., Filloux, A. & Matthews, S., 1 Nov 2016, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1864, 11, p. 1500-1505 6 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Staphylococcal Bap Proteins Build Amyloid Scaffold Biofilm Matrices in Response to Environmental Signals

Taglialegna, A., Navarro, S., Ventura, S., Garnett, J. A., Matthews, S., Penades, J. R., Lasa, I. & Valle, J., Jun 2016, In: PLoS Pathogens. 12, 6, e1005711.

Research output: Contribution to journal › Article › peer-review

Open Access

File

147 Citations (Scopus)

142 Downloads (Pure)

2015

Purification, crystallization and preliminary X-ray diffraction analysis of the Escherichia coli common pilus chaperone EcpB

Garnett, J. A., Diallo, M. & Matthews, S. J., 1 Jan 2015, In: Acta Crystallographica Section F:Structural Biology Communications. 71, p. 676-679 4 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Structural analysis of haemoglobin binding by HpuA from the Neisseriaceae family

Wong, C. T., Xu, Y., Gupta, A., Garnett, J. A., Matthews, S. J. & Hare, S. A., 31 Dec 2015, In: Nature Communications. 6, 10172.

Research output: Contribution to journal › Article › peer-review

Open Access

File

25 Citations (Scopus)

85 Downloads (Pure)

Structural Insight into Archaic and Alternative Chaperone-Usher Pathways Reveals a Novel Mechanism of Pilus Biogenesis

Pakharukova, N., Garnett, J. A., Tuittila, M., Paavilainen, S., Diallo, M., Xu, Y., Matthews, S. J. & Zavialov, A. V., 30 Nov 2015, In: PLoS Pathogens. 11, 11, e1005269.

Research output: Contribution to journal › Article › peer-review

Open Access

File

32 Citations (Scopus)

107 Downloads (Pure)

Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes

Miliara, X., Garnett, J. A., Tatsuta, T., Abid Ali, F., Baldie, H., Pérez-Dorado, I., Simpson, P., Yague, E., Langer, T. & Matthews, S., 1 Jul 2015, In: EMBO Reports. 16, 7, p. 824-835 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

55 Citations (Scopus)

166 Downloads (Pure)

Structure-function analysis reveals that the Pseudomonas aeruginosa Tps4 two-partner secretion system is involved in CupB5 translocation

Garnett, J. A., Muhl, D., Douse, C. H., Hui, K., Busch, A., Omisore, A., Yang, Y., Simpson, P., Marchant, J., Waksman, G., Matthews, S. & Filloux, A., 1 May 2015, In: Protein science. 24, 5, p. 670-687 18 p.

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

2014

A new method to determine in vivo interactomes reveals binding of the Legionella pneumophila effector PieE to multiple rab GTPases

Mousnier, A., Schroeder, G. N., Stoneham, C. A., So, E. C., Garnett, J. A., Yu, L., Matthews, S. J., Choudhary, J. S., Hartland, E. L. & Frankel, G., 12 Aug 2014, In: Mbio. 5, 4, e01148-14.

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Crystal structures of stapled and hydrogen bond surrogate peptides targeting a fully buried protein-helix interaction

Douse, C. H., Maas, S. J., Thomas, J. C., Garnett, J. A., Sun, Y., Cota, E. & Tate, E. W., 17 Oct 2014, In: Acs Chemical Biology. 9, 10, p. 2204-2209 6 p.

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Structural Insight into Host Recognition by Aggregative Adherence Fimbriae of Enteroaggregative Escherichia coli

Berry, A. A., Yang, Y., Pakharukova, N., Garnett, J. A., Lee, W. C., Cota, E., Marchant, J., Roy, S., Tuittila, M., Liu, B., Inman, K. G., Ruiz-Perez, F., Mandomando, I., Nataro, J. P., Zavialov, A. V. & Matthews, S., 1 Jan 2014, In: PLoS Pathogens. 10, 9

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors

Lambert, S. M., Langley, D. R., Garnett, J. A., Angell, R., Richard, K., Meanwell, N. A. & Matthews, S. J., Jun 2014, In: Protein science. 23, 6, p. 723-734 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

92 Citations (Scopus)

The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation

Young, J. C., Clements, A., Lang, A. E., Garnett, J. A., Munera, D., Arbeloa, A., Pearson, J., Hartland, E. L., Matthews, S. J., Mousnier, A., Barry, D. J., Way, M., Schlosser, A., Aktories, K. & Frankel, G., 19 Dec 2014, In: Nature Communications. 5, 5887 .

Research output: Contribution to journal › Article › peer-review

Open Access

33 Citations (Scopus)

The peptide-binding cavity is essential for ALS3-mediated adhesion of Candida albicans to human cells

Lin, J., Oh, S. H., Jones, R., Garnett, J. A., Salgado, P. S., Rusnakova, S., Matthews, S. J., Hoyer, L. L. & Cota, E., 27 Jun 2014, In: Journal of Biological Chemistry. 289, 26, p. 18401-18412 12 p.

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

2012

Interactions in bacterial biofilm development: A structural perspective

Garnett, J. A. & Matthews, S., 1 Dec 2012, In: Current Protein and Peptide Science. 13, 8, p. 739-755 17 p.

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Promoting crystallisation of the Salmonella enteritidis fimbriae 14 pilin SefD using deuterium oxide

Liu, B., Garnett, J. A., Lee, W. C., Lin, J., Salgado, P., Taylor, J., Xu, Y., Lambert, S., Cota, E. & Matthews, S., 4 May 2012, In: Biochemical and Biophysical Research Communications. 421, 2, p. 208-213 6 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Structural insight into the role of Streptococcus parasanguinis Fap1 within oral biofilm formation

Garnett, J. A., Simpson, P. J., Taylor, J., Benjamin, S. V., Tagliaferri, C., Cota, E., Chen, Y. Y. M., Wu, H. & Matthews, S., 6 Jan 2012, In: Biochemical and Biophysical Research Communications. 417, 1, p. 421-426 6 p.

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Structural insights into the biogenesis and biofilm formation by the Escherichia coli common pilus

Garnett, J. A., Martínez-Santos, V. I., Saldaña, Z., Pape, T., Hawthorne, W., Chan, J., Simpson, P. J., Cota, E., Puente, J. L., Girón, J. A. & Matthews, S., 6 Mar 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 10, p. 3950-3955 6 p.

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

2011

Complete ¹H, ¹³C and ¹⁵N NMR assignments for donor-strand complemented AafA, the major pilin of aggregative adherence fimbriae (AAF/II) from enteroaggregative E. coli

Yang, Y., Berry, A. A., Lee, W. C., Garnett, J. A., Marchant, J., Levine, J. A., Simpson, P. J., Fogel, S. A., Varney, K. M., Matthews, S. J., Nataro, J. P. & Inman, K. G., 1 Apr 2011, In: Biomolecular NMR Assignments. 5, 1, p. 1-5 5 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Crystallization and initial crystallographic analysis of AafA: The major adhesive subunit of the enteroaggregative Escherichia coli AAF/II pilus

Yang, Y., Garnett, J. A. & Matthews, S., 1 Apr 2011, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 67, 4, p. 454-456 3 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Crystallization and initial crystallographic analysis of the Streptococcus parasanguinis FW213 Fap1 - NR_α adhesive domain at pH 5.0

Garnett, J. A., Ramboarina, S., Lee, W. C., Tagliaferri, C., Wu, W. & Matthews, S., 1 Feb 2011, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 67, 2, p. 274-276 3 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

The role of Sialyl glycan recognition in host tissue tropism of the avian parasite Eimeria Tenella

Lai, L., Bumstead, J., Liu, Y., Garnett, J., Campanero-Rhodes, M. A., Blake, D. P., Palma, A. S., Chai, W., Ferguson, D. J. P., Simpson, P., Feizi, T., Tomley, F. M. & Matthews, S., 1 Oct 2011, In: PLoS Pathogens. 7, 10, e1002296.

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

2010

EspM2 is a RhoA guanine nucleotide exchange factor

Arbeloa, A., Garnett, J., Lillington, J., Bulgin, R. R., Berger, C. N., Lea, S. M., Matthews, S. & Frankel, G., 1 May 2010, In: Cellular Microbiology. 12, 5, p. 654-664 11 p.

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

2009

Detailed insights from microarray and crystallographic studies into carbohydrate recognition by microneme protein 1 (MIC1) of Toxoplasma gondii

Garnett, J. A., Liu, Y., Leon, E., Allman, S. A., Friedrich, N., Saouros, S., Curry, S., Soldati-Favre, D., Davis, B. G., Feizi, T. & Matthews, S., 1 Sept 2009, In: Protein science. 18, 9, p. 1935-1947 13 p.

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Potent fluoro-oligosaccharide probes of adhesion in Toxoplasmosis

Allman, S. A., Jensen, H. H., Vijayakrishnan, B., Garnett, J. A., Leon, E., Liu, Y., Anthony, D. C., Sibson, N. R., Feizi, T., Matthews, S. & Davis, B. G., 12 Oct 2009, In: ChemBioChem. 10, 15, p. 2522-2529 8 p.

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

2008

2-Aminotetralones: Novel inhibitors of MurA and MurZ

Dunsmore, C. J., Miller, K., Blake, K. L., Patching, S. G., Henderson, P. J. F., Garnett, J. A., Stubbings, W. J., Phillips, S. E. V., Palestrant, D. J., Angeles, J. D. L., Leeds, J. A., Chopra, I. & Fishwick, C. W. G., 1 Mar 2008, In: BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS. 18, 5, p. 1730-1734 5 p.

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Structure and Function of the Arginine Repressor-Operator Complex from Bacillus subtilis

Garnett, J. A., Marincs, F., Baumberg, S., Stockley, P. G. & Phillips, S. E. V., 29 May 2008, In: Journal of Molecular Biology. 379, 2, p. 284-298 15 p.

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

2007

A Beta-Sheet Interaction Interface Directs the Tetramerisation of the Miz-1 POZ Domain

Stead, M. A., Trinh, C. H., Garnett, J. A., Carr, S. B., Baron, A. J., Edwards, T. A. & Wright, S. C., 2 Nov 2007, In: Journal of Molecular Biology. 373, 4, p. 820-826 7 p.

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

A high-resolution structure of the DNA-binding domain of AhrC, the arginine repressor/activator protein from Bacillus subtilis

Garnett, J. A., Baumberg, S., Stockley, P. G. & Phillips, S. E. V., 26 Nov 2007, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 63, 11, p. 914-917 4 p.

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Structure of the C-terminal effector-binding domain of AhrC bound to its corepressor L-arginine

Garnett, J. A., Baumberg, S., Stockley, P. G. & Phillips, S. E. V., 26 Nov 2007, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 63, 11, p. 918-921 4 p.

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

James Garnett

Research output

Search results