Projects per year
Search results
-
Active
RNA-trans-splicing as therapeutic modality for C9orf72 Amyotrophic Lateral Sclerosis
Ruepp, M.-D. (Primary Investigator), Mizielinska, S. (Co-Investigator) & academic, A. (Co-Investigator)
UKDRI UK Dementia Research Institute
1/05/2025 → 30/04/2027
Project: Research
-
Nuclear to synaptic signalling dysregulation by Annexin A11 in ALS
Smith, B. (Primary Investigator), Mitchell, J. (Co-Investigator), Mizielinska, S. (Co-Investigator), Ruepp, M.-D. (Co-Investigator), Troakes, C. (Co-Investigator) & Vance, C. (Co-Investigator)
MNDA Motor Neurone Disease Association
1/04/2025 → 31/03/2026
Project: Research
-
Decoding spatio-temporal kinetics of local mRNA translation in neurons using a new single-molecule imaging platform
Ruepp, M.-D. (Primary Investigator) & Khuperkar, D. (Co-Investigator)
UKDRI UK Dementia Research Institute
1/04/2025 → 31/03/2026
Project: Research
-
Synaptic dysfunction in ALS-FUS
Vance, C. (Primary Investigator), Ruepp, M.-D. (Co-Investigator) & Shaw, C. (Co-Investigator)
MNDA Motor Neurone Disease Association
1/03/2025 → 29/02/2028
Project: Research
-
UKDRI MND Theme Funding - Contribution to PhD Studentship TDP-43 Cell Models
Mizielinska, S. (Primary Investigator) & Ruepp, M.-D. (Co-Investigator)
UKDRI UK Dementia Research Institute
1/02/2025 → 31/01/2026
Project: Research
-
Targeted induction of the cold-shock protein RBM3 to prevent synapse loss and neurodegeneration in ALS/FTD
Ruepp, M.-D. (Primary Investigator) & Serio, A. (Co-Investigator)
14/10/2024 → 13/05/2026
Project: Research
-
Elucidating the non-cell autonomous role of FTD/ALS-linked mutations in p62 in iPSCs-derived astrocytes
Jimenez Sanchez, M. (Primary Investigator), Mizielinska, S. (Co-Investigator) & Ruepp, M.-D. (Co-Investigator)
1/10/2024 → 30/09/2025
Project: Research
-
MNDA Non-Cli: Perturbation of chaperones regulating FG nucleoporin homeostasis in C9ORF72 ALS/FTD: Therapeutic implications for C9ORF72 ALS/FTD. (MNDA Non-Clinical Junior Fellowship Full Application)
Ruepp, M.-D. (Primary Investigator) & Solomon, D. (Co-Investigator)
Motor Neurone Disease Association
1/07/2024 → 30/06/2027
Project: Research
-
Dissecting the molecular determinants of TDP-43 targeting for ALS/FTD
Mizielinska, S. (Primary Investigator) & Ruepp, M.-D. (Co-Investigator)
UKDRI UK Dementia Research Institute
1/07/2024 → 30/06/2025
Project: Research
-
Vectorised U7 snRNAs as gene therapy approach for ALS/FTD
Ruepp, M.-D. (Primary Investigator)
UKDRI UK Dementia Research Institute
28/05/2024 → 27/05/2027
Project: Research
-
The Phase Separation Dependent And Independent Interactive Of TDP-43
Ruepp, M.-D. (Primary Investigator)
UKDRI UK Dementia Research Institute
1/10/2023 → 30/09/2025
Project: Research
-
FULL submission - Dissecting FUS’ cytoplasmic toxic gain-of-function(s) in ALS
Ruepp, M.-D. (Primary Investigator)
MNDA Motor Neurone Disease Association
1/10/2023 → 30/09/2026
Project: Research
-
UK DRI QQ2: UK Dementia Research Institute Centre Award QQ2
Ule, J. (Primary Investigator), Marzi, S. (Co-Investigator), Mizielinska, S. (Co-Investigator), Ruepp, M.-D. (Co-Investigator) & Shaw, C. (Co-Investigator)
UKDRI UK Dementia Research Institute
1/04/2023 → 31/03/2028
Project: Research
-
Elucidating the Pathomolecular Determinants of Neurodegeneration in FUS-linked Amyotrophic Lateral Sclerosis
Ruepp, M.-D. (Primary Investigator)
1/07/2021 → 30/09/2026
Project: Research
-
Finished
DRI-TAP23\3: Mutant FUS degraders as a new therapeutic modality for paediatric and juvenile ALS.
Ruepp, M.-D. (Primary Investigator)
UKDRI UK Dementia Research Institute
1/11/2023 → 31/05/2025
Project: Research
-
Dissecting the Molecular Determinants of Cytoplasmic Gain of Function Pathomechanisms in TDP-43-linked Amyotrophic Lateral Sclerosis
Mizielinska, S. (Primary Investigator) & Ruepp, M.-D. (Co-Investigator)
Robert Packard Center for ALS Research at Johns Hopkins
1/07/2023 → 30/06/2024
Project: Research
-
AAV gene therapy for mutant FUS Amyotrophic Lateral Sclerosis
Lee, Y. (Primary Investigator), Ruepp, M.-D. (Co-Investigator), Shaw, C. (Co-Investigator) & Vance, C. (Co-Investigator)
1/10/2022 → 30/09/2024
Project: Research
-
Vectorised chimeric U7 snRNPs as therapeutic approach for ALS/FTD with TDP-43 pathology
Ruepp, M.-D. (Primary Investigator) & Shaw, C. (Co-Investigator)
UKDRI UK Dementia Research Institute
1/03/2022 → 31/03/2024
Project: Research
-
Identification of disrupted transcriptomic profiles in C9orf72 iPSC-derived cerebral cortical organoid models of FTD
O'Brien, N. (Primary Investigator), Mizielinska, S. (Co-Investigator) & Ruepp, M.-D. (Co-Investigator)
UKDRI UK Dementia Research Institute
1/01/2022 → 31/01/2025
Project: Research
-
Elucidating the Pathomolecular Determinants of Neurodegeneration in FUS-linked ALS
Ruepp, M.-D. (Primary Investigator)
1/06/2021 → 31/01/2025
Project: Research
-
Targeting FET proteins using synthetic RNA aptamers.
Jutzi, D. (Primary Investigator) & Ruepp, M.-D. (Co-Investigator)
UKDRI UK Dementia Research Institute
1/04/2021 → 31/03/2022
Project: Research
-
What Is The Mechanism Of RBM3-mediated Neuroprotection
Ruepp, M.-D. (Primary Investigator)
UKDRI UK Dementia Research Institute
1/01/2021 → 30/06/2024
Project: Research
-
Alzheimer’s Research UK King’s College London Network Centre Grant
Bateman, J. (Primary Investigator), Aarsland, D. (Co-Investigator), Cash, D. (Co-Investigator), Fanto, M. (Co-Investigator), Giese, P. (Co-Investigator), Hanger, D. (Co-Investigator), Hirth, F. (Co-Investigator), Malcangio, M. (Co-Investigator), Miller, C. (Co-Investigator), Mitchell, J. (Co-Investigator), Mondal, M. (Co-Investigator), Noble, W. (Co-Investigator), Parsons, R. (Co-Investigator), Ruepp, M.-D. (Co-Investigator), Serrano Navacerrada, M. E. (Co-Investigator), So, P.-W. (Co-Investigator), Sreedharan, J. (Co-Investigator), Troakes, C. (Co-Investigator), Vagnoni, A. (Co-Investigator), Vance, C. (Co-Investigator), Vernon, A. (Co-Investigator) & academic, A. (Co-Investigator)
1/09/2020 → 30/09/2022
Project: Research
-
Understanding the role of pathological cleavage in TDP-43 phase-separation
Ruepp, M.-D. (Primary Investigator)
1/03/2020 → 29/02/2024
Project: Research
-
Identifying Molecular Ageing signatures of Neural Stem Cells to uncover novel Geroneuroprotectors
Thuret, S. (Primary Investigator) & Ruepp, M.-D. (Co-Investigator)
1/10/2019 → 30/09/2023
Project: Research
-
Identification of converging minor intron splicing defects in ALS and elucidation of their therapeutic potential
Ruepp, M.-D. (Primary Investigator) & Mizielinska, S. (Co-Investigator)
Motor Neurone Disease Association
1/09/2019 → 28/02/2023
Project: Research
-
Elucidating early stage ALS pathomecanisms that drive mitochondrial dysfunction
Ruepp, M.-D. (Primary Investigator) & Devoy, A. (Co-Investigator)
1/07/2019 → 31/12/2022
Project: Research
-
UK DRI Associate Director's Flexible Funding
Shaw, C. (Primary Investigator), Mizielinska, S. (Co-Investigator), Pastore, A. (Co-Investigator), Cho, K. (Co-Investigator), Rajendran, L. (Co-Investigator) & Ruepp, M.-D. (Co-Investigator)
UK Dementia Research Institute
1/07/2019 → 31/03/2023
Project: Research
-
Dissecting the pathobiology of ALS using the FUS Delta14 mouse model
Devoy, A. (Primary Investigator) & Ruepp, M.-D. (Co-Investigator)
Motor Neurone Disease Association
1/01/2019 → 31/03/2022
Project: Research
-
Elucidation of Selective Motor Neuron Death in Amyotrophic Lateral Sclerosis
Ruepp, M.-D. (Primary Investigator)
1/06/2018 → 30/09/2019
Project: Research
-
Van Geest Neurosciences Donation
Shaw, C. (Primary Investigator), Aarsland, D. (Co-Investigator), Cho, K. (Co-Investigator), Ruepp, M.-D. (Co-Investigator), Mizielinska, S. (Co-Investigator) & Svenningsson, P. (Co-Investigator)
John and Lucille van Geest Foundation
1/08/2017 → 31/07/2023
Project: Research