Louisa James
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Personal profile

Research interests

My research aims to find out how different micro-environments can influence B cells and antibody production. To this end I use a variety of cellular and molecular techniques in combination, to study immune responses in tissue and blood from human volunteers. I have a particular interest in allergic disease since it represents a classic example of aberrant antibody production resulting from a loss of tolerance mediated by chronic inflammation in tissue. 

Ultimately I plan to exploit the findings of my research to identify B cell epitopes for antigen-specific immunotherapy. This approach, which aims to restore immune tolerance, is inspired by my doctoral and post-doctoral research on allergen immunotherapy, in which I identified a role for blocking antibodies in mediating long-term clinical tolerance (James L.K., et.al. 2011). 

Since joining the Randall Division of Cell & Molecular Biophysics I set up a method to isolate, clone and express monoclonal antibodies from single B cells (James L.K., et.al. 2012). Following this I established a project to examine local antibody diversity in mucosal tissue using next generation sequencing (Wu Y.C. & James L.K., et.al. 2014). My current work, funded by King’s Health Partners, aims to combine single B cell analysis and high throughput immunoglobulin repertoire analysis to decipher the relationship between B cell phenotype and antibody function.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Doctor of Philosophy, Mechanisms of Immunotherapy for Seasonal Allergic Rhinitis, Imperial College London

Award Date: 1 Jan 2007

Bachelor of Science, King's College London

Award Date: 1 Jan 2002

Keywords

  • Q Science (General)
  • Immunology
  • Allergy
  • IgE
  • IgG4
  • Immunotherapy
  • Antibody

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