Research output per year
Research output per year
Personal profile
Research interests
Cryo-electron microscopy, Neuroscience, Cell cytoskeleton.
Microtubules are essential dynamic cytoplasmic filaments, serving structural roles and as platforms for molecular motors and compartmentalised signalling. Microtubule organisation is regulated by an array of binding partners. Microtubules and associated proteins are indispensable to eukaryotic cellular fundamentals including cell division, differentiation and plasticity. Their dysfunction or hijack are implicated in cancers, neurological conditions and infectious diseases. The Atherton group aims to unveil the mechanisms of microtubule-associated regulators and molecular motors integral to cellular function and dysfunction, with a central nervous system emphasis, primarily using the powerful and popular technique of cryo-electron microscopy to determine structure-function relationships at various scales.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Research output
- 11 Article
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A microtubule RELION-based pipeline for cryo-EM image processing
Cook, A. D., Manka, S. W., Wang, S., Moores, C. A. & Atherton, J. M., 2020, In: Journal of Structural Biology. 209, 1, 107402.Research output: Contribution to journal › Article › peer-review
Open Access29 Citations (Scopus) -
The mechanism of kinesin inhibition by kinesin binding protein
Atherton, J., Hummel, J. J., Olieric, N., Locke, J., Peña, A., Rosenfeld, S. S., Steinmetz, M. O., Hoogenraad, C. C. & Moores, C. A., 30 Nov 2020, (E-pub ahead of print) In: eLife. 9, p. 1-78 78 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
Structural determinants of microtubule minus end preference in CAMSAP CKK domains
Atherton, J., Luo, Y., Xiang, S., Yang, C., Rai, A., Jiang, K., Stangier, M., Vemu, A., Cook, A. D., Wang, S., Roll-Mecak, A., Steinmetz, M. O., Akhmanova, A., Baldus, M. & Moores, C. A., 20 Nov 2019, In: Nature Communications. 10, p. 1-16 5236.Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Citations (Scopus)153 Downloads (Pure) -
Microtubule architecture in vitro and in cells revealed by cryo-electron tomography
Atherton, J. M., Stouffer, M., Francis, F. & Moores, C. A., 2018, In: Acta Crystallographica Section D Structural Biology.Research output: Contribution to journal › Article › peer-review
58 Citations (Scopus) -
Mitotic phosphorylation by Nek6 and Nek7 reduces microtubule affinity of EML4 to alter spindle dynamics and promote chromosome congression
Fry, A. M., Adib, R., Montgomery, J. M., Atherton, J. M., O'Regan, L., Richards, M., Straatman, K. R., Roth, D., Straube , A., Bayliss , R. & Moores , C. A., 2018, In: Science Signaling.Research output: Contribution to journal › Article › peer-review
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Structural and functional studies of the VAPB-PTPIP51 ER-mitochondria tethering proteins in neurodegenerative diseases
Miller, C. (Primary Investigator), Atherton, J. (Co-Investigator), Mitchell, J. (Co-Investigator), Noble, W. (Co-Investigator) & Vagnoni, A. (Co-Investigator)
30/10/2023 → 29/10/2026
Project: Research
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Mechanisms of kinesin control by kinesin binding protein
Atherton, J. (Primary Investigator)
BBSRC Biotechnology and Biological Sciences Research Council
5/01/2022 → 4/04/2025
Project: Research
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A cryo-electron microscope for structural biology (including single-particle and tomography) at KCL.
Conte, M. (Primary Investigator), Atherton, J. (Co-Investigator), Beavil, A. (Co-Investigator), Bergeron, J. (Co-Investigator), Booth, P. (Co-Investigator), Burrone, J. (Co-Investigator), Carlton, J. (Co-Investigator), De Nicola, G. (Co-Investigator), Ehler, E. (Co-Investigator), Fleck, R. (Co-Investigator), Fraternali, F. (Co-Investigator), Garnett, J. (Co-Investigator), Gautel, M. (Co-Investigator), Isaacson, R. (Co-Investigator), Kampourakis, T. (Co-Investigator), Malim, M. (Co-Investigator), McDonnell, J. (Co-Investigator), Neil, S. (Co-Investigator), Odendall, C. (Co-Investigator), Pfuhl, M. (Co-Investigator), Politis, A. (Co-Investigator), Steiner, R. (Co-Investigator) & Sutton, B. (Co-Investigator)
BBSRC Biotechnology and Biological Sciences Research Council
1/08/2022 → 31/07/2023
Project: Research
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SECMALS: A dual DLS and SEC-MALS instrumentation to characterize the oligomerization of protein samples for structural biology, mechanistic biology, and therapeutic development
Bergeron, J. (Primary Investigator), Atherton, J. (Co-Investigator), Beavil, A. (Co-Investigator), Booth, P. (Co-Investigator), Conte, M. (Co-Investigator), Garnett, J. (Co-Investigator), Isaacson, R. (Co-Investigator), Malim, M. (Co-Investigator), Muller, M. (Co-Investigator), Pfuhl, M. (Co-Investigator), Politis, A. (Co-Investigator), Sanderson, M. (Co-Investigator), Steiner, R. (Co-Investigator), Surman, A. (Co-Investigator) & Sutton, B. (Co-Investigator)
BBSRC Biotechnology and Biological Sciences Research Council
3/11/2021 → 31/10/2022
Project: Research
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Ultrastructural characterisation of the myelination process by cryo-electron tomography
Atherton, J. (Primary Investigator)
31/03/2021 → 30/03/2022
Project: Research