Research output per year
Research output per year
Professor
In any intricate developmental process, the encoded genes are interpreted as myriad intercellular and intracellular interactions, all of which must occur at the right time and place. With this in mind, we are developing new methods to block or alter the activities of individual proteins in a drug-dependent manner. Our goal is to expand the repertoire of molecular tools available to developmental biologists.
The biological problem that we are interested in is the development of the neural crest and its derivatives, including the craniofacial skeleton. At present, we are developing chemical tools to study the roles of GSK-3 and Wnt signaling in the neural crest. We are using two model systems, the frog Xenopus laevis and the mouse.
Xenopus embryos are abundant and live in an aquatic environment, allowing easy manipulation and drug accessibility; thus, we are using Xenopus to study early patterning and to rapidly test new tools. We then adapt these tools to mammalian systems.
In the mouse, we are currently studying the development of the bony skull, using conventional and drug-dependent alleles of GSK-3β.
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Doctor of Philosophy, University of California, Berkeley
Award Date: 1 Jan 2003
Bachelor of Arts, Columbia University
Award Date: 1 Jan 1994
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
1/10/2022 → 30/09/2026
Project: Research
Headlines Craniofacial Support
1/04/2023 → 30/06/2024
Project: Research
BBSRC Biotechnology and Biological Sciences Research Council
30/09/2022 → 31/03/2023
Project: Research
Karen Liu (Member)
Activity: Other › Types of External academic engagement - Contribution to the work of national or international committees and working groups
Karen Liu (Member)
Activity: Other › Types of External academic engagement - Contribution to the work of national or international committees and working groups
Karen Liu (Organiser)
Activity: Participating in or organising an event › Participation in workshop, seminar, course
Karen Liu (Organiser)
Activity: Participating in or organising an event › Participation in conference
Karen Liu (Organiser)
Activity: Participating in or organising an event › Participation in conference
Liu, Karen (Recipient), 2001
Prize: Fellowship awarded competitively