Research output per year
Research output per year
Personal profile
Research interests
Cardiac excitation-contraction coupling; fluorescence spectromicroscopy of Ca2+; changes in the passive and active (contractile) properties of the cardiac myofilaments in heart disease.
Research interests (short)
Changes in the contractile properties of the cardiac myofilaments in heart disease.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Right Ventricle Has Normal Myofilament Function But Shows Perturbations in the Expression of Extracellular Matrix Genes in Patients With Tetralogy of Fallot Undergoing Pulmonary Valve Replacement
Brayson, D., Holohan, S. J., Bardswell, S. C., Arno, M., Lu, H., Jensen, H. K., Tran, P. K., Barallobre-Barreiro, J., Mayr, M., Dos Remedios, C. G., Tsang, V. T., Frigiola, A. & Kentish, J. C., 18 Aug 2020, In: Journal of the American Heart Association. 9, 16, p. e015342Research output: Contribution to journal › Article › peer-review
Open Access9 Citations (Scopus) -
The right ventricle of Tetralogy of Fallot patients undergoing pulmonary valve replacement has normal myofilament function but shows perturbations to the expression of extracellular matrix genes
Brayson, D., Holohan, S-J., Bardswell, S. C., Arno, M., Lu, H., Jensen, H. K., Kiet Tran, P., Barallobre-Barreiro, J., Mayr, M., G.dos Remedios, C., T. Tsang, V., Frigiola, A. & Kentish, J., 28 May 2020, (Accepted/In press) In: Journal of the American Heart Association.Research output: Contribution to journal › Article › peer-review
Open AccessFile134 Downloads (Pure) -
Monophosphorylation of cardiac troponin-I at Ser23/24 is sufficient to regulate cardiac myofibrillar Ca2+ sensitivity and calpain-induced proteolysis
Martin-garrido, A., Biesiadecki, B. J., Salhi, H. E., Shaifta, Y., Dos Remedios, C. G., Ayaz-guner, S., Cai, W., Ge, Y., Avkiran, M. & Kentish, J. C., 1 Jun 2018, In: Journal of Biological Chemistry. 293, 22, p. 8588-8599Research output: Contribution to journal › Article › peer-review
Open AccessFile29 Citations (Scopus)223 Downloads (Pure) -
A model of cardiac contraction based on novel measurements of tension development in human cardiomyocytes
Land, S., Park-Holohan, S. J., Smith, N. P., dos Remedios, C. G., Kentish, J. C. & Niederer, S. A., 1 May 2017, In: Journal of Molecular and Cellular Cardiology. 106, 0, p. 68-83 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile94 Citations (Scopus)539 Downloads (Pure) -
Reduced First-Phase Ejection Fraction and Sustained Myocardial Wall Stress in Hypertensive Patients with Diastolic Dysfunction: A Manifestation of Impaired Shortening Deactivation That Links Systolic to Diastolic Dysfunction and Preserves Systolic Ejection Fraction
Gu, H., Li, Y., Fok, H., Simpson, J., Kentish, J., Shah, A. & Chowienczyk, P., 1 Apr 2017, In: Hypertension. 69, 4, p. 633-640 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile45 Citations (Scopus)93 Downloads (Pure)
Projects
- 20 Finished
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Mechanistic Stratification of Heart Failure with Preserved Ejection Fraction Patients
Niederer, S., Holohan, S., Kentish, J., Land, S., Perera, D. & Unknown, U.
1/10/2015 → 30/09/2018
Project: Research
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Modelling the human heart: An integrated experimental and computational study
Kentish, J., Niederer, S. & Smith, N.
BBSRC Biotechnology and Biological Sciences Research Council
1/05/2012 → 30/11/2015
Project: Research