Research output per year
Research output per year
Personal profile
Research interests
Research focusses on the development of enzymes capable of delivering targeted cytosine methylation to predetermined DNA sequences. We are using these enzymes to simulate the methylation patterns observed in cancer patients, to determine the actual role of DNA methylation in disease progression. An additional and emerging basic research program seeks to address the effects of gene mutations associated with epigenetic components of the cell, that are being increasingly found in leukaemia patients, in the desease process.
Research interests (short)
DNA methylation, epigenetics, histone signatures, targeted methylation, zinc finger technology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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- 6 Similar Profiles
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Epigenetics in focus: Pathogenesis-of myelodysplastic syndromes and the role of hypomethylating agents
Santini, V., Melnick, A., Maciejewski, J. P., Duprez, E., Nervi, C., Cocco, L., Ford, K. G. & Mufti, G., Nov 2013, In: Critical Reviews in Oncology/Hematology. 88, 2, p. 231-245 15 p.Research output: Contribution to journal › Literature review › peer-review
26 Citations (Scopus) -
Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome
Mian, S. A., Smith, A. E., Kulasekararaj, A. G., Kizilors, A., Mohamedali, A. M., Lea, N. C., Mitsopoulos, K., Ford, K., Nasser, E., Seidl, T. & Mufti, G. J., Jul 2013, In: Haematologica. 98, 7, p. 1058-1066 9 p.Research output: Contribution to journal › Article › peer-review
75 Citations (Scopus) -
Heritable gene repression through the action of a directed DNA methyltransferase at a chromosomal locus
Smith, A. E., Hurd, P. J., Bannister, A. J., Kouzarides, T. & Ford, K. G., 11 Apr 2008, In: Journal of Biological Chemistry. 283, 15, p. 9878 - 9885 8 p.Research output: Contribution to journal › Article › peer-review
36 Citations (Scopus) -
Role of cyclin D3 in regulating the G1 -> S-phase transition
Williams, S., Orr, S. J., Ford, K. G. & Thomas, N. S. B., 2008, In: British Journal of Haematology. 141, p. 75 1 p.Research output: Contribution to journal › Meeting abstract
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Directed de novo DNA methylation of a genomic locus leads to heritable transcriptional repression
Ford, K. G., Hurd, P. J., Bannister, A. J., Kouzarides, T. & Smith, A. E., 2007, In: Blood. 110, 11, p. 343 1 p.Research output: Contribution to journal › Meeting abstract
Projects
- 21 Finished
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A role for DNA methylation in splicing
Ford, K. (Primary Investigator)
1/09/2014 → 31/08/2017
Project: Research
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DNA methylation and aberrant splicing in leukaemia
Ford, K. (Primary Investigator)
1/02/2014 → 31/01/2017
Project: Research
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Development of enhanced gene specific technology for the isolation of proteins binding at a single locus in vivo
Farzaneh, F. (Primary Investigator) & Ford, K. (Primary Investigator)
BBSRC Biotechnology and Biological Sciences Research Council
1/03/2013 → 26/08/2014
Project: Research
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Exploing the mechanistic link between DNA methylaion and splicing in leukaemia
Ford, K. (Primary Investigator)
1/01/2013 → 31/12/2015
Project: Research
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Understanding the role and impact of variable DNA methylation densities at gene promoters and gene bodies, in disease onset and progression in leukaemia
Ford, K. (Primary Investigator)
1/01/2013 → 31/12/2015
Project: Research
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British Society of Gene Therapy, Warwick University,
Ford, K. (Speaker)
Mar 2007 → …Activity: Participating in or organising an event › Participation in conference
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Have recently reviewed articles for Biological Chemistry and FEBS letters (Journal)
Ford, K. (Editor)
2001 → …Activity: Publication peer-review and editorial work › Publication peer-review