Research output per year
Research output per year
Personal profile
Biographical details
Luke studied Medicine and Neuroscience at Newcastle University. He completed a Masters in Psychiatric Research at King’s College London before undertaking clinical academic training in psychiatry and experimental medicine as an NIHR Academic Clinical Fellow and NIHR Maudsley BRC Clinical Research Fellow. He has conducted research investigating brain glutamate dynamics in healthy and psychiatric groups and is interested in understanding the rapid acting antidepressant mechanisms of treatments including ketamine and psilocybin. Luke has been awarded an MRC Clinical Research Training Fellowship and will undertake his PhD, investigating the acute neural mechanisms of antidepressant response to ketamine, under the supervision of Dr James Stone, Prof Mitul Mehta and Prof Allan Young at King’s College London.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Aticaprant: (a κ-opioid receptor antagonist) for major depressive disorder
Hampsey, E., Jelen, L. & Young, A. H., 2024, In: Expert Opinion on Emerging Drugs. 29, 3, p. 193-204 12 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile2 Citations (Scopus)34 Downloads (Pure) -
Effects of diazepam on hippocampal blood flow in people at clinical high risk for psychosis
Livingston, N. R., Kiemes, A., Devenyi, G. A., Knight, S., Lukow, P. B., Jelen, L. A., Reilly, T., Dima, A., Nettis, M. A., Casetta, C., Agyekum, T., Zelaya, F., Spencer, T., De Micheli, A., Fusar-Poli, P., Grace, A. A., Williams, S. C. R., McGuire, P., Egerton, A., Chakravarty, M. M., & 1 others, Aug 2024, In: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 49, 9, p. 1448-1458 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Guidelines for ketamine use in clinical psychiatry practice
Jelen, L. A., McShane, R. & Young, A. H., 10 May 2024, In: BJPsych Open. 10, 3, p. e107 e107.Research output: Contribution to journal › Review article › peer-review
Open Access2 Citations (Scopus) -
A transdiagnostic systematic review and meta-analysis of ketamine's anxiolytic effects
Hartland, H., Mahdavi, K., Jelen, L. A., Strawbridge, R., Young, A. H. & Alexander, L., Aug 2023, In: Journal of psychopharmacology (Oxford, England). 37, 8, p. 764-774 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)116 Downloads (Pure) -
Opioid Mechanisms and the Treatment of Depression
Jelen, L. A., Young, A. H. & Mehta, M. A., 4 Nov 2023, (E-pub ahead of print) In: Current topics in behavioral neurosciences.Research output: Contribution to journal › Article › peer-review