Research output per year
Research output per year
Personal profile
Biographical details
Jernej obtained his BSc in Molecular Biology from the University of Ljubljana, Slovenia in 1999, and PhD and short postdoc with Bob Darnell at the Rockefeller University, New York, during 2000-2006.
Jernej started his research group at the MRC Laboratory of Molecular Biology in Cambridge in July 2006, in April 2013, the group moved to the Queen Square UCL Institute of Neurology in London, and in August 2016 was seconded to The Francis Crick Institute.
In 2020, Jernej started a satellite team at the Institute of Chemistry in Ljubljana funded by ERC advanced grant.
Jernej is an EMBO fellow and member of London RNA club.
In April 2022, Jernej was appointed as UK DRI Centre Director at King's College London based at the Maurice Wohl Clinical Neuroscience Institute.
Research interests (short)
RNA biology and the role of RNA in neurodegenerative diseases.
Development of techniques that integrate biochemistry and computational biology to obtain a comprehensive map of interactions between proteins and their RNA partners within cells.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Group Leader , Natl Inst Chem, National Institute of Chemistry - Slovenia
20 Jan 2020 → 31 Oct 2024
Seconded Group Leader , Francis Crick Institute
16 Aug 2016 → 30 Sept 2022
Professor of Molecular Neuroscience
1 Apr 2013 → 31 Mar 2022
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion
Lin*, J. Q., Khuperkar*, D., Pavlou, S., Makarchuk, S., Patikas, N., Lee, F. C., Zbiegly, J. M., Kang, J., Field, S. F., Bailey, D. M., Freeman, J. L., Ule, J., Metzakopian, E., Ruepp, M.-D. & Mallucci, G. R., 17 Jul 2023, In: The EMBO journal. 42, 14, p. e113168Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
A computationally-enhanced hiCLIP atlas reveals Staufen1 RNA binding features and links 3'UTR structure to RNA metabolism
Ule, J., Chakrabarti, A. M., Lee, F. C. Y., Luscombe, N. M. & Iosub, I., 1 Jan 2022, Cold Spring Harbor Laboratory Press.Research output: Working paper/Preprint › Preprint
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CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1
Hluchý, M., Gajdušková, P., Ruiz de los Mozos, I., Rájecký, M., Kluge, M., Berger, B. T., Slabá, Z., Potěšil, D., Weiß, E., Ule, J., Zdráhal, Z., Knapp, S., Paruch, K., Friedel, C. C. & Blazek, D., 22 Sept 2022, In: Nature. 609, 7928, p. 829-834 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)271 Downloads (Pure) -
Identifying ribosome heterogeneity using ribosome profiling
Alkan, F., Wilkins, O. G., Hernández-Pérez, S., Ramalho, S., Silva, J., Ule, J. & Faller, W. J., 9 Sept 2022, In: Nucleic Acids Research. 50, 16, p. e95Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)86 Downloads (Pure) -
m6A reader Pho92 is recruited co-transcriptionally and couples translation efficacy to mRNA decay to promote meiotic fitness in yeast
Ule, J., Varier, R. A., Sideri, T., Capitanchik, C., Manova, Z., Calvani, E., Rossi, A., Edupuganti, R., Ensinck, I., Chan, V. W. C., Patel, H., Kirkpatrick, J., Faull, P. A., Snijders, A. P., Vermeulen, M., Ralser, M., Luscombe, N. M. & van Werven, F. J., 1 Jan 2022, Cold Spring Harbor Laboratory Press.Research output: Working paper/Preprint › Preprint
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Disentangling a new paradigm for mutual homeostasis of aggregation-prone proteins
Miller, A. (Primary Investigator) & Ule, J. (Co-Investigator)
1/11/2024 → 31/10/2029
Project: Research
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The role of nuclear speckles in the mutual homeostasis of aggregation-prone proteins
Miller, A. (Primary Investigator) & Ule, J. (Co-Investigator)
UKDRI UK Dementia Research Institute
1/10/2024 → 30/09/2025
Project: Research
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The role of O-GlcNAcylation as a convergent protective mechanism from ALS/FTD mutations
James, O. G. (Primary Investigator), Ule, J. (Co-Investigator) & Zagalak, J. (Co-Investigator)
UKDRI UK Dementia Research Institute
1/06/2024 → 31/05/2025
Project: Research
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Understanding the modifiers of dysregulated RNA metabolism in ALS/FTD
Ule, J. (Primary Investigator) & James, O. G. (Co-Investigator)
1/02/2024 → 31/01/2029
Project: Research
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Neuronal Tau-RNA interactions in health and disease
Ule, J. (Primary Investigator)
10/01/2024 → 9/01/2026
Project: Research
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EMBO European Molecular Biology Organisation (External organisation)
Ule, J. (Member)
1 Jan 2017 → 31 Dec 2021Activity: Membership › Membership of committee
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EMBO European Molecular Biology Organisation (External organisation)
Ule, J. (Member)
1 Jan 2016Activity: Membership › Membership of network
Prizes
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RNA society mid-career award 2020
Ule, J. (Recipient), 6 Dec 2019
Prize: Prize (including medals and awards)