Research output per year
Research output per year
Personal profile
Research interests
The current research of our group is focused in the field of vascular sciences. First, we study the effects of mechnical stress (shear stress, flow patterns) on endothelial cell differentiation and endothelium integrity and the underlying mechanism, especially the potential role of HDACs. We have found that HDAC3 is essential for shear stress-induced endothelial cell differentiation, while HDAC7 is involved in smooth muscle cell differentiation. The detailed mechanism is under investigation. We also study the potential role of HDACs in the maintenance of endothelial cell homeostasis. Second, We study the role of ER stress transducer XBP1 in the maintenance of endothelial cell integrity and its involvement in atherosclerotic lesion development. We have found that XBP1 is essential for endothelial cell survival under oxidative stress, and that enforced expression of spliced XBP1 will induce atherosclerotic lesion development.
Research interests (short)
Stem cell differentiation; atherosclerosis; vascular biology; mechanical signal transduction; ER stress; HDACs.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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A novel nested gene Aff3ir participates in vascular remodelling by enhancing endothelial cell differentiation in mice
Zeng, L., 27 May 2024, In: Genes & Diseases.Research output: Contribution to journal › Article › peer-review
Open Access -
Efficient healing of diabetic wounds by MSC-EV-7A composite hydrogel via suppression of inflammation and enhancement of angiogenesis
Long, X., Yuan, Q., Tian, R., Zhang, W., Liu, L., Yang, M., Yuan, X., Deng, Z., Li, Q., Sun, R., Kang, Y., Peng, Y., Kuang, X., Zeng, L. & Yuan, Z., 8 Feb 2024, (E-pub ahead of print) In: Biomaterials Science.Research output: Contribution to journal › Article › peer-review
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Exercise prevents fatal stress-induced myocardial injury in obese mice
Dun, Y., Hu, Z., You, B., Du, Y., Zeng, L., Zhao, Y., Liu, Y., Wu, S., Cui, N., Yang, F. & Liu, S., 2023, In: Frontiers in Endocrinology . 14, 1223423.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity
Romeo, S., Secco, I., Schneider, E., Reumiller, C. M., Santos, C. X. C., Zoccarato, A., Musale, V., Pooni, A., Yin, X., Theofilatos, K., Cellone Trevelin, S., Zeng, L., Mann, G., Pathak, V., Harkin, K., Stitt, A. W., Medina, R. J., Margariti, A., Mayr, M., Shah, A., & 2 others, 30 Aug 2023, (Accepted/In press) In: Nature Communications. 19 p.Research output: Contribution to journal › Article › peer-review
File90 Downloads (Pure) -
Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity
Romeo, S. G., Secco, I., Schneider, E., Reumiller, C. M., Santos, C. X. C., Zoccarato, A., Musale, V., Pooni, A., Yin, X., Theofilatos, K., Trevelin, S. C., Zeng, L., Mann, G. E., Pathak, V., Harkin, K., Stitt, A. W., Medina, R. J., Margariti, A., Mayr, M., Shah, A. M., & 2 others, Dec 2023, In: Nature Communications. 14, 1, 5552.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus)
Projects
- 14 Finished
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The role of HDAC7 alternative translation in endothelial cell activation and cardiac fibrosis
1/09/2017 → 31/08/2021
Project: Research
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The role of XBP1-mediated novel type IV collagen isoform in progenitor cell migration
1/09/2016 → 30/06/2019
Project: Research
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HDAC3 and 7 involved in stem/progenitor cell differentiation and EC survival, immune response etc
1/04/2016 → 31/03/2018
Project: Research
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The role of the endothelial cell differentiation-related LAF4IR in vascular repair
1/10/2015 → 31/12/2018
Project: Research
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the role of an XBP1-mediated novel isoform of type IV collagen in vascular smooth muscle and progenitor cell migration
1/07/2015 → 30/06/2018
Project: Research