Research output per year
Research output per year
My research aims to find out how different micro-environments can influence B cells and antibody production. To this end I use a variety of cellular and molecular techniques in combination, to study immune responses in tissue and blood from human volunteers. I have a particular interest in allergic disease since it represents a classic example of aberrant antibody production resulting from a loss of tolerance mediated by chronic inflammation in tissue.
Ultimately I plan to exploit the findings of my research to identify B cell epitopes for antigen-specific immunotherapy. This approach, which aims to restore immune tolerance, is inspired by my doctoral and post-doctoral research on allergen immunotherapy, in which I identified a role for blocking antibodies in mediating long-term clinical tolerance (James L.K., et.al. 2011).
Since joining the Randall Division of Cell & Molecular Biophysics I set up a method to isolate, clone and express monoclonal antibodies from single B cells (James L.K., et.al. 2012). Following this I established a project to examine local antibody diversity in mucosal tissue using next generation sequencing (Wu Y.C. & James L.K., et.al. 2014). My current work, funded by King’s Health Partners, aims to combine single B cell analysis and high throughput immunoglobulin repertoire analysis to decipher the relationship between B cell phenotype and antibody function.
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Doctor of Philosophy, Mechanisms of Immunotherapy for Seasonal Allergic Rhinitis, Imperial College London
Award Date: 1 Jan 2007
Bachelor of Science, King's College London
Award Date: 1 Jan 2002
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Editorial › peer-review
Research output: Contribution to journal › Letter › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
James, L. (Primary Investigator)
1/07/2016 → 30/06/2021
Project: Research
James, L. (Primary Investigator) & Santos, A. (Co-Investigator)
1/10/2015 → 30/09/2018
Project: Research
James, L. (Primary Investigator) & Sutton, B. (Co-Investigator)
8/06/2015 → 30/06/2016
Project: Research
James, L. (Primary Investigator)
1/05/2015 → 30/04/2020
Project: Research
James, L. (Peer reviewer)
Activity: Publication peer-review and editorial work › Publication peer-review
James, L. (Peer reviewer)
Activity: Publication peer-review and editorial work › Publication peer-review
James, L. (Peer reviewer)
Activity: Publication peer-review and editorial work › Publication peer-review
James, L. (Peer reviewer)
Activity: Publication peer-review and editorial work › Publication peer-review
James, L. (Peer reviewer)
Activity: Publication peer-review and editorial work › Publication peer-review
James, L. (Recipient), Mar 2006
Prize: Prize (including medals and awards)
James, L. (Recipient), 2011
Prize: Prize (including medals and awards)
James, L. (Recipient), Nov 2010
Prize: Fellowship awarded competitively