Malcolm Irving

Finished

Dynamic regulation of the heartbeat by myosin filaments

Irving, M. (Primary Investigator)

Wellcome Trust

1/09/2019 → 31/08/2024

Project: Research

Targeting the myofilaments to correct heart muscle dysfunction

Kampourakis, T. (Primary Investigator) & Irving, M. (Co-Investigator)

BHF British Heart Foundation

1/09/2019 → 31/08/2022

Project: Research

BHF Research Excellence Award

Shah, A. (Primary Investigator), Botnar, R. (Co-Investigator), Chowienczyk, P. (Co-Investigator), Eaton, P. (Co-Investigator), Garcia-Manyes, S. (Co-Investigator), Gautel, M. (Co-Investigator), Giacca, M. (Co-Investigator), Irving, M. (Co-Investigator), Lamata de la Orden, P. (Co-Investigator), Marber, M. (Co-Investigator), Mayr, M. (Co-Investigator), Otsu, K. (Co-Investigator), Ourselin, S. (Co-Investigator), Parsons, M. (Co-Investigator), Razavi, R. (Co-Investigator), Schnabel, J. (Co-Investigator), Shanahan, C. (Co-Investigator), Xu, Q. (Co-Investigator) & Phinikaridou, A. (Co-Investigator)

BHF British Heart Foundation

1/04/2019 → 31/03/2024

Project: Research

Regulation of Contraction by the thick filaments in skeletal muscle

Irving, M. (Primary Investigator)

MRC Medical Research Council

1/12/2018 → 3/09/2023

Project: Research

Cardiac thick filament modulators: A potential new class of heart failure therapeutics

Kampourakis, T. (Primary Investigator) & Irving, M. (Co-Investigator)

BHF British Heart Foundation

1/10/2017 → 31/12/2018

Project: Research

Dual-filament regulation optimises the performance of heart muscle

Brunello, E. (Primary Investigator) & Irving, M. (Co-Investigator)

BHF British Heart Foundation

1/04/2017 → 31/03/2022

Project: Research

King’s NMR Facility for structural biology, metabolic profiling and drug discovery

Conte, M. (Primary Investigator), Avkiran, M. (Co-Investigator), Blower, P. (Co-Investigator), Dodding, M. (Co-Investigator), Eaton, P. (Co-Investigator), Gautel, M. (Co-Investigator), Irving, M. (Co-Investigator), Malim, M. (Co-Investigator), Marber, M. (Co-Investigator), Mayr, M. (Co-Investigator), McDonnell, J. (Co-Investigator), Otsu, K. (Co-Investigator), Pastore, A. (Co-Investigator), Pfuhl, M. (Co-Investigator), Poston, L. (Co-Investigator), Shah, A. (Co-Investigator), Shanahan, C. (Co-Investigator), Shattock, M. (Co-Investigator) & Williamson, C. (Co-Investigator)

BHF British Heart Foundation, Wellcome Trust

1/01/2017 → 31/12/2021

Project: Research

A novel signaling pathway in the regulation of cardiac contractility: mechano-sensing in the myosin filaments

Irving, M. (Primary Investigator)

BHF British Heart Foundation

1/09/2016 → 31/08/2019

Project: Research

Myosin Binding Protein-C: a key regulator of cardiac output

Kampourakis, T. (Primary Investigator), Gautel, M. (Co-Investigator) & Irving, M. (Co-Investigator)

BHF British Heart Foundation

1/03/2016 → 31/03/2020

Project: Research

King's NMR Facility for metabolic profiling, structural biology and drug discovery

Conte, M. (Primary Investigator), Dodding, M. (Co-Investigator), Irving, M. (Co-Investigator), Malim, M. (Co-Investigator) & Mason, J. (Co-Investigator)

1/10/2015 → 30/09/2020

Project: Research

Myosin-linked mechanisms for the regulation of muscle contraction

Irving, M. (Primary Investigator)

MRC Medical Research Council

1/09/2015 → 31/08/2018

Project: Research

High Resolution Ultrastructural Imaging Core Facility. A multiplatform electron microscopyfacility, with enabling high-resolution 3D and cryo-EM imaging from the nano to meso scale atKing's College London

Fleck, R. (Primary Investigator), Botnar, R. (Co-Investigator), Burrone, J. (Co-Investigator), Houart, C. (Co-Investigator), Irving, M. (Co-Investigator), McGrath, J. (Co-Investigator), Miller, C. (Co-Investigator), Ng, T. (Co-Investigator), Steel, K. (Co-Investigator) & Watt, F. (Co-Investigator)

1/07/2014 → 30/06/2019

Project: Research

Stem cell migration in development and disease

Irving, M. (Primary Investigator) & Sanz Moreno, V. (Co-Investigator)

1/05/2014 → 30/04/2018

Project: Research

Novel regulatory mechanisms in skeletal muscle

Irving, M. (Primary Investigator)

1/03/2014 → 28/02/2017

Project: Research

Cypher Scanning Probe Microscope (SPM) System

Garcia-Manyes, S. (Primary Investigator) & Irving, M. (Co-Investigator)

31/01/2014 → 31/03/2014

Project: Research

Novel mechanisms in muscle regulation

Fusi, L. (Primary Investigator) & Irving, M. (Co-Investigator)

1/09/2013 → 31/08/2018

Project: Research

The in situ mechanism of calcium sensitization by cardiovascular drugs that target troponon

Irving, M. (Primary Investigator)

CIHR Canadian Institutes of Health Research

1/06/2013 → 31/05/2016

Project: Research

Multiparametric advanced fluorescence imaging strategies for in situ analysis of live cell signalling

Irving, M. (Primary Investigator), Ameer-Beg, S. (Co-Investigator), Cox, S. (Co-Investigator), Gautel, M. (Co-Investigator), Geissmann, F. (Co-Investigator), Hughes, S. (Co-Investigator), Jones, G. E. (Co-Investigator), Owen, D. (Co-Investigator), Parsons, M. (Co-Investigator), Ridley, A. (Co-Investigator), Suhling, K. (Co-Investigator) & Watt, F. (Co-Investigator)

MRC Medical Research Council

1/02/2013 → 12/02/2018

Project: Research

Myosin regulatory light chain: modulator of cardiac function in health and disease

Irving, M. (Primary Investigator) & Sun, Y.-B. (Co-Investigator)

BHF British Heart Foundation

1/11/2012 → 30/11/2015

Project: Research

In silico and in vitro studies of cell-cell interactions leading to neoplasia

Irving, M. (Primary Investigator)

1/11/2012 → 31/10/2017

Project: Research

Coupling the molecular motor Kinesin-1 to new cargo, functions and diseases

Irving, M. (Primary Investigator) & Dodding, M. (Co-Investigator)

Wellcome Trust

1/07/2012 → 30/06/2017

Project: Research

A chemical approach to understanding cell division

Eggert, U. (Primary Investigator), Irving, M. (Primary Investigator) & Roth, F. (Co-Investigator)

1/06/2011 → 31/05/2016

Project: Research

Fluorescent probes of protein conformation in cells

Fraternali, F. (Primary Investigator), Irving, M. (Primary Investigator) & Sun, Y.-B. (Primary Investigator)

1/10/2010 → 30/09/2013

Project: Research

New tools for optical proteomics

Richards, D. (Primary Investigator), Coolen, T. (Co-Investigator), Irving, M. (Co-Investigator), Ng, T. (Co-Investigator), Suhling, K. (Co-Investigator) & Watson, T. (Co-Investigator)

1/10/2009 → 31/03/2011

Project: Research

Non-muscle myosin II as an integrator of pliability, integrin-mediated adhesion and growth factors in cell migration

Irving, M. (Primary Investigator) & academic, A. (Primary Investigator)

1/10/2009 → 30/09/2014

Project: Research

Molecular mechanism of the myosin motor in skeletal muscle.

Irving, M. (Primary Investigator)

Wellcome Trust

1/07/2009 → 28/02/2013

Project: Research

Control of myofilament calcium-sensitivity: a key determinant of the physiology and pathology of heart muscle

Sun, Y.-B. (Primary Investigator) & Irving, M. (Co-Investigator)

BHF British Heart Foundation

1/03/2009 → 28/02/2014

Project: Research

Molecular basis of force generation in skeletal muscle

Irving, M. (Primary Investigator) & Brunello, E. (Co-Investigator)

Royal Society

1/01/2009 → 31/03/2009

Project: Research

Molecular Mechanisms of Polyalanine Expansion Disorders.

Irving, M. (Primary Investigator)

1/10/2008 → 30/09/2013

Project: Research

BHF Centre of Research Excellence

Avkiran, M. (Primary Investigator), Blower, P. (Primary Investigator), Botnar, R. (Primary Investigator), Chowienczyk, P. (Primary Investigator), Eaton, P. (Primary Investigator), Ehler, E. (Primary Investigator), Garcia-Manyes, S. (Primary Investigator), Gautel, M. (Primary Investigator), Geissmann, F. (Primary Investigator), Hussain, M. (Primary Investigator), Irving, M. (Primary Investigator), Kalra, L. (Primary Investigator), Marber, M. (Primary Investigator), Mayr, M. (Primary Investigator), Nagel, E. (Primary Investigator), Otsu, K. (Primary Investigator), Razavi, R. (Primary Investigator), Ridley, A. (Primary Investigator), Shah, A. (Primary Investigator), Shanahan, C. (Primary Investigator), Smith, N. (Primary Investigator), Xu, Q. (Primary Investigator), Alastruey, J. (Co-Investigator), Ameer-Beg, S. (Co-Investigator), Bishop, M. (Co-Investigator), Brain, S. (Co-Investigator), Burgoyne, J. (Co-Investigator), Conte, M. (Co-Investigator), Dhanjal, T. (Co-Investigator), Eminaga, S. (Co-Investigator), Eykyn, T. (Co-Investigator), Gee, T. (Co-Investigator), Heintzmann, R. (Co-Investigator), Hughes, S. (Co-Investigator), Iskratsch, T. (Co-Investigator), Ivetic, A. (Co-Investigator), Jones, G. E. (Co-Investigator), Kentish, J. (Co-Investigator), Lamata de la Orden, P. (Co-Investigator), Lombardi, G. (Co-Investigator), Mullen, G. (Co-Investigator), Okonko, D. (Co-Investigator), Parsons, M. (Co-Investigator), Pfuhl, M. (Co-Investigator), Phinikaridou, A. (Co-Investigator), Rodaway, A. (Co-Investigator), Shattock, M. (Co-Investigator), Sinkus, R. (Co-Investigator), Springett, R. (Co-Investigator), Steiner, R. (Co-Investigator), Stroud, M. (Co-Investigator), Sun, Y.-B. (Co-Investigator), Wardle, F. (Co-Investigator), Warren, D. (Co-Investigator), Webb, A. (Co-Investigator), Zampetaki, A. (Co-Investigator), Zeng, L. (Co-Investigator) & academic, A. (Co-Investigator)

BHF British Heart Foundation

1/01/2008 → 31/03/2019

Project: Research

Molecular mechanism of muscle regulation by troponin.

Irving, M. (Primary Investigator) & Trentham, D. (Co-Investigator)

MRC Medical Research Council

1/04/2007 → 30/09/2011

Project: Research

Optical proteomic technology for in-situ analysis of protein interaction networks

Irving, M. (Primary Investigator), Heintzmann, R. (Co-Investigator), Ng, T. (Co-Investigator), Richards, D. (Co-Investigator) & Suhling, K. (Co-Investigator)

EPSRC Engineering and Physical Sciences Research Council

24/10/2005 → 23/02/2010

Project: Research