James Maccabe

James Maccabe

Professor, Professor

  • Phone80757
  • 9580

Personal profile

Research interests

After an intercalated BSc in Psychology and Basic Medical Sciences, Professor MacCabe qualified in medicine at the University of London in 1995 and completed his basic and higher specialist training in Psychiatry at the Maudsley Hospital from 1997 to 2004. He obtained a joint MRC/Department of Health Special Training Fellowship in Health of the population research in 2004, in collaboration with the Department of Medical Epidemiology and Biostatistics at Karolinska Institute, Stockholm. He obtained an MSc in Epidemiology from the London School of Hygiene and Tropical Medicine in 2006 and a PhD in 2008. In 2009 he was awarded a Clinical Senior Lectureship by the Higher Education Funding Council for England. He was awarded a personal chair as Professor of Epidemiology and Therapeutics at King's College London in 2019. 

Professor MacCabe has been honorary consultant psychiatrist at the National Psychosis Unit since 2005, where he is responsible for treating inpatients with severe psychosis and conducting clinical trials. Prof MacCabe serves on the Board of Trustees of the mental health charity, SANE.

Professor MacCabe's research in treatment refractory schizophrenia personalised medicine mirrors his clinical work, and is geared towards helping people whose psychosis has not responded to standard antipsychotic treatment.  His research includes work on the epidemiology, genetics and neurochemistry underlying treatment refractory schizophrenia, and identifying biomarkers that may be used in personalised medicine. Much of his research is conducted in collaboration with UK and international partners. 

Research interests (short)

Epidemiology of schizophrenia and bipolar disorder, premorbid cognitive function, high intelligence, creativity, fertility, age at onset. Treatment refractory psychosis and its treatment, clozapine.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 5 - Gender Equality
  • SDG 10 - Reduced Inequalities
  • SDG 16 - Peace, Justice and Strong Institutions

Education/Academic qualification

Education, Senior Fellow, Higher Education Academy

Award Date: 7 Dec 2018

Doctor of Philosophy, Psychiatric Epidemiology, King's College London

Award Date: 1 Jan 2008

Master of Science, Epidemiology, LSHTM London School of Hygiene and Tropical Medicine

Award Date: 1 Jan 2006

Bachelor of Medicine and Bachelor of Surgery, University of London

Award Date: 1 Jan 1995

Bachelor of Science, Psychology and Basic Medical Sciences, University of London

Award Date: 1 Jan 1992

External positions

Academic Director, Psychosis Clinical Academic Group, King's Health Partners Academic Health Science Centre

Oct 2022Oct 2025

Trustee, Psychosis, SANE



  • RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
  • Epidemiology
  • Personalised medicine
  • psychiatric epidemiology
  • Schizophrenia
  • psychosis
  • Bipolar Disorder
  • Clozapine
  • treatment resistant schizophrenia
  • RA0421 Public health. Hygiene. Preventive Medicine
  • Epidemiology
  • RZ Other systems of medicine
  • Psychiatry
  • psychiatric epidemiology
  • Schizophrenia
  • Bipolar Disorder
  • psychosis
  • RM Therapeutics. Pharmacology
  • Stratified medicine
  • Personalised medicine
  • Pharmacogenetics


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