Manu Shankar-Hari

Manu Shankar-Hari

Professor

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Biographical details

Manu Shankar-Hari MSc(Epidemiology) PhD(Immunology) MB BS MD FRCA FFICM

Manu Shankar-Hari, undertook a period of clinical training as a junior doctor in Guy's and St Thomas' Hospital NHS Trust, University College London Hosptial NHS Trust, The Royal Free Hospital, St Mary's Hospital and at a number of regional district general hospitals around London. Manu was awarded PhD for his basic science (immunology) research into in B-lymphocyte and immunoglobulins biology in sepsis, at King's College London. He also completed formal research training in Epidemiology at the London School of Hygeine and Tropical Medicine, that led to a MSc.

He was appointed as a consultant physician in Intensive Care Medicine at Guy's and St Thomas' Hospital NHS Foundation Trust in 2009, where he continues to work as a clinician. He was awarded the prestigious NIHR Clinician Scientist Award in 2016, which is the primary funding stream for his research activity.

Research interests (short)

Dr Manu Shankar-Hari's unique research perspective comes from combining a formal training in epidemiology and basic science (immunology). His translational research is deeply influenced by CA Janeway’s work on lymphocyte receptor diversity, and G Rose’s conceptual arguments entitled ‘Sick individuals and sick populations’, which is reflected in the research programme he leads on.

Manu's research explores ways to improve acute and longer-term outcomes in adult critically ill sepsis and ARDS patients, by linking the illness immunobiology to trial design.

Research aims

Immunobiology

  • Lymphocyte abnormalities during sepsis-related critical illness and in sepsis survivor populations
  • Immune phenotypes and immune recovery patterns during sepsis-related critical illness

 Epidemiology and trial design

  • Epidemiology of Sepsis and ARDS related critical illness
  • Causality, modifiable determinants and dominant mechanisms in critical illness

Principal (Chief) Investigator projects

The following projects are funded by grants from the NIHR and the EME programme

  • VACIRiSS Trial - Vaccination for immune recovery following sepsis (EudraCT Number -  2017-002236-17)

Sepsis survivors are at much higher risk of infection-related rehospitalisation and death. The aim of VACIRiSS trial is to evaluate the immunogenicity of single dose 13-valent conjugate pneumococcal vaccine in preventing infection related rehospitalisation or death in sepsis survivors and to collect outcome event data with necessary precision to inform future definitive trial design.

http://www.guysandstthomasbrc.nihr.ac.uk/microsites/vaciriss/

  •  Investigate the epidemiology of infection-related rehospitalisation and death in sepsis survivors

Outcomes after critical illness reflect a complex interplay between patient characteristics, risk factors for critical illness, treatments in the ICU, and critical illness itself. This study builds on routinely collected data in England and uses in-depth epidemiological features of infection related rehospitalisation and death to improve longer term outcomes. 

  • Defining ARDS and sepsis sub-phenotypes: a re-analysis of two trials to inform stratified medicine approach with future trials

Acute Respiratory Distress Syndrome (ARDS) and sepsis are the two most common illnesses in the critically ill, with increasing incidence and high mortality and many statisitically negative trials. This research programme aims to identify homogenous groups (sub-phenotypes) such as patients with clinical or biological features or treatment response characteristics to inform future trial design by enriching patient populations likely to benefit the most from interventions.

 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 2 - Zero Hunger
  • SDG 3 - Good Health and Well-being
  • SDG 13 - Climate Action

Education/Academic qualification

PhD (Immunology), Doctor of Philosophy, B Lymphocytes, Immunoglobulins AND Free Light Chains in Sepsis, King's College London

Epidemiology, Master in Science, LSHTM London School of Hygiene and Tropical Medicine

MB BS, Bachelor of Medicine and Bachelor of Surgery

MD, Doctor of Medicine, Dose response study of inhaled nitric oxide in acute respiratory distress syndrome, AIIMS All India Institute of Medical Sciences

External positions

Senior Clinical Scientist, Intensive Care National Audit and Research Centre

3 Sept 2018 → …

Honorary Senior Research Associate, Intensive Care Medicine, University College London, Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom. Electronic address: m.singer@ucl.ac.uk.

1 Nov 201731 Jan 2019

NIHR Clinician Scientist, NIHR National Institute For Health & Care Research

1 Feb 201731 Jan 2022

Consultant Physician in Intensive Care Medicine, GSTT Guy's and St Thomas' NHS Foundation Trust

5 May 2009 → …

Keywords

  • R Medicine (General)
  • Intensive Care Medicine
  • Sepsis
  • HA Statistics
  • Epidemiology
  • Causation in Medicine

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