King's College London

Research portal

Dr Karen Liu

Research interests

In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists.

The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse.

Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems.

In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3&#946.

 

Participation in workshop, seminar, course

Cold Spring Harbor Lab Xenopus Course

Liu, K. (Organiser)
20142019

Activity: Participating in or organising an eventParticipation in workshop, seminar, course

Types of External academic engagement - Contribution to the work of national or international committees and working groups

Biosciences Skills and Careers Panel Postdoctoral Subgroup

Liu, K. (Member)
20172019

Activity: OtherTypes of External academic engagement - Contribution to the work of national or international committees and working groups

Biosciences Skills and Careers Strategy Advisory Panel

Liu, K. (Member)
20172019

Activity: OtherTypes of External academic engagement - Contribution to the work of national or international committees and working groups

Xenopus Resource Development

Liu, K. (Member)
20092010

Activity: OtherTypes of External academic engagement - Contribution to the work of national or international committees and working groups

Participation in conference

Xenopus PI Meeting

Liu, K. (Organiser)
Sep 2010 → …

Activity: Participating in or organising an eventParticipation in conference

International Xenopus Resource Committee

Liu, K. (Organiser)
Nov 2009 → …

Activity: Participating in or organising an eventParticipation in conference

British Society for Developmental Biology

Liu, K. (Speaker)
Apr 2008 → …

Activity: Participating in or organising an eventParticipation in conference

Gordon Conference Craniofacial Morphogenesis

Liu, K. (Speaker)
Feb 2008 → …

Activity: Participating in or organising an eventParticipation in conference

Society for Developmental Biology,

Liu, K. (Speaker)
Jul 2005 → …

Activity: Participating in or organising an eventParticipation in conference

Gordon Conference Developmental Biology

Liu, K. (Speaker)
Jun 2005 → …

Activity: Participating in or organising an eventParticipation in conference

International Xenopus Meeting

Liu, K. (Speaker)
Sep 2004 → …

Activity: Participating in or organising an eventParticipation in conference

Publication peer-review

Journal of Clinical Investigations (Journal)

Liu, K. (Peer reviewer)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Chemistry & Biology (Journal)

Liu, K. (Peer reviewer)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Developmental Dynamics (Journal)

Liu, K. (Peer reviewer)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Developmental Biology (Journal)

Liu, K. (Peer reviewer)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Development (Cambridge): for advances in developmental biology and stem cells (Journal)

Liu, K. (Peer reviewer)
2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Types of Award - Fellowship awarded competitively

Regenerative Medicine Fellow, Stanford University 2004-6

Liu, K. (Recipient)
20042006

Activity: OtherTypes of Award - Fellowship awarded competitively

New York State Regents Scholarship, 4 years

Liu, K. (Recipient)
19881992

Activity: OtherTypes of Award - Fellowship awarded competitively

Empire State Scholarship, 4 years

Liu, K. (Recipient)
19881992

Activity: OtherTypes of Award - Fellowship awarded competitively

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