Revealing the secrets of the genome provided the basis for a better understanding of cellular and molecular mechanisms. However, as neither the genomic sequence nor the transcriptional profile can be directly correlated with protein expression, the importance of measuring protein levels has become increasingly clear. The promise of proteomics is to perform large scale-studies of gene expression at the protein level, leading to the discovery of novel proteins, novel markers of diseases, novel pathophysiological mechanisms and, last but not least, novel targets for drug development, providing a strong impetus for investment in these new technologies. Without doubts, proteomics will redefine biomedical research in the postgenomic era. In cardiovascular research, however, proteomics is still in its infancy. Our objective is to identify protein changes in vascular disease and to translate them into a functional context by combining proteomics with other -omic technologies such as transcriptomics and metabolomics.

To advance our understanding of cardiovascular disease by combining proteomics with metabolomics.