Research output per year
Research output per year
Personal profile
Research interests
Molecular mechanisms in contraction and regulation of striated muscle.
Research interests (short)
Click here for the Irving group webpage
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Dive into the research topics where Malcolm Irving is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Activation of skeletal muscle is controlled by a dual-filament mechano-sensing mechanism
Brunello, E., Marcucci, L., Irving, M. & Fusi, L., 30 May 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 22, e2302837120.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)60 Downloads (Pure) -
Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle
Caremani, M., Fusi, L., Reconditi, M., Piazzesi, G., Narayanan, T., Irving, M., Lombardi, V., Linari, M. & Brunello, E., 4 Dec 2023, In: Journal of General Physiology. 155, 12Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
In situ FRET-based localization of the N-terminus of myosin binding protein-C in heart muscle cells
Chandler, J., Treacy, C., Ameer-Beg, S., Ehler, E., Irving, M. & Kampourakis, T., 21 Mar 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 12, e2222005120.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)133 Downloads (Pure) -
Activation of the myosin motors in fast-twitch muscle of the mouse is controlled by mechano-sensing in the myosin filaments
Hill, C., Brunello, E., Fusi, L., Garcia Ovejero, J. & Irving, M., 1 Sept 2022, In: The Journal of Physiology. 600, 17, p. 3983-4000 18 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
Cooling intact and demembranated trabeculae from rat heart releases myosin motors from their inhibited conformation
Garcia Ovejero, J., Fusi, L., Holohan, S-J., Ghisleni, A., Narayanan, T., Irving, M. & Brunello, E., 7 Mar 2022, In: Journal of General Physiology. 154, 3, e202113029.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)61 Downloads (Pure)
Projects
- 40 Finished
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Targeting the myofilaments to correct heart muscle dysfunction
1/09/2019 → 31/08/2022
Project: Research
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BHF Research Excellence Award
Shah, A., Botnar, R., Chowienczyk, P., Eaton, P., Garcia-Manyes, S., Gautel, M., Giacca, M., Irving, M., Lamata de la Orden, P., Marber, M., Mayr, M., Otsu, K., Ourselin, S., Parsons, M., Razavi, R., Schnabel, J., Shanahan, C., Xu, Q. & Phinikaridou, A.
1/04/2019 → 31/03/2024
Project: Research
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Regulation of Contraction by the thick filaments in skeletal muscle
1/12/2018 → 3/09/2023
Project: Research
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Cardiac thick filament modulators: A potential new class of heart failure therapeutics
1/10/2017 → 31/12/2018
Project: Research
Activities
- 1 Types of External academic engagement - Membership of external research organisation
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Biotechnology and Biological Sciences Research Council
Malcolm Irving (Member)
2001 → 2006Activity: Other › Types of External academic engagement - Membership of external research organisation