Jonathan Coleman

16999

Citations

Research interests (short)

Extending psychiatric genomics to identify related and relevant biology

Biographical details

Following my undergraduate degree in Natural Sciences, I joined the Social, Genetic and Developmental Psychiatry (SGDP) Centre as a MSc+PhD student, working with Thalia Eley and Gerome Breen on genomic methods to study gene-environment interplay. As part of that, I performed the initial genome-wide association studies on cognitive behavioural therapy response in anxiety. I then joined Prof Breen's group as a postdoctoral researcher, working broadly in psychiatric genomics, but particularly on depression and its relationship to comorbid traits. Since January 2020, I am a Lecturer in Statistical Genetics at the SGDP, where I will focus on translating statistical genetic findings from psychiatric research to understand related and relevant biology.

Research interests

The application of polygenic risk scores to biological phenotypes and to the study of individuals
The integration of biological data to inform conclusions from statistical genetic methods
The genetic epidemiology of psychiatric disorders, particularly post-traumatic stress disorder

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

SDG 3 Good Health and Well-being
SDG 10 Reduced Inequalities
SDG 16 Peace, Justice and Strong Institutions

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125 Article
2 Editorial
2 Letter
2 Review article
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Genome-wide association studies of binge-eating behaviour and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes
Coleman, J., 10 Apr 2026, (Accepted/In press) In: Nature Mental Health.
Research output: Contribution to journal › Article › peer-review

Open Access
File

12 Downloads (Pure)
Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder
ter Kuile, A. R., Mitchell, B. L., Lee, S.-H., Morneau-Vaillancourt, G., Skelton, M., Coleman, J., Davies, H. L., Mundy, J., Peel, A. J., Hübel, C., Davies, M. R., Fürtjes, A. E., Ahmad, Z., Lin, Y., Adey, B. N., McGregor, T., Zvrskovec, J., Hotopf, M., Kalsi, G. & Hirsch, C. & 2 others, Breen, G. & Eley, T., 29 Jun 2026, (E-pub ahead of print) In: Molecular Psychiatry. 14 p.
Research output: Contribution to journal › Article

Open Access
File
15 Downloads (Pure)
Genome-wide meta-analysis of quantitatively measured generalized anxiety symptoms in individuals of European ancestry
Skelton, M., Mitchell, B. L., Assary, E., Li, D., Morneau-Vaillancourt, G., Murphy, A. E., ter Kuile, A. R., Wang, R., Adams, M., Byrne, E. M., Corfield, E., Grimes, P. Z., Hannigan, L., Jihua, H., Kõiv, K., Kwong, A. S. F., Papiol, S., Johanne H, P., Pistis, G. & Castelao, E. & 4 others, Strom, N., Breen, G., Coleman, J. & Eley, T., 9 Jun 2026, (E-pub ahead of print) In: Nature Human Behaviour.
Research output: Contribution to journal › Article

Open Access
File
1 Citation (Scopus)

29 Downloads (Pure)
Isolating the Genetic Component of Mania in Bipolar Disorder
Merola, G. P., Zvrskovec, J., Wang, R., Li, Y. K., Castellini, G., Ricca, V., Coleman, J., Vassos, E. & Breen, G., 27 Jan 2026, (E-pub ahead of print) In: Biological psychiatry.
Research output: Contribution to journal › Article › peer-review

Open Access
File
10 Downloads (Pure)
Fine-mapping genomic loci refines bipolar disorder risk genes
Koromina, M., Ravi, A., Panagiotaropoulou, G., Schilder, B. M., Humphrey, J., Braun, A., Bigdeli, T., Chatzinakos, C., Coombes, B. J., Kim, J., Liu, X., Terao, C., O'Connell, K. S., Adams, M. J., Adolfsson, R., Alda, M., Alfredsson, L., Andlauer, T. F. M., Andreassen, O. A. & Antoniou, A. & 113 others, Baune, B. T., Bengesser, S., Biernacka, J., Boehnke, M., Bosch, R., Cairns, M. J., Carr, V. J., Casas, M., Catts, S., Cichon, S., Corvin, A., Craddock, N., Dafnas, K., Dalkner, N., Dannlowski, U., Degenhardt, F., Di Florio, A., Dikeos, D., Fellendorf, F. T., Ferentinos, P., Forstner, A. J., Forty, L., Frye, M., Fullerton, J. M., Gawlik, M., Gizer, I. R., Gordon-Smith, K., Green, M. J., Grigoroiu-Serbanescu, M., Guzman-Parra, J., Hahn, T., Henskens, F., Hillert, J., Jablensky, A. V., Jones, L., Jones, I., Jonsson, L., Kelsoe, J. R., Kircher, T., Kirov, G., Kittel-Schneider, S., Kogevinas, M., Landén, M., Leboyer, M., Lenger, M., Lissowska, J., Lochner, C., Loughland, C., MacIntyre, D. J., Martin, N. G., Maratou, E., Mathews, C. A., Mayoral, F., McElroy, S. L., McGregor, N. W., McIntosh, A., McQuillin, A., Michie, P., Mitchell, P. B., Moutsatsou, P., Mowry, B., Müller-Myhsok, B., Myers, R. M., Nenadić, I., Nievergelt, C. M., Nöthen, M. M., Nurnberger, J., 'Donovan, M. O., 'Donovan, C. O., Ophoff, R. A., Owen, M. J., Pantelis, C., Pato, C., Pato, M. T., Patrinos, G. P., Pawlak, J. M., Perlis, R. H., Porichi, E., Posthuma, D., Ramos-Quiroga, J. A., Reif, A., Reininghaus, E. Z., Ribasés, M., Rietschel, M., Schall, U., Schofield, P. R., Schulze, T. G., Scott, L., Scott, R. J., Serretti, A., Smoller, J. W., Świątkowska, B., Soler Artigas, M., Stein, D. J., Streit, F., Toma, C., Tooney, P., Vawter, M. P., Vieta, E., Vincent, J. B., Waldman, I. D., Weickert, C. S., Weickert, T., Witt, S. H., Hong, K. S., Ikeda, M., Iwata, N., Won, H.-H., Edenberg, H. J., Ripke, S., Raj, T., Coleman, J. R. I. & Mullins, N., 25 Jun 2025, In: Nature Neuroscience. 28, 7, p. 1393-1403 11 p.
Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus)

4 Finished
5 Active

MHG-GLAD: The Mental Health Goals Omics Project (MHG Omics): A UK Multi-Omics Infrastructure and Resource for Mood Disorders
Breen, G. (Primary Investigator), Coleman, J. (Co-Investigator), Cummins, N. (Co-Investigator), Eley, T. (Co-Investigator), Herle, M. (Co-Investigator) & Vassos, E. (Co-Investigator)
MRC Medical Research Council
1/12/2025 → 31/03/2030
Project: Research
BioRes280: SLaM 400K BioResource MH Renewal 2025-2029
Breen, G. (Primary Investigator) & Coleman, J. (Co-Investigator)
NIHR National Institute For Health & Care Research
1/04/2025 → 31/03/2029
Project: Research
PRADA: “Prescribing the Right Agent for Depression in Adults (PRADA): an adaptive randomised trial using a web-based multi-modal clinical decision support system to personalise antidepressant treatment in routine healthcare across the world”
Breen, G. (Primary Investigator) & Coleman, J. (Co-Investigator)
Wellcome Trust
1/11/2024 → 31/10/2028
Project: Research
Maudsley BRC: NIHR SLaM BRC
Hotopf, M. (Primary Investigator), Brose, L. (Co-Investigator), Brown, J. (Co-Investigator), Chalder, T. (Co-Investigator), Cleare, A. (Co-Investigator), Coleman, J. (Co-Investigator), Cunningham, J. (Co-Investigator), Dazzan, P. (Co-Investigator), Deluca, P. (Co-Investigator), Desrivieres, S. (Co-Investigator), Di Forti, M. (Co-Investigator), Dobson, R. (Co-Investigator), Drummond, C. (Co-Investigator), Dutta, R. (Co-Investigator), Egerton, A. (Co-Investigator), Emsley, R. (Co-Investigator), Gilchrist, G. (Co-Investigator), Gillett, A. (Co-Investigator), Goadsby, P. (Co-Investigator), Happe, F. (Co-Investigator), Hirsch, C. (Co-Investigator), Hoffmann, J. (Co-Investigator), Ismail, K. (Co-Investigator), Koutsouleris, N. (Co-Investigator), Lewis, C. (Co-Investigator), Marsden, J. (Co-Investigator), McAlonan, G. (Co-Investigator), McNeill, A. (Co-Investigator), Mehta, M. (Co-Investigator), Mondelli, V. (Co-Investigator), Moran, R. (Co-Investigator), Moss-Morris, R. (Co-Investigator), Neale, J. (Co-Investigator), Pariante, C. (Co-Investigator), Pile, V. (Co-Investigator), Powell, T. (Co-Investigator), Robson, D. (Co-Investigator), Rucker, J. (Co-Investigator), Schmidt, U. (Co-Investigator), Sonuga-Barke, E. (Co-Investigator), Stahl, D. (Co-Investigator), Stewart, R. (Co-Investigator), Strang, J. (Co-Investigator), Sweeney, A. (Co-Investigator), Turkheimer, F. (Co-Investigator), Vassos, E. (Co-Investigator), Wong, C. (Co-Investigator), Wykes, T. (Co-Investigator), Young, A. (Co-Investigator), Zahn, R. (Co-Investigator) & Zelaya, F. (Co-Investigator)
NIHR National Institute For Health & Care Research
1/12/2022 → 30/11/2027
Project: Research
Integrating polygenic risk scores with clinical drug development
Lewis, C. (Primary Investigator) & Coleman, J. (Co-Investigator)
UCB Pharma Ltd
1/10/2022 → 30/09/2026
Project: Research

R code for a latent class analysis of the UK Biobank data (Version 2)
Yapp, E., Davis, K., Coleman, J. & Booth, T., King's College London, 15 Apr 2021
DOI: 10.18742/rdm01-727, https://kcl.figshare.com/articles/software/R_code_for_a_latent_class_analysis_of_the_UK_Biobank_data_Version_2_/16473960
Dataset
Genome-wide association study of facial emotion recognition in children and association with polygenic risk for mental health disorders
Munafo, M., Coleman, J., Reed, Z., Lester, K., Keers, R., Gerome Breen & Eley, T., University of Bristol, 5 Nov 2019
DOI: 10.5523/bris.13l8yadatwq602lusa9g9ss786
Dataset
R code for a latent class analysis of the UK Biobank data
Yapp, E., Davis, K., Coleman, J. & Booth, T., King's College London, 1 Jun 2020
DOI: 10.18742/rdm01-603, https://kcl.figshare.com/articles/software/R_code_for_a_latent_class_analysis_of_the_UK_Biobank_data/16473912
Dataset
Code for use in R statistics with UK Biobank Mental Health Questionnaire data
Coleman, J. R. & Davis, K., Mendeley, 21 Sept 2017
DOI: 10.17632/kv677c2th4.1
Dataset
Summary statistics for three depression phenotypes in UK Biobank
Howard, D., Adams, M., Shirali, M., Clarke, T.-K., Marioni, R., Davies, G., Coleman, J., Alloza, C., Shen, X., Barbu, M., Wigmore, E., Gibson, J., 23andMe Research Team, Hagenaars, S., Lewis, C., Ward, J., Smith, D., Sullivan, P., Haley, C., Breen, G., Deary, I. & McIntosh, A., University of Edinburgh, 16 May 2018
DOI: 10.7488/ds/2350
Dataset

Jonathan Coleman

Personal profile

Research interests (short)

Biographical details

Research interests

Expertise related to UN Sustainable Development Goals

Fingerprint

Collaborations and top research areas from the last five years

Dive into details

Genome-wide association studies of binge-eating behaviour and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes

Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder

Genome-wide meta-analysis of quantitatively measured generalized anxiety symptoms in individuals of European ancestry

Isolating the Genetic Component of Mania in Bipolar Disorder

Fine-mapping genomic loci refines bipolar disorder risk genes

MHG-GLAD: The Mental Health Goals Omics Project (MHG Omics): A UK Multi-Omics Infrastructure and Resource for Mood Disorders

BioRes280: SLaM 400K BioResource MH Renewal 2025-2029

PRADA: “Prescribing the Right Agent for Depression in Adults (PRADA): an adaptive randomised trial using a web-based multi-modal clinical decision support system to personalise antidepressant treatment in routine healthcare across the world”

Maudsley BRC: NIHR SLaM BRC

Integrating polygenic risk scores with clinical drug development

R code for a latent class analysis of the UK Biobank data (Version 2)

Genome-wide association study of facial emotion recognition in children and association with polygenic risk for mental health disorders

R code for a latent class analysis of the UK Biobank data

Code for use in R statistics with UK Biobank Mental Health Questionnaire data

Summary statistics for three depression phenotypes in UK Biobank

Jonathan Coleman

Personal profile

Research interests (short)

Biographical details

Research interests

Expertise related to UN Sustainable Development Goals

Fingerprint

Collaborations and top research areas from the last five years

Research output

Projects

Datasets