Research output per year
Research output per year
Personal profile
Research interests
My laboratory investigates host-pathogen interactions and mucosal immunity, particularly targeting the opportunistic fungal pathogen Candida albicans. We utilise molecular, cellular, immunological, functional genomic and proteomic techniques in our studies and our work has made several important advances to both the fungal and mucosal immunity fields. We have identified a epithelial MAPK signalling mechanism that discriminates between the yeast and hyphal form of C. albicans, which has implications to our understanding of how mucosal tissues recognise commensal and pathogenic C. albicans. More recently, we discovered that C. albicans hyphae secrete a cytolytic peptide toxin, which we named Candidalysin, that accounts for epithelial activation and induction of immunity. The ultimate goal of our research is to understand the disease process and to translate research discoveries into clinical practice.
Research interests (short)
Host-pathogen interactions, Candida pathogenesis, Innate immunity, Epithelial biology, Pattern recognition
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Candida albicans secreted aspartyl proteinases and human mucosal candidosis, King's College London
Award Date: 1 Jan 2001
Bachelor of Science, University of East London
Award Date: 1 Jan 1992
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Collaborations and top research areas from the last five years
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Candidalysin is a fungal peptide toxin critical for mucosal infection
Moyes, D. L., Wilson, D., Richardson, J. P., Mogavero, S., Tang, S. X., Wernecke, J., Hofs, S., Gratacap, R. L., Robbins, J., Runglall, M., Murciano, C., Blagojevic, M., Thavaraj, S., Forster, T. M., Hebecker, B., Kasper, L., Vizcay-Barrena, G., Iancu, S. I., Kichik, N. & Hader, A. & 11 others, , 7 Apr 2016, In: NATURE. 532, 7597, p. 64-68 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile644 Citations (Scopus)334 Downloads (Pure) -
Immune regulation by fungal strain diversity in inflammatory bowel disease
Li, X. V., Leonardi, I., Putzel, G. G., Semon, A., Fiers, W. D., Kusakabe, T., Lin, W.-Y., Gao, I. H., Doron, I., Gutierrez-Guerrero, A., DeCelie, M. B., Mesko, M., Chen, Y., Naglik, J. R., Hube, B., Scherl, E. J. & Iliev, I. D., 24 Mar 2022, In: NATURE. 603, 7902, p. 672-678 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile153 Citations (Scopus)181 Downloads (Pure) -
Candida Albicans Elicits Protective Allergic Responses Via Platelet Mediated T helper 2 and T helper 17 Cell Polarization
Wu, Y., Zeng, Z., Guo, Y., Song, L., Weatherhead, J. E., Huang, X., Zeng, Y., Bimler, L., Chang, C.-Y., Knight, J. M., Valladolid, C., Sun, H., Cruz, M. A., Hube, B., Naglik, J. R., Luong, A. U., Kheradmand, F. & Corry, D. B., 9 Nov 2021, In: Immunity. 54, 11, p. 2595-2610.e7Research output: Contribution to journal › Article › peer-review
Open AccessFile52 Citations (Scopus)130 Downloads (Pure) -
Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor
Ho, J., Yang, X., Nikou, S. A., Kichik, N., Donkin, A., Ponde, N. O., Richardson, J. P., L. Gratacap, R., S. Archambault, L., P. Zwirner, C., Murciano, C., Henley-Smith, R., Thavaraj, S., J. Tynan, C., L. Gaffen, S., Hube, B., T. Wheeler, R., Moyes, D. L. & Naglik, J. R., 1 Dec 2019, In: Nature Communications. 10, 1, 2297.Research output: Contribution to journal › Article › peer-review
Open AccessFile110 Citations (Scopus)273 Downloads (Pure) -
CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment
Drummond, R. A., Swamydas, M., Oikonomou, V., Zhai, B., Dambuza, I. M., C. Schaefer, B., Bohrer, A. C., D. Mayer-Barber, K., A. Lira, S., Iwakura, Y., G. Filler, S., D. Brown, G., Hube, B., Naglik, J. R., M. Hohl, T. & S. Lionakis, M., 1 May 2019, In: Nature Immunology. 20, 5, p. 559-570 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile167 Citations (Scopus)103 Downloads (Pure)
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Host and Fungal Regulation of Type 17 Immunity to Oral Candidiasis
Naglik, J. (Primary Investigator)
NIH National Institutes of Health
1/08/2022 → 31/07/2025
Project: Research
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Identification of novel innate protective mechanisms against mucosal pathogens resulting from differential pattern recognition
Naglik, J. (Primary Investigator)
Project: Research
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biofilm: A microfluidic system and confocal microscope for the molecular and mechanistic characterisation of microbial biofilms
Garnett, J. (Primary Investigator), Bergeron, J. (Co-Investigator), Bergholt, M. (Co-Investigator), Carpenter, G. (Co-Investigator), Dyson, A. (Co-Investigator), Elsharkawy, S. (Co-Investigator), Flak, M. (Co-Investigator), Jones, S. (Co-Investigator), Mason, J. (Co-Investigator), Moyes, D. (Co-Investigator), Naglik, J. (Co-Investigator), Neves, J. (Co-Investigator), Proctor, G. (Co-Investigator), Rahman, M. (Co-Investigator), Sailem, H. (Co-Investigator) & Sousa Moreno, V. (Co-Investigator)
BBSRC Biotechnology and Biological Sciences Research Council
1/08/2023 → 31/07/2024
Project: Research
Activities
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48th Annual Meeting of the British Society for Medical Mycology, Cardiff, UK
Naglik, J. (Organiser)
Apr 2012 → …Activity: Participating in or organising an event › Participation in conference
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Host-fungal interactions: pathogenicity versus immunity, BioPark Hertfordshire, UK
Naglik, J. (Chair)
Oct 2011 → …Activity: Participating in or organising an event › Participation in conference
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EuroSciCon: Host-fungal interactions: pathogenicity versus immunity, BioPark Hertfordshire, UK
Naglik, J. (Organiser)
Oct 2011 → …Activity: Participating in or organising an event › Participation in conference
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47th Annual Meeting of the British Society for Medical Mycology, Glasgow, UK
Naglik, J. (Organiser)
Apr 2011 → …Activity: Participating in or organising an event › Participation in conference
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for International Journal for Microbiology Special Issue: “Host-fungal interactions: pathogenicity versus immunity (Journal)
Naglik, J. (Editor)
2011 → …Activity: Publication peer-review and editorial work › Editorial activity
Prizes
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Executive Board Member for the British Society for Medical Mycology (Meetings Secretary)
Naglik, J. (Recipient), 2009
Prize: Election to learned society