King's College London

Research portal

Dr Leonard Schalkwyk

  1. DNA methylation aging clocks: Challenges and recommendations

    Bell, C. G., Lowe, R., Adams, P. D., Baccarelli, A. A., Beck, S., Bell, J. T., Christensen, B. C., Gladyshev, V. N., Heijmans, B. T., Horvath, S., Ideker, T., Issa, J. P. J., Kelsey, K. T., Marioni, R. E., Reik, W., Relton, C. L., Schalkwyk, L. C., Teschendorff, A. E., Wagner, W., Zhang, K. & 1 others, Rakyan, V. K., 25 Nov 2019, In : Genome Biology. 20, 1, 249.

    Research output: Contribution to journalReview article

  2. Genome-wide DNA methylation profiling identifies convergent molecular signatures associated with idiopathic and syndromic autism in post-mortem human brain tissue

    Wong, C. C. Y., Smith, R., Hannon, E., Ramaswami, G., Parikshak, N. N., Assary, E., Troakes, C., Poschmann, J., Schalkwyk, L. C., Sun, W., Prabhakar, S., Geschwind, D. H. & Mill, J., 1 Jul 2019, In : Human Molecular Genetics. 28, 13, p. 2201-2211 11 p.

    Research output: Contribution to journalArticle

  3. Bigmelon: Tools for analysing large DNA methylation datasets

    Gorrie-Stone, T. J., Smart, M. C., Saffari, A., Malki, K., Hannon, E., Burrage, J., Mill, J., Kumari, M. & Schalkwyk, L. C., 15 Mar 2019, In : BIOINFORMATICS. 35, 6, p. 981-986 6 p.

    Research output: Contribution to journalArticle

  4. A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex

    Marzi, S. J., Leung, S. K., Ribarska, T., Hannon, E., Smith, A. R., Pishva, E., Poschmann, J., Moore, K., Troakes, C., Al-Sarraj, S., Beck, S., Newman, S., Lunnon, K., Schalkwyk, L. C. & Mill, J., 1 Nov 2018, In : Nature Neuroscience. 21, 11, p. 1618-1627 10 p.

    Research output: Contribution to journalArticle

  5. Mitochondrial genes are altered in blood early in Alzheimer's disease

    Lunnon, K., Keohane, A., Pidsley, R., Newhouse, S., Riddoch-Contreras, J., Thubron, E. B., Devall, M., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Schalkwyk, L., Dobson, R., Malik, A. N., Powell, J., Lovestone, S. & Hodges, A., 1 May 2017, In : Neurobiology of Aging. 53, p. 36-47 12 p.

    Research output: Contribution to journalArticle

  6. An integrated genetic-epigenetic analysis of schizophrenia: Evidence for co-localization of genetic associations and differential DNA methylation

    Hannon, E., Dempster, E., Viana, J., Burrage, J., Smith, A. R., Macdonald, R., St Clair, D., Mustard, C., Breen, G., Therman, S., Kaprio, J., Toulopoulou, T., Pol, H. E. H., Bohlken, M. M., Kahn, R. S., Nenadic, I., Hultman, C. M., Murray, R. M., Collier, D. A., Bass, N. & 4 others, Gurling, H., McQuillin, A., Schalkwyk, L. & Mill, J., 30 Aug 2016, In : Genome Biology. 17, 1, 176.

    Research output: Contribution to journalArticle

  7. Transcriptome analysis of genes and gene networks involved in aggressive behavior in mouse and zebrafish

    Malki, K., Du Rietz, E., Crusio, W. E., Pain, O., Paya-Cano, J., Karadaghi, R. L., Sluyter, F., de Boer, S. F., Sandnabba, K., Schalkwyk, L. C., Asherson, P. & Tosto, M. G., 19 Apr 2016, In : American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics.

    Research output: Contribution to journalArticle

  8. ViPAR: A software platform for the Virtual Pooling and Analysis of Research Data

    Carter, K. W., Francis, R. W., Carter, K. W., Francis, R. W., Bresnahan, M., Gissler, M., Grønborg, T. K., Gross, R., Gunnes, N., Hammond, G., Hornig, M., Hultman, C. M., Huttunen, J., Langridge, A., Leonard, H., Newman, S., Parner, E. T., Petersson, G., Reichenberg, A., Sandin, S. & 10 others, Schendel, D. E., Schalkwyk, L., Sourander, A., Steadman, C., Stoltenberg, C., Suominen, A., Surén, P., Susser, E., Sylvester Vethanayagam, A. & Yusof, Z., 11 Apr 2016, In : International Journal of Epidemiology. 45, 2, p. 408-416 9 p.

    Research output: Contribution to journalArticle

  9. Comparative mRNA analysis of behavioral and genetic mouse models of aggression

    Malki, K., Tosto, M. G., Pain, O., Sluyter, F., Mineur, Y. S., Crusio, W. E., de Boer, S., Sandnabba, K. N., Kesserwani, J., Robinson, E., Schalkwyk, L. C. & Asherson, P., Apr 2016, In : American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 171B, 3, p. 427-436 10 p.

    Research output: Contribution to journalArticle

  10. Effects of advanced paternal age on trajectories of social behavior in offspring

    Janecka, M., Manduca, A., Servadio, M., Trezza, V., Smith, R., Mill, J., Schalkwyk, L. C., Reichenberg, A. & Fernandes, C., Jul 2015, In : Genes, brain, and behavior. 14, 6, p. 443-53 11 p.

    Research output: Contribution to journalArticle

  11. Methylomic trajectories across human fetal brain development

    Spiers, H., Hannon, E., Schalkwyk, L., Smith, R., Wong, C. W., O'Donovan, M., Bray, N. & Mill, J., 2015, In : Genome Research. 15 p.

    Research output: Contribution to journalArticle

  12. The inflammatory cytokines: Molecular biomarkers for major depressive disorder?

    Martin, C., Tansey, K. E., Schalkwyk, L. C. & Powell, T., 2015, In : Biomarkers in Medicine. 9, 2, p. 169-180 12 p.

    Research output: Contribution to journalArticle

  13. Genes and Gene Networks Implicated in Aggression Related Behaviour

    Malki, K., Pain, O., Du Rietz, E., Tosto, M. G., Paya-cano, J., Sandnabba, K. N., De Boer, S., Schalkwyk, L. C. & Sluyter, F., 1 Oct 2014, In : NEUROGENETICS. 15, 4, p. 255-266 12 p.

    Research output: Contribution to journalArticle

  14. Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

    De Jager, P. L., Srivastava, G., Lunnon, K., Burgess, J., Schalkwyk, L. C., Yu, L., Eaton, M. L., Keenan, B. T., Ernst, J., McCabe, C., Tang, A., Raj, T., Replogle, J., Brodeur, W., Gabriel, S., Chai, H. S., Younkin, C., Younkin, S. G., Zou, F., Szyf, M. & 9 others, Epstein, C. B., Schneider, J. A., Bernstein, B. E., Meissner, A., Ertekin-Taner, N., Chibnik, L. B., Kellis, M., Mill, J. & Bennett, D. A., Sep 2014, In : Nature Neuroscience. 17, 9, p. 1156-1163 8 p.

    Research output: Contribution to journalArticle

  15. Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

    Lunnon, K., Smith, R., Hannon, E., De Jager, P. L., Srivastava, G., Volta, M., Troakes, C., Al-Sarraj, S., Burrage, J., Macdonald, R., Condliffe, D., Harries, L. W., Katsel, P., Haroutunian, V., Kaminsky, Z., Joachim, C., Powell, J., Lovestone, S., Bennett, D. A., Schalkwyk, L. C. & 1 others, Mill, J., Sep 2014, In : Nature Neuroscience. 17, 9, p. 1164-1170 7 p.

    Research output: Contribution to journalArticle

  16. Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain

    Condliffe, D., Wong, A., Troakes, C., Proitsi, P., Patel, Y., Chouliaras, L., Fernandes, C., Cooper, J., Lovestone, S., Schalkwyk, L., Mill, J. & Lunnon, K., Aug 2014, In : Neurobiology of Aging. 35, 8, p. 1850-1854 5 p.

    Research output: Contribution to journalArticle

  17. The correlation between reading and mathematics ability at age twelve has a substantial genetic component

    Davis, O. S. P., Band, G., Pirinen, M., Haworth, C. M. A., Meaburn, E. L., Kovas, Y., Harlaar, N., Docherty, S. J., Hanscombe, K. B., Trzaskowski, M., Curtis, C. J. C., Strange, A., Freeman, C., Bellenguez, C., Su, Z., Pearson, R., Vukcevic, D., Langford, C., Deloukas, P., Hunt, S. & 31 others, Gray, E., Dronov, S., Potter, S. C., Tashakkori-Ghanbaria, A., Edkins, S., Bumpstead, S. J., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Duncanson, A., Jankowski, J. A. Z., Markus, H. S., Mathew, C. G., Palmer, C. N. A., Rautanen, A., Sawcer, S. J., Trembath, R. C., Viswanathan, A. C., Wood, N. W., Barroso, I., Peltonen, L., Dale, P. S., Petrill, S. A., Schalkwyk, L. S., Craig, I. W., Lewis, C. M., Price, T. S., Plomin, R. & Wellcome Trust Case Control Consortium, 8 Jul 2014, In : Nature Communications. 5, 6 p., 4204.

    Research output: Contribution to journalArticle

  18. Mood-stabilizers differentially affect housekeeping gene expression in human cells

    Powell, T., Powell-Smith, G., Haddley, K., Mcguffin, P., Quinn, J., Schalkwyk, L. C., Farmer, A. E. & D'Souza, U. M., Jun 2014, In : International Journal of Methods in Psychiatric Research. 23, 2, p. 279-288 10 p.

    Research output: Contribution to journalArticle

  19. The endogenous and reactive depression subtypes revisited: integrative animal and human studies implicate multiple distinct molecular mechanisms underlying major depressive disorder

    Malki, K., Keers, R., Tosto, M. G., Lourdusamy, A., Carboni, L., Domenici, E., Uher, R., McGuffin, P. & Schalkwyk, L. C., 7 May 2014, In : BMC Medicine. 12, 14 p., 73.

    Research output: Contribution to journalArticle

  20. Transcriptomic changes in the frontal cortex associated with paternal age

    Smith, R. G., Fernandes, C., Kember, R., Schalkwyk, L. C., Buxbaum, J., Reichenberg, A. & Mill, J., 23 Mar 2014, In : Molecular Autism. 5, 7 p., 24.

    Research output: Contribution to journalArticle

  21. Putative Transcriptomic Biomarkers in the Inflammatory Cytokine Pathway Differentiate Major Depressive Disorder Patients from Control Subjects and Bipolar Disorder Patients

    Powell, T., McGuffin, P., D'Souza, U. M., Cohen-Woods, S., Hosang, G. M., Martin, C., Matthews, K., Day, R. K., Farmer, A. E., Tansey, K. E. & Schalkwyk, L. C., 11 Mar 2014, In : PL o S One . 9, 3, 9 p., e91076.

    Research output: Contribution to journalArticle

  22. Differential methylation of the TRPA1 promoter in pain sensitivity

    Bell, J. T., Loomis, A. K., Butcher, L. M., Gao, F., Zhang, B., Hyde, C. L., Sun, J., Wu, H., Ward, K., Harris, J., Scollen, S., Davies, M. N., Schalkwyk, L. C., Mill, J., Williams, F. M. K., Li, N., Deloukas, P., Beck, S., McMahon, S. B., Wang, J. & 3 others, John, S. L., Spector, T. D. & MuTHER Consortium, Feb 2014, In : Nature Communications. 5, N/A, 11 p., 2978.

    Research output: Contribution to journalArticle

  23. Effect of chronic valproic acid treatment on hepatic gene expression profile in wfs1 knockout mouse

    Punapart, M., Eltermaa, M., Oflijan, J., Sütt, S., Must, A., Kõks, S., Schalkwyk, L. C., Fernandes, C., Vasar, E., Soomets, U. & Terasmaa, A., 2014, In : PPAR Research. 2014, 349525.

    Research output: Contribution to journalArticle

  24. A data-driven approach to preprocessing Illumina 450K methylation array data

    Pidsley, R., Wong, C., Volta, M., Lunnon, K., Mill, J. & Schalkwyk, L. C., 1 May 2013, In : BMC GENOMICS. 14, N/A, 10 p., 293.

    Research output: Contribution to journalArticle

  25. Peripheral blood RNA gene expression profiling in patients with bacterial meningitis

    Lill, M., Kõks, S., Soomets, U., Schalkwyk, L. C., Fernandes, C., Lutsar, I. & Taba, P., 18 Mar 2013, In : Frontiers in Neuroscience. 7, 33.

    Research output: Contribution to journalArticle

  26. Genetic variation in hippocampal microRNA expression differences in C57BL/6 J X DBA/2 J (BXD) recombinant inbred mouse strains

    Parsons, M. J., Grimm, C., Paya-Cano, J. L., Fernandes, C., Liu, L., Philip, V. M., Chesler, E. J., Nietfeld, W., Lehrach, H. & Schalkwyk, L. C., 13 Sep 2012, In : BMC GENOMICS. 13, 1, 476.

    Research output: Contribution to journalArticle

  27. Stochastic Choice of Allelic Expression in Human Neural Stem Cells

    Jeffries, A. R., Perfect, L., Ledderose, J., Schalkwyk, L. C., Bray, N. J., Mill, J. & Price, J., Sep 2012, In : Stem Cells. 30, 9, p. 1938-1947 10 p.

    Research output: Contribution to journalArticle

  28. Pharmacoproteomic investigation into antidepressant response in two mouse inbred strains

    Malki, K., Campbell, J., Davies, M., Keers, R., Uher, R., Ward, M., Paya-Cano, J., Aitchinson, K. J., Binder, E., Sluyter, F., Kuhn, K., Selzer, S., Craig, I., McGuffin, P. & Schalkwyk, L. C., Aug 2012, In : Proteomics. 12, 14, p. 2355-2365 11 p.

    Research output: Contribution to journalArticle

  29. Reduced anxiety and depression-like behaviours in the circadian period mutant mouse afterhours

    Keers, R., Pedroso, I., Breen, G., Aitchison, K. J., Nolan, P. M., Cichon, S., Noethen, M. M., Rietschel, M., Schalkwyk, L. C. & Fernandes, C., 2012, In : PLoS ONE. 7, 6, p. - 10 p., e38263.

    Research output: Contribution to journalArticle

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