King's College London

Research portal

Professor Manuel Mayr

  1. Preclinical development of a miR-132 inhibitor for heart failure treatment

    Foinquinos, A., Batkai, S., Genschel, C., Viereck, J., Rump, S., Gyöngyösi, M., Traxler, D., Riesenhuber, M., Spannbauer, A., Lukovic, D., Weber, N., Zlabinger, K., Hašimbegović, E., Winkler, J., Fiedler, J., Dangwal, S., Fischer, M., Roche, J. D. L., Wojciechowski, D., Kraft, T. & 8 others, Garamvölgyi, R., Neitzel, S., Chatterjee, S., Yin, X., Bär, C., Mayr, M., Xiao, K. & Thum, T., 1 Dec 2020, In : Nature Communications. 11, 1, 633.

    Research output: Contribution to journalArticle

  2. Extracellular Matrix in Vascular Disease, Part 2/4: JACC Focus Seminar

    Barallobre-Barreiro, J., Loeys, B., Mayr, M., Rienks, M., Verstraeten, A. & Kovacic, J. C., 5 May 2020, In : Journal of the American College of Cardiology. 75, 17, p. 2189-2203 15 p.

    Research output: Contribution to journalReview article

  3. Circulating microRNA levels indicate platelet and leukocyte activation in endotoxemia despite platelet p2y12 inhibition

    Braza-Boïls, A., Barwari, T., Gutmann, C., Thomas, M. R., Judge, H. M., Joshi, A., Pechlaner, R., Shankar-Hari, M., Ajjan, R. A., Sabroe, I., Storey, R. F. & Mayr, M., 2 Apr 2020, In : International Journal of Molecular Sciences. 21, 8, 2897.

    Research output: Contribution to journalArticle

  4. FURIN Expression in Vascular Endothelial Cells Is Modulated by a Coronary Artery Disease–Associated Genetic Variant and Influences Monocyte Transendothelial Migration

    Yang, X., Yang, W., McVey, D. G., Zhao, G., Hu, J., Poston, R. N., Ren, M., Willeit, K., Coassin, S., Willeit, J., Webb, T. R., Samani, N. J., Mayr, M., Kiechl, S. & Ye, S., 18 Feb 2020, In : Journal of the American Heart Association. 9, 4, e014333.

    Research output: Contribution to journalArticle

  5. Aspirin, clopidogrel and prasugrel monotherapy in patients with type 2 diabetes mellitus: A double-blind randomised controlled trial of the effects on thrombotic markers and microRNA levels

    Parker, W. A. E., Schulte, C., Barwari, T., Phoenix, F., Pearson, S. M., Mayr, M., Grant, P. J., Storey, R. F. & Ajjan, R. A., 7 Jan 2020, In : Cardiovascular Diabetology. 19, 1, 3.

    Research output: Contribution to journalArticle

  6. A plasma proteogenomic signature for fibromuscular dysplasia

    Olin, J. W., Di Narzo, A. F., D'Escamard, V., Kadian-Dodov, D., Cheng, H., Georges, A., King, A., Thomas, A., Barwari, T., Michelis, K. C., Bouchareb, R., Bander, E., Anyanwu, A., Stelzer, P., Filsoufi, F., Florman, S., Civelek, M., Debette, S., Jeunemaitre, X., Björkegren, J. L. M. & 4 others, Mayr, M., Bouatia-Naji, N., Hao, K. & Kovacic, J. C., 1 Jan 2020, In : Cardiovascular Research. 116, 1, p. 63-77 15 p.

    Research output: Contribution to journalArticle

  7. Accepted/In press

    ApoCIII-Lp(a) complexes in conjunction with Lp(a)-OxPL predict rapid progression of aortic stenosis

    Capoulade, R., Torzewski, M., Mayr, M., Chan, K. L., Mathieu, P., Bossé, Y., Dumesnil, J. G., Tam, J., Teo, K. K., Burnap, S. A., Schmid, J., Gobel, N., Franke, U. F. W., Sanchez, A., Witztum, J. L., Yang, X., Yeang, C., Arsenault, B., Després, J. P., Pibarot, P. & 1 others, Tsimikas, S., 1 Jan 2020, (Accepted/In press) In : Heart. 315840.

    Research output: Contribution to journalArticle

  8. Accepted/In press

    Pkm2 regulates cardiomyocyte cell cycle and promotes cardiac regeneration

    Magadum, A., Singh, N., Kurian, A. A., Munir, I., Mehmood, T., Brown, K., Sharkar, M. T. K., Chepurko, E., Sassi, Y., Oh, J. G., Lee, P., Santos, C. X. C., Gaziel-Sovran, A., Zhang, G., Cai, C. L., Kho, C., Mayr, M., Shah, A. M., Hajjar, R. J. & Zangi, L., 1 Jan 2020, (Accepted/In press) In : Circulation. p. 1249-1265 17 p.

    Research output: Contribution to journalArticle

  9. Cartilage-like composition of keloid scar extracellular matrix suggests fibroblast mis-differentiation in disease

    Barallobre-Barreiro, J., Woods, E., Bell, R. E., Easton, J. A., Hobbs, C., Eager, M., Baig, F., MacKenzie Ross, A., Mallipeddi, R., Powell, B., Soldin, M., Mayr, M. & Shaw, T. J., 30 Oct 2019, In : Matrix Biology Plus.

    Research output: Contribution to journalArticle

  10. TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation

    Grund, A., Szaroszyk, M., Korf-Klingebiel, M., Malek Mohammadi, M., Trogisch, F. A., Schrameck, U., Gigina, A., Tiedje, C., Gaestel, M., Kraft, T., Hegermann, J., Batkai, S., Thum, T., Perrot, A., Remedios, C. D., Riechert, E., Völkers, M., Doroudgar, S., Jungmann, A., Bauer, R. & 9 others, Yin, X., Mayr, M., Wollert, K. C., Pich, A., Xiao, H., Katus, H. A., Bauersachs, J., Müller, O. J. & Heineke, J., 1 Oct 2019, In : EMBO Molecular Medicine. 11, 10, e10018.

    Research output: Contribution to journalArticle

  11. Glycoproteomic Analysis of the Aortic Extracellular Matrix in Marfan Patients.

    Yin, X., Wanga, S., Fellows, A. L., Barallobre-Barreiro, J., Lu, R., Davaapil, H., Franken, R., Fava, M., Baig, F., Skroblin, P., Xing, Q., Koolbergen, D. R., Groenink, M., Zwinderman, A. H., Balm, R., de Vries, C. J. M., Mulder, B. J. M., Viner, R., Jahangiri, M., Reinhardt, D. P. & 3 others, Sinha, S., de Waard, V. & Mayr, M., 1 Sep 2019, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 39, 9, p. 1859–1873 15 p.

    Research output: Contribution to journalArticle

  12. Locally different proteome in aortas from patients with stenotic tricuspid and bicuspid aortic valves†

    Forte, A., Yin, X., Fava, M., Bancone, C., Cipollaro, M., De Feo, M., Mayr, M., Jahangiri, M. & Della Corte, A., 1 Sep 2019, In : European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 56, 3, p. 458-469 12 p.

    Research output: Contribution to journalArticle

  13. Comparative Analysis of Circulating Noncoding RNAs Versus Protein Biomarkers in the Detection of Myocardial Injury

    Schulte, C., Barwari, T., Joshi, A., Theofilatos, K., Zampetaki, A., Barallobre-Barreiro, J., Singh, B., Sörensen, N. A., Neumann, J. T., Zeller, T., Westermann, D., Blankenberg, S., Marber, M. S., Liebetrau, C. & Mayr, M., 19 Jul 2019, In : Circulation Research. 125, 3, p. 328-340 13 p., 10.1161.

    Research output: Contribution to journalArticle

  14. Apolipoprotein Profiles in Very Preterm and Term-Born Preschool Children

    Posod, A., Pechlaner, R., Yin, X., Burnap, S. A., Kiechl, S. J., Willeit, J., Witztum, J. L., Mayr, M., Kiechl, S. & Kiechl-Kohlendorfer, U., 16 Apr 2019, In : Journal of the American Heart Association. 8, 8, p. e011199 e011199.

    Research output: Contribution to journalArticle

  15. Liver-specific microRNA-122 as prognostic biomarker in patients with chronic systolic heart failure

    Stojkovic, S., Koller, L., Sulzgruber, P., Hülsmann, M., Huber, K., Mayr, M., Hengstenberg, C., Wojta, J. & Niessner, A., 1 Jan 2019, In : International Journal of Cardiology.

    Research output: Contribution to journalArticle

  16. Optogenetic monitoring of the glutathione redox state in engineered human myocardium

    Trautsch, I., Heta, E., Soong, P. L., Levent, E., Nikolaev, V. O., Bogeski, I., Katschinski, D. M., Mayr, M. & Zimmermann, W. H., 1 Jan 2019, In : Frontiers in Physiology. 10, APR, 272.

    Research output: Contribution to journalArticle

  17. Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology

    de Boer, R. A., De Keulenaer, G., Bauersachs, J., Brutsaert, D., Cleland, J. G., Diez, J., Du, X. J., Ford, P., Heinzel, F. R., Lipson, K. E., McDonagh, T., Lopez-Andres, N., Lunde, I. G., Lyon, A. R., Pollesello, P., Prasad, S. K., Tocchetti, C. G., Mayr, M., Sluijter, J. P. G., Thum, T. & 8 others, Tschöpe, C., Zannad, F., Zimmermann, W. H., Ruschitzka, F., Filippatos, G., Lindsey, M. L., Maack, C. & Heymans, S., 1 Jan 2019, In : EUROPEAN JOURNAL OF HEART FAILURE. 21, 3, p. 272-285 14 p.

    Research output: Contribution to journalReview article

  18. In Aptamers They Trust: The Caveats of the SOMAscan Biomarker Discovery Platform from SomaLogic

    Joshi, A. & Mayr, M., 27 Nov 2018, In : Circulation. 138, 22, p. 2482-2485 4 p.

    Research output: Contribution to journalArticle

  19. Inhibition of Pro-Fibrotic MicroRNA-21 Affects Platelets and their Releasate

    Barwari, T., Eminaga, S., Mayr, U., Lu, R., Armstrong, P. C., Chan, M. V., Sahraei, M., Fernandez-Fuertes, M., Moreau, T., Barallobre-Barreiro, J., Lynch, M., Yin, X., Schulte, C., Baig, F., Pechlaner, R., Langley, S. R., Zampetaki, A., Santer, P., Weger, M., Plasenzotti, R. & 10 others, Schosserer, M., Grillari, J., Kiechl, S., Willeit, J., Shah, A. M., Ghevaert, C., Warner, T. D., Fernández-Hernando, C., Suárez, Y. & Mayr, M., 2 Nov 2018, In : JCI Insight.

    Research output: Contribution to journalArticle

  20. Metabolic changes in hypertrophic cardiomyopathies: Scientific update from the working group of myocardial function of the European Society of Cardiology

    Van Der Velden, J., Tocchetti, C. G., Varricchi, G., Bianco, A., Sequeira, V., Hilfiker-Kleiner, D., Hamdani, N., Leite-Moreira, A. F., Mayr, M., Falcao-Pires, I., Thum, T., Dawson, D. K., Balligand, J. L. & Heymans, S., 1 Aug 2018, In : Cardiovascular Research. 114, 10, p. 1273-1280 8 p.

    Research output: Contribution to journalReview article

  21. Comparison of MOLLI, shMOLLLI, and SASHA in discrimination between health and disease and relationship with histologically derived collagen volume fraction

    Child, N., Suna, G., Dabir, D., Yap, M., Rogers, T., Kathirgamanathan, M., Arroyo-ucar, E., Hinojar, R., Mahmoud, I., Young, C., Wendler, O., Mayr, M., Sandhu, B., Morton, G., Muhly-reinholz, M., Dimmeler, S., Nagel, E. & Puntmann, V. O., Jul 2018, In : European Heart Journal-Cardiovascular Imaging. 19, 7, p. 768–776

    Research output: Contribution to journalArticle

  22. MicroRNA-24 and the Diabetic Heart

    Rienks, M., Joshi, A. & Mayr, M., Jun 2018, In : JACC: Basic to Translational Science. 3, 3, p. 363-365 3 p.

    Research output: Contribution to journalEditorial

  23. Role of ADAMTS-5 in Aortic Dilatation and Extracellular Matrix Remodeling

    Fava, M., Barallobre-Barreiro, J., Mayr, U., Lu, R., Didangelos, A., Baig, F., Lynch, M., Catibog, N. R., Joshi, A., Barwari, T., Yin, X., Jahangiri, M. & Mayr, M., 5 Apr 2018, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 2018, 38, p. 1537-1548 11 p., 10.1161/ATVBAHA.117.310562.

    Research output: Contribution to journalLiterature review

  24. MicroRNA-21 and the Vulnerability of Atherosclerotic Plaques

    Barwari, T., Rienks, M. & Mayr, M., 21 Mar 2018, In : Molecular Therapy.

    Research output: Contribution to journalArticle

  25. The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC

    Frantz, S., Falcao-Pires, I., Balligand, J-L., Bauersachs, J., Brutsaert, D., Ciccarelli, M., Dawson, D., de Windt, L. J., Giacca, M., Hamdani, N., Hilfiker-Kleiner, D., Hirsch, E., Leite-Moreira, A., Mayr, M., Thum, T., Tocchetti, C. G., van der Velden, J., Varricchi, G. & Heymans, S., Mar 2018, In : EUROPEAN JOURNAL OF HEART FAILURE. p. 445-459

    Research output: Contribution to journalArticle

  26. Cardiovascular Risk Beyond Low-Density Lipoprotein Cholesterol∗

    Mayr, M., Gerszten, R. & Kiechl, S., 13 Feb 2018, In : Journal of the American College of Cardiology. 71, 6, p. 633-635 3 p.

    Research output: Contribution to journalArticle

  27. An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology

    Lourenço, A. P., Leite-Moreira, A. F., Balligand, J-L., Bauersachs, J., Dawson, D., de Boer, R. A., de Windt, L. J., Falcão-Pires, I., Fontes-Carvalho, R., Franz, S., Giacca, M., Hilfiker-Kleiner, D., Hirsch, E., Maack, C., Mayr, M., Pieske, B., Thum, T., Tocchetti, C. G., Brutsaert, D. L. & Heymans, S., Feb 2018, In : EUROPEAN JOURNAL OF HEART FAILURE. 20, 2, p. 216-227

    Research output: Contribution to journalArticle

  28. Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries

    Suna, G., Wojakowski, W., Lynch, M., Barallobre-Barreiro, J., Yin, X., Mayr, U., Baig, F., Lu, R., Fava, M., Hayward, R., Molenaar, C., White, S. J., Roleder, T., Milewski, K., Gasior, P., Buszman, P. P., Buszman, P. E., Jahangiri, M., Shanahan, C., Hill, J. M. & 1 others, Mayr, M., 9 Jan 2018, In : Circulation (Baltimore). 137, 2, p. 166-183

    Research output: Contribution to journalArticle

  29. Extracellular vesicle crosstalk between the myocardium and immune system upon infarction

    Burnap, S. A. & Mayr, M., 1 Jan 2018, In : Circulation Research. 123, 1, p. 15-17 3 p.

    Research output: Contribution to journalEditorial

  30. The emerging role of the ADAMTS family in vascular diseases

    Rienks, M., Barallobre-Barreiro, J. & Mayr, M., 1 Jan 2018, In : Circulation Research. 123, 12, p. 1279-1281 3 p.

    Research output: Contribution to journalReview article

  31. Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation

    Nabeebaccus, A. A., Zoccarato, A., Hafstad, A. D., Santos, C. X., Aasum, E., Brewer, A. C., Zhang, M., Beretta, M., Yin, X., West, J. A., Schröder, K., Griffin, J. L., Eykyn, T. R., Abel, E. D., Mayr, M. & Shah, A. M., 21 Dec 2017, In : JCI Insight. 2, 24

    Research output: Contribution to journalArticle

  32. Plasma Proteomics for Epidemiology: Increasing Throughput with Standard-Flow Rates

    Yin, X., Baig, F., Haudebourg, E., Blankley, R. T., Gandhi, T., Müller, S., Reiter, L., Hinterwirth, H., Pechlaner, R., Tsimikas, S., Santer, P., Willeit, J., Kiechl, S., Witztum, J. L., Sullivan, A. & Mayr, M., Dec 2017, In : Circulation-Cardiovascular Genetics. 10, 6

    Research output: Contribution to journalArticle

  33. Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling

    Sassi, Y., Avramopoulos, P., Ramanujam, D., Grüter, L., Werfel, S., Giosele, S., Brunner, A-D., Esfandyari, D., Papadopoulou, A. S., De Strooper, B., Hübner, N., Kumarswamy, R., Thum, T., Yin, X., Mayr, M., Laggerbauer, B. & Engelhardt, S., 20 Nov 2017, In : Nature Communications. 8, 1, p. 1614 1 p.

    Research output: Contribution to journalArticle

  34. Genetic Dissection of the Impact of miR-33a and miR-33b during the Progression of Atherosclerosis

    Price, N. L., Rotllan, N., Canfrán-Duque, A., Zhang, X., Pati, P., Arias, N., Moen, J., Mayr, M., Ford, D. A., Baldán, Á., Suárez, Y. & Fernández-Hernando, C., 31 Oct 2017, In : Cell Reports. 21, 5, p. 1317-1330 14 p.

    Research output: Contribution to journalArticle

  35. What are the prospects of apolipoprotein profiling for cardiovascular disease?

    Baig, F. & Mayr, M., 2 Sep 2017, In : EXPERT REVIEW OF MOLECULAR DIAGNOSTICS. 17, 9, p. 805-807 3 p.

    Research output: Contribution to journalEditorial

  36. CRISPR/Cas9 editing reveals novel mechanisms of clustered microRNA regulation and function

    Lataniotis, L., Albrecht, A., Kok, F. O., Monfries, C. A. L., Benedetti, L., Lawson, N. D., Hughes, S., Steinhofel, K., Mayr, M. & Zampetaki, A., 17 Aug 2017, In : Scientific Reports. 7, 1, p. 8585

    Research output: Contribution to journalArticle

  37. Downregulation of MicroRNA-126 Augments DNA Damage Response in Cigarette Smokers and COPD Patients

    Paschalaki, K. E., Zampetaki, A., Baker, J. R., Birrell, M. A., Starke, R. D., Belvisi, M. G., Donnelly, L. E., Mayr, M., Randi, A. M. & Barnes, P. J., 28 Jul 2017, In : American Journal of Respiratory and Critical Care Medicine.

    Research output: Contribution to journalArticle

  38. Long Noncoding RNAs and Angiogenesis: Regulatory Information for Chromatin Remodeling

    Zampetaki, A. & Mayr, M., 3 Jul 2017, In : Circulation (Baltimore). 136, 1, p. 80-82

    Research output: Contribution to journalArticle

  39. Proteomics of the epicardial fat secretome and its role in post-operative atrial fibrillation

    Viviano, A., Yin, X., Zampetaki, A., Fava, M., Gallagher, M., Mayr, M. & Jahangiri, M., 5 Jun 2017, In : EUROPACE. eux113.

    Research output: Contribution to journalArticle

  40. CRISPR/CAS9 GENE EDITING REVEALS NOVEL TERTIARY CONSTRAINTS IN CLUSTERED MIRNA PROCESSING

    Lataniotis, L., Albrecht, A., Kok, F., Monfries, C., Benedetti, L., Lawson, N. D., Hughes, S. M., Steinhofel, K., Mayr, M. & Zampetaki, A., Jun 2017, In : Heart. 103, p. A133-A133

    Research output: Contribution to journalArticle

  41. Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart

    Perrino, C., Barabási, A-L., Condorelli, G., Davidson, S. M., De Windt, L., Dimmeler, S., Engel, F. B., Hausenloy, D. J., Hill, J. A., Van Laake, L. W., Lecour, S., Leor, J., Madonna, R., Mayr, M., Prunier, F., Sluijter, J. P. G., Schulz, R., Thum, T., Ytrehus, K. & Ferdinandy, P., Jun 2017, In : Cardiovascular Research. 113, 7, p. 725-736 12 p.

    Research output: Contribution to journalArticle

  42. Mitochondria and ageing: Role in heart, skeletal muscle and adipose tissue

    Boengler, K., Kosiol, M., Mayr, M., Schulz, R. & Rohrbach, S., Jun 2017, In : Journal of cachexia sarcopenia and muscle. 8, 3, p. 349–369

    Research output: Contribution to journalArticle

  43. Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques

    Langley, S. R., Willeit, K., Didangelos, A., Matic, L. P., Skroblin, P., Barallobre-barreiro, J., Lengquist, M., Rungger, G., Kapustin, A., Kedenko, L., Molenaar, C., Lu, R., Barwari, T., Suna, G., Yin, X., Iglseder, B., Paulweber, B., Willeit, P., Shalhoub, J., Pasterkamp, G. & 7 others, Davies, A. H., Monaco, C., Hedin, U., Shanahan, C. M., Willeit, J., Kiechl, S. & Mayr, M., 3 Apr 2017, In : Journal of Clinical Investigation. 127, 4, p. 1546-1560

    Research output: Contribution to journalArticle

  44. Very-Low-Density Lipoprotein–Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III

    Pechlaner, R., Tsimikas, S., Yin, X., Willeit, P., Baig, F., Santer, P., Oberhollenzer, F., Egger, G., Witztum, J. L., Alexander, V. J., Willeit, J., Kiechl, S. & Mayr, M., 21 Feb 2017, In : Journal of the American College of Cardiology. 69, 7, p. 789-800 12 p.

    Research output: Contribution to journalArticle

  45. Circulating MicroRNA-122 is associated with the risk of new-onset metabolic syndrome and type 2 diabetes

    Willeit, P., Skroblin, P., Moschen, A. R., Yin, X., Kaudewitz, D., Zampetaki, A., Barwari, T., Whitehead, M., Ramírez, C. M., Goedeke, L., Rotllan, N., Bonora, E., Hughes, A. D., Santer, P., Fernández-Hernando, C., Tilg, H., Willeit, J., Kiechl, S. & Mayr, M., 1 Feb 2017, In : Diabetes. 66, 2, p. 347-357 11 p.

    Research output: Contribution to journalArticle

  46. High-density lipoproteins in high resolution: Will proteomics solve the paradox for cardiovascular risk?

    Baig, F., Joshi, A. & Mayr, M., 1 Feb 2017, In : Proteomics. 17, 3-4, 1600426.

    Research output: Contribution to journalComment/debate

  47. MicroRNA Biomarkers and Platelet Reactivity: The Clot Thickens

    Sunderland, N., Skroblin, P., Barwari, T., Huntley, R. P., Lu, R., Joshi, A., Lovering, R. C. & Mayr, M., 20 Jan 2017, In : Circulation Research. 120, 2, p. 418-435 18 p.

    Research output: Contribution to journalReview article

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