King's College London

Research portal

Dr Manasi Nandi

Research interests

Dr Manasi Nandi is a Senior Lecturer in Integrative Pharmacology. Her research focuses on cardiovascular regulation, in disorders including pulmonary hypertension and septic shock. She has used pharmacological, disease modifying and genetically modified systems, undertaking an integrative approach, to identify novel therapeutic targets for the treatment of vascular dysfunction. She completed her PhD at the Institute of Child Health and post doctoral training at University College London in the laboratory of Professor Patrick Vallance. During this time, she developed a number of in vivo systems to characterise a novel mouse mutant and small molecule, and identified a nitric oxide modifying pathway as a novel target for the treatment of septic shock. This project led to the award of a Wellcome Trust Seeding Drug Discovery Grant to UCL, on which she was the biology project manager. She was awarded a British Heart Foundation Intermediate Fellowship immediately prior to commencing her lectureship at King’s College London in 2009.

Since joining King’s, her research has been supported by funders including the British Heart Foundation, BBSRC, University of London and The Royal Society.

Current Research Interests:

1)      The investigation of nitric oxide modifying pathways including the role and regulation of tetrahydrobiopterin (a nitric oxide synthase cofactor) in the progression of hypertension and septic shock.

2)      The development of translatable preclinical research models to understand whole body responses to sepsis, trauma and other cardiovascular diseases with a particular focus multi-parameter analysis including hemodynamic and blood flow measurements in the macro and micro circulation.

3)      The refinement of preclinical models to improve experimental animal welfare whilst optimising scientific outputs (in conjunction with an RSPCA expert working group)

4)      The detailed investigation of physiological waveforms (e.g. blood pressure) using a novel mathematical method developed by Prof Philip Aston (Mathematics, University of Surrey). The project is currently partnering up with physiologists and clinicians within King’s Health Partners and beyond to translate the maths outputs to the patient’s bedside.

Editorial activity

Pharmacology research & perspectives (Journal)

Manasi Nandi (Editorial board member)

Jun 2021 → …

Activity: Publication peer-review and editorial workEditorial activity

Journal of the Royal Society of Medicine (Journal)

Manasi Nandi (Editor)

Sep 2019 → …

Activity: Publication peer-review and editorial workEditorial activity

Types of External academic engagement - Membership of peer review panel or committee

Health and Environmental Sciences Institute Thrive Advisory board

Manasi Nandi (Advisor)

1 Sep 2021 → …

Activity: OtherTypes of External academic engagement - Membership of peer review panel or committee

Medical Research Council grant review

Manasi Nandi (Reviewer)

16 Jun 2021

Activity: OtherTypes of External academic engagement - Membership of peer review panel or committee

NC3Rs training fellowship assessment panel

Manasi Nandi (Reviewer)

1 Sep 2019 → …

Activity: OtherTypes of External academic engagement - Membership of peer review panel or committee

Types of Public engagement and outreach - Media article or participation

Eureka a dose of science Big data is all around us but we are not using it

Manasi Nandi (Reviewer)

4 Apr 2019

Activity: OtherTypes of Public engagement and outreach - Media article or participation

Using animals for biomedical research why education holds the key

Manasi Nandi (Contributor)

13 Jun 2018

Activity: OtherTypes of Public engagement and outreach - Media article or participation

Reining in chaos to save lives ADI Instruments heroes

Manasi Nandi (Interviewee)

6 Jun 2018

Activity: OtherTypes of Public engagement and outreach - Media article or participation

Big data in sepsis detection

Manasi Nandi (Reviewer)

2 Jun 2018

Activity: OtherTypes of Public engagement and outreach - Media article or participation

Science Gallery London Blood: Cardiomorph

Manasi Nandi (Reviewer)

Oct 2017

Activity: OtherTypes of Public engagement and outreach - Media article or participation

Cardiomorph

Manasi Nandi (Reviewer)

May 2017

Activity: OtherTypes of Public engagement and outreach - Media article or participation

Greenwich Maths Time: Can maths solve sepsis?

Manasi Nandi (Reviewer)

May 2017

Activity: OtherTypes of Public engagement and outreach - Media article or participation

Can maths solve sepsis? British Science Festival

Manasi Nandi (Reviewer)

8 Sep 2016

Activity: OtherTypes of Public engagement and outreach - Media article or participation

What's your angle? London Science Museum

Manasi Nandi (Reviewer)

Nov 2015

Activity: OtherTypes of Public engagement and outreach - Media article or participation

Types of External academic engagement - Invited talk

Making the Most of Physiological 'Big' Data - a Maths in Medicine Case Study'

Manasi Nandi (Reviewer)

Jun 2017

Activity: OtherTypes of External academic engagement - Invited talk

Reconstructing blood pressure waveforms for the earlier detection of disease

Manasi Nandi (Reviewer)

Dec 2016

Activity: OtherTypes of External academic engagement - Invited talk

Reconstructing blood pressure waveforms for the earlier detection of disease

Manasi Nandi (Reviewer)

28 Oct 2016

Activity: OtherTypes of External academic engagement - Invited talk

Reconstructing blood pressure waveforms for the earlier detection of sepsis: a maths in medicine case study

Manasi Nandi (Reviewer)

Sep 2016

Activity: OtherTypes of External academic engagement - Invited talk

Animal models of sepsis and maximising data usage: a refinement and reduction case study

Manasi Nandi (Reviewer)

Jul 2016

Activity: OtherTypes of External academic engagement - Invited talk

Blended Learning on a Pharmacology course

Manasi Nandi (Reviewer)

22 Jun 2016

Activity: OtherTypes of External academic engagement - Invited talk

Lessons Learned

Manasi Nandi (Reviewer)

15 Jan 2016

Activity: OtherTypes of External academic engagement - Invited talk

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