John Powell

2023

Psychosis Endophenotypes: A Gene-Set-Specific Polygenic Risk Score Analysis

Genetic Risk and Outcome of Psychosis (GROUP) Study, Psychosis Endophenotypes International Consortium (PEIC) & Wang, B., Nov 2023, In: Schizophrenia Bulletin. 49, 6, p. 1625-1636 12 p.

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1 Citation (Scopus)

2022

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Indonesia Schizophrenia Consortium, PsychENCODE, Psychosis Endophenotypes International Consortium, SynGO Consortium & Schizophrenia Working Group of the Psychiatric Genomics Consortium, 21 Apr 2022, In: Nature. 604, 7906, p. 502-508 7 p.

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1264 Citations (Scopus)

2021

A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts

Schizophrenia Working Group of the Psychiatric Genomics Consortium & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 1 Nov 2021, In: Biological psychiatry. 90, 9, p. 611-620 10 p.

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119 Citations (Scopus)

Genetic copy number variants, cognition and psychosis: a meta-analysis and a family study

Thygesen, J. H., Presman, A., Harju-seppänen, J., Irizar, H., Jones, R., Kuchenbaecker, K., Lin, K., Alizadeh, B. Z., Austin-zimmerman, I., Bartels-velthuis, A., Bhat, A., Bruggeman, R., Cahn, W., Calafato, S., Crespo-facorro, B., De Haan, L., De Zwarte, S. M. C., Di Forti, M., Díez-revuelta, Á. & Hall, J. & 37 others, Hall, M.-H., Iyegbe, C., Jablensky, A., Kahn, R., Kalaydjieva, L., Kravariti, E., Lawrie, S., Luykx, J. J., Mata, I., Mcdonald, C., Mcintosh, A. M., Mcquillin, A., Muir, R., Ophoff, R., Picchioni, M., Prata, D. P., Ranlund, S., Rujescu, D., Rutten, B. P. F., Schulze, K., Shaikh, M., Schirmbeck, F., Simons, C. J. P., Toulopoulou, T., Van Amelsvoort, T., Van Haren, N., Van Os, J., Van Winkel, R., Vassos, E., Walshe, M., Weisbrod, M., Zartaloudi, E., Bell, V., Powell, J., Lewis, C. M., Murray, R. M. & Bramon, E., 1 Sept 2021, In: Molecular Psychiatry. 26, 9, p. 5307-5319

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22 Citations (Scopus)

2019

A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer’s disease

Ashton, N. J., Nevado-Holgado, A. J., Barber, I. S., Lynham, S., Gupta, V. B., Chatterjee, P., Goozee, K., Hone, E., Pedrini, S., Blennow, K., Schöll, M., Zetterberg, H., Ellis, K. A., Bush, A. I., Rowe, C., Villemagne, V. L., Ames, D., Masters, C. L., Aarsland, D. & Powell, J. F. & 3 others, Lovestone, S., Martins, R. N. & Hye, A., 6 Feb 2019, In: Science Advances. 5, 2, eaau7220.

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59 Citations (Scopus)

Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer’s disease

Baker, E., Sims, R., Leonenko, G., Frizzati, A., Harwood, J. C., Grozeva, D., Morgan, K., Passmore, P., Holmes, C., Powell, J., Brayne, C., Gill, M., Mead, S., Bossù, P., Spalletta, G., Goate, A. M., Cruchaga, C., Maier, W., Heun, R. & Jessen, F. & 16 others, Peters, O., Dichgans, M., FröLich, L., Ramirez, A., Jones, L., Hardy, J., Ivanov, D., Hill, M., Holmans, P., Allen, N. D., Morgan, B. P., Seshadri, S., Schellenberg, G. D., Amouyel, P., Williams, J. & Escott-Price, V., 1 Jul 2019, In: PLoS ONE. 14, 7, e0218111.

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21 Citations (Scopus)

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Alzheimer Disease Genetics Consortium (ADGC), Mar 2019, In: Nature Genetics. 51, 3, p. 414-430 17 p.

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1868 Citations (Scopus)

Telomere length is greater in ALS than in controls: A whole genome sequencing study

Al Khleifat, A., Iacoangeli, A., Shatunov, A., Fang, T., Sproviero, W., Jones, A. R., Opie-Martin, S., Morrison, K. E., Shaw, P. J., Shaw, C. E. D., Powell, J. F., Dobson, R. J. B., Newhouse, S. & Al-Chalabi, A., 3 Apr 2019, In: Amyotrophic lateral sclerosis & frontotemporal degeneration. 20, 3-4, p. 229-234 6 p., IAFD 1586951.

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21 Citations (Scopus)

235 Downloads (Pure)

2018

A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease

AESG, Hartl, D., May, P., Gu, W., Mayhaus, M., Pichler, S., Spaniol, C., Glaab, E., Bobbili, D. R., Antony, P., Koegelsberger, S., Kurz, A., Grimmer, T., Morgan, K., Vardarajan, B. N., Reitz, C., Hardy, J., Bras, J., Guerreiro, R. & Balling, R. & 12 others, Schneider, J. G., Riemenschneider, M., Sassi, C., Gibbs, J. R., Hernandez, D., Brookes, K. J., Guetta-Baranes, T., Francis, P. T., Lupton, M. K., Brown, K., Powell, J. & Singleton, A., 9 Jul 2018, In: Molecular Psychiatry. 11 p.

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46 Citations (Scopus)

Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology

Smith, R. G., Hannon, E., De Jager, P. L., Chibnik, L., Lott, S. J., Condliffe, D., Smith, A. R., Haroutunian, V., Troakes, C., Al-Sarraj, S., Bennett, D. A., Powell, J., Lovestone, S., Schalkwyk, L., Mill, J. & Lunnon, K., 14 Mar 2018, In: Alzheimer's & Dementia. 14, 12, p. 1580-1588

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127 Citations (Scopus)

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Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: Critical influence of CSF1R and NOTCH3

Sassi, C., Nalls, M. A., Ridge, P. G., Gibbs, J. R., Lupton, M. K., Troakes, C., Lunnon, K., Al-Sarraj, S., Brown, K. S., Medway, C., Lord, J., Turton, J., Bras, J., Blumenau, S., Thielke, M., Josties, C., Freyer, D., Dietrich, A., Hammer, M. & Baier, M. & 10 others, Dirnagl, U., Morgan, K., Powell, J. F., Kauwe, J. S., Cruchaga, C., Goate, A. M., Singleton, A. B., Guerreiro, R., Hodges, A. & Hardy, J., Jun 2018, In: Neurobiology of Aging. p. 179.e17-179.e29

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37 Citations (Scopus)

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Red blood cell indices and anaemia as causative factors for cognitive function deficits and for Alzheimer's disease

Winchester, L. M., Powell, J., Lovestone, S. & Nevado-Holgado, A. J., 28 Jun 2018, In: Genome medicine. 10, 1, 51.

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52 Citations (Scopus)

Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders

Genetic Risk and Outcome of Psychosis (GROUP) consortium, Sept 2018, In: The British journal of psychiatry : the journal of mental science. 213, 3, p. 535-541 7 p.

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41 Citations (Scopus)

2017

An Examination of Polygenic Score Risk Prediction in Individuals with First Episode Psychosis

Vassos, E., Di Forti, M., Coleman, J., Iyegbe, C., Prata, D., Euesden, J., O'Reilly, P., Curtis, C., Kolliakou, A., Patel, H., Newhouse, S., Traylor, M., Ajnakina, O., Mondelli, V., Marques, T. R., Gardner-Sood, P., Aitchison, K. J., Powell, J., Atakan, Z. & Greenwood, K. E. & 10 others, Smith, S., Ismail, K., Pariante, C., Gaughran, F., Dazzan, P., Markus, H. S., David, A. S., Lewis, C. M., Murray, R. M. & Breen, G., 15 Mar 2017, In: Biological psychiatry. 81, 6, p. 470-477 8 p.

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155 Citations (Scopus)

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A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains

Ranlund, S., Calafato, S., Thygesen, J. H., Lin, K., Cahn, W., Crespo-Facorro, B., de Zwarte, S. M. C., Díez, Á., Di Forti, M., Iyegbe, C., Jablensky, A., Jones, R., Hall, M. H., Kahn, R., Kalaydjieva, L., Kravariti, E., Mcdonald, C., Mcintosh, A. M., Mcquillin, A. & Picchioni, M. & 13 others, Prata, D. P., Rujescu, D., Schulze, K., Shaikh, M., Toulopoulou, T., van Haren, N., van Os, J., Vassos, E., Walshe, M., Lewis, C., Murray, R. M., Powell, J. & Bramon, E., 29 Aug 2017, (E-pub ahead of print) In: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 177, 1, p. 21-34

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58 Citations (Scopus)

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Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease

Kim, M., Nevado-Holgado, A., Whiley, L., Snowden, S. G., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Thambisetty, M., Dobson, R. J. B., Powell, J. E., Lupton, M. K., Simmons, A., Velayudhan, L., Lovestone, S., Proitsi, P. & Legido-Quigley, C., 3 Oct 2017, In: JOURNAL OF ALZHEIMERS DISEASE. 60, 3, p. 809-817

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77 Citations (Scopus)

254 Downloads (Pure)

ATXN2 trinucleotide repeat length correlates with risk of ALS

Sproviero, W., Shatunov, A., Stahl, D., Shoai, M., van Rheenen, W., Jones, A. R., Al-Sarraj, S., Andersen, P. M., Bonini, N. M., Conforti, F. L., Van Damme, P., Daoud, H., Del Mar Amador, M., Fogh, I., Forzan, M., Gaastra, B., Gellera, C., Gitler, A. D., Hardy, J. & Fratta, P. & 27 others, La Bella, V., Le Ber, I., Van Langenhove, T., Lattante, S., Lee, Y.-C., Malaspina, A., Meininger, V., Millecamps, S., Orrell, R., Rademakers, R., Robberecht, W., Rouleau, G., Ross, O. A., Salachas, F., Sidle, K., Smith, B. N., Soong, B.-W., Sorarù, G., Stevanin, G., Kabashi, E., Troakes, C., van Broeckhoven, C., Veldink, J. H., van den Berg, L. H., Shaw, C. E., Powell, J. F. & Al-Chalabi, A., Mar 2017, In: Neurobiology of Aging. 51, p. 178.e1-178.e9

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96 Citations (Scopus)

278 Downloads (Pure)

Mitochondrial genes are altered in blood early in Alzheimer's disease

Lunnon, K., Keohane, A., Pidsley, R., Newhouse, S., Riddoch-Contreras, J., Thubron, E. B., Devall, M., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Schalkwyk, L., Dobson, R., Malik, A. N., Powell, J., Lovestone, S. & Hodges, A., 1 May 2017, In: Neurobiology of Aging. 53, p. 36-47 12 p.

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136 Citations (Scopus)

351 Downloads (Pure)

No Genetic Overlap between Circulating Iron Levels and Alzheimer's Disease

Lupton, M. K., Benyamin, B., Proitsi, P., Nyholt, D. R., Ferreira, M. A., Montgomery, G. W., Heath, A. C., Madden, P. A., Medland, S. E., Gordon, S. D., Lovestone, S., Tsolaki, M., Kloszewska, I., Soininen, H., Mecocci, P., Vellas, B., Powell, J. F., Bush, A. I., Wright, M. J. & Martin, N. G. & 1 others, Whitfield, J. B., 3 Jul 2017, In: JOURNAL OF ALZHEIMERS DISEASE. 59, 1, p. 85-99 15 p.

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11 Citations (Scopus)

297 Downloads (Pure)

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Sims, R., van der Lee, S. J., Naj, A. C., Bellenguez, C., Badarinarayan, N., Jakobsdottir, J., Kunkle, B. W., Boland, A., Raybould, R., Bis, J. C., Martin, E. R., Grenier-Boley, B., Heilmann-Heimbach, S., Chouraki, V., Kuzma, A. B., Sleegers, K., Vronskaya, M., Ruiz, A., Graham, R. R. & Olaso, R. & 31 others, Hoffmann, P., Grove, M. L., Vardarajan, B. N., Hiltunen, M., Nöthen, M. M., White, C. C., Hamilton-Nelson, K. L., Epelbaum, J., Maier, W., Choi, S.-H., Beecham, G. W., Dulary, C., Herms, S., Smith, A. V., Funk, C. C., Derbois, C., Forstner, A. J., Ahmad, S., Li, H., Bacq, D., Harold, D., Satizabal, C. L., Valladares, O., Lupton, M. K., Proitsi, P., Hodges, A., Patel, Y., Al-Chalabi, A., Shaw, C. E., Powell, J. & ARUK Consortium, 1 Sept 2017, In: Nature Genetics. 49, p. 1373-1384

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688 Citations (Scopus)

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Rheumatoid arthritis and risk for Alzheimer's disease: A systematic review and meta-analysis and a Mendelian Randomization study

Policicchio, S., Ahmad, A. N., Powell, J. & Proitsi, P., 1 Dec 2017, In: Scientific Reports. 7, 1, 12861.

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35 Citations (Scopus)

212 Downloads (Pure)

2016

ABCA7 p.G215S as potential protective factor for Alzheimer’s disease

Sassi, C., Nalls, M. A., Ridge, P. G., Gibbs, R., Ding, J., Lupton, M. K., Troakes, C., Lunnon, K., Al-Sarraj, S., Brown, K. S., Medway, C., Clement, N., Lord, J., Turton, J., Bras, J., Almeida, M. R., Passmore, P., Craig, D., Johnston, J. & McGuinness, B. & 30 others, Todd, S., Heun, R., Kölsch, H., Kehoe, P. G., Vardy, E. R. L. C., Hooper, N. M., Mann, D. M., Pickering-Brown, S., Brown, K., Lowe, J., Morgan, K., Smith, A. D., Wilcock, G., Warden, D., Holmes, C., Holstege, H., Louwersheimer, E., van der Flier, W., Scheltens, P., Van Swieten, J. C., Santana, I., Oliveira, C., Morgan, K., Powell, J. F., Kauwe, J. S., Cruchaga, C., Goate, A. M., Singleton, A. B., Guerreiro, R. & Hardy, J., 20 Apr 2016, (E-pub ahead of print) In: Neurobiology of Aging.

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47 Citations (Scopus)

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A novel Alzheimer disease locus located near the gene encoding tau protein

Jun, G., Ibrahim-Verbaas, C. A., Vronskaya, M., Lambert, J.-C., Chung, J., Naj, A. C., Kunkle, B. W., Wang, L.-S., Bis, J. C., Bellenguez, C., Harold, D., Lunetta, K. L., Destefano, A. L., Grenier-Boley, B., Sims, R., Beecham, G. W., Smith, A. V., Chouraki, V., Hamilton-Nelson, K. L. & Ikram, M. A. & 31 others, Fievet, N., Denning, N., Martin, E. R., Schmidt, H., Kamatani, Y., Dunstan, M. L., Valladares, O., Laza, A. R., Zelenika, D., Ramirez, A., Foroud, T. M., Choi, S.-H., Boland, A., Becker, T., Kukull, W. A., van der Lee, S. J., Pasquier, F., Cruchaga, C., Beekly, D., Fitzpatrick, A. L., Hanon, O., Gill, M., Barber, R., Gudnason, V., Campion, D., Love, S., Bennett, D. A., Amin, N., Powell, J. F., IGAP Consortium & Proitsi, P., Jan 2016, In: Molecular Psychiatry. 21, 1, p. 108-17 10 p.

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195 Citations (Scopus)

Association of a Locus in the CAMTA1 Gene With Survival in Patients With Sporadic Amyotrophic Lateral Sclerosis

Fogh, I., Lin, K., Tiloca, C., Rooney, J., Gellera, C., Diekstra, F. P., Ratti, A., Shatunov, A., Van Es, M. A., Proitsi, P., Jones, A., Sproviero, W., Chiò, A., McLaughlin, R. L., Sorarù, G., Corrado, L., Stahl, D., Del Bo, R., Cereda, C. & Castellotti, B. & 29 others, Glass, J. D., Newhouse, S., Dobson, R., Smith, B. N., Topp, S., Van Rheenen, W., Meininger, V., Melki, J., Morrison, K. E., Shaw, P. J., Leigh, P. N., Andersen, P. M., Comi, G. P., Ticozzi, N., Mazzini, L., D'Alfonso, S., Traynor, B. J., Van Damme, P., Robberecht, W., Brown, R. H., Landers, J. E., Hardiman, O., Lewis, C. M., Van Den Berg, L. H., Shaw, C. E., Veldink, J. H., Silani, V., Al-Chalabi, A. & Powell, J., 1 Jul 2016, In: JAMA Neurology. 73, 7, p. 812-820 9 p.

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59 Citations (Scopus)

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Association of blood lipids with Alzheimer's disease: A comprehensive lipidomics analysis

Proitsi, P., Kim, M., Whiley, L., Simmons, A., Sattlecker, M., Velayudhan, L., Lupton, M. K., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Lovestone, S., Powell, J. F., Dobson, R. J. B. & Legido-Quigley, C., 28 Sept 2016, In: Alzheimer's & Dementia. 13, 2, p. 140-151 12 p.

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153 Citations (Scopus)

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Genetic influences on schizophrenia and subcortical brain volumes: Large-scale proof of concept

Psychosis Endophenotypes International Consortium, 23 Feb 2016, In: Nature Neuroscience. 19, 3, p. 420-431 12 p.

Research output: Contribution to journal › Article › peer-review

171 Citations (Scopus)

Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases

Guerreiro, R., Escott-Price, V., Darwent, L., Parkkinen, L., Ansorge, O., Hernandez, D. G., Nalls, M. A., Clark, L., Honig, L., Marder, K., van der Flier, W., Holstege, H., Louwersheimer, E., Lemstra, A., Scheltens, P., Rogaeva, E., St George-Hyslop, P., Londos, E., Zetterberg, H. & Ortega-Cubero, S. & 27 others, Pastor, P., Ferman, T. J., Graff-Radford, N. R., Ross, O. A., Barber, I., Braae, A., Brown, K., Morgan, K., Maetzler, W., Berg, D., Troakes, C., Al-Sarraj, S., Lashley, T., Compta, Y., Revesz, T., Lees, A., Cairns, N. J., Halliday, G. M., Mann, D., Pickering-Brown, S., Powell, J., Lunnon, K., Lupton, M. K., Dickson, D., Hardy, J., Singleton, A. & Bras, J., 1 Feb 2016, In: Neurobiology of Aging. 38, p. 214.e7–214.e10

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72 Citations (Scopus)

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Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

van Rheenen, W., Shatunov, A., Dekker, A. M., McLaughlin, R. L., Diekstra, F. P., Pulit, S. L., van der Spek, R. A. A., Võsa, U., de Jong, S., Robinson, M. R., Yang, J., Fogh, I., van Doormaal, P. T., Tazelaar, G. H. P., Koppers, M., Blokhuis, A. M., Sproviero, W., Jones, A. R., Kenna, K. P. & van Eijk, K. R. & 31 others, Harschnitz, O., Schellevis, R. D., Brands, W. J., Medic, J., Menelaou, A., Vajda, A., Ticozzi, N., Lin, K., Rogelj, B., Vrabec, K., Ravnik-Glavač, M., Koritnik, B., Zidar, J., Leonardis, L., Grošelj, L. D., Millecamps, S., Salachas, F., Meininger, V., de Carvalho, M., Pinto, S., Fratta, P., Topp, S., Curtis, C., Shaw, C. E., Smith, B. N., Leigh, P. N., Powell, J., Lewis, C. M., Breen, G., Al-Chalabi, A. & PARALS Registry, Sept 2016, In: Nature Genetics. 48, p. 1043–1048

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427 Citations (Scopus)

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Influence of coding variability in APP-Aβ metabolism genes in sporadic Alzheimer's disease

Sassi, C., Ridge, P. G., Nalls, M. A., Gibbs, R., Ding, J., Lupton, M. K., Troakes, C., Lunnon, K., Al-Sarraj, S., Brown, K. S., Medway, C., Lord, J., Turton, J., Morgan, K., Powell, J. F., Kauwe, J. S., Cruchaga, C., Bras, J., Goate, A. M. & Singleton, A. B. & 18 others, Guerreiro, R., Hardy, J., Passmore, P., Craig, D., Johnston, J., McGuinness, B., Todd, S., Heun, R., Kölsch, H., Kehoe, P. G., Hooper, N. M., Vardy, E. R. L. C., Mann, D. M., Lowe, J., David Smith, A., Wilcock, G., Warden, D. & Holmes, C., 1 Jun 2016, In: PL o S One . 11, 6, e0150079.

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29 Citations (Scopus)

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No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study

Johnson, E. C., Bjelland, D. W., Howrigan, D. P., Abdellaoui, A., Breen, G., Borglum, A., Cichon, S., Degenhardt, F., Forstner, A. J., Frank, J., Genovese, G., Heilmann-Heimbach, S., Herms, S., Hoffman, P., Maier, W., Mattheisen, M., Morris, D., Mowry, B., Müller-Mhysok, B. & Neale, B. & 297 others, Nenadic, I., Nöthen, M. M., O’Dushlaine, C., Rietschel, M., Ruderfer, D. M., Rujescu, D., Schulze, T. G., Simonson, M. A., Stahl, E., Strohmaier, J., Witt, S. H., Ripke, S., Neale, B. M., Corvin, A., Walters, J. T. R., Farh, K. H., Holmans, P. A., Lee, P., Bulik-Sullivan, B., Collier, D. A., Huang, H., Pers, T. H., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F., Bacanu, S. A., Begemann, M., Belliveau, R. A., Bene, J., Bergen, S. E., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Bruggeman, R., Buccola, N. G., Buckner, R. L., Byerley, W., Cahn, W., Cai, G., Campion, D., Cantor, R. M., Carr, V. J., Carrera, N., Catts, S. V., Chambert, K. D., Chan, R. C. K., Chen, R. Y. L., Chen, E. Y. H., Cheng, W., Cheung, E. F. C., Chong, S. A., Robert Cloninger, C., Cohen, D., Cohen, N., Cormican, P., Craddock, N., Crowley, J. J., Curtis, D., Davidson, M., Davis, K. L., Del Favero, J., Demontis, D., Dikeos, D., Dinan, T., Djurovic, S., Donohoe, G., Drapeau, E., Duan, J., Dudbridge, F., Durmishi, N., Eichhammer, P., Eriksson, J., Escott-Price, V., Essioux, L., Fanous, A. H., Farrell, M. S., Franke, L., Freedman, R., Freimer, N. B., Friedl, M., Friedman, J. I., Fromer, M., Georgieva, L., Giegling, I., Giusti-Rodríguez, P., Godard, S., Goldstein, J. I., Golimbet, V., Gopal, S., Gratten, J., de Haan, L., Hammer, C., Hamshere, M. L., Hansen, M., Hansen, T., Haroutunian, V., Hartmann, A. M., Henskens, F. A., Hirschhorn, J. N., Hoffmann, P., Hofman, A., Hollegaard, M. V., Hougaard, D. M., Ikeda, M., Joa, I., Julià, A., Kahn, R. S., Kalaydjieva, L., Karachanak-Yankova, S., Karjalainen, J., Kavanagh, D., Kennedy, J. L., Khrunin, A., Kim, Y., Klovins, J., Knowles, J. A., Konte, B., Kucinskas, V., Kucinskiene, Z. A., Kuzelova-Ptackova, H., Kähler, A. K., Laurent, C., Chee Keong, J. L., Hong Lee, S., Legge, S. E., Lerer, B., Li, M., Li, T., Liang, K. Y., Lieberman, J., Limborska, S., Loughland, C. M., Lubinski, J., Lönnqvist, J., Macek, M., Magnusson, P. K. E., Maher, B. S., Mallet, J., Marsal, S., Mattingsdal, M., McCarley, R. W., McDonald, C., McIntosh, A. M., Meier, S., Meijer, C. J., Melegh, B., Melle, I., Mesholam-Gately, R. I., Metspalu, A., Michie, P. T., Milani, L., Milanova, V., Mokrab, Y., Morris, D. W., Mors, O., Murphy, K. C., Murray, R. M., Myin-Germeys, I., Müller-Myhsok, B., Nelis, M., Nertney, D. A., Nestadt, G., Nicodemus, K. K., Nikitina-Zake, L., Nisenbaum, L., Nordin, A., O'Callaghan, E., O'Dushlaine, C., Anthony O'Neill, F., Oh, S. Y., Olincy, A., Olsen, L., Van Os, J., Pantelis, C., Papadimitriou, G. N., Papiol, S., Parkhomenko, E., Pato, M. T., Paunio, T., Pejovic-Milovancevic, M., Perkins, D. O., Pietiläinen, O., Pimm, J., Pocklington, A. J., Powell, J., Price, A., Pulver, A. E., Purcell, S. M., Quested, D., Rasmussen, H. B., Reichenberg, A., Reimers, M. A., Richards, A. L., Roffman, J. L., Roussos, P., Salomaa, V., Sanders, A. R., Schall, U., Schubert, C. R., Schwab, S. G., Scolnick, E. M., Scott, R. J., Seidman, L. J., Shi, J., Sigurdsson, E., Silagadze, T., Silverman, J. M., Sim, K., Slominsky, P., Smoller, J. W., So, H. C., Spencer, C. C. A., Stahl, E. A., Stefansson, H., Steinberg, S., Stogmann, E., Straub, R. E., Strengman, E., Scott Stroup, T., Subramaniam, M., Suvisaari, J., Svrakic, D. M., Szatkiewicz, J. P., Söderman, E., Thirumalai, S., Toncheva, D., Tosato, S., Veijola, J., Waddington, J., Walsh, D., Wang, D., Wang, Q., Webb, B. T., Weiser, M., Wildenauer, D. B., Williams, N. M., Williams, S., Wolen, A. R., Wong, E. H. M., Wormley, B. K., Xi, H. S., Zai, C. C., Zheng, X., Zimprich, F., Wray, N. R., Stefansson, K., Visscher, P. M., Adolfsson, R., Andreassen, O. A., Blackwood, D. H. R., Bramon, E., Buxbaum, J. D., Børglum, A. D., Darvasi, A., Domenici, E., Ehrenreich, H., Esko, T., Gejman, P. V., Gill, M., Gurling, H., Hultman, C. M., Iwata, N., Jablensky, A. V., Jönsson, E. G., Kendler, K. S., Kirov, G., Knight, J., Lencz, T., Levinson, D. F., Li, Q. S., Liu, J., Malhotra, A. K., McCarroll, S. A., McQuillin, A., Moran, J. L., Mortensen, P. B., Mowry, B. J., Nöthen, M. M., Ophoff, R. A., Owen, M. J., Palotie, A., Pato, C. N., Petryshen, T. L., Posthuma, D., Riley, B. P., Sham, P. C., Sklar, P., Clair, D. S., Weinberger, D. R., Wendland, J. R., Werge, T., Daly, M. J., O'Donovan, M. C., Sullivan, P. F. & Keller, M. C., 28 Oct 2016, In: PL o S Genetics. 12, 10, e1006343.

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Rare genetic variation in UNC13A may modify survival in amyotrophic lateral sclerosis

Gaastra, B., Shatunov, A., Pulit, S., Jones, A. R., Sproviero, W., Gillett, A., Chen, Z., Kirby, J., Fogh, I., Powell, J. F., Leigh, P. N., Morrison, K. E., Shaw, P. J., Shaw, C. E., van den Berg, L. H., Veldink, J. H., Lewis, C. M. & Al-Chalabi, A., 2 Sept 2016, In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration . 17, 7-8, p. 593-599 7 p.

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22 Citations (Scopus)

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The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume

Lupton, M. K., Strike, L., Hansell, N. K., Wen, W., Mather, K. A., Armstrong, N. J., Thalamuthu, A., McMahon, K. L., de Zubicaray, G. I., Assareh, A. A., Simmons, A., Proitsi, P., Powell, J. F., Montgomery, G. W., Hibar, D. P., Westman, E., Tsolaki, M., Kloszewska, I., Soininen, H. & Mecocci, P. & 9 others, Velas, B., Lovestone, S., Brodaty, H., Ames, D., Trollor, J. N., Martin, N. G., Thompson, P. M., Sachdev, P. S. & Wright, M. J., 1 Apr 2016, In: Neurobiology of Aging. 40, p. 68-77 10 p.

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98 Citations (Scopus)

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2015

Common polygenic variation enhances risk prediction for Alzheimer's disease

Escott-Price, V., Sims, R., Bannister, C., Harold, D., Vronskaya, M., Majounie, E., Badarinarayan, N., GERAD/PERADES, Proitsi, P., IGAP consortia, Morgan, K., Passmore, P., Holmes, C., Powell, J., Brayne, C., Gill, M., Mead, S., Goate, A., Cruchaga, C. & Lambert, J.-C. & 10 others, van Duijn, C., Maier, W., Ramirez, A., Holmans, P., Jones, L., Hardy, J., Seshadri, S., Schellenberg, G. D., Amouyel, P. & Williams, J., 1 Dec 2015, In: Brain. 138, 12, p. 3673-3684 12 p.

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303 Citations (Scopus)

Convergent genetic and expression data implicate immunity in Alzheimer's disease

International Genomics of Alzheimer's Disease Consortium (IGAP)†, , Jun 2015, In: Alzheimer's & Dementia. 11, 6, p. 658-671

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162 Citations (Scopus)

Interaction between DRD2 and AKT1 genetic variations on risk of psychosis in cannabis users: a case–control study

Colizzi, M., Iyegbe, C., Powell, J., Blasi, G., Bertolino, A., Murray, R. M. & Di Forti, M., 1 Jul 2015, (E-pub ahead of print) In: NPJ SCHIZOPHRENIA. 1, 15025 .

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29 Citations (Scopus)

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Interaction Between Functional Genetic Variation of DRD2 and Cannabis Use on Risk of Psychosis

Colizzi, M., Iyegbe, C., Powell, J., Ursini, G., Porcelli, A., Bonvino, A., Taurisano, P., Romano, R., Masellis, R., Blasi, G., Morgan, C., Aitchison, K., Mondelli, V., Luzi, S., Kolliakou, A., David, A., Murray, R. M., Bertolino, A. & Forti, M. D., 1 Sept 2015, In: Schizophrenia Bulletin. 41, 5, p. 1171-1182 12 p.

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Proportion of patients in south London with first-episode psychosis attributable to use of high potency cannabis: A case-control study

Di Forti, M., Marconi, A., Carra, E., Fraietta, S., Trotta, A., Bonomo, M., Bianconi, F., Gardner-Sood, P., O'Connor, J., Russo, M., Stilo, S. A., Marques, T. R., Mondelli, V., Dazzan, P., Pariante, C., David, A. S., Gaughran, F., Atakan, Z., Iyegbe, C. & Powell, J. & 3 others, Morgan, C., Lynskey, M. & Murray, R. M., Mar 2015, In: The Lancet Psychiatry. 2, 3, p. 233-238 6 p.

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434 Citations (Scopus)

Stratified gene expression analysis identifies major amyotrophic lateral sclerosis genes

Jones, A. R., Troakes, C., King, A., Sahni, V., De Jong, S., Bossers, K., Papouli, E., Mirza, M., Al-Sarraj, S., Shaw, C. E., Shaw, P. J., Kirby, J., Veldink, J. H., Macklis, J. D., Powell, J. F. & Al-Chalabi, A., 19 Feb 2015, (E-pub ahead of print) In: Neurobiology of Aging. p. 2006.e1-2006.e9 9 p.

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18 Citations (Scopus)

2014

A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation

Bramon, E., Pirinen, M., Strange, A., Lin, K., Freeman, C., Bellenguez, C., Su, Z., Band, G., Pearson, R., Vukcevic, D., Langford, C., Deloukas, P., Hunt, S., Gray, E., Dronov, S., Potter, S. C., Tashakkori-Ghanbaria, A., Edkins, S., Bumpstead, S. J. & Arranz, M. J. & 31 others, Bakker, S., Bender, S., Bruggeman, R., Cahn, W., Chandler, D., Collier, D. A., Crespo-Facorro, B., Dazzan, P., de Haan, L., Di Forti, M., Dragović, M., Giegling, I., Hall, J., Iyegbe, C., Jablensky, A., Kravariti, E., Mata, I., McDonald, C., Pariante, C. M., Picchioni, M., Shaikh, M., Toulopoulou, T., Van Os, J., Walshe, M., Mathew, C. G., Plomin, R., Trembath, R. C., Lewis, C. M., Murray, R. M., Powell, J. & Psychosis Endophenotypes International Consortium, 1 Mar 2014, In: Biological psychiatry. 75, 5, p. 386-397 12 p.

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42 Citations (Scopus)

A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis

Fogh, I., Ratti, A., Gellera, C., Lin, K., Tiloca, C., Moskvina, V., Corrado, L., Sorarù, G., Cereda, C., Corti, S., Gentilini, D., Calini, D., Castellotti, B., Mazzini, L., Querin, G., Gagliardi, S., Del Bo, R., Conforti, F. L., Siciliano, G. & Inghilleri, M. & 31 others, Saccà, F., Bongioanni, P., Penco, S., Corbo, M., Sorbi, S., Filosto, M., Ferlini, A., Di Blasio, A. M., Signorini, S., Shatunov, A., Jones, A., Shaw, P. J., Morrison, K. E., Farmer, A. E., Van Damme, P., Robberecht, W., Chiò, A., Traynor, B. J., Sendtner, M., Melki, J., Meininger, V., Hardiman, O., Andersen, P. M., Leigh, N. P., Glass, J. D., Shaw, C. E., Weale, M. E., Lewis, C. M., Al-Chalabi, A., Powell, J. & the SLAGEN Consortium Collaborators, 15 Apr 2014, In: Human Molecular Genetics. 23, 8, p. 2220-2231 12 p., N/A.

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109 Citations (Scopus)

Alleles that increase risk for type 2 diabetes mellitus are not associated with increased risk for Alzheimer's disease

Proitsi, P., Lupton, M. K., Velayudhan, L., Hunter, G., Newhouse, S., Lin, K., Fogh, I., Tsolaki, M., Daniilidou, M., Pritchard, M., Craig, D., Todd, S., Johnston, J. A., McGuinness, B., Kloszewska, I., Soininen, H., Mecocci, P., Vellas, B., Passmore, P. A. & Sims, R. & 7 others, Williams, J., Brayne, C., Stewart, R., Sham, P., Lovestone, S., Powell, J. F. & Alzheimer's Disease Neuroimaging Initiative, Dec 2014, In: Neurobiology of Aging. 35, 12, p. 2883.e3-2883.e10 8 p., 2883.

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9 Citations (Scopus)

Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood

Proitsi, P., Lee, S. H., Lunnon, K., Keohane, A., Powell, J., Troakes, C., Al-Sarraj, S., Furney, S., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Lovestone, S., Hodges, A. & AddNeuroMed Consortium, Feb 2014, In: Neurobiology of Aging. 35, 2, p. 279-290 12 p.

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43 Citations (Scopus)

Biological insights from 108 schizophrenia-associated genetic loci

Ripke, S., Neale, B. M., Corvin, A., Walters, J. T. R., Farh, K.-H., Holmans, P. A., Lee, P., Bulik-Sullivan, B., Collier, D. A., Huang, H., Pers, T. H., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F., Bacanu, S. A., Begemann, M., Belliveau, R. A. & Bene, J. & 33 others, Bergen, S. E., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Bruggeman, R., Buccola, N. G., Buckner, R. L., Byerley, W., Cahn, W., Cai, G., Campion, D., Cantor, R. M., Carr, V. J., Carrera, N., Catts, S. V., Chambert, K. D., Chan, R. C. K., Chen, R. Y. L., Chen, E. Y. H., Cheng, W., Cheung, E. F. C., Chong, S. A., Cloninger, C. R., Cohen, D., Cohen, N., Cormican, P., Craddock, N., Murray, R. M., Van Os, J., Powell, J., Psychiat Genomics Consortium, Psychosis Endophenotypes Int Conso & Wellcome Trust Case-Control Consor, 24 Jul 2014, In: NATURE. 511, 7510, p. 421-427 17 p.

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5982 Citations (Scopus)

Common variant at 16p11.2 conferring risk of psychosis

Steinberg, S., De Jong, S., Mattheisen, M., Costas, J., Demontis, D., Jamain, S., Pietilainen, O. P. H., Lin, K., Papiol, S., Huttenlocher, J., Sigurdsson, E., Vassos, E., Giegling, I., Breuer, R., Fraser, G., Walker, N., Melle, I., Djurovic, S., Agartz, I. & Tuulio-henriksson, A. & 30 others, Suvisaari, J., Lonnqvist, J., Paunio, T., Olsen, L., Hansen, T., Ingason, A., Pirinen, M., Strengman, E., Hougaard, D. M., Orntoft, T., Didriksen, M., Hollegaard, M. V., Nordentoft, M., Abramova, L., Kaleda, V., Arrojo, M., Sanju??n, J., Arango, C., Etain, B., Curran, S., Bolton, P., Surguladze, S., Farmer, A., Martin, N. G., Van Os, J., Powell, J., Murray, R., O'Neill, F. A., Wellcome Trust Case Control Consortium 2 & Collier, D. A., Jan 2014, In: Molecular Psychiatry. 19, 1, p. 108-114 7 p.

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84 Citations (Scopus)

Exome sequencing identifies 2 novel presenilin 1 mutations (p.L166V and p.S230R) in British early-onset Alzheimer's disease

Sassi, C., Guerreiro, R., Gibbs, R., Ding, J., Lupton, M. K., Troakes, C., Lunnon, K., Al-Sarraj, S., Brown, K. S., Medway, C., Lord, J., Turton, J., Mann, D., Snowden, J., Neary, D., Harris, J., Bras, J., Morgan, K., Powell, J. F. & Singleton, A. & 2 others, Hardy, J. & ARUK Consortium, Oct 2014, In: Neurobiology of Aging. 35, 10, 4 p., 2422.e13-2422.e16.

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29 Citations (Scopus)

Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a Mendelian randomization analysis

Proitsi, P., Lupton, M. K., Velayudhan, L., Newhouse, S., Fogh, I., Tsolaki, M., Daniilidou, M., Pritchard, M., Kloszewska, I., Soininen, H., Mecocci, P., Vellas, B., Williams, J., Stewart, R., Sham, P., Lovestone, S., Powell, J. F. & Alzheimer's Disease Neuroimaging Initiative, Sept 2014, In: PL o S Medicine. 11, 9, p. e1001713 15 p.

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Genetic Predisposition to Increased Blood Cholesterol and Triglyceride Lipid Levels and Risk of Alzheimer Disease: A Mendelian Randomization Analysis

Proitsi, P., Lupton, M. K., Velayudhan, L., Newhouse, S., Fogh, I., Tsolaki, M., Daniilidou, M., Pritchard, M., Kloszewska, I., Soininen, H., Mecocci, P., Vellas, B., Williams, J., Harold, D., Sims, R., Gerrish, A., Chapman, J., Escott-Price, V., Abraham, R. & Hollingworth, P. & 74 others, Hamshere, M., Singh Pahwa, J., Dowzell, K., Williams, A., Jones, N., Thomas, C., Stretton, A., Morgan, A., Williams, K., Lovestone, S., Powell, J. F., Proitsi, P., Lupton, M. K., Brayne, C., Rubinsztein, D. C., Gill, M., Lawlor, B., Lynch, A., Morgan, K., Brown, K., Passmore, P., Craig, D., Mcguinness, B., Johnston, J. A., Todd, S., Holmes, C., Mann, D., Smith, A. D., Love, S., Kehoe, P. G., Hardy, J., Guerreiro, R., Singleton, A., Mead, S., Fox, N., Rossor, M., Collinge, J., Maier, W., Jessen, F., Heun, R., Schürmann, B., Ramirez, A., Becker, T., Herold, C., Lacour, A., Drichel, D., Van Den Bussche, H., Heuser, I., Kornhuber, J., Wiltfang, J., Dichgans, M., Frölich, L., Hampel, H., Hüll, M., Rujescu, D., Goate, A., Kauwe, J. S. K., Cruchaga, C., Nowotny, P., Morris, J. C., Mayo, K., Livingston, G., Bass, N. J., Gurling, H., Mcquillin, A., Gwilliam, R., Deloukas, P., Nöthen, M. M., Holmans, P., O'donovan, M., Owen, M. J., Williams, J., Stewart, R. & Sham, P., 16 Sept 2014, In: PLoS Medicine. 11, 9

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Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease

Escott-Price, V., Bellenguez, C., Wang, L.-S., Choi, S.-H., Harold, D., Jones, L., Holmans, P., Gerrish, A., Vedernikov, A., Richards, A., DeStefano, A. L., Lambert, J.-C., Ibrahim-Verbaas, C. A., Naj, A. C., Sims, R., Jun, G., Bis, J. C., Beecham, G. W., Grenier-Boley, B. & Russo, G. & 31 others, Thornton-Wells, T. A., Denning, N., Smith, A. V., Chouraki, V., Thomas, C., Ikram, M. A., Zelenika, D., Vardarajan, B. N., Kamatani, Y., Lin, C.-F., Schmidt, H., Kunkle, B., Dunstan, M. L., Vronskaya, M., Johnson, A. D., Ruiz, A., Bihoreau, M.-T., Reitz, C., Pasquier, F., Hollingworth, P., Hanon, O., Fitzpatrick, A. L., Buxbaum, J. D., Campion, D., Crane, P. K., Baldwin, C., Becker, T., Lovestone, S., Proitsi, P., Powell, J. F. & United Kingdom Brain Expression, 12 Jun 2014, In: PL o S One . 9, 6, 13 p., e94661.

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97 Citations (Scopus)

Heritability of amyotrophic lateral sclerosis

Fogh, I., Al-Chalabi, A. & Powell, J., 1 Dec 2014, In: JAMA Neurology. 71, 12, p. 1579-1580 2 p.

Research output: Contribution to journal › Article › peer-review

Investigating the role of rare coding variability in Mendelian dementia genes (APP, PSEN1, PSEN2, GRN, MAPT, and PRNP) in late-onset Alzheimer's disease

Sassi, C., Guerreiro, R., Gibbs, R., Ding, J., Lupton, M. K., Troakes, C., Al-Sarraj, S., Niblock, M., Gallo, J. M., Adnan, J., Killick, R., Brown, K. S., Medway, C., Lord, J., Turton, J., Bras, J., Morgan, K., Powell, J. F., Singleton, A. & Hardy, J., Dec 2014, In: Neurobiology of Aging. 35, 12, p. 2881.e1-2881.e6 6 p.

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58 Citations (Scopus)

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John Powell

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