Research output per year
Research output per year
Personal profile
Research interests
Molecular mechanisms in contraction and regulation of striated muscle.
Research interests (short)
Click here for the Irving group webpage
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Dual Filament Regulation of Relaxation in Mammalian Fast Skeletal Muscle
Hill, C., Kalakoutis, M., Arcidiacono, A., Paradine Cullup, F., Wang, Y., Fukutani, A., Narayanan, T., Brunello, E., Fusi, L. & Irving, M., 24 Jan 2025, (Accepted/In press) In: Proceedings of the National Academy of Sciences of the United States of America.Research output: Contribution to journal › Article › peer-review
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Activation of skeletal muscle is controlled by a dual-filament mechano-sensing mechanism
Brunello, E., Marcucci, L., Irving, M. & Fusi, L., 30 May 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 22, e2302837120.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)94 Downloads (Pure) -
Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle
Caremani, M., Fusi, L., Reconditi, M., Piazzesi, G., Narayanan, T., Irving, M., Lombardi, V., Linari, M. & Brunello, E., 4 Dec 2023, In: Journal of General Physiology. 155, 12Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
In situ FRET-based localization of the N-terminus of myosin binding protein-C in heart muscle cells
Chandler, J., Treacy, C., Ameer-Beg, S., Ehler, E., Irving, M. & Kampourakis, T., 21 Mar 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 12, e2222005120.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)155 Downloads (Pure) -
Activation of the myosin motors in fast-twitch muscle of the mouse is controlled by mechano-sensing in the myosin filaments
Hill, C., Brunello, E., Fusi, L., Garcia Ovejero, J. & Irving, M., 1 Sept 2022, In: The Journal of Physiology. 600, 17, p. 3983-4000 18 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (Scopus)
Projects
- 40 Finished
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Dynamic regulation of the heartbeat by myosin filaments
Irving, M. (Primary Investigator)
1/09/2019 → 31/08/2024
Project: Research
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Targeting the myofilaments to correct heart muscle dysfunction
Kampourakis, T. (Primary Investigator) & Irving, M. (Co-Investigator)
1/09/2019 → 31/08/2022
Project: Research
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BHF Research Excellence Award
Shah, A. (Primary Investigator), Botnar, R. (Co-Investigator), Chowienczyk, P. (Co-Investigator), Eaton, P. (Co-Investigator), Garcia-Manyes, S. (Co-Investigator), Gautel, M. (Co-Investigator), Giacca, M. (Co-Investigator), Irving, M. (Co-Investigator), Lamata de la Orden, P. (Co-Investigator), Marber, M. (Co-Investigator), Mayr, M. (Co-Investigator), Otsu, K. (Co-Investigator), Ourselin, S. (Co-Investigator), Parsons, M. (Co-Investigator), Razavi, R. (Co-Investigator), Schnabel, J. (Co-Investigator), Shanahan, C. (Co-Investigator), Xu, Q. (Co-Investigator) & Phinikaridou, A. (Co-Investigator)
1/04/2019 → 31/03/2024
Project: Research
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Regulation of Contraction by the thick filaments in skeletal muscle
Irving, M. (Primary Investigator)
1/12/2018 → 3/09/2023
Project: Research
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Cardiac thick filament modulators: A potential new class of heart failure therapeutics
Kampourakis, T. (Primary Investigator) & Irving, M. (Co-Investigator)
1/10/2017 → 31/12/2018
Project: Research
Activities
- 1 Types of External academic engagement - Membership of external research organisation
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Biotechnology and Biological Sciences Research Council
Irving, M. (Member)
2001 → 2006Activity: Other › Types of External academic engagement - Membership of external research organisation