Kathryn Lester

2021

Evidence for distinct genetic and environmental influences on fear acquisition and extinction

Purves, K. L., Krebs, G., McGregor, T., Constantinou, E., Lester, K., Barry, T., Craske, M. G., Young, K., Breen, G. & Eley, T. C., 8 Jun 2021, (Accepted/In press) In: Psychological Medicine.

Research output: Contribution to journal › Article › peer-review

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Large-scale remote fear conditioning: demonstration of associations with anxiety using the FLARe smartphone app

McGregor, T., Purves, K., Constantinou, E., Baas, J., Barry, T., Craske, M. G., Carr, E., Lester, K., Palaiologou, E., Breen, G., Young, K. & Eley, T., 14 Feb 2021, (Accepted/In press) In: Depression and Anxiety.

Research output: Contribution to journal › Article › peer-review

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Therapygenetic effects of 5-HTTLPR on cognitive-behavioral therapy in anxiety disorders: A meta-analysis

Schiele, M. A., Reif, A., Lin, J., Alpers, G. W., Andersson, E., Andersson, G., Arolt, V., Bergström, J., Carlbring, P., Eley, T. C., Esquivel, G., Furmark, T., Gerlach, A. L., Hamm, A., Helbig-Lang, S., Hudson, J. L., Lang, T., Lester, K. J., Lindefors, N., Lonsdorf, T. B., & 11 othersPauli, P., Richter, J., Rief, W., Roberts, S., Rück, C., Schruers, K. R. J., Thiel, C., Wittchen, H. U., Domschke, K., Weber, H. & Lueken, U., Mar 2021, In: European Neuropsychopharmacology. 44, p. 105-120 16 p.

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6 Citations (Scopus)

90 Downloads (Pure)

2019

Validating the use of a smartphone app for remote administration of a fear conditioning paradigm

Purves, K. L., Constantinou, E., McGregor, T., Lester, K. J., Barry, T. J., Treanor, M., Sun, M., Margraf, J., Craske, M. G., Breen, G. & Eley, T. C., 1 Dec 2019, In: Behaviour Research and Therapy. 123, 103475.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Citations (Scopus)

2018

Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression

Culverhouse, R. C., Saccone, N. L., Horton, A. C., Anstey, K. J., Banaschewski, T., Burmeister, M., Cohen-Woods, S., Etain, B., Fisher, H. L., Goldman, N., Guillaume, S., Horwood, J., Juhasz, G., Lester, K. J., Mandelli, L., Middeldorp, C. M., Olié, E., Villafuerte, S., Air, T. M., Araya, R., & 64 othersBowes, L., Byrne, E. M., Coffey, C., Coventry, W. L., Gawronski, K. A. B., Glei, D., Hatzimanolis, A., Hottenga, J-J., Jaussent, I., Jawahar, C., Jennen-Steinmetz, C., Kramer, J. R., Lajnef, M., Zu Schwabedissen, H. M., Nauck, M., Nederhof, E., Petschner, P., Peyrot, W. J., Schwahn, C., Sinnamon, G., Tian, Y., Toben, C., Van der Auwera, S., Wainwright, N., Willemsen, G., Anderson, I. M., Arolt, V., Åslund, C., Bagdy, G., Baune, B. T., Bellivier, F., Boomsma, D. I., Courtet, P., Dannlowski, U., de Geus, E. J. C., Deakin, J. F. W., Easteal, S., Eley, T., Fergusson, D. M., Goate, A. M., Gonda, X., Grabe, H. J., Holzman, C., Laucht, M., Munafò, M. R., Nilsson, K. W., Oldehinkel, A. J., Olsson, C. A., Ormel, J., Otte, C., Patton, G. C., Penninx, B. W. J. H., Ritchie, K., Sarchiapone, M., Scheid, J. M., Serretti, A., Stefanis, N. C., Surtees, P. G., Völzke, H., Weinstein, M., Whooley, M., Nurnberger, J. I., Breslau, N. & Bierut, L. J., 1 Jan 2018, In: Molecular Psychiatry. 23, 1, p. 133-142

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242 Citations (Scopus)

341 Downloads (Pure)

DNA methylation of FKBP5 and response to exposure-based psychological therapy

Roberts, S., Keers, R., Breen, G., Coleman, J. R. I., Jöhren, P., Kepa, A., Lester, K. J., Margraf, J., Scheider, S., Teismann, T., Wannemüller, A., Eley, T. C. & Wong, C. C. Y., 18 Oct 2018, (E-pub ahead of print) In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics.

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46 Citations (Scopus)

224 Downloads (Pure)

Environmental sensitivity in children: Development of the Highly Sensitive Child Scale and identification of sensitivity groups

Pluess, M., Assary, E., Lionetti, F., Lester, K., Krapohl, E., Aron, E. N. & Aron, A., Jan 2018, In: Developmental Psychology. 54, 1, p. 51-70

Research output: Contribution to journal › Article › peer-review

Open Access

194 Citations (Scopus)

The utility of the SCAS-C/P to detect specific anxiety disorders among clinically anxious children

Reardon, T., Creswell, C., Lester, K., Arendt, K., Blatter-Meunier, J., Bögels, S. M., Coleman, J. R. I., Cooper, P., Heiervang, E., Herren, C., Hogendoorn, S. M., Hudson, J. L., Keers, R., Lyneham, H. J., Marin, C., Nauta, M., Rapee, R. M., Roberts, S., Schneider, S., Silverman, W. K., & 4 othersThastum, M., Thirlwall, K., Wergeland, G. J. & Eley, T. C., 31 Dec 2018, (Accepted/In press) In: Psychological Assessment.

Research output: Contribution to journal › Article › peer-review

2017

Genome-wide association study of facial emotion recognition in children, and association with polygenic risk for mental health disorders

Coleman, J. R. I., Lester, K. J., Keers, R., Munafò, M. R., Breen, G. D. & Eley, T. C., Oct 2017, In: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 174, 7, p. 701-711

Research output: Contribution to journal › Article › peer-review

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23 Citations (Scopus)

226 Downloads (Pure)

Genome-wide expression and response to exposure-based psychological therapy for anxiety disorders

Roberts, S., Wong, C. C. Y., Breen, G., Coleman, J. R. I., De Jong, S., Jöhren, P., Keers, R., Curtis, C., Lee, S. H., Margraf, J., Schneider, S., Teismann, T., Wannemüller, A., Lester, K. J. & Eley, T. C., 29 Aug 2017, (E-pub ahead of print) In: Translational psychiatry. 7, 8, 1219.

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17 Citations (Scopus)

212 Downloads (Pure)

The dopamine D2 receptor mediates approach-avoidance tendencies in smokers

Zlomuzica, A., Machulska, A., Roberts, S., von Glischinski, M., Rinck, M., Lester, K. J., Eley, T. C. & Margraf, J., 31 Mar 2017, (E-pub ahead of print) In: European Archives Of Psychiatry And Clinical Neuroscience. p. 1-8 8 p.

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14 Citations (Scopus)

218 Downloads (Pure)

The role of KIBRA in reconstructive episodic memory

Zlomuzica, A., Preusser, F., Roberts, S. L., Woud, M. L., Lester, K. J., Dere, E., Eley, T. C. & Margraf, J., 28 Aug 2017, (Accepted/In press) In: Molecular Medicine.

Research output: Contribution to journal › Article › peer-review

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2016

A genome-wide test of the differential susceptibility hypothesis reveals a genetic predictor of differential response to psychological treatments for child anxiety disorders

Keers, R., Coleman, J., Lester, K. J., Roberts, S. L., Breen, G. D., Thastum, M., Bögels, S., Schneider, S., Heiervang, E., Meiser-Stedman, R., Nauta, M., Creswell, C., Thirlwall, K., Rapee, R. M., Hudson, J. L., Lewis, C. M., Plomin, R. J. & Eley, T. C., 5 Apr 2016, In: Psychotherapy and Psychosomatics. 85, 3, p. 146-158 13 p.

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94 Citations (Scopus)

283 Downloads (Pure)

Cognitive Vulnerabilities for Depression and Anxiety in Childhood: Specificity of Anxiety Sensitivity and Rumination

Brown, H. M., Meiser-Stedman, R., Woods, H. & Lester, K. J., 1 Jan 2016, In: Behavioural and Cognitive Psychotherapy. 44, 1, p. 30-42

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21 Citations (Scopus)

84 Downloads (Pure)

Genetic variation in the endocannabinoid system and response to Cognitive Behavior Therapy for child anxiety disorders

Lester, K. J., Coleman, J., Roberts, S., Keers, R., Breen, G., Bögels, S., Creswell, C., Hudson, J. L., Mckinnon, A., Nauta, M., Rapee, R. M., Schneider, S., Silverman, W. K., Thastum, M., Waite, P., Wergeland, G. J. H. & Eley, T. C., 27 Jun 2016, (E-pub ahead of print) In: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics.

Research output: Contribution to journal › Article › peer-review

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25 Citations (Scopus)

170 Downloads (Pure)

Genome-wide association study of response to cognitive behavioural therapy in children with anxiety disorders

Coleman, J., Lester, K. J., Keers, R., Roberts, S., Curtis, C. J., Arendt, K., Bogels, S., Cooper, P., Creswell, C., Dalgleish, T., Hartman, C., Heiervang, E., Hötzel, K., Hudson, J. L., In-Albon, T., Lavallee, K., Lyneham, H., Marin, C., Meiser-Stedman, R., Morris, T., & 11 othersNauta, M., Rapee, R. M., Schneider, S., Schneider, S. C., Silverman, W. K., Thastum, M., Thirlwall, K., Waite, P., Wergeland, G. J., Breen, G. D. & Eley, T. C., 17 Mar 2016, (E-pub ahead of print) In: British Journal of Psychiatry. 208, 3

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39 Citations (Scopus)

209 Downloads (Pure)

Separate and combined effects of genetic variants and pre-treatment whole blood gene expression on response to exposure-based cognitive behavioural therapy for anxiety disorders

Coleman, J., Lester, K. J., Roberts, S., Keers, R., Lee, S. H., De Jong, S., Gaspar, H., Teismann, T., Wannemüller, A., Schneider, S., Jöhren, P., Margraf, J., Breen, G. & Eley, T. C., 4 Jul 2016, (E-pub ahead of print) In: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry. p. 1-34 34 p.

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8 Citations (Scopus)

367 Downloads (Pure)

2015

Attentional Control Theory in Childhood: Enhanced Attentional Capture by Non-emotional and Emotional Distractors in Anxiety and Depression

Waszczuk, M. A., Brown, H. M., Eley, T. C. & Lester, K. J., 23 Nov 2015, In: PL o S One . 10, 11, 14 p.

Research output: Contribution to journal › Article › peer-review

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13 Citations (Scopus)

215 Downloads (Pure)

Clinical Predictors of Response to Cognitive-Behavioral Therapy in Pediatric Anxiety Disorders: The Genes for Treatment (GxT) Study

Hudson, J., Keers, R., Roberts, S., Coleman, J., Breen, G., Arendt, K., Bogels, S., Cooper, P., Creswell, C., Hartman, C. A., Heiervang, E., Hotzel, K., In-Albon, T., Lavallee, K., Lyneham, H. J., Marin, C. E., McKinnon, A., Meiser-Stedman, R., Morris, T., Nauta, M., & 10 othersRapee, R., Schneider, S., Schneider, S., Silverman, W., Thastum, M., Thirlwall, K., Waite, P., Wergeland, G. J., Lester, K. & Eley, T., 1 Jun 2015, In: Journal of the American Academy of Child and Adolescent Psychiatry. 54, 6, p. 454–463

Research output: Contribution to journal › Article › peer-review

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121 Citations (Scopus)

208 Downloads (Pure)

Epigenome-wide DNA methylation analysis of monozygotic twins discordant for diurnal preference

Wong, C. C. Y., Parsons, M. J., Lester, K. J., Burrage, J., Eley, T. C., Mill, J., Dempster, E. & Gregory, A., 2015, (Accepted/In press) In: TWIN RESEARCH AND HUMAN GENETICS.

Research output: Contribution to journal › Article › peer-review

HPA axis related genes and response to psychological therapies: Genetics and epigenetics

Roberts, S., Keers, R., Lester, K. J., Coleman, J., Breen, G., Arendt, K., Blatter-Meunier, J., Cooper, P., Creswell, C., Fjermestad, K., Havik, O. E., Herren, C., Hogendoorn, S. M., Hudson, J. L., Krause, K., Lyneham, H. J., Morris, T., Nauta, M., Rapee, R. M., Rey, Y., & 8 othersSchneider, S., Schneider, S. C., Silverman, W. K., Thastum, M., Thirlwall, K., Waite, P., Eley, T. C. & Wong, C. C. Y., 7 Oct 2015, (E-pub ahead of print) In: Depression and Anxiety. 10 p.

Research output: Contribution to journal › Article › peer-review

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75 Citations (Scopus)

174 Downloads (Pure)

Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders

Lester, K., Roberts, S., Keers, R., Coleman, J., Breen, G., Wong, C., Xu, X., Arendt, K., Blatter-Meunier, J., Bögels, S., Cooper, P., Creswell, C., Heiervang, E., Herren, C., Hogendoorn, S., Hudson, J., Krause, K., Lyneham, H., McKinnon, A., Morris, T., & 12 othersNauta, M., Rapee, R., Rey, Y., Schneider, S., Schneider, S., Silverman, W., Smith, P., Thastum, M., Thirlwall, K., Waite, P., Wergeland, G. J. & Eley, T., 20 Aug 2015, In: British Journal of Psychiatry. 7 p.

Research output: Contribution to journal › Article › peer-review

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24 Citations (Scopus)

237 Downloads (Pure)

2014

Genome-wide Methylomic Analysis of Monozygotic Twins Discordant for Adolescent Depression

Dempster, E. L., Wong, C., Lester, K. J., Burrage, J., Gregory, A. M., Mill, J. & Eley, T. C., 15 Dec 2014, In: Biological psychiatry. 76, 12, p. 977-983 7 p.

Research output: Contribution to journal › Article › peer-review

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102 Citations (Scopus)

81 Downloads (Pure)

Paediatric Obsessive-Compulsive Disorder and Depressive Symptoms: Clinical Correlates and CBT Treatment Outcomes

Brown, H. M., Lester, K. J., Jassi, A., Heyman, I. & Krebs, G., 1 Jul 2014, In: Journal of Abnormal Child Psychology. 43, 5, p. 933-942 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Citations (Scopus)

Polymorphisms in the circadian expressed genes PER3 and ARNTL2 are associated with diurnal preference and GNβ3 with sleep measures

Parsons, M. J., Lester, K. J., Barclay, N. L., Archer, S. N., Nolan, P. M., Eley, T. C. & Gregory, A. M., 2014, (E-pub ahead of print) In: Journal of Sleep Research.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Citations (Scopus)

Psychometric properties of reaction time based experimental paradigms measuring anxiety-related information-processing biases in children

Brown, H. M., Eley, T. C., Broeren, S., Macleod, C., Rinck, M., Hadwin, J. A. & Lester, K. J., Jan 2014, In: Journal of Anxiety Disorders. 28, 1, p. 97-107 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

110 Citations (Scopus)

Serotonin Transporter Methylation and Response to Cognitive Behaviour Therapy in Children with Anxiety Disorders

Roberts, S., Lester, K. J., Hudson, J. L., Rapee, R. M., Creswell, C., Cooper, P. J., Thirlwall, K. J., Coleman, J. R. I., Breen, G., Wong, C. C. Y. & Eley, T. C., Sept 2014, In: Translational psychiatry. 4, 5 p., e444.

Research output: Contribution to journal › Article › peer-review

Open Access

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98 Citations (Scopus)

66 Downloads (Pure)

2013

Attentional threat avoidance and familial risk are independently associated with childhood anxiety disorders: Attentional bias and childhood anxiety

Brown, H. M., McAdams, T., Lester, K. J., Goodman, R., Clark, D. M. & Eley, T. C., Jun 2013, In: Journal of Child Psychology and Psychiatry. 54, 6, p. 678-85 8 p., N/A.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Citations (Scopus)

Predicting outcomes following cognitive behaviour therapy in child anxiety disorders: the influence of genetic, demographic and clinical information

Hudson, J. L., Lester, K. J., Lewis, C. M., Tropeano, M., Creswell, C., Collier, D. A., Cooper, P., Lyneham, H. J., Morris, T., Rapee, R. M., Roberts, S., Donald, J. A. & Eley, T. C., Oct 2013, In: Journal of Child Psychology and Psychiatry. 54, 10, p. 1086-1094 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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64 Citations (Scopus)

235 Downloads (Pure)

Relevance Is in the Eye of the Beholder: Attentional Bias to Relevant Stimuli in Children

Broeren, S. & Lester, K. J., Apr 2013, In: EMOTION. 13, 2, p. 262-269 8 p.

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Replication of Genome-Wide association studies (GWAS) loci for sleep in the British G1219 cohort

Parsons, M. J., Lester, K. J., Barclay, N. L., Nolan, P. M., Eley, T. C. & Gregory, A. M., Jul 2013, In: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 162, 5, p. 431-438 8 p.

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Therapygenetics: Using genetic markers to predict response to psychological treatment for mood and anxiety disorders

Lester, K. J. & Eley, T. C., 1 Jan 2013, In: Biology of mood & anxiety disorders. 3, 1, 4.

Research output: Contribution to journal › Article › peer-review

2012

Maternal anxiety and cognitive biases towards threat in their own and their child's environment

Lester, K. J., Field, A. P. & Cartwright-hatton, S., Oct 2012, In: Journal of Family Psychology. 26, 5, p. 756-766

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Neurotrophic gene polymorphisms and response to psychological therapy

Lester, K., Hudson, J. L., Tropeano, M., Creswell, C., Collier, D., Farmer, A., Lyneham, H. J., Rapee, R. M. & Eley, T., 1 May 2012, In: Translational psychiatry. 2, e108.

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Therapygenetics: the 5HTTLPR and response to psychological therapy

Eley, T. C., Hudson, J. L., Creswell, C., Tropeano, M., Lester, K. J., Cooper, P., Farmer, A., Lewis, C. M., Lyneham, H. J., Rapee, R. M., Uher, R., Zavos, H. M. S. & Collier, D. A., Mar 2012, In: Molecular Psychiatry. 17, 3, p. 236 - 237 2 p.

Research output: Contribution to journal › Letter › peer-review

130 Citations (Scopus)

Therapygenetics: Predicting response to CBT in child anxiety from specific genetic markers

Eley, T., Hudson, J., Creswell, C., Tropeano, M., Lester, K., Cooper, P., Farmer, A., Lewis, C., Lyneham, H., Rapee, R., Uher, R., Zavos, H. & Collier, D., Nov 2012, In: Behavior Genetics. 42, 6, p. 932-932 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

2011

But what about the Empress of Racnoss? The allocation of attention to spiders and Doctor Who in a visual search task is predicted by fear and expertise

Purkis, H. M., Lester, K. J. & Field, A. P., Dec 2011, In: EMOTION. 11, 6, p. 1484-1488

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Experimental Modification of Interpretation Bias about Animal Fear in Young Children: Effects on Cognition, Avoidance Behavior, Anxiety Vulnerability, and Physiological Responding

Lester, K. J., Field, A. P. & Muris, P., 1 Nov 2011, In: Journal of Clinical Child and Adolescent Psychology. 40, 6, p. 864-877

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Experimental modification of interpretation bias regarding social and animal fear in children

Lester, K. J., Field, A. P. & Muris, P., Jun 2011, In: Journal of Anxiety Disorders. 25, 5, p. 697-705

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Modifying cognitive errors promotes cognitive well being: A new approach to bias modification

Lester, K. J., Mathews, A., Davison, P. S., Burgess, J. L. & Yiend, J., Sept 2011, In: Journal of Behavior Therapy and Experimental Psychiatry. 42, 3, p. 298 - 308 11 p.

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

They are afraid of the animal, so therefore I am too: Influence of peer modeling on fear beliefs and approach–avoidance behaviors towards animals in typically developing children

Broeren, S., Lester, K. J., Muris, P. & Field, A. P., Jan 2011, In: Behaviour Research and Therapy. 49, 1, p. 50-57

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Training children to approach or avoid novel animals: Effects on self-reported attitudes and fear beliefs and information-seeking behaviors

Huijding, J., Muris, P., Lester, K. J., Field, A. P. & Joosse, G., 1 Oct 2011, In: Behaviour Research and Therapy. 49, 10, p. 606-613

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

2010

Are children's own interpretations of ambiguous situations based on how they perceive their mothers have interpreted ambiguous situations for them in the past?

Lester, K. J., Seal, K., Nightingale, Z. C. & Field, A. P., Jan 2010, In: Journal of Anxiety Disorders. 24, 1, p. 102-108

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Is There Room for ‘Development’ in Developmental Models of Information Processing Biases to Threat in Children and Adolescents?

Field, A. P. & Lester, K. J., 1 Dec 2010, In: Clinical Child and Family Psychology Review. 13, 4, p. 315-332

Research output: Contribution to journal › Article › peer-review

125 Citations (Scopus)

2009

Do anxious parents interpretive biases towards threat extend into their child's environment?

Lester, K. J., Field, A. P., Oliver, S. & Cartwright-hatton, S., 1 Feb 2009, In: Behaviour Research and Therapy. 47, 2, p. 170-174 5 p.

Research output: Contribution to journal › Article › peer-review

72 Citations (Scopus)

Long term outcome of primary care depression

Yiend, J., Paykel, E., Merritt, R., Lester, K., Doll, H. & Burns, T., 1 Nov 2009, In: Journal of Affective Disorders. 118, 1-3, p. 79-86 8 p.

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Short-term serotonergic but not noradrenergic antidepressant administration reduces attentional vigilance to threat in healthy volunteers

Murphy, S. E., Yiend, J., Lester, K. J., Cowen, P. J. & Harmer, C. J., Mar 2009, In: International Journal of Neuropsychopharmacology . 12, 2, p. 169-179 11 p.

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

2008

Evaluative conditioning: missing, presumed dead

Field, A. P., Lascelles, K. R. R., Lester, K. J., Askew, C. & Davey, G. C. L., 1 Jun 2008, In: Netherlands Journal of Psychology. 64, 2, p. 46-64 19 p.

Research output: Contribution to journal › Article › peer-review

2005

A funding model for a psychological service to plastic and reconstructive surgery in UK practice

Clarke, A., Lester, K. J., Withey, S. J. & Butler, P. E. M., 1 Jul 2005, In: British Journal of Plastic Surgery. 58, 5, p. 708-713 6 p., N/A.

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Communicating risk information in genetic counseling: An observational study

Michie, S., Lester, K., Pinto, J. & Marteau, T. M., 1 Oct 2005, In: Health Education and Behavior. 32, 5, p. 589-598 10 p.

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Kathryn Lester

Research output

Search results