King's College London

Research portal

Professor Kinya Otsu

Research interests

Heart failure can be defined as “cardiomyocyte-deficiency syndrome”. Three types of cell death, namely apoptosis, necrosis and autophagic death, have been reported. Various types of cardiomyocyte death may play an important role in the development and progression of heart failure. Our research aims to (a) characterize various types of cardiomyocyte death and test the above hypothesis, (b) elucidate underlying mechanisms that are involved (c) examine whether the regulation of cell death may be a novel therapeutic approach to treat patients with heart failure. Our research involves the application of integrated in vivo physiological studies, molecular, cell biological, imaging and signalling studies using gene-targeting mice to investigate the role of cardiomyocyte death in development of heart failure.

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454