Julian Naglik

Julian Naglik

Professor

  • Phone86123
  • SE1 1UL

    United Kingdom

  • 8306
    Citations

Personal profile

Research interests

My laboratory investigates host-pathogen interactions and mucosal immunity, particularly targeting the opportunistic fungal pathogen Candida albicans. We utilise molecular, cellular, immunological, functional genomic and proteomic techniques in our studies and our work has made several important advances to both the fungal and mucosal immunity fields. We have identified a epithelial MAPK signalling mechanism that discriminates between the yeast and hyphal form of C. albicans, which has implications to our understanding of how mucosal tissues recognise commensal and pathogenic C. albicans. More recently, we discovered that C. albicans hyphae secrete a cytolytic peptide toxin, which we named Candidalysin, that accounts for epithelial activation and induction of immunity. The ultimate goal of our research is to understand the disease process and to translate research discoveries into clinical practice.

 

The Naglik laboratory

Research interests (short)

Host-pathogen interactions, Candida pathogenesis, Innate immunity, Epithelial biology, Pattern recognition

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Doctor of Philosophy, Candida albicans secreted aspartyl proteinases and human mucosal candidosis, King's College London

Award Date: 1 Jan 2001

Bachelor of Science, University of East London

Award Date: 1 Jan 1992

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