The focus of our lab is to understand the molecular and cellular mechanisms underlying muscle weakness in a number of diseases. Our primary interest is congenital myopathies and muscular dystrophies. However, we also collaborate with other research groups to study muscle weakness in response to cancer and ageing. We hope that our work will provide sufficient knowledge to identify drug targets and design novel therapeutic interventions.

In our lab, we use human and animal muscle samples, and apply techniques ranging from single molecule biophysics to muscle cell physiology and from X-ray diffraction to high-resolution confocal microscopy.