Search results

• Finished

  A cryo-electron microscope for structural biology (including single-particle and tomography) at KCL.

  Conte, M., Atherton, J., Beavil, A., Bergeron, J., Booth, P., Burrone, J., Carlton, J., De Nicola, G., Ehler, E., Fleck, R., Fraternali, F., Garnett, J., Gautel, M., Isaacson, R., Kampourakis, T., Malim, M., McDonnell, J., Neil, S., Odendall, C., Pfuhl, M., Politis, A., Steiner, R. & Sutton, B.

  BBSRC Biotechnology and Biological Sciences Research Council

  1/08/2022 → 31/07/2023

  Project: Research

• Human secreted IgD: structure, interactions and mechanisms in allergic inflammation and asthma

  McDonnell, J., Beavil, A., Sutton, B. & academic, A.

  MRC Medical Research Council

  1/02/2021 → 30/06/2024

  Project: Research

• UKRI CoA: Elucidating the mechanisms of accelerated dissociation and allosteric processes in the antibody immunoglobulin E

  McDonnell, J.

  EPSRC Engineering and Physical Sciences Research Council

  1/11/2020 → 28/02/2021

  Project: Research

• Isothermal titration calorimetry instrumentation for structural biology, biological mechanisms and drug discovery

  Conte, M., Gautel, M., McDonnell, J., Isaacson, R., M. Barry, S., Garnett, J., Steiner, R., Muller, M., Pfuhl, M., Bergeron, J., Malim, M., Naglik, J., Kampourakis, T., Burgoyne, J., Pastore, A. & De Nicola, G.

  BBSRC Biotechnology and Biological Sciences Research Council

  1/10/2020 → 30/09/2021

  Project: Research

• UKRI CoA: Elucidating the mechanisms of allostery and accelerated dissociation in immunoglobulin E

  McDonnell, J.

  EPSRC Engineering and Physical Sciences Research Council

  1/08/2020 → 31/10/2020

  Project: Research

• Impact of the distinctive properties of human IgE on the activities of the B cell receptor and its implications for allergic disease and asthma

  Sutton, B., Beavil, A., Cox, S., Gould, H. & McDonnell, J.

  1/04/2017 → 31/03/2022

  Project: Research

• Elucidating the mechanisms of accelerated dissociation and allosteric processes in the antibody immunoglobulin E

  McDonnell, J. & Sutton, B.

  BBSRC Biotechnology and Biological Sciences Research Council

  1/01/2017 → 31/12/2019

  Project: Research

• King’s NMR Facility for structural biology, metabolic profiling and drug discovery

  Conte, M., Avkiran, M., Blower, P., Dodding, M., Eaton, P., Gautel, M., Irving, M., Malim, M., Marber, M., Mayr, M., McDonnell, J., Otsu, K., Pastore, A., Pfuhl, M., Poston, L., Shah, A., Shanahan, C., Shattock, M. & Williamson, C.

  BHF British Heart Foundation, Wellcome Trust

  1/01/2017 → 31/12/2021

  Project: Research

• MICA - Understanding allostery and accelerated dissociation in immunoglobulin E

  McDonnell, J. & Sutton, B.

  4/01/2016 → 3/01/2019

  Project: Research

• Biophysical analyses of the scavenger receptor CD36 as a target for intervention in atherosclerosis

  McDonnell, J. & academic, A.

  1/09/2015 → 31/08/2017

  Project: Research

• Demonstrating the feasibility of a novel avidity-based therapeutic antibody platform

  McDonnell, J., Beavil, A. & Sutton, B.

  3/08/2015 → 29/07/2016

  Project: Research

• Allosteric modulation of IgE with respect to interaction with FceRI and CD23

  McDonnell, J. & Sutton, B.

  UCB Pharma Ltd

  7/01/2013 → 6/01/2017

  Project: Research

• The role of CD23 in the regulation of inflammatory immune responses and target validation for therapeutic intervention

  McDonnell, J., Beavil, A., Gould, H. & Sutton, B.

  9/01/2012 → 8/01/2015

  Project: Research

• Structures and interactions of an allergy regulatory molecule

  McDonnell, J. & Beavil, A.

  Novartis Pharmaceuticals UK Ltd

  5/10/2011 → 4/10/2014

  Project: Research

• Development of a small-molecule IgE inhibitor for asthma and allergic disease

  McDonnell, J., Mountford, D., Sutton, B., Williams, G., Beavil, A., Dombrowicz, D. & Hutchings, R.

  1/01/2011 → 31/12/2013

  Project: Research

• The functional effects of stabilization of a molten globule-like domain from immunoglobulin E

  McDonnell, J.

  1/10/2010 → 30/09/2013

  Project: Research

• Chracterisation of small molecule inhibitors of the interaction between immunoglobulin E and CD23

  McDonnell, J.

  1/07/2010 → 27/08/2010

  Project: Research

• Identification of small-molecule inhibitors of IgE regulatory proteins

  McDonnell, J., Beavil, A. & Sutton, B.

  Asthma UK

  1/10/2009 → 30/09/2010

  Project: Research

• The C3d/CR2 interaction and its role in autoimmune disorders

  McDonnell, J.

  Arthritis Research UK

  1/09/2009 → 30/09/2011

  Project: Research

• King's Centre for Biomolecular Spectroscopy

  Sutton, B., Conte, M., Drake, A., Gautel, M., McDonnell, J. & Sanderson, M.

  Wellcome Trust

  1/11/2008 → 30/04/2015

  Project: Research

• Allergenicity and allergen dominance: structural requirements for IgE-dependent recognition by B cells and effector cells

  Lack, G., Sutton, B., Beavil, A., Gould, H., Heintzmann, R. & McDonnell, J.

  MRC Medical Research Council

  21/06/2006 → 20/12/2016

  Project: Research

• Structural studies of protein-protein interactions of the IgE network

  Sutton, B., Gould, H. & McDonnell, J.

  MRC Medical Research Council

  1/12/2003 → 30/11/2006

  Project: Research