King's College London

Research portal

Manu Shankar-Hari

  1. The interaction between arterial oxygenation and carbon dioxide and hospital mortality following out of hospital cardiac arrest: a cohort study

    McGuigan, P. J., Shankar-Hari, M., Harrison, D. A., Laffey, J. G. & McAuley, D. F., 12 Jun 2020, In : CRITICAL CARE. 24, 1, p. 336

    Research output: Contribution to journalArticle

  2. Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration in COVID-19 (REALIST-COVID-19): A structured summary of a study protocol for a randomised, controlled trial

    Gorman, E., Shankar-Hari, M., Hopkins, P., Tunnicliffe, W. S., Perkins, G. D., Silversides, J., McGuigan, P., Jackson, C., Boyle, R., McFerran, J., McDowell, C., Campbell, C., McFarland, M., Smythe, J., Thompson, J., Williams, B., Curley, G., Laffey, J. G., Clarke, M., O'Kane, C. & 1 others, McAuley, D. F., 3 Jun 2020, In : Trials. 21, 1, 1 p.

    Research output: Contribution to journalLetter

  3. Relationship between norepinephrine dose, tachycardia and outcome in septic shock: A multicentre evaluation

    Domizi, R., Calcinaro, S., Harris, S., Beilstein, C., Boerma, C., Chiche, J-D., D'Egidio, A., Damiani, E., Donati, A., Koetsier, P. M., Madden, M. P., McAuley, D. F., Morelli, A., Pelaia, P., Royer, P., Shankar-Hari, M., Wickboldt, N., Zolfaghari, P. & Singer, M., Jun 2020, In : Journal of Critical Care. 57, p. 185-190

    Research output: Contribution to journalArticle

  4. Demographic Shifts, Case Mix, Activity, and Outcome for Elderly Patients Admitted to Adult General ICUs in England, Wales, and Northern Ireland

    Jones, A., Toft-Petersen, A. P., Shankar-Hari, M., Harrison, D. A. & Rowan, K. M., 1 Apr 2020, In : Critical Care Medicine. 48, 4, p. 466-474 9 p.

    Research output: Contribution to journalArticle

  5. Rate and risk factors for rehospitalisation in sepsis survivors: systematic review and meta-analysis

    Shankar-Hari, M., Saha, R., Wilson, J., Prescott, H. C., Harrison, D., Rowan, K., Rubenfeld, G. D. & Adhikari, N. K. J., 1 Apr 2020, In : Intensive Care Medicine. 46, 4, p. 619-636 18 p.

    Research output: Contribution to journalReview article

  6. Lack of Clinical Benefit of Interferon β-1a Among Patients With Severe Acute Respiratory Distress Syndrome: Time to Overhaul Drug Trials in ARDS?

    Shankar-Hari, M. & Calfee, C. S., 25 Feb 2020, In : JAMA. 323, 8, p. 713-715 3 p.

    Research output: Contribution to journalEditorial

  7. Could stress ulcer prophylaxis increase mortality in high-acuity patients?

    Harhay, M. O., Young, P. J. & Shankar-Hari, M., 19 Feb 2020, In : Intensive Care Medicine. 46, 4, p. 793-795 3 p.

    Research output: Contribution to journalEditorial

  8. Is T Cell Exhaustion a Treatable Trait in Sepsis?

    Fish, M., Swanson, C. M. & Shankar-Hari, M., 12 Feb 2020, Annual Update in Intensive Care and Emergency Medicine 2020. Vincent, J-L. (ed.). Cham: Springer International Publishing, p. 271-279 9 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  9. Maternal Risk Modeling in Critical Care-Development of a Multivariable Risk Prediction Model for Death and Prolonged Intensive Care

    Simpson, N. B., Shankar-Hari, M., Rowan, K. M., Cecconi, M., von Dadelszen, P., Huning, E. Y-S., Magee, L. A., Payne, B. A., Quinn, A. C. & Harrison, D. A., 9 Jan 2020, In : Critical Care Medicine. p. 663-672 10 p.

    Research output: Contribution to journalArticle

  10. Should we consider blocking the inhibitory immune checkpoint molecules for treating T cell exhaustion in sepsis?

    Shankar-Hari, M., Fish, M. & Azoulay, E., 1 Jan 2020, In : Intensive Care Medicine. 46, 1, p. 119-121 3 p.

    Research output: Contribution to journalEditorial

  11. Trials on oxygen supplementation in sepsis: better late than never

    Perner, A., De Jong, A. & Shankar-Hari, M., 1 Jan 2020, In : Intensive Care Medicine. 46, 1, p. 116-118 3 p.

    Research output: Contribution to journalEditorial

  12. Current gaps in sepsis immunology: new opportunities for translational research

    Rubio, I., Osuchowski, M. F., Shankar-Hari, M., Skirecki, T., Winkler, M. S., Lachmann, G., La Rosée, P., Monneret, G., Venet, F., Bauer, M., Brunkhorst, F. M., Kox, M., Cavaillon, J-M., Uhle, F., Weigand, M. A., Flohé, S. B., Wiersinga, W. J., Martin-Fernandez, M., Almansa, R., Martin-Loeches, I. & 10 others, Torres, A., Giamarellos-Bourboulis, E. J., Girardis, M., Cossarizza, A., Netea, M. G., van der Poll, T., Scherag, A., Meisel, C., Schefold, J. C. & Bermejo-Martín, J. F., 1 Dec 2019, In : Lancet Infectious Diseases. 19, 12, p. e422-e436

    Research output: Contribution to journalReview article

  13. Sepsis hysteria: excess hype and unrealistic expectations

    Singer, M., Inada-Kim, M. & Shankar-Hari, M., 26 Oct 2019, In : Lancet. 394, 10208, p. 1513-1514 2 p.

    Research output: Contribution to journalLetter

  14. Focus on sepsis

    Møller, M. H., Alhazzani, W. & Shankar-Hari, M., 1 Oct 2019, In : Intensive Care Medicine. 45, 10, p. 1459-1461 3 p.

    Research output: Contribution to journalEditorial

  15. Population enrichment for critical care trials: phenotypes and differential outcomes

    Shankar-Hari, M. & Rubenfeld, G. D., 1 Oct 2019, In : CURRENT OPINION IN CRITICAL CARE. 25, 5, p. 489-497 9 p.

    Research output: Contribution to journalReview article

  16. Lung Recruitability in Severe Acute Respiratory Distress Syndrome Requiring Extracorporeal Membrane Oxygenation

    Camporota, L., Caricola, E. V., Bartolomeo, N., Di Mussi, R., Wyncoll, D. L. A., Meadows, C. I. S., Amado-Rodriguez, L., Vasques, F., Sanderson, B., Glover, G. W., Barrett, N. A., Shankar-Hari, M. & Grasso, S., 1 Sep 2019, In : Critical Care Medicine. 47, 9, p. 1177-1183 7 p.

    Research output: Contribution to journalArticle

  17. Risk Factors at Index Hospitalization Associated With Longer-term Mortality in Adult Sepsis Survivors

    Shankar-Hari, M., Harrison, D. A., Ferrando-Vivas, P., Rubenfeld, G. D. & Rowan, K., 31 May 2019, In : JAMA Network open. 2, 5, p. e194900

    Research output: Contribution to journalArticle

  18. Heterogeneity of treatment effect by baseline risk of mortality in critically ill patients: re-analysis of three recent sepsis and ARDS randomised controlled trials

    Santhakumaran, S., Gordon, A., Prevost, A. T., O’Kane, C., McAuley, D. F. & Shankar-Hari, M., 3 May 2019, In : CRITICAL CARE. 23, 1, 156.

    Research output: Contribution to journalArticle

  19. Readmission Diagnoses After Pediatric Severe Sepsis Hospitalization

    Carlton, E. F., Kohne, J. G., Shankar-Hari, M. & Prescott, H. C., 1 Apr 2019, In : Critical Care Medicine. 47, 4, p. 583-590 8 p.

    Research output: Contribution to journalArticle

  20. Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: infection and sepsis

    Barnes, J., Hunter, J., Harris, S., Shankar-Hari, M., Diouf, E., Jammer, I., Kalkman, C., Klein, A. A., Corcoran, T., Dieleman, S., Grocott, M. P. W., Mythen, M. G., Myles, P., Gan, T. J., Kurz, A., Peyton, P., Sessler, D., Tramèr, M., Cyna, A., De Oliveira Gildasio S., J. & 76 others, Wu, C., Jensen, M., Kehlet, H., Botti, M., Boney, O., Haller, G., Grocott, M., Cook, T., Fleisher, L., Neuman, M., Story, D., Gruen, R., Bampoe, S., Evered, L., Scott, D., Silbert, B., van Dijk, D., Chan, M., Grocott, H., Eckenhoff, R., Rasmussen, L., Eriksson, L., Beattie, S., Wijeysundera, D., Landoni, G., Leslie, K., Biccard, B., Howell, S., Nagele, P., Richards, T., Lamy, A., Lalu, M., Pearse, R., Mythen, M., Canet, J., Moller, A., Gin, T., Schultz, M., Pelosi, P., Gabreu, M., Futier, E., Creagh-Brown, B., Fowler, A., Abbott, T., Klein, A., Cooper, D. J., McIlroy, D., Bellomo, R., Shaw, A., Prowle, J., Karkouti, K., Billings, J., Mazer, D., Jayarajah, M., Murphy, M., Bartoszko, J., Sneyd, R., Morris, S., George, R., Moonesinghe, R., Shulman, M., Lane-Fall, M., Nilsson, U., Stevenson, N., Cooper, J. DJ., van Klei, W., Cabrini, L., Miller, T., Pace, N., Jackson, S., Buggy, D., Short, T., Riedel, B., Gottumukkala, V., Alkhaffaf, B. & Johnson, M., 1 Apr 2019, In : British Journal of Anaesthesia. 122, 4, p. 500-508 9 p.

    Research output: Contribution to journalReview article

  21. Acute Respiratory Distress Syndrome (ARDS) Phenotyping

    Shankar-Hari, M., Fan, E. & Ferguson, N., 5 Dec 2018, In : Intensive Care Medicine.

    Research output: Contribution to journalArticle

  22. Major surgery and the immune system: from pathophysiology to treatment

    Shankar Hari, M. & Summers, C., Dec 2018, In : CURRENT OPINION IN CRITICAL CARE. 24, 6, p. 588-593

    Research output: Contribution to journalArticle

  23. Lessons From ARDS for Non-ARDS Research: Remembrance of Trials Past

    Rubenfeld, G. D. & Shankar-Hari, M., 13 Nov 2018, In : JAMA. 320, 18, p. 1863-1865 3 p.

    Research output: Contribution to journalArticle

  24. Early PREdiction of sepsis using leukocyte surface biomarkers: the ExPRES-sepsis cohort study

    Shankar-Hari, M., Datta, D., Wilson, J., Assi, V., Stephen, J., Weir, C. J., Rennie, J., Antonelli, J., Bateman, A., Felton, J. M., Warner, N., Judge, K., Keenan, J., Wang, A., Burpee, T., Brown, A. K., Lewis, S. M., Mare, T., Roy, A. I., Wright, J. & 7 others, Hulme, G., Dimmick, I., Gray, A., Rossi, A. G., Simpson, A. J., Morris, A. C. & Walsh, T. S., 5 Oct 2018, In : Intensive Care Medicine. p. 1-13 13 p.

    Research output: Contribution to journalArticle

  25. A Comparison of Mortality From Sepsis in Brazil and England: The Impact of Heterogeneity in General and Sepsis-Specific Patient Characteristics

    Ranzani, O. T., Shankar-Hari, M., Harrison, D. A., Rabello, L. S., Salluh, J. I. F., Rowan, K. M. & Soares, M., 20 Sep 2018, In : Critical Care Medicine. Online First

    Research output: Contribution to journalArticle

  26. Corticosteroid therapy for sepsis: a clinical practice guideline

    Lamontagne, F., Rochwerg, B., Lytvyn, L., Guyatt, G. H., Møller, M. H., Annane, D., Kho, M. E., Adhikari, N. K. J., Machado, F., Vandvik, P. O., Dodek, P., Leboeuf, R., Briel, M., Hashmi, M., Camsooksai, J., Shankar-Hari, M., Baraki, M. K., Fugate, K., Chua, S., Marti, C. & 4 others, Cohen, D., Botton, E., Agoritsas, T. & Siemieniuk, R. A. C., 10 Aug 2018, In : BMJ. 362

    Research output: Contribution to journalArticle

  27. Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: Secondary Analysis of a Randomized Controlled Trial

    Calfee, C., Delucchi, K., Sinha, P., Matthay, M., Hackett, J., Shankar-Hari, M., McDowell, C., G. Laffey, J., O’Kane, C. & McAuley, D. F., 2 Aug 2018, In : The lancet. Respiratory medicine.

    Research output: Contribution to journalArticle

  28. Relationship between Anaemia, Haemolysis, Inflammation and Haem Oxygenase-1 at Admission with Sepsis: a pilot study

    Ekregbesi, P., Shankar-Hari, M., Bottomley, C., Riley, E. M. & Mooney, J. P., 25 Jul 2018, In : Scientific Reports. 8, 1, 11198 .

    Research output: Contribution to journalArticle

  29. Cell-surface signatures of immune dysfunction risk-stratify critically ill patients: INFECT study

    Morris, A. C., Datta, D., Shankar-Hari, M., Stephen, J., Weir, C. J., Rennie, J., Antonelli, J., Bateman, A., Warner, N., Judge, K., Keenan, J., Wang, A., Burpee, T., Brown, K. A., Lewis, S. M., Mare, T., Roy, A. I., Hulme, G., Dimmick, I., Rossi, A. G. & 2 others, Simpson, A. J. & Walsh, T. S., 11 Jun 2018, In : Intensive Care Medicine. 9 p.

    Research output: Contribution to journalArticle

  30. Race, ethnicity, and sepsis: beyond adjusted odds ratios

    Shankar-Hari, M. & Rubenfeld, G. D., Jun 2018, In : Critical Care Medicine. 46, 6

    Research output: Contribution to journalEditorial

  31. Do Sepsis-3 criteria facilitate earlier recognition of sepsis and septic shock? A retrospective cohort study

    Scheer, C. S., Kuhn, S-O., Fuchs, C., Vollmer, M., Modler, A., Brunkhorst, F., Shankar-Hari, M., Hahnenkamp, K., Gründling, M. & Rehberg, S., 8 May 2018, In : Shock. Publish Ahead of Print

    Research output: Contribution to journalArticle

  32. Lymphocyte subset expression and serum concentrations of PD-1/PD-L1 in sepsis - pilot study

    Wilson, J. K., Zhao, Y., Singer, M., Spencer, J. & Shankar-Hari, M., 17 Apr 2018, In : CRITICAL CARE.

    Research output: Contribution to journalArticle

  33. Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study)

    Welte, T., Dellinger, P., Ebelt, H., Ferrer, M., Opal, S., Singer, M., Vincent, J-L., Werdan, K., Martin‐Loeches, I., Almirall, J., Artigas, A., Ignacio Ayestarán, J., Nuding, S., Ferrer, R., Sirgo Rodríguez, G., Shankar-Hari, M., Álvarez‐Lerma, F., Riessen, R., Sirvent, JM., Kluge, S. & 23 others, Zacharowski, K., Bonastre Mora, J., Lapp, H., Wöbker, G., Achtzehn, U., Brealey, D., Kempa, A., Sánchez García, M., Brederlau, J., Kochanek, M., Peer Reschreiter, H., Wise, M., Belohradsky, B., Bobenhausen, I., Dälken, B., Dubovy, P., Langohr, P., Mayer, M., Schüttrumpf, J., Wartenberg‐Demand, A., Wippermann, U., Wolf, D. & Torres, A., 9 Apr 2018, In : Intensive Care Medicine.

    Research output: Contribution to journalArticle

  34. In Pursuit of Precision Medicine in the Critically Ill

    Shankar-Hari, M., Summers, C. & Baillie, K., 23 Mar 2018, In Pursuit of Precision Medicine in the Critically Ill. p. 649-658

    Research output: Chapter in Book/Report/Conference proceedingConference paper

  35. Estimating attributable fraction of mortality from sepsis to inform clinical trials

    Shankar-Hari, M., Harrison, D., Rowan, K. & Rubenfeld, G., 31 Jan 2018, In : Journal of Critical Care.

    Research output: Contribution to journalArticle

  36. Immunoglobulins and Sepsis

    Shankar-Hari, M., Bruun Madsen, M. & Turgeon, A., 18 Jan 2018, In : Intensive Care Medicine.

    Research output: Contribution to journalArticle

  37. Caring for Sepsis Patients: An Update

    Shankar-Hari, M. & Singer, M., Jan 2018, In : Critical Care Clinics. 34, 1, p. xiii-xv

    Research output: Contribution to journalArticle

  38. Immune Activation in Sepsis

    Conway-Morris, A., Wilson, J. & Shankar-Hari, M., Jan 2018, In : Critical Care Clinics. 34, 1, p. 29-42

    Research output: Contribution to journalArticle

  39. qSOFA, cue confusion

    Singer, M. & Shankar-Hari, M., 2018, In : Annals of Internal Medicine.

    Research output: Contribution to journalEditorial

  40. Septic shock resuscitation in the first hour

    Simpson, N., Lamontagne, F. & Shankar-Hari, M., 1 Dec 2017, In : CURRENT OPINION IN CRITICAL CARE. 23, 6, p. 561–566

    Research output: Contribution to journalArticle

  41. Acceptance and transfer to a regional severe respiratory failure and veno-venous extracorporeal membrane oxygenation (ECMO) service: predictors and outcomes

    Gillon, S. A., Rowland, K., Shankar-Hari, M., Camporota, L., Glover, G. W., Wyncoll, D. L. A., Barrett, N. A., Ioannou, N. & Meadows, C. I. S., 23 Nov 2017, In : Anaesthesia.

    Research output: Contribution to journalArticle

  42. Just Because Things Are Not Different, Does Not Mean They Are the Same: Biomarker Patterns in Acute Respiratory Distress Syndrome

    Shankar-Hari, M. & Rubenfeld, G. D., 1 Nov 2017, In : Critical Care Medicine. 45, 11, p. 1955-1957 3 p.

    Research output: Contribution to journalArticle

  43. The intensive care medicine research agenda on septic shock

    Perner, A., Gordon, A. C., Angus, D. C., Lamontagne, F., Machado, F., Russell, J. A., Timsit, J-F., Marshall, J. C., Myburgh, J., Shankar-Hari, M. & Singer, M., Sep 2017, In : Intensive Care Medicine. 43, 9, p. 1294–1305

    Research output: Contribution to journalArticle

  44. Divide and conquer: identifying acute respiratory distress syndrome subphenotypes

    Shankar-Hari, M. & McAuley, D. F., 17 Jul 2017, In : Thorax. 72, 10, p. 867-869 3 p.

    Research output: Contribution to journalArticle

  45. How could we enhance translation of sepsis immunology to inform immunomodulation trials in sepsis?

    Shankar-Hari, M., 26 May 2017, In : CRITICAL CARE. 21, 1, p. 125

    Research output: Contribution to journalEditorial

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