King's College London

Research portal

Professor Kinya Otsu

  1. Cytokine mRNA degradation in cardiomyocytes restrains sterile inflammation in pressure overloaded hearts

    Omiya, S., Omori, Y., Taneike, M., Murakawa, T., Ito, J., Tanada, Y., Nishida, K., Yamaguchi, O., Satoh, T., Shah, A. M., Akira, S. & Otsu, K., 25 Feb 2020, In : Circulation. 141, 8, p. 667-677 11 p.

    Research output: Contribution to journalArticle

  2. Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M

    Abe, H., Takeda, N., Isagawa, T., Semba, H., Nishimura, S., Morioka, M. S., Nakagama, Y., Sato, T., Soma, K., Koyama, K., Wake, M., Katoh, M., Asagiri, M., Neugent, M. L., Kim, J. W., Stockmann, C., Yonezawa, T., Inuzuka, R., Hirota, Y., Maemura, K. & 5 others, Yamashita, T., Otsu, K., Manabe, I., Nagai, R. & Komuro, I., 27 Jun 2019, In : Nature Communications. 10, 1, 2824.

    Research output: Contribution to journalArticle

  3. Involvement of p38 in Age-Related Decline in Adult Neurogenesis via Modulation of Wnt Signaling

    Kase, Y., Otsu, K., Shimazaki, T. & Okano, H., 11 Jun 2019, In : Stem Cell Reports. 12, 6, p. 1313–1328 16 p.

    Research output: Contribution to journalArticle

  4. Administration of a TLR9 inhibitor attenuates the development and progression of heart failure in mice

    Ueda, H., Yamaguchi, O., Taneike, M., Akazawa, Y., Wada-Kobayashi, H., Sugihara, R., Yorifuji, H., Nakayama, H., Omiya, S., Murakawa, T., Sakata, Y. & Otsu, K., Jun 2019, In : JACC: Basic to Translational Science. 4, 3, p. 348-363 16 p., 10.

    Research output: Contribution to journalArticle

  5. ROS amplification drives mouse spermatogonial stem cell self-renewal

    Morimoto, H., Kanastu-Shinohara, M., Ogonuki, N., Kamimura, S., Ogura, A., Yabe-Nishimura, C., Mori, Y., Morimoto, T., Watanabe, S., Otsu, K., Yamamoto, T. & Shinohara, T., 2 Apr 2019, In : Life Science Alliance. 2, 2, p. e201900374 13 p., e201900374.

    Research output: Contribution to journalArticle

  6. A Mammalian Mitophagy Receptor, Bcl2-L-13, Recruits the ULK1 Complex to Induce Mitophagy

    Murakawa, T., Okamoto, K., Omiya, S., Taneike, M., Yamaguchi, O. & Otsu, K., 8 Jan 2019, In : Cell Reports. 26, 2, p. 338-345.e6

    Research output: Contribution to journalArticle

  7. Protein kinase p38α signaling in dendritic cells regulates colon inflammation and tumorigenesis

    Zheng, T., Zhang, B., Chen, C., Ma, J., Meng, D., Huang, J., Hu, R., Liu, X., Otsu, K., Liu, A. C., Li, H., Yin, Z. & Huang, G., 26 Dec 2018, In : Proceedings of the National Academy of Sciences of the United States of America.

    Research output: Contribution to journalArticle

  8. Targeted ablation of p38α MAPK suppresses denervation-induced muscle atrophy

    Yuasa, K., Okubo, K., Yoda, M., Otsu, K., Ishii, Y., Nakamura, M., Itoh, Y. & Horiuchi, K., 1 Dec 2018, In : Scientific Reports. 8, 1, 9037.

    Research output: Contribution to journalArticle

  9. Mitochondrial DNA as an inflammatory mediator in cardiovascular diseases

    Otsu, K. & Nakayama, H., 15 Mar 2018, In : Biochemical J. p. 839-852 475.

    Research output: Contribution to journalReview article

  10. p38α signaling in Langerhans cells promotes the development of IL-17–producing T cells and psoriasiform skin inflammation

    Zheng, T., Zhao, W., Li, H., Xiao, S., Hu, R., Han, M., Liu, H., Liu, Y., Otsu, K., Liu, X. & Huang, G., 13 Mar 2018, In : Science Signaling. 11, 521, eaao1685.

    Research output: Contribution to journalReview article

  11. Mitochondria and sterile inflammation in the heart

    Nakayama, H. & Otsu, K., 1 Feb 2018, In : Current Opinion in Physiology. 1, p. 68-74 7 p.

    Research output: Contribution to journalReview article

  12. Fibroblast-Specific Genetic Manipulation of p38 MAPK in vivo Reveals its Central Regulatory Role in Fibrosis

    Molkentin, J. D., Bugg, D., Ghearing, N., Dorn, L. E., Kim, P., Sargent, M. A., Gunaje, J., Otsu, K. & Davis, J., 8 Aug 2017, In : Circulation (Baltimore). 136, p. 549-561

    Research output: Contribution to journalArticle

  13. Sterile Inflammation and Degradation Systems in Heart Failure

    Nishida, K. & Otsu, K., 25 Apr 2017, In : Circulation Journal. 81, 5, p. 622-628

    Research output: Contribution to journalReview article

  14. Inflammation and metabolic cardiomyopathy

    Nishida, K. & Otsu, K., 15 Mar 2017, In : Cardiovascular Research. 113, 4, p. 389-398

    Research output: Contribution to journalReview article

  15. Loss of functionally redundant p38 isoforms in T cells enhances regulatory T cell induction

    Hayakawa, M., Hayakawa, H., Petrova, T., Ritprajak, P., Sutavani, R. V., Jiménez-Andrade, G. Y., Sano, Y., Choo, M. K., Seavitt, J., Venigalla, R. K. C., Otsu, K., Georgopoulos, K., Arthur, J. S. C. & Park, J. M., 3 Feb 2017, In : Journal of Biological Chemistry. 292, 5, p. 1762-1772

    Research output: Contribution to journalArticle

  16. Toll-like receptor 9 prevents cardiac rupture after myocardial infarction in mice independently of inflammation

    Omiya, S., Omori, Y., Taneike, M., Protti, A., Yamaguchi, O., Akira, S., Shah, A., Nishida, K. & Otsu, K., Dec 2016, In : American Journal of Physiology (Heart and Circulatory Physiology). 311, 6, p. H1485-H1497

    Research output: Contribution to journalArticle

  17. ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism

    Tian, Z., Miyata, K., Kadomatsu, T., Horiguchi, H., Fukushima, H., Tohyama, S., Ujihara, Y., Okumura, T., Yamaguchi, S., Zhao, J., Endo, M., Morinaga, J., Sato, M., Sugizaki, T., Zhu, S., Terada, K., Sakaguchi, H., Komohara, Y., Takeya, M., Takeda, N. & 10 others, Araki, K., Manabe, I., Fukuda, K., Otsu, K., Wada, J., Murohara, T., Mohri, S., Yamashita, J. K., Sano, M. & Oike, Y., 28 Sep 2016, In : Nature Communications. 7, 19 p., 13016.

    Research output: Contribution to journalArticle

  18. Glycoproteomics Reveals Decorin Peptides with Anti-Myostatin Activity in Human Atrial Fibrillation

    Barallobre-Barreiro, J., Gupta, S. K., Zoccarato, A., Kitazume-Taneike, R., Fava, M., Yin, X., Werner, T., Hirt, M. N., Zampetaki, A., Viviano, A., Chong, M., Bern, M., Kourliouros, A., Domenech, N., Willeit, P., Shah, A. M., Jahangiri, M., Schaefer, L., Fischer, J. W., Iozzo, R. V. & 6 others, Viner, R., Thum, T., Heineke, J., Kichler, A., Otsu, K. & Mayr, M., 13 Sep 2016, In : Circulation (Baltimore). 134, 11, p. 817-832 16 p.

    Research output: Contribution to journalArticle

  19. p38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress

    Karigane, D., Kobayashi, H., Morikawa, T., Ootomo, Y., Sakai, M., Nagamatsu, G., Kubota, Y., Goda, N., Matsumoto, M., Nishimura, E. K., Soga, T., Otsu, K., Suematsu, M., Okamoto, S., Suda, T. & Takubo, K., 4 Aug 2016, In : Cell Stem Cell. 19, 2, p. 192-204 13 p.

    Research output: Contribution to journalArticle

  20. “Autophagy in the Heart”: Special Issue: Autophagy in the Heart

    Otsu, K., 11 Jun 2016, In : Journal of Molecular and Cellular Cardiology. 95, p. 1 1 p.

    Research output: Contribution to journalEditorial

  21. Autophagy during cardiac remodeling

    Nishida, K. & Otsu, K., Jun 2016, In : Journal of Molecular and Cellular Cardiology. 95, p. 11-18 95.

    Research output: Contribution to journalReview article

  22. Receptor-mediated mitophagy

    Yamaguchi, O., Murakawa, T., Nishida, K. & Otsu, K., Jun 2016, In : Journal of Molecular and Cellular Cardiology. 95, p. 50-56 95.

    Research output: Contribution to journalReview article

  23. Ataxia telangiectasia mutated in cardiac fibroblasts regulates doxorubicin-induced cardiotoxicity

    Zhan, H., Aizawa, K., Sun, J., Tomida, S., Otsu, K., Conway, S. J., McKinnon, P. J., Manabe, I., Komuro, I., Miyagawa, K., Nagai, R. & Suzuki, T., 1 May 2016, In : Cardiovascular Research. 110, 1, p. 85-95 11 p.

    Research output: Contribution to journalArticle

  24. Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement from the American Heart Association

    Murphy, E., Ardehali, H., Balaban, R. S., DiLisa, F., Dorn, G. W., Kitsis, R. N., Otsu, K., Ping, P., Rizzuto, R., Sack, M. N., Wallace, D. & Youle, R. J., 28 Apr 2016, In : Circulation Research. 118, 12, p. 1960-1991 32 p.

    Research output: Contribution to journalArticle

  25. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Otsu, K. & Jungbluth, H., 21 Jan 2016, In : Autophagy. 12, 1

    Research output: Contribution to journalEditorial

  26. Macromolecular Degradation Systems and Cardiovascular Aging

    Nakayama, H., Nishida, K. & Otsu, K., 2016, In : Circulation Research. 118, 10, p. 1577-1592 118.

    Research output: Contribution to journalReview article

  27. Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

    Murakawa, T., Yamaguchi, O., Hashimoto, A., Hikoso, S., Takeda, T., Oka, T., Yasui, H., Ueda, H., Akazawa, Y., Nakayama, H., Taneike, M., Misaka, T., Omiya, S., Shah, A. M., Yamamoto, A., Nishida, K., Ohsumi, Y., Okamoto, K., Sakata, Y. & Otsu, K., 6 Jul 2015, In : Nature Communications. 6, p. 7527 1 p.

    Research output: Contribution to journalArticle

  28. Degradation systems in heart failure

    Nishida, K., Yamaguchi, O. & Otsu, K., 1 Jul 2015, In : Journal of Molecular and Cellular Cardiology. 84, p. 212-222 11 p.

    Research output: Contribution to journalArticle

  29. Tissue-Specific Regulation of p38α-Mediated Inflammation in Con A-Induced Acute Liver Damage

    Kang, Y., Bang, B-R., Otsuka, M. & Otsu, K., 15 May 2015, In : Journal of Immunology. 194, 10, p. 4759-4766

    Research output: Contribution to journalArticle

  30. MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway

    Kuwabara, Y., Horie, T., Baba, O., Watanabe, S., Nishiga, M., Usami, S., Izuhara, M., Nakao, T., Nishino, T., Otsu, K., Kita, T., Kimura, T. & Ono, K., 16 Jan 2015, In : Circulation Research. 116, 2, p. 279-288 10 p.

    Research output: Contribution to journalArticle

  31. Endogenous Ghrelin Attenuates Pressure Overload-Induced Cardiac Hypertrophy via a Cholinergic Anti-Inflammatory Pathway

    Mao, Y., Tokudome, T., Kishimoto, I., Otani, K., Nishimura, H., Yamaguchi, O., Otsu, K., Miyazato, M. & Kangawa, K., 1 Jan 2015, In : Hypertension. 65, 6, p. 1238-1244 7 p.

    Research output: Contribution to journalArticle

  32. The role of autophagic degradation in the heart

    Nishida, K., Taneike, M. & Otsu, K., 1 Jan 2015, In : Journal of Molecular and Cellular Cardiology. 78, p. 73-79 7 p.

    Research output: Contribution to journalArticle

  33. BCL2L13 is a mammalian homolog of the yeast mitophagy receptor Atg32

    Otsu, K., Murakawa, T. & Yamaguchi, O., 2015, In : Autophagy. 11, 10, p. 1932-1933 2 p.

    Research output: Contribution to journalReview article

  34. Genetic modulation of the SERCA activity does not affect the Ca2+ leak from the cardiac sarcoplasmic reticulum

    Morimoto, S., Hongo, K., Kusakari, Y., Komukai, K., Kawai, M., O-Uchi, J., Nakayama, H., Asahi, M., Otsu, K., Yoshimura, M. & Kurihara, S., Jan 2014, In : Cell Calcium. 55, 1, p. 17-23 7 p.

    Research output: Contribution to journalArticle

  35. Sex-Specific Control of Central Nervous System Autoimmunity by p38 Mitogen-Activated Protein Kinase Signaling in Myeloid Cells

    Krementsov, D. N., Noubade, R., Dragon, J. A., Otsu, K., Rincon, M. & Teuscher, C., Jan 2014, In : Annals of Neurology. 75, 1, p. 50-66 17 p.

    Research output: Contribution to journalArticle

  36. Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart

    Arita, Y., Nakaoka, Y., Matsunaga, T., Kidoya, H., Yamamizu, K., Arima, Y., Kataoka-Hashimoto, T., Ikeoka, K., Yasui, T., Masaki, T., Yamamoto, K., Higuchi, K., Park, J-S., Shirai, M., Nishiyama, K., Yamagishi, H., Otsu, K., Kurihara, H., Minami, T., Yamauchi-Takihara, K. & 6 others, Koh, G. Y., Mochizuki, N., Takakura, N., Sakata, Y., Yamashita, J. K. & Komuro, I., 2014, In : Nature Communications. 5, 14 p., 4552.

    Research output: Contribution to journalArticle

  37. Autophagy-mediated degradation is necessary for regression of cardiac hypertrophy during ventricular unloading

    Oyabu, J., Yamaguchi, O., Hikoso, S., Takeda, T., Oka, T., Murakawa, T., Yasui, H., Ueda, H., Nakayama, H., Taneike, M., Omiya, S., Shah, A. M., Nishida, K. & Otsu, K., 29 Nov 2013, In : Biochemical and Biophysical Research Communications. 441, 4, p. 787-792 6 p.

    Research output: Contribution to journalArticle

  38. Translation of hemodynamic stress to sterile inflammation in the heart

    Nakayama, H. & Otsu, K., Nov 2013, In : TRENDS IN ENDOCRINOLOGY AND METABOLISM. 24, 11, p. 546-553 8 p.

    Research output: Contribution to journalReview article

  39. Rheb (Ras Homologue Enriched in Brain)-dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation Becomes Indispensable for Cardiac Hypertrophic Growth after Early Postnatal Period

    Tamai, T., Yamaguchi, O., Hikoso, S., Takeda, T., Taneike, M., Oka, T., Oyabu, J., Murakawa, T., Nakayama, H., Uno, Y., Horie, K., Nishida, K., Sonenberg, N., Shah, A. M., Takeda, J., Komuro, I. & Otsu, K., 5 Apr 2013, In : Journal of Biological Chemistry. 288, 14, p. 10176-10187 12 p., N/A.

    Research output: Contribution to journalArticle

  40. Cooperation between proteolytic systems in cardiomyocyte recycling

    Yamaguchi, O., Taneike, M. & Otsu, K., 1 Oct 2012, In : Cardiovascular Research. 96, 1, p. 46-52 7 p.

    Research output: Contribution to journalLiterature review

  41. Role of Autophagy in Aging

    Yamaguchi, O. & Otsu, K., Sep 2012, In : Journal of Cardiovascular Pharmacology. 60, 3, p. 242-247 6 p.

    Research output: Contribution to journalLiterature review

  42. Pathological neoangiogenesis depends on oxidative stress regulation by ATM

    Okuno, Y., Nakamura-Ishizu, A., Otsu, K., Suda, T. & Kubota, Y., Aug 2012, In : Nature Medicine. 18, 8, p. 1208-1216 9 p.

    Research output: Contribution to journalArticle

  43. Perilipin 5, a Lipid Droplet-binding Protein, Protects Heart from Oxidative Burden by Sequestering Fatty Acid from Excessive Oxidation

    Kuramoto, K., Okamura, T., Yamaguchi, T., Nakamura, T. Y., Wakabayashi, S., Morinaga, H., Nomura, M., Yanase, T., Otsu, K., Usuda, N., Matsumura, S., Inoue, K., Fushiki, T., Kojima, Y., Hashimoto, T., Sakai, F., Hirose, F. & Osumi, T., 6 Jul 2012, In : Journal of Biological Chemistry. 287, 28, p. 23852-23863 12 p.

    Research output: Contribution to journalArticle

  44. Cell type-specific targeting dissociates the therapeutic from the adverse effects of protein kinase inhibition in allergic skin disease

    Ritprajak, P., Hayakawa, M., Sano, Y., Otsu, K. & Park, J. M., 5 Jun 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 23, p. 9089-9094 6 p.

    Research output: Contribution to journalArticle

  45. Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

    Oka, T., Hikoso, S., Yamaguchi, O., Taneike, M., Takeda, T., Tamai, T., Oyabu, J., Murakawa, T., Nakayama, H., Nishida, K., Akira, S., Yamamoto, A., Komuro, I. & Otsu, K., 10 May 2012, In : NATURE. 485, 7397, p. 251-255 6 p.

    Research output: Contribution to journalArticle

  46. Signaling via the kinase p38 alpha programs dendritic cells to drive T(H)17 differentiation and autoimmune inflammation

    Huang, G., Wang, Y., Vogel, P., Kanneganti, T-D., Otsu, K. & Chi, H., Feb 2012, In : Nature Immunology. 13, 2, p. 152 - 161 10 p.

    Research output: Contribution to journalArticle

  47. Calpain protects the heart from hemodynamic stress

    Taneike, M., Mizote, I., Morita, T., Watanabe, T., Hikoso, S., Yamaguchi, O., Takeda, T., Oka, T., Tamai, T., Oyabu, J., Murakawa, T., Nakayama, H., Nishida, K., Takeda, J., Mochizuki, N., Komuro, I. & Otsu, K., 16 Sep 2011, In : Nucleic Acids research and the Journal of Biological Chemistry. 286, 37, p. 32170-7 8 p.

    Research output: Contribution to journalArticle

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