Search results

• 2024

  Different dysregulations of CYFIP1 and CYFIP2 in distinct types of dementia

  Peng, X., Wellard, N., Ghosh, A. G., Troakes, C. & Giese, P., Jan 2024, In: Brain Research Bulletin. 206, 110849.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dementia 100%
  • Hippocampus 66%
  • Dementia with Lewy Bodies 50%
  • Frontotemporal Dementia 33%
  • Synapse 16%
  1 Citation (Scopus)

• The intellectual disability risk gene Kdm5b regulates long term memory consolidation in the hippocampus

  Perez Sisques, L., Bhatt, S., Matuleviciute, R., Gileadi, T., Kramar, E., Graham, A., Garcia, F. G., Keiser, A., Matheos, D. P., Cain, J., Pittman, A. M., Andreae, L., Fernandes, C., Wood, M. A., Giese, P. & Basson, A., 8 May 2024, (E-pub ahead of print) In: The Journal of neuroscience : the official journal of the Society for Neuroscience.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Long-Term Memory 100%
  • Hippocampus 100%
  • Memory Consolidation 100%
  • Demethylase 60%
  • Lysine 40%

• Using deep learning to quantify neuronal activation from single-cell and spatial transcriptomic data

  Bahl, E., Chatterjee, S., Mukherjee, U., Elsadany, M., Vanrobaeys, Y., Lin, L-C., McDonough, M., Resch, J., Giese, K. P., Abel, T. & Michaelson, J. J., 26 Jan 2024, In: Nature Communications. 15, 1, 779.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Brain 100%
  • Neuronal Activity 66%
  • Long-Term Memory 33%
  • Synaptic Plasticity 33%
  • Molecular Processes 33%
• 2022

  Cysteine string protein alpha accumulates with early pre-synaptic dysfunction in Alzheimer's disease

  Rupawala, H., Shah, K., Davies, C., Rose, J., Colom-Cadena, M., Peng, X., Granat, L., Aljuhani, M., Mizuno, K., Troakes, C., Gomez Perez-Nievas, B., Morgan, A., So, P-W., Hortobagyi, T., Spires-Jones, T., Noble, W. & Giese, P., 23 Jul 2022, In: Brain Communications. 4, 4, p. fcac192 fcac192.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Protein 100%
  • Synapse 50%
  • Beta Amyloid 50%
  • Brain 25%
  • Dementia 12%
  4 Citations (Scopus)

  132 Downloads (Pure)

• Endoplasmic reticulum chaperone genes encode effectors of long-term memory

  Chatterjee, S., Bahl, E., Mukherjee, U., Walsh, E. N., Shetty, M. S., Yan, A. L., Vanrobaeys, Y., Lederman, J. D., Giese, K. P., Michaelson, J. & Abel, T., 25 Mar 2022, In: Science Advances. 8, 12, p. eabm6063 eabm6063.

  Research output: Contribution to journal › Article › peer-review

  • Gene 100%
  • Dementia 100%
  • Chaperone 100%
  • Endoplasmic reticulum 100%
  • Long Term Memory 100%
  12 Citations (Scopus)

• Mice Lacking the cAMP Effector Protein POPDC1 Show Enhanced Hippocampal Synaptic Plasticity

  Shetty, M. S., Ris, L., Schindler, R. F. R., Mizuno, K., Fedele, L., Giese, K. P., Brand, T. & Abel, T., 3 Aug 2022, In: Cerebral cortex (New York, N.Y. : 1991). 32, 16, p. 3457-3471 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein 100%
  • Nerve Cell Plasticity 100%
  • Synaptic Plasticity 100%
  • Potentiation 20%
  • Signaling Mechanism 20%
  3 Citations (Scopus)
• 2021

  Effects of Low-Dose Gestational TCDD Exposure on Behavior and on Hippocampal Neuron Morphology and Gene Expression in Mice

  Gileadi, T. E., Swamy, A. K., Hore, Z., Horswell, S., Ellegood, J., Mohan, C., Mizuno, K., Lundebye, A-K., Giese, K. P., Stockinger, B., Hogstrand, C., Lerch, J. P., Fernandes, C. & Basson, M. A., May 2021, In: Environmental Health Perspectives. 129, 5, p. 57002 1 p., 057002.

  Research output: Contribution to journal › Article › peer-review

  • Behavior (Neuroscience) 100%
  • Hippocampus 100%
  • Neuron 100%
  • 2,3,7,8-Tetrachlorodibenzodioxin 100%
  • Brain 66%
  15 Citations (Scopus)

• Effects of low-dose gestational TCDD exposure on behaviour, hippocampal neuron morphology and gene expression in mice

  Gileadi, T., Swamy, A., Hore, Z., Horsewell, S., Ellegood, J., Mohan, C., Mizuno, K., Lundebye, A-K., Giese, P., Stockinger, B., Hogstrand, C., Lerch, J., Fernandes, C. & Basson, M. A., 29 Mar 2021, (Accepted/In press) In: Environmental Health Perspectives.

  Research output: Contribution to journal › Article › peer-review

• PSD-95 in CA1 Area Regulates Spatial Choice Depending on Age

  Cały, A., Sliwinska, M. A., Ziółkowska, M., Łukasiewicz, K., Pagano, R., Dzik, J. M., Kalita, K., Bernas, T., Stewart, M. G., Giese, K. P. & Radwanska, K., 17 Mar 2021, In: Journal of Neuroscience. 41, 11, p. 2329-2343 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Synaptic Plasticity 100%
  • Dendritic Spine 100%
  • Hippocampus 66%
  • Social Interaction 33%
  • Cognitive Process 33%
  8 Citations (Scopus)
• 2020

  Alzheimer's disease-related dysregulation of mRNA translation causes key pathological features with ageing

  Ghosh, A., Mizuno, K., Tiwari, S., Proitsi, P., Gomez Perez-Nievas, B., Glennon, E., Martinez Nunez, R. & Giese, P., 16 Jun 2020, In: Translational psychiatry. 10, 1, p. 192

  Research output: Contribution to journal › Article › peer-review

  File

  • Amino Acid Activation 100%
  • Tau 50%
  • Reduction (Chemistry) 50%
  • Hippocampus 33%
  • Binding Protein 25%
  48 Citations (Scopus)

  111 Downloads (Pure)

• Long-lasting transcription in hippocampal area CA1 after contextual fear conditioning

  Mizuno, K., Jeffries, A., Abel, T. & Giese, P., 12 May 2020, (Accepted/In press) In: Neurobiology of learning and memory.

  Research output: Contribution to journal › Article › peer-review

  File

  • Long-Term Memory 100%
  • Fear Conditioning 100%
  • Memory Consolidation 100%
  • Transcription Factors 33%
  • Hippocampus 33%
  41 Downloads (Pure)

• Long-term Memory Upscales Volume of Postsynaptic Densities in the Process that Requires Autophosphorylation of αCaMKII

  Śliwińska, M. A., Cały, A., Borczyk, M., Ziółkowska, M., Skonieczna, E., Chilimoniuk, M., Bernaś, T., Giese, K. P. & Radwanska, K., 14 Apr 2020, In: Cerebral cortex (New York, N.Y. : 1991). 30, 4, p. 2573-2585 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Long-Term Memory 100%
  • Dendritic Spine 80%
  • Synapse 40%
  • Brain 40%
  • Vertebral Column 40%
  12 Citations (Scopus)

• Pharmacological activation of Nr4a rescues age-associated memory decline

  Chatterjee, S., Walsh, E. N., Yan, A. L., Giese, K. P., Safe, S. & Abel, T., 1 Jan 2020, In: Neurobiology of Aging. 85, p. 140-144 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Transcription Factors 100%
  • Synaptic Plasticity 49%
  • Cognitive Disorders 49%
  18 Citations (Scopus)

• The CBP KIX domain regulates long-term memory and circadian activity

  Chatterjee, S., Angelakos, C. C., Bahl, E., Hawk, J. D., Gaine, M. E., Poplawski, S. G., Schneider-Anthony, A., Yadav, M., Porcari, G. S., Cassel, J. C., Giese, K. P., Michaelson, J. J., Lyons, L. C., Boutillier, A. L. & Abel, T., 1 Dec 2020, In: BMC Biology. 18, 1, 155.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Long-Term Memory 100%
  • Cyclic AMP Responsive Element Binding Protein Binding Protein 100%
  • CREB-binding Protein 100%
  • Gene 57%
  • Water Maze 28%
  16 Citations (Scopus)

• Transcriptional corepressor SIN3A regulates hippocampal synaptic plasticity via Homer1/mGluR5 signaling

  Bridi, M., Schoch, H., Florian, C., Poplawski, S. G., Banerjee, A., Hawk, J. D., Porcari, G. S., Lejards, C., Hahn, C. G., Giese, K. P., Havekes, R., Spruston, N. & Abel, T., 12 Mar 2020, In: JCI Insight. 5, 5, e92385.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nerve Cell Plasticity 100%
  • Synaptic Plasticity 100%
  • Epigenetic Modification 40%
  • Gene 40%
  • Long Term Potentiation 40%
  19 Citations (Scopus)
• 2019

  Alzheimer’s disease-related dysregulation of protein synthesis causes key pathological features with ageing

  Ghosh, A., Mizuno, K., Tiwari, S. S., Proitsi, P., Gomez Perez-Nievas, B., Glennon, E. B. C., Martinez Nunez, R. T. & Giese, K. P., 21 Dec 2019, In: bioRxiv.

  Research output: Contribution to journal › Article

  Open Access

• Multi-input synapses, but not LTP-strengthened synapses, correlate with hippocampal memory storage in aged mice

  Aziz, W., Kraev, I., Mizuno, K., Kirby, A. J., Fang, T., Rupawala, H. J., Kasbi, K., Rothe, S., Jozsa, F., Rosenblum, K., Stewart, M. & Giese, K. P., 4 Nov 2019, In: Current biology : CB. 29, 21, p. 3600-3610.e4 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Synapse 100%
  • Dendritic Spine 28%
  • Brain 14%
  • Hippocampus 14%
  • Presynaptic Terminal 14%
  32 Citations (Scopus)

  150 Downloads (Pure)
• 2017

  Age-dependent changes in autophosphorylation of alpha calcium/calmodulin dependent kinase II in hippocampus and amygdala after contextual fear conditioning

  Fang, T., Kasbi, K., Rothe, S., Aziz, W. & Giese, K. P., Sept 2017, In: Brain Research Bulletin. 134, p. 18-23 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hippocampus 100%
  • Kinase 100%
  • Amygdala 100%
  • Fear Conditioning 100%
  • Threonine 37%
  3 Citations (Scopus)

  190 Downloads (Pure)

• Prevention of long-term memory loss after retrieval by an endogenous CaMKII inhibitor

  Vigil, F. A., Mizuno, K., Lucchesi, W., Valls-Comamala, V. & Giese, K. P., 2017, In: Scientific Reports. 7, p. 1-9 4040.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Long-Term Memory 100%
  • Hippocampus 22%
  • Threonine 22%
  • Synapse 11%
  • Memory Consolidation 11%
  24 Citations (Scopus)

  196 Downloads (Pure)
• 2016

  A cascade of change towards Alzheimer's disease due to reduced expression of a synaptic regulator

  Tiwari, S. S., Mizuno, K., Ghosh, A., Aziz, W., Troakes, C., Daoud, J., Golash, V., Noble, W. J., Hortobagyi, T. & Giese, K. P., 2016, In: Brain.

  Research output: Contribution to journal › Article › peer-review

• Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss

  Tiwari, S. S., Mizuno, K., Ghosh, A., Aziz, W., Troakes, C., Daoud, J., Golash, V., Noble, W., Hortobágyi, T. & Giese, K. P., 1 Oct 2016, In: Brain : a journal of neurology. 139, 10, p. 2751 - 2765

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Protein 100%
  • Tau 100%
  • Hippocampus 27%
  • Calcium 18%
  • Calmodulin 18%
  46 Citations (Scopus)

  187 Downloads (Pure)

• Contextual Fear Conditioning Induces Differential Alternative Splicing

  Poplawski, S. G., Peixoto, L., Porcari, G. S., Wimmer, M. E., McNally, A. G., Mizuno, K., Peter Giese, K., Chatterjee, S., Koberstein, J. N., Risso, D., Speed, T. P. & Abel, T., Oct 2016, In: Neurobiology of learning and memory. 134, B, p. 221-235

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Alternative Splicing 100%
  • Fear Conditioning 100%
  • Contextual Fear Conditioning 100%
  • Attention 25%
  • Long-Term Memory 25%
  20 Citations (Scopus)

  183 Downloads (Pure)

• Phosphorylation of K+ channels at single residues regulates memory formation

  Vernon, J., Irvine, E. E., Peters, M., Jeyalaban, J. & Giese, K. P., 15 Mar 2016, In: Learning & memory (Cold Spring Harbor, N.Y.). 23, 4

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neuron 100%
  • Behavior (Neuroscience) 49%
  • Protein Kinase A 49%
  • Gene Delivery 49%
  5 Citations (Scopus)

  172 Downloads (Pure)
• 2015

  Calcium/calmodulin-dependent kinase II and Alzheimer's disease

  Ghosh, A. & Giese, K. P., 24 Nov 2015, In: Molecular Brain Research. 8, 1, 78.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Isotopes of Calcium 100%
  • Phosphotransferase 100%
  • Kinase 100%
  • Disease 33%
  • Patient 33%
  142 Citations (Scopus)

• CaM Kinases: From Memories to Addiction

  Müller, C. P., Quednow, B. B., Lourdusamy, A., Kornhuber, J., Schumann, G. & Giese, K. P., 7 Dec 2015, (E-pub ahead of print) In: Trends in Pharmacological Sciences.

  Research output: Contribution to journal › Article › peer-review

  • Calmodulin 100%
  • Glutamatergic 42%
  • Nerve Cell Plasticity 42%
  • Synaptic Plasticity 42%
  • Behavior (Neuroscience) 28%
  30 Citations (Scopus)

• Effects of p35 mutations associated with mental retardation on the cellular function of p35-CDK5

  Takada, S., Mizuno, K., Saito, T., Asada, A., Giese, K. P. & Hisanaga, S., 15 Oct 2015, In: PL o S One . 10, 10, e0140821.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cyclin Dependent Kinase 5 100%
  • Neuron 75%
  • Brain 50%
  • Kinase 25%
  • Neuronal Migration 25%
  2 Citations (Scopus)

  150 Downloads (Pure)

• Evidence that the presynaptic vesicle protein CSPalpha is a key player in synaptic degeneration and protection in Alzheimer's disease

  Tiwari, S. S., D Orange, M., Troakes, C., Shurovi, B. N., Engmann, O., Noble, W., Hortobágyi, T. & Giese, K. P., 29 Jan 2015, In: Molecular Brain Research. 8, 6.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cerebellum 100%
  • Synapse 75%
  • Neuroprotective Agent 24%
  • Forebrain 24%
  • Hippocampus 24%
  32 Citations (Scopus)

• Mapping fear memory consolidation and extinction-specific expression of JunB

  Radwanska, K., Schenatto-Pereira, G., Ziółkowska, M., Łukasiewicz, K. & Giese, K. P., 1 Nov 2015, In: Neurobiology Of Learning And Memory. 125, p. 106-112 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Memory Consolidation 100%
  • Hippocampus 50%
  • Amygdala 50%
  • Brain 25%
  • AP-1 Transcription Factor 25%
  7 Citations (Scopus)

• Memory acquisition and retrieval impact different epigenetic processes that regulate gene expression

  Peixoto, L. L., Wimmer, M. E., Poplawski, S. G., Tudor, J. C., Kenworthy, C. A., Liu, S., Mizuno, K., Garcia, B. A., Zhang, N. R., Giese, K. P. & Abel, T., 26 May 2015, In: BMC GENOMICS. 16, 5, 15 p., S5.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Brain 100%
  • Behavior (Neuroscience) 50%
  • Long-Term Memory 50%
  • MicroRNA 50%
  • Splicing Factor 50%
  49 Citations (Scopus)

  220 Downloads (Pure)

• The Notch intracellular domain represses CRE-dependent transcription

  Hallaq, R., Volpicelli, F., Cuchillo-Ibanez, I., Hooper, C., Mizuno, K., Uwanogho, D., Causevic, M., Asuni, A., To, A., Soriano, S., Giese, K. P., Lovestone, S. & Killick, R., Mar 2015, In: Cellular Signalling. 27, 3, p. 621–629 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Transcription 100%
  • Notch 100%
  • Gene 40%
  • Mammal 20%
  • Secretase 20%
  24 Citations (Scopus)

  213 Downloads (Pure)

• αCaMKII autophosphorylation mediates neuronal activation in the hippocampal dentate gyrus after alcohol and cocaine in mice

  Schöpf, I., Easton, A. C., Solati, J., Golub, Y., Kornhuber, J., Giese, K. P. & Müller, C. P., 30 Mar 2015, In: Neuroscience Letters. 591, p. 65-68 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Behavior (Neuroscience) 100%
  • C-Fos 100%
  • Neuronal Plasticity 100%
  13 Citations (Scopus)
• 2014

  Generation of the Cdk5 activator p25 is a memory mechanism that is affected in early Alzheimer's disease

  Giese, K. P., May 2014, In: Frontiers in Molecular Neuroscience. 7, N/A, p. N/A 4 p., 36.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein 100%
  • Neurofibrillary Tangle 100%
  • Calcium 50%
  • Tau 50%
  • Light 50%
  19 Citations (Scopus)

• Long-term potentiation can be induced in the CA1 region of hippocampus in the absence of αCaMKII T286-autophosphorylation

  Villers, A., Giese, K. P. & Ris, L., Nov 2014, In: Learning & memory (Cold Spring Harbor, N.Y.). 21, 11, p. 616-626 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Hippocampus 100%
  • Long Term Potentiation 100%
  • Synapse 50%
  • Pyramidal Cell 50%
  • Synaptic Specificity 50%
  16 Citations (Scopus)

• Object-location training elicits an overlapping but temporally distinct transcriptional profile from contextual fear conditioning

  Poplawski, S. G., Schoch, H., Wimmer, M., Hawk, J. D., Walsh, J. L., Giese, K. P. & Abel, T., 2014, (E-pub ahead of print) In: Neurobiology Of Learning And Memory.

  Research output: Contribution to journal › Article › peer-review

  • Fear Conditioning 100%
  • Hippocampus 28%
  • Real-Time Polymerase Chain Reaction 14%
  15 Citations (Scopus)

• αCaMKII controls the establishment of cocaine's reinforcing effects in mice and humans

  Easton, A. C., Lourdusamy, A., Havranek, M., Mizuno, K., Solati, J., Golub, Y., Clarke, T-K., Vallada, H., Laranjeira, R., Desrivières, S., Moll, G. H., Mössner, R., Kornhuber, J., Schumann, G., Giese, K. P., Fernandes, C., Quednow, B. B. & Müller, C. P., 7 Oct 2014, (E-pub ahead of print) In: Translational psychiatry. 4, 9 p., e457.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Human 100%
  • Nucleus Accumbens 22%
  • Sensitization 11%
  • Rodent 11%
  • Microdialysis 11%
  32 Citations (Scopus)

  203 Downloads (Pure)
• 2013

  Erratum to: CAMK2A polymorphisms predict working memory performance in humans (Molecular Psychiatry (2012) DOI: 10.1038/mp.2012.114)

  Easton, A., Lourdusamy, A., Loth, E., Torro, R., Giese, K. P., Kornhuber, J., De Quervain, D. J. F., Papassotiropoulos, A., Fernandes, C., Müller, C. P. & Schumann, G., Aug 2013, In: Molecular Psychiatry. 18, 8, p. 951 1 p.

  Research output: Contribution to journal › Article › peer-review

• The roles of protein kinases in learning and memorY

  Giese, K. P. & Mizuno, K., Oct 2013, In: Learning & memory (Cold Spring Harbor, N.Y.). 20, 10, p. 540-552 13 p., N/A.

  Research output: Contribution to journal › Article › peer-review

  • Protein Kinases 100%
  • Kinase 60%
  • Ion Channel 40%
  • CGMP-dependent Protein Kinase 40%
  • Memory Consolidation 40%
  189 Citations (Scopus)

• αCaMKII autophosphorylation controls the establishment of alcohol-induced conditioned place preference in mice

  Easton, A. C., Lucchesi, W., Mizuno, K., Fernandes, C., Schumann, G., Giese, K. P. & Mueller, C. P., 1 Sept 2013, In: Behavioural brain research. 252, N/A, p. 72-76 5 p., N/A.

  Research output: Contribution to journal › Article › peer-review

  • Ethanol 100%
  • Wild Type Mouse 33%
  • Drinking Behavior 33%
  • Alcohol Abuse 33%
  • Fight-or-Flight Response 33%
  33 Citations (Scopus)
• 2012

  Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity

  Costello, D. A., Claret, M., Al-Qassab, H., Plattner, F., Irvine, E. E., Choudhury, A. I., Giese, K. P., Withers, D. J. & Pedarzani, P., 27 Feb 2012, In: PL o S One . 7, 2, e31124.

  Research output: Contribution to journal › Article › peer-review

  • Brain 100%
  • Synaptic Plasticity 100%
  • Hippocampus 40%
  • Cognitive Disorders 40%
  • Hyperglycemia 40%
  62 Citations (Scopus)

• CAMK2A polymorphisms predict working memory performance in humans

  The IMAGEN Consortium, 2012, In: Molecular Psychiatry.

  Research output: Contribution to journal › Article › peer-review
  19 Citations (Scopus)

• Long-lasting regulation of hippocampal Bdnf gene transcription after contextual fear conditioning

  Mizuno, K., Dempster, E., Mill, J. & Giese, K. P., Aug 2012, In: Genes, Brain and Behavior. 11, 6, p. 651-659 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Long-Term Memory 100%
  • Fear Conditioning 100%
  • Brain-Derived Neurotrophic Factor 50%
  • Hippocampus 50%
  • DNA Methylation 50%
  90 Citations (Scopus)
• 2011

  Cyclin-Dependent Kinase 5 Activator p25 Is Generated During Memory Formation and Is Reduced at an Early Stage in Alzheimer's Disease

  Engmann, O., Hortobagyi, T., Thompson, A. J., Guadagno, J., Troakes, C., Soriano, S., Al-Sarraj, S., Kim, Y. & Giese, K. P., 15 Jul 2011, In: Biological psychiatry. 70, 2, p. 159 - 168 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Cyclin Dependent Kinase 5 100%
  • Optics 22%
  • Brain 11%
  • Synaptic Plasticity 11%
  • Neurotoxicity 11%
  37 Citations (Scopus)

• Deletion of Lkb1 in Pro-Opiomelanocortin Neurons Impairs Peripheral Glucose Homeostasis in Mice

  Claret, M., Smith, M. A., Knauf, C., Al-Qassab, H., Woods, A., Heslegrave, A., Piipari, K., Emmanuel, J. J., Colom, A., Valet, P., Cani, P. D., Begum, G., White, A., Mucket, P., Peters, M., Mizuno, K., Batterham, R. L., Giese, K. P., Ashworth, A., Burcelin, R., & 3 othersAshford, M. L., Carling, D. & Withers, D. J., Mar 2011, In: Diabetes. 60, 3, p. 735 - 745 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuron 100%
  • Glucose Homeostasis 100%
  • Hydroxymethylglutaryl Coenzyme A Reductase Kinase 40%
  • Regulatory Mechanism 30%
  • Energy 30%
  45 Citations (Scopus)

• Insulin receptor substrate 2 is a negative regulator of memory formation

  Irvine, E. E., Drinkwater, L., Radwanska, K., Al-Qassab, H., Smith, M. A., O'Brien, M., Kielar, C., Choudhury, A. I., Krauss, S., Cooper, J. D., Withers, D. J. & Giese, K. P., Jun 2011, In: Learning and Memory . 18, 6, p. 375 - 383 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Brain 100%
  • Synapse 66%
  • Insulin 66%
  • Forebrain 66%
  • Dendritic Spine 66%
  50 Citations (Scopus)

• Mechanism for long-term memory formation when synaptic strengthening is impaired

  Radwanska, K., Medvedev, N. I., Pereira, G. S., Engmann, O., Thiede, N., Moraes, M. F. D., Villers, A., Irvine, E. E., Maunganidze, N. S., Pyza, E. M., Ris, L., Szymanska, M., Lipinski, M., Kaczmarek, L., Stewart, M. G. & Giese, K. P., 8 Nov 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 45, p. 18471-18475 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Long-Term Memory 100%
  • Synaptogenesis 37%
  • Synapse 25%
  • Mammalian Target of Rapamycin 25%
  • Vertebral Column 25%
  75 Citations (Scopus)

• Mice lacking Ras-GRF1 show contextual fear conditioning but not spatial memory impairments: convergent evidence from two independently generated mouse mutant lines

  d'Isa, R., Clapcote, S. J., Voikar, V., Wolfer, D. P., Giese, K. P., Brambilla, R. & Fasano, S., Dec 2011, In: Frontiers in Behavioral Neuroscience. 5, DECEMBER, 78.

  Research output: Contribution to journal › Article › peer-review

  • Memory Disorder 100%
  • Fear Conditioning 100%
  • Behavior (Neuroscience) 11%
  • Behavioral Test 11%
  • Water Maze 11%
  27 Citations (Scopus)

• Properties of Contextual Memory Formed in the Absence of alpha CaMKII Autophosphorylation

  Irvine, E. E., Danhiez, A., Radwanska, K., Nassim, C., Lucchesi, W., Godaux, E., Ris, L. & Giese, K. P., 28 Jan 2011, In: Molecular Brain Research. 4, 8.

  Research output: Contribution to journal › Article › peer-review

  • Kinase 100%
  • Long-Term Memory 54%
  • Hippocampus 18%
  • Neocortex 18%
  • Fear Conditioning 9%
  29 Citations (Scopus)

• Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition

  Engmann, O., Hortobagyi, T., Pidsley, R., Troakes, C., Bernstein, H-G., Kreutz, M. R., Mill, J., Nikolic, M. & Giese, K. P., Aug 2011, In: Brain. 134, 8, p. 2408 - 2421 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Cognition 100%
  • Brain 28%
  • Cognitive Disorders 28%
  • Cyclin Dependent Kinase 5 28%
  92 Citations (Scopus)

• αCaMKII autophosphorylation controls exploratory activity to threatening novel stimuli

  Easton, A. C., Lucchesi, W., Schumann, G., Giese, K. P., Mueller, C. P. & Fernandes, C., Dec 2011, In: Neuropharmacology. 61, 8, p. 1424-1431 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Anxiety 100%
  • Behavior (Neuroscience) 100%
  • Genotype 25%
  • Behavioral Test 25%
  • Locomotor Activity 25%
  26 Citations (Scopus)
• 2010

  Comparison of a Protein-Level and Peptide-Level Labeling Strategy for Quantitative Proteomics of Synaptosomes Using Isobaric Tags

  Engmann, O., Campbell, J., Ward, M., Giese, K. P. & Thompson, A. J., 7 May 2010, In: JOURNAL OF PROTEOME RESEARCH. 9, 5, p. 2725 - 2733 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein 100%
  • Tandem Mass Spectrometry 50%
  27 Citations (Scopus)