Lingfang Zeng

Lingfang Zeng


  • Phone85270
  • 3187

Personal profile

Research interests

The current research of our group is focused in the field of vascular sciences. First, we study the effects of mechnical stress (shear stress, flow patterns) on endothelial cell differentiation and endothelium integrity and the underlying mechanism, especially the potential role of HDACs. We have found that HDAC3 is essential for shear stress-induced endothelial cell differentiation, while HDAC7 is involved in smooth muscle cell differentiation. The detailed mechanism is under investigation. We also study the potential role of HDACs in the maintenance of endothelial cell homeostasis. Second, We study the role of ER stress transducer XBP1 in the maintenance of endothelial cell integrity and its involvement in atherosclerotic lesion development. We have found that XBP1 is essential for endothelial cell survival under oxidative stress, and that enforced expression of spliced XBP1 will induce atherosclerotic lesion development.

Research interests (short)

Stem cell differentiation; atherosclerosis; vascular biology; mechanical signal transduction; ER stress; HDACs.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being


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Collaborations and top research areas from the last five years

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