Search results

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  Assessing the relevance of Galleria mellonella to antibiotic drug discovery for pulmonary infections

  Mason, J., Amison, R., Page, C., Pitchford, S., Bruce, K., Rahman, M., Castagnolo, D. & Panaretou, B.

  NC3Rs National Centre for the Replacement, Refinement and Reduction of Animals in Research

  3/06/2019 → 2/12/2019

  Project: Research

• Radiolabelled siderophores for novel molecular imaging and treatment of vascular (endo)graft infections

  Abbate, V., Blower, P., Ma, M., Terry, S., Hider, R., Bruce, K. & Cooper, M.

  MRC Medical Research Council

  1/05/2019 → 31/01/2021

  Project: Research

  • Therapeutic Procedure 100%
  • Molecular Imaging 100%
  • Graft Infection 100%

• How do mutations in pssA lead to antiseptic/antibiotic resistance in Pseudomanas aeruginosa

  Mason, J. & Bruce, K.

  PHE Public Health England

  1/10/2018 → 30/09/2022

  Project: Research

• Defining adaptive processes in a model bacterial species by integrating proteomic and metabolomic analytical strategies

  Bruce, K. & Mason, J.

  Ascend Diagnostics Ltd

  1/10/2018 → 30/09/2022

  Project: Research

• Nottingham Molecular Pathology Node (NMPN) for Integrated Multi-platform Biomarker Research and Knowledge Transfer

  Bruce, K.

  MRC Medical Research Council

  1/11/2017 → 31/03/2020

  Project: Research

• How do membrane active antibiotics influence microbiome dysbiosis?

  Mason, J., Tribe, R., Lorenz, C. & Bruce, K.

  PHE Public Health England

  1/10/2017 → 30/09/2021

  Project: Research

  • Antibiotics 100%
  • Dysbiosis 100%

• Airway Infection in Bronchiectasis (Quorum sensing molecule (QSM) biomarkers for Pseudomonas aeruginosa)

  Bruce, K.

  NIHR National Institute For Health & Care Research

  1/04/2017 → 31/03/2022

  Project: Research

• Engineering the Mexican maize rhizosphere

  Mason, J., Beavil, A. & Bruce, K.

  6/03/2017 → 5/03/2019

  Project: Research

• VENTUS-CF: New therapy for Cystic Fibrosis

  Bruce, K.

  1/01/2016 → 31/12/2019

  Project: Research

• A new, multispecies, lung infection model to transform understanding of exacerbation and develop diagnostic andtherapeutic interventions

  Page, C., Bruce, K., Mason, J. & Rahman, M.

  1/10/2015 → 30/09/2017

  Project: Research

• Longitudinal chemical fingerprinting of in vivo models of lung insult using metabolomics and mass spectrometry imaging

  Dailey, L. A., Bruce, K., Legido Quigley, C. & Page, C.

  1/08/2015 → 31/07/2018

  Project: Research

• Exploiting novel biosurfactants produced from probiotics with biomedical applications

  Bruce, K.

  1/01/2015 → 31/12/2016

  Project: Research

• Improving the delivery of antibiotic care for CF patients

  Bruce, K.

  Anna Trust

  1/08/2014 → 31/07/2015

  Project: Research

• Deep sequencing of the airway microbiota in pneumonia post bone marrow transplant

  Sethi, T., Bruce, K. & Mufti, G.

  1/12/2013 → 30/11/2014

  Project: Research

• The Gut-Liver Axis in Liver Failure Syndromes

  Bruce, K., Wendon, J. & Patel, V.

  ICS Intensive Care Society

  1/05/2013 → 31/08/2014

  Project: Research

• How do skin and gut microbiota relate to the risk of atopic eczema and food allergy in infancy?

  Flohr, C., Bruce, K., Lack, G. & Perkin, M.

  British Skin Foundation

  1/02/2013 → 31/10/2015

  Project: Research

• Developing an integrated systems biology approach to understanding bacterial antibiotic response mechanisms

  Mason, J. & Bruce, K.

  4/03/2012 → 3/03/2015

  Project: Research

• The trimethylamine - trimethylamine N-oxide co-metabolism axis: identifying major trimethylamine-generating phylotypes of the intestinal microbiota

  Dolphin, C. & Bruce, K.

  1/03/2012 → 28/02/2014

  Project: Research

• Nanoparticles as vectors of pharmaceutical exposure in the environment: analytical methods to measure occurrence, fate and effect in soil systems

  Barron, L., Bruce, K., Paull, B. & Quinn, B.

  1/01/2011 → 30/06/2013

  Project: Research

• Predicting the risk of Clostridium difficile infection by culture-independent profiling of gastro-intestinal bacterial communities

  Bruce, K. & Rogers, G.

  1/11/2010 → 31/10/2012

  Project: Research

• Modelling bacterial pathogenicity in vitro: the lung

  Bruce, K. & Patel, N.

  4/10/2010 → 3/04/2012

  Project: Research

• Development and characterisation of vectors for delivery of antibiotic trnascription factor decoys (TFDs) to gram negative bacteria

  Mason, J., Bansal, S. & Bruce, K.

  1/10/2010 → 30/09/2014

  Project: Research

• Design, synthesis and functional characterisation of delivery systems for Gram negative targeting Transcription Factor Decoy (TFD) antibiotics

  Mason, J., Bansal, S. & Bruce, K.

  Procarta Biosystems Ltd

  1/10/2010 → 30/09/2014

  Project: Research

• Culture-independent analysis of the impact of fungal populations in cystic fybrosis airways of antibiotic treatment of bacterial lung infections

  Bruce, K. & Rogers, G.

  14/07/2010 → 13/09/2010

  Project: Research

• MIRTAS

  Bruce, K.

  1/07/2010 → 30/06/2014

  Project: Research

• Microbial diversity in chronic lung allograft dysfunction

  Bruce, K. & Rogers, G.

  ROTRF Roche Organ Transplantation Research Foundation

  25/05/2010 → 24/05/2012

  Project: Research

• Health and social impacts of enteric zooonoses in a changing environment

  Bruce, K., Ellis, R. & van der Gast, C.

  1/05/2010 → 30/11/2010

  Project: Research

• MicroCRS

  Bruce, K.

  1/05/2010 → 30/04/2013

  Project: Research

• Cystic Fibrosis exacerbation analysis

  Bruce, K.

  Anna Trust

  1/03/2010 → 30/09/2010

  Project: Research

• Understanding the specificity of antibacterial peptides; integrating transcriptions with simulation and biophysics

  Mason, J., Bruce, K. & Lorenz, C.

  1/10/2009 → 30/09/2012

  Project: Research

• Understanding how antimicrobial peptides function; mechanistic understanding from studies of pseudomonas aeruginosa

  Mason, J. & Bruce, K.

  1/04/2009 → 31/03/2012

  Project: Research

• Biotreatment of oestrogen - a model for the biodegradation of pharmaceutical products and associated waste

  Bruce, K., Lilley, A. & Ren, H.

  ICUK Innovation China UK

  1/03/2009 → 31/05/2009

  Project: Research

• Analysis of the relationhip between air and surface-borne bacteria and lower respiratory tract infections in infants on neonatal wards using molecular genetic-charaterisation

  Bruce, K., Legg, J. & Rogers, G.

  1/12/2008 → 30/11/2011

  Project: Research

• Anaerobic biological treatment of waste metal working fluids

  Bruce, K., Lilley, A. & Yung, J.

  ICUK Innovation China UK

  1/11/2008 → 31/10/2009

  Project: Research

• Understanding antimicrobial peptide mechanisms: a rationale for the improved design of antibiotics and vectors

  Mason, J., Bruce, K., Campopiano, D., Kichler, A. & Mitchell, G.

  MRC Medical Research Council

  1/11/2008 → 31/10/2013

  Project: Research

  • Flexibility 100%
  • Polypeptide Antibiotic Agent 100%
  • Membrane 100%
  • Magainin 75%
  • Antiinfective Agent 66%

• Microbiological assessment of prevention of colonisation of cystic fibrosis patients by Pseudomonas aeruginosa

  Bruce, K.

  SPARKS Sport Aiding Medical Research for Kids

  8/10/2008 → 7/10/2011

  Project: Research

• Modelling the response of bacterial respiratory pathogens under conditions mimicking those in vivo

  Patel, N., Bruce, K. & Forbes, B.

  1/10/2008 → 31/03/2010

  Project: Research

• Culture-independent analysis of bacteria

  Bruce, K.

  Royal Holloway, University of London

  1/09/2008 → 31/08/2009

  Project: Research

• Development and validation of a clincally viable antibiotic susceptibility testing device for biofilms

  Bruce, K.

  1/09/2008 → 31/08/2009

  Project: Research

• An in vitro hypoxic system for characterising bacterial pathogenicity in the lung.

  Patel, N., Bruce, K. & Forbes, B.

  1/07/2008 → 31/12/2009

  Project: Research

• Microbiology of cystic fibrosis exacerbations

  Bruce, K.

  Anna Trust

  1/07/2008 → 14/01/2011

  Project: Research

• The microbiological changes associated with cystic fibrosis exacerbations

  Bruce, K. & Connett, G.

  University Hospital Southampton NHS Foundation Trust

  1/04/2008 → 31/03/2010

  Project: Research

• Bacterial Infections in infectious exacerbation

  Bruce, K.

  Anna Trust

  1/10/2006 → 30/04/2010

  Project: Research

• Molecular microbiological analysis of respiratory specimens sampled from infants with chronic lung disease of prematurity.

  Bruce, K., Connett, G. & Puddy, V.

  Asthma and Lung UK

  1/04/2006 → 30/09/2007

  Project: Research

• Funding for Dr Geraint Rogers.

  Bruce, K.

  University Hospital Southampton NHS Foundation Trust

  1/03/2005 → 28/02/2006

  Project: Research

• The detection and treatment of Pseudomonas aeruginosa in the lungs of paediatric cystic fibrosis patients.

  Bruce, K.

  SPARKS Sport Aiding Medical Research for Kids

  1/02/2005 → 31/01/2006

  Project: Research

• Purchase of a Phoretix 1D Advanced V.5 &Viglen PC: An Analysis of Bacterial Community Profiles

  Bruce, K.

  University of London

  1/04/2001 → 31/03/2002

  Project: Research

• Molecular Characterisation of Integrons within Burkholderia cepacia

  Bruce, K.

  BSAC British Society for Antimicrobial Chemotherapy

  1/04/2001 → 31/12/2003

  Project: Research

• Emergence of Antibiotic Resistance

  Bruce, K.

  Royal Society

  1/04/2001 → 30/09/2001

  Project: Research