Research output per year
Research output per year
- 1 - 50 out of 90 results
Search results
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2023
Harnessing nanomedicine to potentiate the chemo-immuno-2 therapeutic effects of doxorubicin and alendronate co-encapsu-3 lated in pegylated liposomes
Maher, J., 3 Nov 2023, (Accepted/In press) In: Pharmaceutics.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Downloads (Pure) -
Intratumoral pan-ErbB targeted CAR-T for head and neck squamous cell carcinoma: interim analysis of the T4 immunotherapy study
Papa, S., Adami, A., Metoudi, M., Beatson, R., George, M. S., Achkova, D., Williams, E., Arif, S., Reid, F., Elstad, M., Beckley-Hoelscher, N., Douri, A., Delord, M., Lyne, M., Shivapatham, D., Fisher, C., Hope, A., Gooljar, S., Mitra, A., Gomm, L., & 16 others, 2023, In: Journal for ImmunoTherapy of Cancer. 11, 6Research output: Contribution to journal › Article › peer-review
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Intra-Tumoral pan-ErbB Targeted CAR-T for Head and Neck Squamous Cell Carcinoma: Interim Analysis of the T4 Immunotherapy Study
Papa, S., Adami, A., Metoudi, M., Beatson, R., George, M., Achkova, D., Williams, L., Arif, S., Reid, F., Elstad, M., Beckley-Hoelscher, N., Douri, A., Delord, M., Lyne, M., Shivapatham, D., Fisher, C., Hope, A., Gooljar, S., Mitra, A., Gomm, L., & 16 others, 15 Jun 2023, In: Journal for ImmunoTherapy of Cancer. 11, 6, e007162.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
2022
CAR T-Cell Targeting of Macrophage Colony-Stimulating Factor Receptor
Achkova, D., Beatson, R. & Maher, J., 13 Jul 2022, In: Cells. 11, 14, 14 p., 2190.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)57 Downloads (Pure) -
Engineering of an avidity-optimized CD19-specific parallel chimeric antigen receptor that delivers dual CD28 and 4-1BB co-stimulation
Halim, L., Das, K., Larcombe-Young, D., Ajina, A., Candelli, A., Benjamin, R., Dillon, R., Davies, D. & Maher, J., 9 Feb 2022, In: Frontiers in immunology. 13, 836549.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)155 Downloads (Pure) -
Generation and application of TGFβ-educated human Vγ9Vδ2 T cells
Parente-Pereira, A. C., Beatson, R. E., Davies, D. M., Hull, C., Whilding, L. M., Porter, J. C. & Maher, J., 17 Jun 2022, In: STAR Protocols. 3, 2, p. 101319 22 p., 101319.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)29 Downloads (Pure) -
Generation of human parallel chimeric antigen receptor (pCAR) T cells to achieve synergistic T cell co-stimulation
Larcombe-Young, D., Whilding, L., Davies, D., Draper, B., Bechman, N. & Maher, J., 17 Jun 2022, In: STAR Protocols. 3, 2, 28 p., 101414.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)36 Downloads (Pure) -
Highly Effective Liquid and Solid Phase Extraction Methods to Concentrate Radioiodine Isotopes for Radioiodination Chemistry
Davis, C., Li, C., Nie, R., Guzzardi, N., Dworakowska, B., Sadasivam, P., Maher, J., Aboagye, E. O., Lu, Z. & Yan, R., 2022, (E-pub ahead of print) In: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS.Research output: Contribution to journal › Article › peer-review
File24 Downloads (Pure) -
2021
Chimeric Antigen Receptor T Cells Targeting Integrin αvβ6 Expressed on Cholangiocarcinoma Cells
Phanthaphol, N., Somboonpatarakun, C., Suwanchiwasiri, K., Chieochansin, T., Sujjitjoon, J., Wongkham, S., Maher, J., Junking, M. & Yenchitsomanus, P. T., 3 Mar 2021, In: Frontiers in oncology. 11, 657868.Research output: Contribution to journal › Article › peer-review
Open Access22 Citations (Scopus) -
Crosstown Traffic: Lymphodepleting Chemotherapy Drives CAR T Cells
Davies, D. M. & Maher, J., 8 Feb 2021, In: CANCER CELL. 39, 2, p. 138-140 3 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
Development and Validation of a Good Manufacturing Process for IL-4-Driven Expansion of Chimeric Cytokine Receptor-Expressing CAR T-Cells
van Schalkwyk, M. C. I., van der Stegen, S. J. C., Bosshard-Carter, L., Graves, H., Papa, S., Parente-Pereira, A. C., Farzaneh, F., Fisher, C. D., Hope, A., Adami, A. & Maher, J., 15 Jul 2021, In: Cells. 10, 7, 1797.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Generation of hypoxia-sensing chimeric antigen receptor T cells
Kosti, P., Larios Martinez, I., Maher, J. & Arnold, J., 17 Sept 2021, In: STAR Protocols. 2, 3, 100723.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)81 Downloads (Pure) -
Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors
Kosti, P., Opzoomer, J. W., Larios-Martinez, K. I., Henley-Smith, R., Scudamore, C. L., Okesola, M., Taher, M. Y. M., Davies, D. M., Muliaditan, T., Larcombe-Young, D., Woodman, N., Gillett, C. E., Thavaraj, S., Maher, J. & Arnold, J. N., 20 Apr 2021, In: Cell Reports Medicine. 2, 4, 100227.Research output: Contribution to journal › Article › peer-review
Open AccessFile59 Citations (Scopus)72 Downloads (Pure) -
Synergistic signaling by 41BB and CD28 is optimally achieved by membrane proximal positioning within parallel chimeric antigen receptors
Muliaditan, T., Halim, L., Whilding, L., Draper, B., Achkova, D., Kausar, F., Glover, M., Bechman, N., Arulappu, A., Sanchez, J., Flaherty, K. R., Obajdin, J., Grigoriadis, K., Antoine, P., Larcombe-Young, D., Hull, C., Buus, R., Gordon, P., Grigoriadis, A., Davies, D., & 2 others, 21 Dec 2021, (Accepted/In press) In: Cell Reports Medicine.Research output: Contribution to journal › Article › peer-review
File198 Downloads (Pure) -
Synergistic T cell signaling by 41BB and CD28 is optimally achieved by membrane proximal positioning within parallel chimeric antigen receptors
Muliaditan, T., Halim, L., Whilding, L. M., Draper, B., Achkova, D. Y., Kausar, F., Glover, M., Bechman, N., Arulappu, A., Sanchez, J., Flaherty, K. R., Obajdin, J., Grigoriadis, K., Antoine, P., Larcombe-Young, D., Hull, C. M., Buus, R., Gordon, P., Grigoriadis, A., Davies, D. M., & 2 others, 21 Dec 2021, In: Cell Reports Medicine. 2, 12, 100457.Research output: Contribution to journal › Article › peer-review
Open Access24 Citations (Scopus) -
TGF-β1 potentiates Vγ9Vδ2 T-cell adoptive immunotherapy of cancer
Beatson, R., Parente Pereira, A., Halim, L., Cozzetto, D., Hull, C., Whilding, L., Martinez, O., Taylor, C., Obajdin, J., Luu Hoang, K. N., Draper, B., Iqbal, A., Hardiman, T., Zabinski, T., Man, F., T. M. de Rosales, R., Xie, J., Aswad, F., Achkova, D., Ricardo Joseph, C-Y., & 11 others, 18 Nov 2021, (Accepted/In press) In: Cell Reports Medicine.Research output: Contribution to journal › Article › peer-review
File149 Downloads (Pure) -
2020
Antibody response to SARS-CoV-2 infection in humans: A systematic review
Post, N., Eddy, D., Huntley, C., van Schalkwyk, M. C. I., Shrotri, M., Leeman, D., Rigby, S., Williams, S. V., Bermingham, W. H., Kellam, P., Maher, J., Shields, A. M., Amirthalingam, G., Peacock, S. J. & Ismail, S. A., Dec 2020, In: PLoS ONE. 15, 12, e0244126.Research output: Contribution to journal › Article › peer-review
Open Access238 Citations (Scopus) -
Efficient Ex Vivo Expansion of γδ T-Cells from AML Patients Requires Elimination of Circulating Leukemic Blasts
Parente-Pereira, A. C., Krishnamurthy, P., Whilding, L., Ioannou, K., Ciprut, S., Potter, V., Mufti, G., Barber, L., Farzaneh, F. & Maher, J., 28 Dec 2020, In: Advances in Leukemia Research and Treatment. 2, 1, p. 28-33Research output: Contribution to journal › Article › peer-review
File30 Downloads (Pure) -
Engineering of chimeric Natural Killer cell receptors to develop precision adoptive immunotherapies for cancer
Obajdin, J., Davies, D. & Maher, J., 14 Sept 2020, In: Clinical & Experimental Immunology. 202, 1, p. 11-27 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)78 Downloads (Pure) -
Iodine-124 Based Dual Positron Emission Tomography and Fluorescent Labeling Reagents for In Vivo Cell Tracking
Pham, T., Lu, Z., Davis, C., Li, C., Sun, F., Maher, J. & Yan, R., 15 Apr 2020, In: Bioconjugate Chemistry. 31, 4, p. 1107-1116 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)124 Downloads (Pure) -
Organ biodistribution of radiolabelled δγ t cells following liposomal alendronate administration in different mice tumour models
Wang, J. T-W., Hodgins, N., Al-Jamal, W. T., Maher, J., Sosabowski, J. K. & Al-Jamal, K., 2020, In: Nanotheranostics. 4, 2, p. 71-82 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)92 Downloads (Pure) -
The eIF4A inhibitor silvestrol sensitizes T-47D ductal breast carcinoma cells to external-beam radiotherapy
Webb, T. E., Davies, M., Maher, J. & Sarker, D., 1 Sept 2020, In: Clinical and Translational Radiation Oncology. 24, p. 123-126 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)57 Downloads (Pure) -
2019
CAR T-cells targeting the integrin αvβ6 and co-expressing the chemokine receptor CXCR2 demonstrate enhanced homing and efficacy against several solid malignancies
Whilding, L. M., Halim, L., Draper, B., Parente-Pereira, A. C., Zabinski, T., Davies, D. M. & Maher, J., 14 May 2019, (E-pub ahead of print) In: Cancers. 11, 5, p. 1-17 17 p., 674.Research output: Contribution to journal › Article › peer-review
Open AccessFile114 Citations (Scopus)188 Downloads (Pure) -
CAR T Cells Targeting the Tumor MUC1 Glycoprotein Reduce Triple-Negative Breast Cancer Growth
Zhou, R., Yazdanifar, M., Roy, L. D., Whilding, L. M., Gavrill, A., Maher, J. & Mukherjee, P., 1 Jan 2019, In: Frontiers in Immunology. 10, MAY, 1 p., 1149.Research output: Contribution to journal › Article › peer-review
Open Access111 Citations (Scopus) -
In Vivo PET Tracking of 89Zr-Labeled Vγ9Vδ2 T Cells to Mouse Xenograft Breast Tumors Activated with Liposomal Alendronate
Man, F., Lim, L., Volpe, A., Gabizon, A., Shmeeda, H., Draper, B., Parente-Pereira, A. C., Maher, J., Blower, P. J., Fruhwirth, G. O. & T.M. de Rosales, R., 2 Jan 2019, In: Molecular Therapy. 27, 1, p. 219-229 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile75 Citations (Scopus)236 Downloads (Pure) -
New developments in imaging cell-based therapy
Martinez, O., Sosabowski, J., Maher, J. & Papa, S., 12 Apr 2019, (E-pub ahead of print) In: Journal of Nuclear Medicine. 60, 6, p. 730-735 6 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
Overcoming Immunological Resistance Enhances the Efficacy of A Novel Anti-tMUC1-CAR T Cell Treatment against Pancreatic Ductal Adenocarcinoma
Yazdanifar, M., Zhou, R., Grover, P., Williams, C., Bose, M., Moore, L. J., Wu, S. T., Maher, J., Dreau, D. & Mukherjee, A. P., 11 Sept 2019, In: Cells. 8, 9Research output: Contribution to journal › Article › peer-review
Open Access38 Citations (Scopus) -
2018
A Dual Reporter Iodinated Labeling Reagent for Cancer Positron Emission Tomography Imaging and Fluorescence-Guided Surgery
Lu, Z., Pham, T. T., Rajkumar, V., Yu, Z., Pedley, R. B., Arstad, E., Maher, J. & Yan, R., 1 Feb 2018, In: Journal of Medicinal Chemistry. 61 , 4, p. 1636-1645 61 p., 4.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)157 Downloads (Pure) -
Clinically Compliant Spatial and Temporal Imaging of Chimeric Antigen Receptor T-cells
Emami-Shahri, N., Foster, J., Kashani, R., Gazinska, P., Cook, C., Maher, J., Sosabowski, J. & Papa, S., 14 Mar 2018, In: Nature Communications. 9, 1, 12 p., 1081.Research output: Contribution to journal › Article › peer-review
Open AccessFile58 Citations (Scopus)224 Downloads (Pure) -
Enhanced Anti-lymphoma Activity of CAR19-iNKT Cells Underpinned by Dual CD19 and CD1d Targeting
Rotolo, A., Caputo, V. S., Holubova, M., Baxan, N., Dubois, O., Chaudhry, M. S., Xiao, X., Goudevenou, K., Pitcher, D. S., Petevi, K., Kachramanoglou, C., Iles, S., Naresh, K., Maher, J. & Karadimitris, A., 8 Oct 2018, In: CANCER CELL. 34, 4, p. 596-610.E11Research output: Contribution to journal › Article › peer-review
Open AccessFile95 Citations (Scopus)78 Downloads (Pure) -
Pre-clinical development of Chimeric Antigen Receptor T-cell immunotherapy: implications of design for efficacy and safety
Halim, L., Ajina, A. & Maher, J., 21 Apr 2018, (E-pub ahead of print) In: Baillieres Best Practice & Research in Clinical Haematology.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)330 Downloads (Pure) -
2017
CAR T-cell immunotherapy of MET-expressing malignant mesothelioma
Thayaparan, T., Petrovic, R. M. G., Achkova, D. Y., Zabinski, T. S., Davies, D. M., Klampatsa, A., Parente Pereira, A. C., Whilding, L. M., Van Der Stegen, S. J. C., Woodman, N., Sheaf, M., Cochran, J., Spicer, J. F. & Maher, J., 1 Oct 2017, In: OncoImmunology. 6, 12, e1363137.Research output: Contribution to journal › Article › peer-review
Open AccessFile45 Citations (Scopus)203 Downloads (Pure) -
Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection
Boardman, D. A., Philippeos, C., Fruhwirth, G. O., Ibrahim, M. A. A., Hannen, R. F., Cooper, D., Marelli-Berg, F. M., Watt, F. M., Lechler, R. I., Maher, J., Smyth, L. A. & Lombardi, G., 30 Mar 2017, In: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 17, 4, p. 931-943Research output: Contribution to journal › Article › peer-review
Open AccessFile211 Citations (Scopus)243 Downloads (Pure) -
Functionally Active Fc Mutant Antibodies Recognizing Cancer Antigens Generated Rapidly at High Yields
Ilieva, K. M., Fazekas-Singer, J., Achkova, D. Y., Dodev, T. S., Mele, S., Crescioli, S., Bax, H. J., Cheung, A., Karagiannis, P., Correa, I., Figini, M., Marlow, R., Josephs, D. H., Beavil, A. J., Maher, J., Spicer, J. F., Jensen-Jarolim, E., Tutt, A. N. & Karagiannis, S. N., 11 Sept 2017, In: Frontiers in Immunology. 8, SEP, 1112.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)221 Downloads (Pure) -
Generation of human islet-specific regulatory T cells by TCR gene transfer
Hull, C. M., Nickolay, L. E., Estorninho, M., Richardson, M. W., Riley, J. L., Peakman, M., Maher, J. & Tree, T. I. M., 31 May 2017, In: Journal of Autoimmunity. 79, p. 63-73Research output: Contribution to journal › Article › peer-review
Open AccessFile92 Citations (Scopus)467 Downloads (Pure) -
Implementation of National Institute for Health and Care Excellence (NICE) guidance to measure IgA with all coeliac screens: can an affordable solution be devised? IgA measurement in coeliac serological screening
Mac Lochlainn, D. J., Hira-Kazal, R., Varney, H. & Maher, J., 19 May 2017, (E-pub ahead of print) In: Clinical and Experimental Immunology.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)312 Downloads (Pure) -
Intracavitary ‘T4 immunotherapy’ of malignant mesothelioma using pan-ErbB re-targeted CAR T-cells
Klampatsa, A., Achkova, D. Y., Davies, D. M., Parente-Pereira, A. C., Woodman, N., Rosekilly, J., Osborne, G., Thayaparan, T., Bille, A., Sheaf, M., Spicer, J. F., King, J. & Maher, J., 1 May 2017, In: Cancer Letters. 393, p. 52-59Research output: Contribution to journal › Article › peer-review
Open AccessFile47 Citations (Scopus)473 Downloads (Pure) -
Investigating in vitro and in vivo αvβ6 integrin receptor-targeting liposomal alendronate for combinatory γδ T cell immunotherapy
Hodgins, N. O., Al-Jamal, W. T., Wang, J. T-W., Klippstein, R., Sosabowski, J. K., Marshall, J. F., Maher, J. & Al-Jamal, K. T., 28 Jun 2017, In: JOURNAL OF CONTROLLED RELEASE. 256, p. 141-152Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Citations (Scopus)230 Downloads (Pure) -
Targeting of aberrant αvβ6 integrin expression in solid tumors using chimeric antigen receptor-engineered T-cells
Whilding, L. M., Parente Pereira, A. C., Zabinski, T., Davies, D. M., Petrovic, R., Kao, V., Saxena, S. A., Romain, A., Costa-Guerra, J. A., Violette, S., Itamochi, H., Ghaem-Maghami, S., Vallath, S., Marshall, J. F. & Maher, J., 4 Jan 2017, In: Molecular Therapy. 25, 1, p. 259-273Research output: Contribution to journal › Article › peer-review
Open AccessFile60 Citations (Scopus)362 Downloads (Pure) -
2016
Antigen-specificity using chimeric antigen receptors: the future of regulatory T-cell therapy?
Boardman, D., Maher, J., Lechler, R., Smyth, L. & Lombardi, G., 15 Apr 2016, In: Biochemical Society Transactions. 44, 2, p. 342-8 7 p.Research output: Contribution to journal › Article › peer-review
38 Citations (Scopus) -
Exploiting the Metal-Chelating Properties of the Drug Cargo for In Vivo Positron Emission Tomography Imaging of Liposomal Nanomedicines
Edmonds, S., Volpe, A., Shmeeda, H., Parente-Pereira, A. C., Radia, R., Baguña-Torres, J., Szanda, I., Severin, G. W., Livieratos, L., Blower, P. J., Maher, J., Fruhwirth, G. O., Gabizon, A. & T M de Rosales, R., 22 Nov 2016, In: ACS Nano. 10, 11, p. 10294–10307Research output: Contribution to journal › Article › peer-review
Open AccessFile76 Citations (Scopus)284 Downloads (Pure) -
Gated chimeric antigen receptor T-cells: The next logical step in reducing toxicity?
Davies, D. M. & Maher, J., 1 Jun 2016, In: Translational Lung Cancer Research. 5, S1, p. S61-S65Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)398 Downloads (Pure) -
In vitro potency, in vitro and in vivo efficacy of liposomal alendronate in combination with γδ T cell immunotherapy in mice
Hodgins, N. O., Al-Jamal, W. T., Wang, J. T-W., Parente-Pereira, A. C., Liu, M., Maher, J. & Al-Jamal, K. T., 10 Nov 2016, In: JOURNAL OF CONTROLLED RELEASE. 241, p. 229–241Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Citations (Scopus)209 Downloads (Pure) -
Optimising Translational Research Opportunities: A Systematic Review and Narrative Synthesis of Basic and Clinician Scientists' Perspectives of Factors Which Enable or Hinder Translational Research
Fudge, N., Sadler, E., Fisher, H. R., Maher, J., Wolfe, C. D. A. & McKevitt, C., 4 Aug 2016, In: PLOS One. 11, 8, e0160475.Research output: Contribution to journal › Article › peer-review
Open AccessFile49 Citations (Scopus)218 Downloads (Pure) -
Prospects for adoptive immunotherapy of pancreatic cancer using chimeric antigen receptor-engineered T-cells
Alrifai, D., Sarker, D. & Maher, J., Feb 2016, In: Immunopharmacology and Immunotoxicology. 38, 1, p. 50-60Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
Role of the colony-stimulating factor (CSF)/CSF-1 receptor axis in cancer
Achkova, D. & Maher, J., 15 Apr 2016, In: Biochemical Society Transactions. 44, 2, p. 333-341 9 p.Research output: Contribution to journal › Article › peer-review
74 Citations (Scopus) -
The integrin αvβ6: a novel target for CAR T-cell immunotherapy?
Whilding, L., Vallath, S. & Maher, J., 15 Apr 2016, In: Biochemical Society Transactions. 44, 2, p. 349-355Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
The mucin MUC1 modulates the tumor immune microenvironment through the engagement of Siglec-9
Beatson, R., Tajadura-Ortega, V., Achkova, D. Y., Picco, G., Tsourouktsoglou, T-D., Klausing, S., Hillier, M., Maher, J., Noll, T., Crocker, P., Taylor-Papadimitriou, J. & Burchell, J., 1 Nov 2016, In: Nature Immunology. 17, 11, p. 1273-1281Research output: Contribution to journal › Article › peer-review
Open AccessFile217 Citations (Scopus)1203 Downloads (Pure) -
The role of the HGF/Met axis in mesothelioma
Thayaparan, T., Spicer, J. F. & Maher, J., 15 Apr 2016, In: Biochemical Society Transactions. 44, 2, p. 363-370 8 p.Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus) -
2015
CAR T-cell immunotherapy: The path from the by-road to the freeway?
Whilding, L. M. & Maher, J., 1 Dec 2015, In: Molecular Oncology. 9, 10, p. 1994-2018 25 p.Research output: Contribution to journal › Article › peer-review
37 Citations (Scopus)