Jernej Ule

Jernej Ule

Professor

 https://orcid.org/0000-0002-2452-4277
    • 15967
      Citations

    Personal profile

    Biographical details

     

    Jernej obtained his BSc in Molecular Biology from the University of Ljubljana, Slovenia in 1999, and PhD and short postdoc with Bob Darnell at the Rockefeller University, New York, during 2000-2006.

    Jernej started his research group at the MRC Laboratory of Molecular Biology in Cambridge in July 2006, in April 2013, the group moved to the Queen Square UCL Institute of Neurology in London, and in August 2016 was seconded to The Francis Crick Institute.

    In 2020, Jernej started a satellite team at the Institute of Chemistry in Ljubljana funded by ERC advanced grant.

    Jernej is an EMBO fellow and member of London RNA club.

    In April 2022, Jernej was appointed as UK DRI Centre Director at King's College London based at the Maurice Wohl Clinical Neuroscience Institute.

    Research interests (short)

    RNA biology and the role of RNA in neurodegenerative diseases.

    Development of techniques that integrate biochemistry and computational biology to obtain a comprehensive map of interactions between proteins and their RNA partners within cells.

    Expertise related to UN Sustainable Development Goals

    In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

    • SDG 3 - Good Health and Well-being
    • SDG 16 - Peace, Justice and Strong Institutions

    External positions

    Group Leader , Natl Inst Chem, National Institute of Chemistry - Slovenia

    20 Jan 2020 → 31 Oct 2024

    Seconded Group Leader , Francis Crick Institute

    16 Aug 2016 → 30 Sept 2022

    Professor of Molecular Neuroscience

    1 Apr 2013 → 31 Mar 2022

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    Collaborations and top research areas from the last five years

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    • Creation of de novo cryptic splicing for ALS and FTD precision medicine

      Wilkins, O. G., Chien, M. Z. Y. J., Wlaschin, J. J., Barattucci, S., Harley, P., Mattedi, F., Mehta, P. R., Pisliakova, M., Ryadnov, E., Keuss, M. J., Thompson, D., Digby, H., Knez, L., Simkin, R. L., Diaz, J. A., Zanovello, M., Brown, A. L., Darbey, A., Karda, R. & Fisher, E. M. C. & 4 others, Cunningham, T. J., Le Pichon, C. E., Ule, J. & Fratta, P., 4 Oct 2024, In: Science (New York, N.Y.). 386, 6717, p. 61-69 9 p.

      Research output: Contribution to journal › Article › peer-review

      8 Citations (Scopus)

    • From computational models of the splicing code to regulatory mechanisms and therapeutic implications

      Capitanchik, C., Wilkins, O. G., Wagner, N., Gagneur, J. & Ule, J., 2024, (Accepted/In press) In: NATURE REVIEWS GENETICS.

      Research output: Contribution to journal › Review article › peer-review

      3 Citations (Scopus)

    • Interrogation of RNA-protein interaction dynamics in bacterial growth

      Monti, M., Herman, R., Mancini, L., Capitanchik, C., Davey, K., Dawson, C. S., Ule, J., Thomas, G. H., Willis, A. E., Lilley, K. S. & Villanueva, E., 2 May 2024, In: Molecular Systems Biology. 20, 5, p. 573-589 17 p.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      1 Citation (Scopus)

    • Mis-spliced transcripts generate de novo proteins in TDP-43–related Als/FTD

      Seddighi, S., Qi, Y. A., Brown, A. L., Wilkins, O. G., Bereda, C., Belair, C., Zhang, Y. J., Prudencio, M., Keuss, M. J., Khandeshi, A., Pickles, S., Kargbo-Hill, S. E., Hawrot, J., Ramos, D. M., Yuan, H., Roberts, J., Sacramento, E. K., Shah, S. I., Nalls, M. A. & Colón-Mercado, J. M. & 30 others, Reyes, J. F., Ryan, V. H., Nelson, M. P., Cook, C. N., Li, Z., Screven, L., Kwan, J. Y., Mehta, P. R., Zanovello, M., Hallegger, M., Shantaraman, A., Ping, L., Koike, Y., Oskarsson, B., Staff, N. P., Duong, D. M., Ahmed, A., Secrier, M., Ule, J., Jacobson, S., Reich, D. S., Rohrer, J. D., Malaspina, A., Dickson, D. W., Glass, J. D., Ori, A., Seyfried, N. T., Maragkakis, M., Petrucelli, L. & Fratta, P., 2024, In: Science translational medicine. 16, 734, eadg7162.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      44 Citations (Scopus)

    • NEAT1 modulates the TIRR/53BP1 complex to maintain genome integrity

      Kilgas, S., Syed, A., Toolan-Kerr, P., Swift, M. L., Roychoudhury, S., Sarkar, A., Wilkins, S., Quigley, M., Poetsch, A. R., Botuyan, M. V., Cui, G., Mer, G., Ule, J., Drané, P. & Chowdhury, D., Dec 2024, In: Nature Communications. 15, 1, 8438.

      Research output: Contribution to journal › Article › peer-review

      Open Access
      2 Citations (Scopus)
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    • 1 Membership of committee
    • 1 Membership of network