Research output per year
Research output per year
Personal profile
Research interests
The two main research projects focus on understanding mechanisms of staphylococcal (predominantly methicillin-resistant Staphylococcus aureus MRSA) disease pathogenesis and transmission in the hospital setting.
- Identification of a highly bacteraemic strain of MRSA. During 2003/2004 the Trust had high rates of MRSA bacteremia. The result of a detailed epidemiological study identified that a significant reason for this was an extended outbreak on the ICU with a novel variant of MRSA, designated TW. This strain had an enhanced capacity to bind vascular access devices leading to bloodstream invasion. A targeted introduction of basic infection control and a novel decolonisation strategy led to termination of the outbreak. We have performed microarray-based analysis of this strain and are performing full genomic sequencing (collaborators Dr Jodi Lindsay, St George's University of London and Dr Julian Parkhill, Sanger Insititute, Cambridge). We are currently investigating the mechanism of adhesion and invasion in vitro which combined with the awaited genome sequence will potentially provide insight into the basic mechanism of MRSA bacteraemia and identify novel approaches to prevention. It may also identify genetic markers for hyperinvasive strains that can be used to assess the distribution of such strains across the UK for targeted enhanced infection control strategies.
- MRSA transmission dynamics. Following the detailed ICU analysis it became apparent that our enhanced infection control efforts led to a sustained (more than 2 years) prevention of MRSA cluster outbreaks on the ICU and only a residuum of sporadic acquisitions. We are developing mathematical models of transmission dynamics through analysis of data from the ICU over the last 5 years to assess the reduction in risk of MRSA acquisition, assess the confidence with which the reduction can be ascribed to the enhanced interventions and to compare the transmissibility of different strains including TW in collaboration with Dr Ben Cooper, Health Protection Agency).
Research interests (short)
Bacterial disease pathogenesis; staphylococcus aureus; intensive care unit infections; healthcare-associated infections.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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The first reported case of human infection with Variovorax durovernensis; a novel Variovorax sp. isolated from the prosthetic aortic graft of a shepherd
Payne, L., Alcolea-Medina, A., Snell, L. B., Alder, C., Charalampous, T., turnbull, J., Edgeworth, J., Rahul, B., Klein, J. L. & Goodman, A. L., Jan 2024, In: Clinical Infection in Practice. 21, 100332.Research output: Contribution to journal › Article › peer-review
Open Access -
A multisite evaluation of antifungal use in critical care: implications for antifungal stewardship
Logan, C., Hemsley, C., Fife, A., Edgeworth, J., Mazzella, A., Wade, P., Goodman, A., Hopkins, P., Wyncoll, D., Ball, J., Planche, T., Schelenz, S. & Bicanic, T., 1 Jun 2022, In: JAC-Antimicrobial Resistance. 4, 3, dlac055.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
Broad Neutralization of SARS-CoV-2 Variants, Including Omicron, following Breakthrough Infection with Delta in COVID-19-Vaccinated Individuals
Lechmere, T., Snell, L. B., Graham, C., Seow, J., Shalim, Z., Charalampous, T., Alcolea-Medina, A., Batra, R., Nebbia, G., Edgeworth, J., Malim, M. & Doores, K., 17 Mar 2022, In: Mbio. 13, 2Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Citations (Scopus)270 Downloads (Pure) -
Combined epidemiological and genomic analysis of nosocomial SARS-CoV-2 infection early in the pandemic and the role of unidentified cases in transmission
Snell, L. B., Fisher, C. L., Taj, U., Stirrup, O., Merrick, B., Alcolea-Medina, A., Charalampous, T., Signell, A. W., Wilson, H. D., Betancor, G., Kia Ik, M. T., Cunningham, E., Cliff, P. R., Pickering, S., Galao, R. P., Batra, R., Neil, S. J. D., Malim, M. H., Doores, K. J. & Douthwaite, S. T. & 3 others, , Jan 2022, In: CLINICAL MICROBIOLOGY AND INFECTION. 28, 1, p. 93-100 8 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
Descriptive comparison of admission characteristics between pandemic waves and multivariable analysis of the association of the Alpha variant (B.1.1.7 lineage) of SARS-CoV-2 with disease severity in inner London
Snell, L. B., Wang, W., Alcolea-Medina, A., Charalampous, T., Batra, R., de Jongh, L., Higgins, F., Investigators, C.-U. H., Nebbia, G., Wang, Y., Edgeworth, J. & Curcin, V., 8 Feb 2022, In: BMJ Open. 12, 2, p. e055474 e055474.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)177 Downloads (Pure)
Projects
- 8 Finished
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NIHR Biomedical Research Centre. Funding for Financial Years 2017/18, 2018/19
Wolfe, C. (Primary Investigator), Parsons, M. (Primary Investigator), Gould, H. (Primary Investigator), Corrigan, C. (Primary Investigator), Greenough, A. (Primary Investigator), Peakman, M. (Primary Investigator), Vyse, T. (Primary Investigator), Antoniou, M. (Primary Investigator), Oakey, R. (Primary Investigator), McGrath, J. (Primary Investigator), Karagiannis, S. (Primary Investigator), Barker, J. (Primary Investigator), Flohr, C. (Primary Investigator), Tziotzios, C. (Primary Investigator), Whittaker, S. (Primary Investigator), Spector, T. (Primary Investigator), Watt, F. (Primary Investigator), Hayday, A. (Primary Investigator), Spencer, J. (Primary Investigator), Cope, A. (Primary Investigator), Malim, M. (Primary Investigator), Martin Serrano, J. (Primary Investigator), Edgeworth, J. (Primary Investigator), Cason, J. (Primary Investigator), Lord, G. (Primary Investigator), Dorling, A. (Primary Investigator), Sacks, S. (Primary Investigator), Sanchez Fueyo, A. (Primary Investigator), Lombardi, G. (Primary Investigator), Ostermann, M. (Primary Investigator), Shah, A. (Primary Investigator), Marber, M. (Primary Investigator), Mayr, M. (Primary Investigator), Chowienczyk, P. (Primary Investigator), Wells, C. (Primary Investigator), Grigoriadis, A. (Primary Investigator), Sawyer, E. (Primary Investigator), Maher, J. (Primary Investigator), Tribe, R. (Primary Investigator), Ilic, D. (Primary Investigator), Poston, L. (Primary Investigator), Rutherford, M. (Primary Investigator), Gee, T. (Primary Investigator), Blower, P. (Primary Investigator), Edwards, D. (Primary Investigator), Sharpe, P. (Primary Investigator), Streit, A. (Primary Investigator), Naglik, J. (Primary Investigator), Tavassoli, M. (Primary Investigator) & McNaughton, P. (Primary Investigator)
NIHR National Institute For Health & Care Research
1/04/2017 → 31/03/2022
Project: Research
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Repurposing Anticancer Drugs as Antimicrobial Drugs
Rahman, M. (Primary Investigator), Edgeworth, J. (Co-Investigator), Filloux, A. (Co-Investigator), Page, C. (Co-Investigator), Williams, P. (Co-Investigator) & academic, A. (Co-Investigator)
1/06/2016 → 31/05/2021
Project: Research
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Infectious diseases BioBank
Cason, J. (Primary Investigator), Edgeworth, J. (Co-Investigator), Fox, J. (Co-Investigator), Malim, M. (Co-Investigator), Peakman, M. (Co-Investigator), Peters, B. (Co-Investigator), Philpott-Howard, J. (Co-Investigator), Post, F. (Co-Investigator) & academic, A. (Co-Investigator)
1/04/2011 → 31/03/2014
Project: Research
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Pneumococcal protection of the aged by IgM B cells
Dunn-Walters, D. (Primary Investigator), Baxendale, H. (Co-Investigator), Edgeworth, J. (Co-Investigator), Kipling, D. (Co-Investigator) & Spencer, J. (Co-Investigator)
1/11/2007 → 8/07/2012
Project: Research
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NIHR Biomedical Research Centre
Afzali, B. (Primary Investigator), Antoniou, M. (Primary Investigator), Barker, J. (Primary Investigator), Barratt, B. (Primary Investigator), Beighton, D. (Primary Investigator), Bevan, S. (Primary Investigator), Blower, P. (Primary Investigator), Burchell, J. (Primary Investigator), Cason, J. (Primary Investigator), Chappell, L. (Primary Investigator), Cope, A. (Primary Investigator), Corrigan, C. (Primary Investigator), Cunninghame Graham, D. (Primary Investigator), Dontu, G. (Primary Investigator), Edgeworth, J. (Primary Investigator), Farzaneh, F. (Primary Investigator), Gee, T. (Primary Investigator), Gould, H. (Primary Investigator), Green, P. (Primary Investigator), Greenough, A. (Primary Investigator), Grigoriadis, A. (Primary Investigator), Hayday, A. (Primary Investigator), Higginson, I. (Primary Investigator), Kalra, L. (Primary Investigator), Karagiannis, S. (Primary Investigator), Kelly, F. (Primary Investigator), Kemper, C. (Primary Investigator), Lau-Walker, M. (Primary Investigator), Lavender, P. (Primary Investigator), Lee, T. (Primary Investigator), Lempp, H. (Primary Investigator), Lewis, C. (Primary Investigator), Lombardi, G. (Primary Investigator), Lord, G. (Primary Investigator), Marber, M. (Primary Investigator), Mason, J. (Primary Investigator), Mathew, C. (Primary Investigator), McGrath, J. (Primary Investigator), Metcalfe, A. (Primary Investigator), Molokhia, M. (Primary Investigator), Mullen, G. (Primary Investigator), Nagel, E. (Primary Investigator), Neil, S. (Primary Investigator), Nestle, F. (Primary Investigator), Oakey, R. (Primary Investigator), Parker, P. (Primary Investigator), Peakman, M. (Primary Investigator), Perera, D. (Primary Investigator), Purushotham, A. (Primary Investigator), Rasekh Ahmadi, K. (Primary Investigator), Rashid, T. (Primary Investigator), Razavi, R. (Primary Investigator), Ridley, A. (Primary Investigator), Robson, M. (Primary Investigator), Sacks, S. (Primary Investigator), Sanchez Fueyo, A. (Primary Investigator), Santis, G. (Primary Investigator), Sanz Moreno, V. (Primary Investigator), Sawyer, E. (Primary Investigator), Schaeffter, T. (Primary Investigator), Shah, A. (Primary Investigator), Sharpe, P. (Primary Investigator), Simpson, M. (Primary Investigator), Smith, R. (Primary Investigator), Sorinola, I. (Primary Investigator), Spector, T. (Primary Investigator), Spicer, J. (Primary Investigator), Taams, L. (Primary Investigator), Tavassoli, M. (Primary Investigator), Taylor, D. (Primary Investigator), Tree, T. (Primary Investigator), Trembath, R. (Primary Investigator), Tribe, R. (Primary Investigator), Tutt, A. (Primary Investigator), Waltham, M. (Primary Investigator), Watt, F. (Primary Investigator), Webb, A. (Primary Investigator), Wells, C. (Primary Investigator), Whelan, K. (Primary Investigator), Whitaker, J. (Primary Investigator), Whittlesea, C. (Primary Investigator), Williamson, C. (Primary Investigator), Wolfe, C. (Primary Investigator), Yu, V. (Primary Investigator), academic, A. (Primary Investigator), Hughes, S. (Co-Investigator), Montana, G. (Co-Investigator), Rhode, K. (Co-Investigator), Schnabel, J. (Co-Investigator) & Tziotzios, C. (Co-Investigator)
NIHR National Institute For Health & Care Research, DHSC Department of Health and Social Care
1/04/2007 → 31/03/2017
Project: Research
Activities
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London Health Protection Forum
Edgeworth, J. (Keynote/plenary speaker)
Mar 2007 → …Activity: Participating in or organising an event › Participation in conference
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12th International Congress of Mucosal Immunology ~ Boston
Edgeworth, J. (Speaker)
2005 → …Activity: Participating in or organising an event › Participation in conference
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Interscience Conference on Antimicrobial Agents and Chemotherapy ~ Washington
Edgeworth, J. (Speaker)
2005 → …Activity: Participating in or organising an event › Participation in conference
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British Pharmaceutical Conference , Manchester
Edgeworth, J. (Keynote/plenary speaker)
Sept 2004 → …Activity: Participating in or organising an event › Participation in conference
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British Infection Society
Edgeworth, J. (Member)
2001 → …Activity: Other › Types of External academic engagement - Membership of external research organisation
Prizes
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Fellowship of the Royal College of Pathologists
Edgeworth, J. (Recipient), 2007
Prize: Fellowship awarded competitively