Search results

• Finished

  NIHR Senior Investigator 14

  Chappell, L. (Primary Investigator)

  NIHR National Institute For Health & Care Research

  1/04/2021 → 31/03/2025

  Project: Research

• An Investigation of Ethnicity Related Differences in Hypertensive Disorders of Pregnancy amongst Women living in the UK

  Chappell, L. (Primary Investigator), Hysi, P. (Co-Investigator) & Poston, L. (Co-Investigator)

  MRC Medical Research Council

  1/03/2021 → 19/05/2025

  Project: Research

• CAPE: Calcium supplementation for women at high-risk of pre-eclampsia (CAPE)

  Chappell, L. (Primary Investigator)

  NIHR National Institute For Health & Care Research

  1/12/2020 → 30/11/2021

  Project: Research

• Prediction of Fetal Growth Restriction: Individual Participant Data (IPD) Meta-Analysis with Decision Curve Analysis International Predication of Complications in Pregnancy: Fetal Growth restriction (IPPIC-FGR)

  Chappell, L. (Primary Investigator)

  NIHR National Institute For Health & Care Research

  1/01/2020 → 30/06/2021

  Project: Research

  • Meta-Analysis 100%
  • Premature Labor 100%
  • Small for Gestational Age 100%
  • Odds Ratio 80%
  • Stillbirth 60%

• Placental growth fActor Repeat sampling for Reduction of adverse perinatal Outcomes in women with suspecTed pre-eclampsia: the Parrot-2 study

  Chappell, L. (Primary Investigator), Webster, L. (Primary Investigator), Shennan, A. (Co-Investigator) & Seed, P. (Co-Investigator)

  J P Moulton Charitable Foundation

  1/04/2019 → 31/03/2023

  Project: Research

• CRADLE-4: Can Reduction of Adverse pregnancy outcomes occur with planned DeLivery vs.Expectant management in pre-eclampsia?

  Shennan, A. (Primary Investigator), Chappell, L. (Co-Investigator), Sandall, J. (Co-Investigator) & Seed, P. (Co-Investigator)

  MRC Medical Research Council

  1/09/2018 → 31/08/2022

  Project: Research

• WILL (When to Induce Labour to Limit risk in pregnancy hypertension) – a multicentre, randomised controlled trial

  Magee, L. (Primary Investigator), Chappell, L. (Co-Investigator) & von Dadelszen, P. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/06/2018 → 31/01/2024

  Project: Research

• GCRF: The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) Network: a sub-Saharan network for placental disorders

  von Dadelszen, P. (Primary Investigator), Magee, L. (Co-Investigator), Chappell, L. (Co-Investigator), Poston, L. (Co-Investigator), Sandall, J. (Co-Investigator), Moore, S. (Co-Investigator), Shennan, A. (Co-Investigator), Girardi, G. (Primary Investigator) & Daniels, R. T. (Primary Investigator)

  MRC Medical Research Council

  1/10/2017 → 31/12/2021

  Project: Research

• The Development of Novel Prognostic Indicators in Preterm Preeclampsia

  Chappell, L. (Primary Investigator)

  1/04/2017 → 31/03/2020

  Project: Research

• How do bile acids influence maternal susceptibility to metabolic dysfunction and associated risks for infant and childhood?Health?

  Williamson, C. (Primary Investigator), Chappell, L. (Co-Investigator), Dixon, P. (Co-Investigator), Poston, L. (Co-Investigator), Rutherford, M. (Co-Investigator), Seed, P. (Co-Investigator) & academic, A. (Co-Investigator)

  2/10/2016 → 1/10/2021

  Project: Research

• Optimising the monitoring and management of raised blood pressure during and after pregnancy

  Chappell, L. (Primary Investigator)

  1/04/2016 → 31/03/2021

  Project: Research

• Unravelling protective mechanisms of ursodeoxycholic acid therapy in cholestatic pregnancy

  Williamson, C. (Primary Investigator), Chappell, L. (Co-Investigator), Dixon, P. (Co-Investigator) & Seed, P. (Co-Investigator)

  1/04/2016 → 31/03/2019

  Project: Research

• G14121 NIHR PG Chappell Sandall

  Chappell, L. (Primary Investigator) & Sandall, J. (Co-Investigator)

  1/04/2016 → 31/03/2021

  Project: Research

• Optimising the monitoring and management of raised blood pressure during and after pregnancy

  Chappell, L. (Primary Investigator) & Sandall, J. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/04/2016 → 31/12/2021

  Project: Research

• Unravelling protective mechanisms of ursodeoxycholic acid therapy in cholestatic pregnancy

  Williamson, C. (Primary Investigator), Chappell, L. (Co-Investigator), Dixon, P. (Co-Investigator), Seed, P. (Co-Investigator) & academic, A. (Co-Investigator)

  1/04/2016 → 31/03/2019

  Project: Research

• Prognostic indicators of severe disEAse in women with late preterm pre-eClampsia tO guide deCision-maKing on timing of delivery (PEACOCK study)

  Chappell, L. (Primary Investigator) & Shennan, A. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/04/2016 → 30/06/2019

  Project: Research

• Pre-eclampsia in Hospital: Early Induction or Expectant Management (PHONEIX)

  Chappell, L. (Primary Investigator) & Shennan, A. (Co-Investigator)

  1/02/2016 → 31/01/2018

  Project: Research

• Placental growth factor to Assess and diagnose hypeRtensive pRegnant wOmen: a stepped wedge Trial (PARROT)

  Chappell, L. (Primary Investigator) & Shennan, A. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/02/2016 → 31/01/2019

  Project: Research

• Mechanisms of action of intervention in the PHOENIX trial: in women with preterm pre-eclampsia does planned delivery improve postpartum maternal cardiac function through attenuation of myocardial ischaemia at time of disease (PHOEBE study)?

  McCarthy, F. (Primary Investigator), Chappell, L. (Primary Investigator), Marber, M. (Co-Investigator), Poston, L. (Co-Investigator) & Seed, P. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/01/2016 → 30/09/2019

  Project: Research

• Optimising multidisciplinary teamwork for managing Diabetes In Pregnancy: a mixed methods evaLuation Of the perforMAnce of different Teamwork models (DIPLOMAT)

  Bick, D. (Primary Investigator), Chappell, L. (Co-Investigator), Cornelius, V. (Co-Investigator), Robert, G. (Co-Investigator), Sandall, J. (Co-Investigator) & Taylor, C. (Co-Investigator)

  1/11/2015 → 31/10/2018

  Project: Research

• Improving maternal and perinatal outcomes in high-risk pregnancies

  Chappell, L. (Primary Investigator) & Edwards, D. (Co-Investigator)

  1/10/2015 → 30/09/2020

  Project: Research

• Unravelling protective mechanisms of ursodeoxycholic acid therapy in cholestatic pregnancy

  Williamson, C. (Primary Investigator), Chappell, L. (Co-Investigator), Dixon, P. (Co-Investigator) & Seed, P. (Co-Investigator)

  1/10/2015 → 1/10/2018

  Project: Research

• Accuracy of clinical characteristics, biochemical and ultrasound markers in the prediction of pre-eclampsia: an Individual Patient Data (IPD) Meta-analysis

  Chappell, L. (Primary Investigator), Poon, L. (Primary Investigator) & Poston, L. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/10/2015 → 30/11/2017

  Project: Research

  • Meta-Analysis 100%
  • Premature Labor 100%
  • Small for Gestational Age 100%
  • Odds Ratio 80%
  • Stillbirth 60%

• Improving maternal and perinatal outcomes in high-risk pregnancies

  Chappell, L. (Primary Investigator)

  NIHR National Institute For Health & Care Research

  1/10/2015 → 31/12/2021

  Project: Research

• Structure and function of the placenta from implantation to delivery: a next generation MRI approach

  Rutherford, M. (Primary Investigator), Aljabar, P. (Co-Investigator), Chappell, L. (Co-Investigator), Edwards, D. (Co-Investigator), Hajnal, J. (Co-Investigator), Malamateniou, C. (Co-Investigator), Pasupathy, D. (Co-Investigator) & Sinkus, R. (Co-Investigator)

  NIH National Institutes of Health

  1/09/2015 → 31/08/2021

  Project: Research

• Evaluation of the introduction of a novel device in the management of hypertension and shock in pregnancy in low-resource settings

  Shennan, A. (Primary Investigator), Chappell, L. (Co-Investigator), Sandall, J. (Co-Investigator) & Seed, P. (Co-Investigator)

  MRC Medical Research Council

  14/07/2015 → 13/04/2018

  Project: Research

  • Shock (Circulatory) 100%
  • Case-Control Study 100%
  • Vital Sign 66%
  • Blood Pressure 33%
  • Patient Referral 33%

• Evaluation of the introduction of a novel device in the management of hypertension and shock in pregnancy in low-resource settings

  Shennan, A. (Primary Investigator), Chappell, L. (Co-Investigator), Nathan, H. (Co-Investigator) & Sandall, J. (Co-Investigator)

  1/07/2015 → 30/06/2018

  Project: Research

• Delivering high-quality obstetric trials to improve pregnancy outcomes

  Chappell, L. (Primary Investigator)

  1/03/2015 → 29/02/2020

  Project: Research

• PITCHES: Phase II trial in IntrahepaTic Cholestasis of pregnancy (ICP) to evaluate Efficacy of urSodeoxycholic acid (UDCA) in improving perinatal outcomes with parallel biobank collection for mechanistic studies

  Chappell, L. (Primary Investigator), Dixon, P. (Co-Investigator), Seed, P. (Co-Investigator) & Williamson, C. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/03/2015 → 28/02/2019

  Project: Research

• PRESTO: PRE-eclampsia Screening TO predict risk

  Chappell, L. (Primary Investigator)

  1/02/2015 → 31/01/2018

  Project: Research

• PRESTO: PRE-eclampsia Screening TO predict risk

  Chappell, L. (Primary Investigator)

  1/02/2015 → 31/01/2018

  Project: Research

• Development and validation of Pregnancy and Childbirth Reported Outcome measures in Maternity project (PRO-maternity project)

  Chappell, L. (Primary Investigator)

  1/04/2014 → 30/09/2017

  Project: Research

• Does multidisciplinary teamworking for diabetes and cardiac disease improve neonatal/fetal and maternal outcomes and delivery of care (DEDICATED: a UK wide mixed methods evaluation)

  Bick, D. (Primary Investigator), Taylor, C. (Primary Investigator), Chappell, L. (Co-Investigator), Cornelius, V. (Co-Investigator) & Robert, G. (Co-Investigator)

  1/04/2014 → 31/03/2017

  Project: Research

• PHOENIX - Pre-eclampsia in HOspital: Early iNductIon or eXpectant management

  Shennan, A. (Primary Investigator) & Chappell, L. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/03/2014 → 29/02/2020

  Project: Research

• FALCON - FeAsibility study: Labetalol vs nifedipine for CONtrolling chronic hypertension in pregnancy

  Chappell, L. (Primary Investigator), Cruickshank, K. (Co-Investigator), Seed, P. (Co-Investigator) & Shennan, A. (Co-Investigator)

  KHP King's Health Partners

  1/10/2013 → 31/12/2015

  Project: Research

• Pregnancy and chronic hypertension: Labetalol vs Nifedipine for optimal blood pressure control

  Chappell, L. (Primary Investigator), Seed, P. (Co-Investigator) & Shennan, A. (Co-Investigator)

  1/10/2013 → 30/09/2015

  Project: Research

• PARROT: Placental growth factor in Assessment of women with suspected pre-eclampsia to Reduce maternal morbidity: Randomised Controlled Trial

  Shennan, A. (Primary Investigator), Chappell, L. (Co-Investigator) & Sandall, J. (Co-Investigator)

  1/10/2013 → 31/12/2016

  Project: Research

• Identification of biomarkers in systemic lupus erythematosus using urinary proteomics: improving prediction and diagnosis of pre-eclampsia

  Chappell, L. (Primary Investigator), Bramham, K. (Co-Investigator), Khamashta, M. (Co-Investigator), Mistry, H. (Co-Investigator), Seed, P. (Co-Investigator) & academic, A. (Co-Investigator)

  1/01/2012 → 30/06/2013

  Project: Research

• Identification of biomarkers in Systemic Lupus Erythematosus using urinary proteomics: improving prediction and diagnosis of pre-eclampsia

  Poston, L. (Primary Investigator), Chappell, L. (Co-Investigator) & academic, A. (Co-Investigator)

  1/01/2012 → 29/02/2012

  Project: Research

• Superimposed pre-eclampsia: evaluation of diagnostic and predictive markers in women with chronic kidney disease

  Bramham, K. (Primary Investigator), Chappell, L. (Primary Investigator), Mistry, H. (Co-Investigator), Poston, L. (Co-Investigator) & Seed, P. (Co-Investigator)

  1/08/2011 → 31/07/2013

  Project: Research

• A study to determine whether associations between micronutrient status and susceptibility to oxidative stress play a role in the aetiology of pre-eclampsia

  Mistry, H. (Primary Investigator), Poston, L. (Primary Investigator) & Chappell, L. (Co-Investigator)

  BHF British Heart Foundation

  1/06/2011 → 31/05/2013

  Project: Research

• Diagnosis and prediction of pre-eclampsia using urine proteomics

  Chappell, L. (Primary Investigator), Mistry, H. (Co-Investigator) & Poston, L. (Co-Investigator)

  1/04/2011 → 31/03/2013

  Project: Research

• South London CLRN NIHR Flexibility and Sustainibility funding

  Chappell, L. (Primary Investigator)

  1/10/2010 → 31/03/2011

  Project: Research

• A study to determine whether associations between micronutrient status ands genetic susceptibility to oxidative stress play a role in the aetiology of pre-eclampsia

  Poston, L. (Primary Investigator), Chappell, L. (Co-Investigator), Mistry, H. (Co-Investigator), Morgan, L. (Co-Investigator) & Young, S. (Co-Investigator)

  30/05/2010 → 29/05/2012

  Project: Research

• The role of urinary proteomics in the diagnosis and prediction of pre-eclampsia

  Chappell, L. (Primary Investigator), Mistry, H. (Co-Investigator), North, R. (Co-Investigator) & Poston, L. (Co-Investigator)

  1/04/2010 → 31/03/2012

  Project: Research

• Blood and Urine Micronutrients in Pregnancy Study (BUMPS)

  Chappell, L. (Primary Investigator), Pipkin, F. B. (Co-Investigator), Mistry, H. (Co-Investigator) & Williams, P. (Co-Investigator)

  1/01/2010 → 31/12/2012

  Project: Research

• Urinary proteome profile in healthy human pregnancy

  Chappell, L. (Primary Investigator), Mistry, H. (Co-Investigator) & Poston, L. (Co-Investigator)

  1/10/2009 → 30/09/2012

  Project: Research

• Understanding, predicting and diagnosing adverse pregnancy outcomes in women with chronic hypertension

  Chappell, L. (Primary Investigator), Poston, L. (Primary Investigator), Bramham, K. (Co-Investigator) & academic, A. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/09/2009 → 31/10/2014

  Project: Research

• Understanding the impact and pathogenesis of pre-existing proteninuria in pregnancy

  Bramham, K. (Primary Investigator), Chappell, L. (Co-Investigator), Morris, R. (Co-Investigator), Poston, L. (Co-Investigator) & Thompson, A. (Co-Investigator)

  1/08/2009 → 31/07/2012

  Project: Research

• Prediction of pre-eclampsia using urinary proteomics to elucidate candidate biomarkers

  Chappell, L. (Primary Investigator), Mistry, H. (Primary Investigator) & Poston, L. (Primary Investigator)

  1/05/2009 → 30/04/2012

  Project: Research