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John Murphy

Dr

  • 540
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Personal profile

Research interests

ZFP36 family proteins and their roles in normal and malignant B cells.
The ZFP36 family consists of 3 major human proteins and include ZFP36 (TIS11, TTP, Nup475, GOS24), ZFP36L1 (TIS11b, Berg36, ERF-1, BRF-1) and ZFP36L2 (TIS11d, ERF-2, BRF-2). ZFP36 family proteins function as post-transcriptional regulators of gene expression. They appear to interact with mRNAs containing adenine-uridine rich elements (AREs) in their 3’ untranslated regions and destabilise them. Our studies focus on ZFP36L1 which we originally cloned from human B leukemic cells. There is currently limited information on the mRNA targets and cell functions of this protein. Current interests are in studying the role of ZFP36L1 in normal and malignant B cell development and function and identifying novel target mRNAs of this protein.

Autoantibody targets and functions in anti-phospholipid syndrome and Lupus
We have been interested in characterising autoantibody gene targets in Lupus using cDNA expression libraries. More recently we have focussed on anti-Beta 2 GPI antibodies in anti-phospholipid syndrome (APS) as compelling evidence suggests these antibodies are responsible for pathology in this disease. We characterized APS-derived anti-Beta 2 GPI regulated gene targets in human endothelial cells using gene microarray analysis. Current interests are in trying to identify new therapeutic strategies for APS by interfering with anti-Beta 2 GPI interactions and functional effects using biologics and small molecule inhibitors.

Research interests (short)

1. ZFP36 proteins and B cell functions 2. Autoantibodies in antiphospholipid syndrome and lupus

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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