Jeffrey Seow

2023

Broad and potent neutralizing antibodies are elicited in vaccinated individuals following Delta/BA.1 breakthrough infection

Seow, J., Shalim, Z. A., Graham, C., Kimuda, S., Pillai, A., Lechmere, T., Kurshan, A., Khimji, A. M., Snell, L. B., Nebbia, G., Mant, C., Waters, A., Fox, J., Malim, M. H. & Doores, K. J., 25 Sept 2023, In: Mbio. 14, 5

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2022

ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition-implications for COVID-19

El-Sayed Moustafa, J. S., Jackson, A. U., Brotman, S. M., Guan, L., Villicaña, S., Roberts, A. L., Zito, A., Bonnycastle, L., Erdos, M. R., Narisu, N., Stringham, H. M., Welch, R., Yan, T., Lakka, T., Parker, S., Tuomilehto, J., Seow, J., Graham, C., Huettner, I., Acors, S., & 16 othersKouphou, N., Wadge, S., Duncan, E. L., Steves, C. J., Doores, K. J., Malim, M. H., Collins, F. S., Pajukanta, P., Boehnke, M., Koistinen, H. A., Laakso, M., Falchi, M., Bell, J. T., Scott, L. J., Mohlke, K. L. & Small, K. S., Aug 2022, In: International Journal of Obesity. 46, 8, p. 1478-1486 9 p.

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Open Access

8 Citations (Scopus)

A neutralizing epitope on the SD1 domain of SARS-CoV-2 Spike targeted following infection and vaccination.

Seow, J., Khan, H., Rosa, A., Calvaresi, V., Graham, C., Pickering, S., Pye, V. E., Cronin, N., Huettner, I., Malim, M., Politis, A., Cherepanov, P. & Doores, K., 26 Jul 2022, (Accepted/In press) In: Cell Reports.

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Broad Neutralization of SARS-CoV-2 Variants, Including Omicron, following Breakthrough Infection with Delta in COVID-19-Vaccinated Individuals

Lechmere, T., Snell, L. B., Graham, C., Seow, J., Shalim, Z., Charalampous, T., Alcolea-Medina, A., Batra, R., Nebbia, G., Edgeworth, J., Malim, M. & Doores, K., 17 Mar 2022, In: Mbio. 13, 2

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19 Citations (Scopus)

191 Downloads (Pure)

ChAdOx1 nCoV-19 vaccine elicits monoclonal antibodies with cross-neutralizing activity against SARS-CoV-2 viral variants

Seow, J., Graham, C., Hallett, S., Lechmere, T., Maguire, T., Huettner, I., Cox, D., Khan, H., Pickering, S., Waters, A., Ward, C., Mant, C., Pitcher, M., Spencer, J., Fox, J., Malim, M. & Doores, K., 3 May 2022, In: Cell Reports. 39, 5, 110757.

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6 Citations (Scopus)

Concordance of B- and T-cell responses to SARS-CoV-2 infection, irrespective of symptoms suggestive of COVID-19

Österdahl, M. F., Christakou, E., Hart, D., Harris, F., Shahrabi, Y., Pollock, E., Wadud, M., Spector, T. D., Brown, M. A., Seow, J., Malim, M. H., Steves, C. J., Doores, K. J., Duncan, E. L. & Tree, T., Nov 2022, In: Journal of Medical Virology. 94, 11, p. 5217-5224 8 p.

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4 Citations (Scopus)

77 Downloads (Pure)

Contrasting Modes of New World Arenavirus Neutralization by Immunization-Elicited Monoclonal Antibodies

Ng, W. M., Sahin, M., Krumm, S. A., Seow, J., Zeltina, A., Harlos, K., Paesen, G. C., Pinschewer, D. D., Doores, K. J. & Bowden, T. A., Apr 2022, In: Mbio. 13, 2

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5 Citations (Scopus)

Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19

Joseph, M., Wu, Y., Dannebaum, R., Rubelt, F., Zlatareva, I., Lorenc, A., Du, Z. G., Davies, D., Kyle-Cezar, F., Das, A., Gee, S., Seow, J., Graham, C., Telman, D., Bermejo, C., Lin, H., Asgharian, H., Laing, A. G., Del Molino Del Barrio, I., Monin, L., & 21 othersMuñoz-Ruiz, M., McKenzie, D. R., Hayday, T. S., Francos-Quijorna, I., Kamdar, S., Davis, R., Sofra, V., Cano, F., Theodoridis, E., Martinez, L., Merrick, B., Bisnauthsing, K., Brooks, K., Edgeworth, J., Cason, J., Mant, C., Doores, K. J., Vantourout, P., Luong, K., Berka, J. & Hayday, A. C., 23 Aug 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 34, p. e2201541119 e2201541119.

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6 Citations (Scopus)

SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies

Fielding, C. A., Sabberwal, P., Williamson, J. C., Greenwood, E. J. D., Crozier, T. W. M., Zelek, W., Seow, J., Graham, C., Huettner, I., Edgeworth, J. D., Price, D., Morgan, B. P., Ladell, K., Eberl, M., Humphreys, I. R., Merrick, B., Doores, K., Wilson, S. J., Lehner, P. J., Wang, E. C. Y., & 1 othersStanton, R. J., May 2022, In: eLife. 11, e74489.

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21 Citations (Scopus)

2021

Clinical utility of targeted SARS-CoV-2 serology testing to aid the diagnosis and management of suspected missed, late or post-COVID-19 infection syndromes: Results from a pilot service implemented during the first pandemic wave

Sweeney, N., Merrick, B., Pedro Galão, R., Pickering, S., Botgros, A., Wilson, H. D., Signell, A. W., Betancor, G., Tan, M. K. I., Ramble, J., Kouphou, N., Acors, S., Graham, C., Seow, J., MacMahon, E., Neil, S. J. D., Malim, M. H., Doores, K., Douthwaite, S., Batra, R., & 2 othersNebbia, G. & Edgeworth, J. D., Apr 2021, In: PLoS ONE. 16, 4 April, p. e0249791 e0249791.

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6 Citations (Scopus)

Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant

Graham, C., Seow, J., Huettner, I., Khan, H., Kouphou, N., Acors, S., Winstone, H., Pickering, S., Ribeiro Galao, R. P., Dupont, L., Lista Brotos, M., Jimenez Guardeno, J., Laing, A., Wu, Y., Joseph, M., Muir, L., van Gils, M. J., Ng, W., Duyvesteyn, H., Zhao, Y., & 9 othersBowden, T. A., Shankar-Hari, M., Rosa, A., Cherepanov, P., McCoy, L. E., Hayday, A., Neil, S., Malim, M. & Doores, K., 29 Mar 2021, (Accepted/In press) In: Immunity.

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Safety and immunogenicity of one versus two doses of the COVID-19 vaccine BNT162b2 for patients with cancer: interim analysis of a prospective observational study

Monin, L., Laing, A. G., Muñoz-Ruiz, M., McKenzie, D. R., Del Molino Del Barrio, I., Alaguthurai, T., Domingo-Vila, C., Hayday, T. S., Graham, C., Seow, J., Abdul-Jawad, S., Kamdar, S., Harvey-Jones, E., Graham, R., Cooper, J., Khan, M., Vidler, J., Kakkassery, H., Sinha, S., Davis, R., & 24 othersDupont, L., Francos Quijorna, I., O'Brien-Gore, C., Lee, P. L., Eum, J., Conde Poole, M., Joseph, M., Davies, D., Wu, Y., Swampillai, A., North, B. V., Montes, A., Harries, M., Rigg, A., Spicer, J., Malim, M. H., Fields, P., Patten, P., Di Rosa, F., Papa, S., Tree, T., Doores, K. J., Hayday, A. C. & Irshad, S., Jun 2021, In: The Lancet Oncology. 22, 6, p. 765-778 14 p.

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409 Citations (Scopus)

SARS-CoV-2 can recruit a heme metabolite to evade antibody immunity

Rosa, A., Pye, V. E., Graham, C., Muir, L., Seow, J., Ng, K. W., Cook, N. J., Rees-Spear, C., Parker, E., Silva Dos Santos, M., Rosadas, C., Susana, A., Rhys, H., Nans, A., Masino, L., Roustan, C., Christodoulou, E., Ulferts, R., Wrobel, A. G., Short, C-E., & 20 othersFertleman, M., Sanders, R. W., Heaney, J., Spyer, M., Kjær, S., Riddell, A., Malim, M. H., Beale, R., MacRae, J. I., Taylor, G. P., Nastouli, E., van Gils, M. J., Rosenthal, P. B., Pizzato, M., McClure, M. O., Tedder, R. S., Kassiotis, G., McCoy, L. E., Doores, K. J. & Cherepanov, P., May 2021, In: Science Advances. 7, 22, eabg7607.

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Open Access

71 Citations (Scopus)

SARS-CoV-2 recruits a haem metabolite to evade antibody immunity

Rosa, A., Pye, V. E., Graham, C., Muir, L., Seow, J., Ng, K. W., Cook, N. J., Rees-Spear, C., Parker, E., Dos Santos, M. S., Rosadas, C., Susana, A., Rhys, H., Nans, A., Masino, L., Roustan, C., Christodoulou, E., Ulferts, R., Wrobel, A., Short, C-E., & 20 othersFertleman, M., Sanders, R. W., Heaney, J., Spyer, M., Kjær, S., Riddell, A., Malim, M. H., Beale, R., MacRae, J. I., Taylor, G. P., Nastouli, E., van Gils, M. J., Rosenthal, P. B., Pizzato, M., McClure, M. O., Tedder, R. S., Kassiotis, G., McCoy, L. E., Doores, K. J. & Cherepanov, P., 26 Jan 2021, In: MedRxiv.

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Single dose of BNT162b2 mRNA vaccine against SARS-CoV-2 induces high frequency of neutralising antibody and polyfunctional T-cell responses in patients with myeloproliferative neoplasms

Harrington, P., de Lavallade, H., Doores, K. J., O'Reilly, A., Seow, J., Graham, C., Lechmere, T., Radia, D., Dillon, R., Shanmugharaj, Y., Espehana, A., Woodley, C., Saunders, J., Curto-Garcia, N., O'Sullivan, J., Raj, K., Kordasti, S., Malim, M. H., Harrison, C. N. & McLornan, D. P., Dec 2021, In: Leukemia. 35, 12, p. 3573-3577 5 p.

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37 Citations (Scopus)

Single dose of BNT162b2 mRNA vaccine against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) induces neutralising antibody and polyfunctional T-cell responses in patients with chronic myeloid leukaemia

Harrington, P., Doores, K. J., Radia, D., O'Reilly, A., Lam, H. P. J., Seow, J., Graham, C., Lechmere, T., McLornan, D., Dillon, R., Shanmugharaj, Y., Espehana, A., Woodley, C., Saunders, J., Curto-Garcia, N., O'Sullivan, J., Raj, K., Kordasti, S., Malim, M. H., Harrison, C., & 1 othersde Lavallade, H., Sept 2021, In: British Journal of Haematology. 194, 6, p. 999-1006 8 p.

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50 Citations (Scopus)

The effect of spike mutations on SARS-CoV-2 neutralization

SAFER Investigators, 23 Mar 2021, In: Cell Reports. 34, 12, p. 108890 108890.

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136 Citations (Scopus)

The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate

Gee, S., Chandiramani, M., Seow, J., Pollock, E., Modestini, C., Das, A., Tree, T., Doores, K., Tribe, R. & Gibbons, D., Dec 2021, In: Nature Immunology. 22, 12, p. 1490-1502 13 p.

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51 Citations (Scopus)

23 Downloads (Pure)

2020

A dynamic COVID-19 immune signature includes associations with poor prognosis

Laing, A. G., Lorenc, A., del Molino del Barrio, I., Das, A., Fish, M., Monin, L., Muñoz-Ruiz, M., McKenzie, D. R., Hayday, T. S., Francos-Quijorna, I., Kamdar, S., Joseph, M., Davies, D., Davis, R., Jennings, A., Zlatareva, I., Vantourout, P., Wu, Y., Sofra, V., Cano, F., & 30 othersGreco, M., Theodoridis, E., Freedman, J., Gee, S., Chan, J. N. E., Ryan, S., Bugallo-Blanco, E., Peterson, P., Kisand, K., Haljasmägi, L., Chadli, L., Moingeon, P., Martinez, L., Merrick, B., Bisnauthsing, K., Brooks, K., Ibrahim, M. A. A., Mason, J., Lopez Gomez, F., Babalola, K., Abdul-Jawad, S., Cason, J., Mant, C., Seow, J., Graham, C., Doores, K. J., Di Rosa, F., Edgeworth, J., Shankar-Hari, M. & Hayday, A. C., 1 Oct 2020, In: Nature Medicine. 26, 10, p. 1623-1635 13 p.

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568 Citations (Scopus)

Comparative assessment of multiple COVID-19 serological technologies supports continued evaluation of point-of-care lateral flow assays in hospital and community healthcare settings

Pickering, S., Betancor, G., Galão, R. P., Merrick, B., Signell, A. W., Wilson, H. D., Kia Ik, M. T., Seow, J., Graham, C., Acors, S., Kouphou, N., Steel, K. J. A., Hemmings, O., Patel, A., Nebbia, G., Douthwaite, S., O'Connell, L., Luptak, J., McCoy, L. E., Brouwer, P., & 11 othersvan Gils, M. J., Sanders, R. W., Martinez Nunez, R., Bisnauthsing, K., O'Hara, G., MacMahon, E., Batra, R., Malim, M. H., Neil, S. J. D., Doores, K. J. & Edgeworth, J. D., 24 Sept 2020, In: PLoS Pathogens. 16, 9, 19 p., e1008817.

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77 Citations (Scopus)

142 Downloads (Pure)

Estimates of the rate of infection and asymptomatic COVID-19 disease in a population sample from SE England

Wells, P. M., Doores, K. J., Couvreur, S., Nunez, R. M., Seow, J., Graham, C., Acors, S., Kouphou, N., Neil, S. J. D., Tedder, R. S., Matos, P. M., Poulton, K., Lista, M. J., Dickenson, R. E., Sertkaya, H., Maguire, T. J. A., Scourfield, E. J., Bowyer, R. C. E., Hart, D., O'Byrne, A., & 11 othersSteel, K. J. A., Hemmings, O., Rosadas, C., McClure, M. O., Capedevilla-pujol, J., Wolf, J., Ourselin, S., Brown, M. A., Malim, M. H., Spector, T. & Steves, C. J., Dec 2020, In: Journal of Infection. 81, 6, p. 931-936 6 p.

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34 Citations (Scopus)

Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans

Seow, J., Graham, C., Merrick, B., Acors, S., Pickering, S., Steel, K. J. A., Hemmings, O., O’Byrne, A., Kouphou, N., Galao, R. P., Betancor, G., Wilson, H. D., Signell, A. W., Winstone, H., Kerridge, C., Huettner, I., Jimenez-Guardeño, J. M., Lista, M. J., Temperton, N., Snell, L. B., & 22 othersBisnauthsing, K., Moore, A., Green, A., Martinez, L., Stokes, B., Honey, J., Izquierdo-Barras, A., Arbane, G., Patel, A., Tan, M. K. I., O’Connell, L., O’Hara, G., MacMahon, E., Douthwaite, S., Nebbia, G., Batra, R., Martinez-Nunez, R., Shankar-Hari, M., Edgeworth, J. D., Neil, S. J. D., Malim, M. H. & Doores, K. J., 1 Dec 2020, In: Nature Microbiology. 5, 12, p. 1598-1607 10 p.

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810 Citations (Scopus)

49 Downloads (Pure)

Molecular rationale for antibody-mediated targeting of the hantavirus fusion glycoprotein

Rissanen, I., Stass, R., Krumm, S. A., Seow, J., Hulswit, R. J., Paesen, G. C., Hepojoki, J., Vapalahti, O., Lundkvist, Å., Reynard, O., Volchkov, V., Doores, K. J., Huiskonen, J. T. & Bowden, T. A., 22 Dec 2020, In: eLife. 9

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13 Citations (Scopus)

2019

A structural basis for antibody-mediated neutralization of Nipah virus reveals a site of vulnerability at the fusion glycoprotein apex

Avanzato, V. A., Oguntuyo, K. Y., Escalera-Zamudio, M., Gutierrez, B., Golden, M., Kosakovsky Pond, S. L., Pryce, R., Walter, T. S., Seow, J., Doores, K. J., Pybus, O. G., Munster, V. J., Lee, B. & Bowden, T. A., 10 Dec 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 50, p. 25057-25067 11 p.

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30 Citations (Scopus)

35 Downloads (Pure)

Jeffrey Seow

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