Search results

• 2023

  A faecal metabolite signature of impaired fasting glucose: results from two independent population-based cohorts

  Nogal, A., Tettamanzi, F., Dong, Q., Louca, P., Visconti, A., Christiansen, C., Breuninger, T., Linseisen, J., Grallert, H., Wawro, N., Asnicar, F., Wong, K., Baleanu, A-F., Michelotti, G. A., Segata, N., Falchi, M., Peters, A., Franks, P. W., Bagnardi, V., Spector, T. D., & 4 othersBell, J. T., Gieger, C., Valdes, A. M. & Menni, C., 12 Sept 2023, (E-pub ahead of print) In: Diabetes.

  Research output: Contribution to journal › Article › peer-review

  • Metabolite 100%
  • Glucose 100%
  • Gut Microbiome 57%
  • Microbiome 44%
  • Host 14%

• Escape from X-inactivation in twins exhibits intra- and inter-individual variability across tissues and is heritable

  Zito, A., Roberts, A., Visconti, A., Rossi, N., Andres Ejarque, R., Nardone, S., El-Sayed Moustafa, J., Falchi, M. & Small, K., 21 Feb 2023, In: PLoS Genetics. 19, 2, e1010556.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tissues 100%
  • X-Inactivation 100%
  • X Chromosome Inactivation 87%
  • Immunocompetent Cell 25%
  • Cells 25%
  3 Citations (Scopus)

• European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

  23andMe Research Team, 4 Oct 2023, In: Nature Communications. 14, 1, p. 6172 6172.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Association 100%
  • Immunoregulation 100%
  • Atopic Dermatitis 100%
  • Genome-Wide Association Study 100%
  • Gene 50%

• Genetic and gut microbiome determinants of SCFA circulating and fecal levels, postprandial responses and links to chronic and acute inflammation

  Nogal, A., Asnicar, F., Vijay, A., Kouraki, A., Visconti, A., Louca, P., Wong, K., Baleanu, A-F., Giordano, F., Wolf, J., Hadjigeorgiou, G., Davies, R., Michelotti, G. A., Franks, P. W., Berry, S., Falchi, M., Ikram, A., Ollivere, B. J., Zheng, A., Nightingale, J., & 6 othersMassimo, M., Segata, N., Bulsiewicz, W. J., Spector, T., Valdes, A. M. & Menni, C., 2023, In: Gut Microbes. 15, 1, 2240050.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genetics 100%
  • Microbiome 100%
  • Short-Chain Fatty Acid 100%
  • Inflammation 100%
  • Short Chain Fatty Acid 100%

• Long-COVID fatigue is not predicted by pre-pandemic plasma IL-6 levels in mild COVID-19

  Freidin, M. B., Cheetham, N., Duncan, E. L., Steves, C. J., Doores, K. J., Malim, M. H., Rossi, N., Lord, J. M., Franks, P. W., Borsini, A., Granville Smith, I., Falchi, M., Pariante, C. & Williams, F. M. K., May 2023, In: Inflammation Research. 72, 5, p. 947-953 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • COVID-19 100%
  • Plasma 100%
  • Interleukin-6 100%
  • Fatigue 100%
  • Postcovid Syndrome 100%
  1 Citation (Scopus)

  22 Downloads (Pure)

• The person-to-person transmission landscape of the gut and oral microbiomes

  Valles-Colomer, M., Blanco-Míguez, A., Manghi, P., Asnicar, F., Dubois, L., Golzato, D., Armanini, F., Cumbo, F., Huang, K. D., Manara, S., Masetti, G., Pinto, F., Piperni, E., Punčochář, M., Ricci, L., Zolfo, M., Farrant, O., Goncalves, A., Selma-Royo, M., Binetti, A. G., & 23 othersBecerra, J. E., Han, B., Lusingu, J., Amuasi, J., Amoroso, L., Visconti, A., Steves, C. M., Falchi, M., Filosi, M., Tett, A., Last, A., Xu, Q., Qin, N., Qin, H., May, J., Eibach, D., Corrias, M. V., Ponzoni, M., Pasolli, E., Spector, T. D., Domenici, E., Collado, M. C. & Segata, N., 2 Feb 2023, In: Nature. 614, 7946, p. 125-135 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oral Microbiome 100%
  • Gut Microbiome 100%
  • Host 66%
  • Species 66%
  • Microbiome 66%
  46 Citations (Scopus)

• The secondary bile acid isoursodeoxycholate is associated with postprandial lipaemia, inflammation and appetite, and changes post bariatric surgery

  Louca, P., Meijnikman, A., Nogal MacHo, A., Asnicar, F., Attaye, I., Vijay, A., Kouraki, A., Visconti, A., Wong, K., Berry, S., Leeming, E., Mompeo Masachs, O., Tettamanzi, F., Baleanu, A-F., Falchi, M., Hadjigeorgiou, G., Wolf, J., Acherman, Y., Van de Laar, A., Gerdes, V., & 9 othersMichelotti, G., Franks, P., Segata, N., Mangino, M., Spector, T., Bulsiewicz, W., Nieuwdorp, M., Valdes, A. & Menni, C., 2023, In: Cell Reports Medicine.

  Research output: Contribution to journal › Article › peer-review

• Total serum N-glycans associate with response to immune checkpoint inhibition therapy and survival in patients with advanced melanoma

  Visconti, A., Rossi, N., Deriš, H., Lee, K. A., Hanić, M., Trbojević-Akmačić, I., Thomas, A. M., Bolte, L. A., Björk, J. R., Hooiveld-Noeken, J. S., Board, R., Harland, M., Newton-Bishop, J., Harries, M., Sacco, J. J., Lorigan, P., Shaw, H. M., de Vries, E. G. E., Fehrmann, R. S. N., Weersma, R. K., & 7 othersSpector, T. D., Nathan, P., Hospers, G. A. P., Sasieni, P., Bataille, V., Lauc, G. & Falchi, M., 18 Feb 2023, In: BMC Cancer. 23, 1, p. 166 166.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Inpatient 100%
  • Combination Therapy 100%
  • Survival 100%
  • Association 100%
  • Serum 100%
  3 Citations (Scopus)
• 2022

  ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition-implications for COVID-19

  El-Sayed Moustafa, J. S., Jackson, A. U., Brotman, S. M., Guan, L., Villicaña, S., Roberts, A. L., Zito, A., Bonnycastle, L., Erdos, M. R., Narisu, N., Stringham, H. M., Welch, R., Yan, T., Lakka, T., Parker, S., Tuomilehto, J., Seow, J., Graham, C., Huettner, I., Acors, S., & 16 othersKouphou, N., Wadge, S., Duncan, E. L., Steves, C. J., Doores, K. J., Malim, M. H., Collins, F. S., Pajukanta, P., Boehnke, M., Koistinen, H. A., Laakso, M., Falchi, M., Bell, J. T., Scott, L. J., Mohlke, K. L. & Small, K. S., Aug 2022, In: International Journal of Obesity. 46, 8, p. 1478-1486 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lysozyme 100%
  • Angiotensin 100%
  • Macrophage 14%
  • Heritability 14%
  • Insulin 14%
  8 Citations (Scopus)

• A genome-wide analysis of 340 318 participants identifies four novel loci associated with the age of first spectacle wear

  UK Biobank Eye & Vision Consortium, Patasova, K., Khawaja, A. P., Wojciechowski, R., Mahroo, O. A., Falchi, M., Rahi, J. S., Hammond, C. J. & Hysi, P. G., 25 Aug 2022, In: Human Molecular Genetics. 31, 17, p. 3012-3019 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Age 100%
  • Refractive Error 100%
  • Genetics 30%
  • Time 30%
  • Nested Gene 10%

• Association analyses of rare variants identify two genes associated with refractive error

  Patasova, K., Haarman, A. E. G., Musolf, A. M., Mahroo, O. A., Rahi, J. S., Falchi, M., Verhoeven, V. J. M., Bailey-Wilson, J. E., Klaver, C. C. W., Duggal, P., Klein, A., Guggenheim, J. A., Hammond, C. J. & Hysi, P. G., Sept 2022, In: PLoS ONE. 17, 9 September, e0272379.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nested Gene 100%
  • Association 100%
  • Gene 100%
  • Refractive Error 100%
  • Genome Wide Association Study 62%
  1 Citation (Scopus)

• Circulating inflammatory proteins associate with response to immune checkpoint inhibition therapy in patients with advanced melanoma

  Rossi, N., Lee, K. A., Bermudez, M. V., Visconti, A., Thomas, A. M., Bolte, L. A., Björk, J. R., de Ruijter, L. K., Newton-Bishop, J., Harland, M., Shaw, H. M., Harries, M., Sacco, J., Board, R., Lorigan, P., de Vries, E. G. E., Segata, N., Taams, L., Papa, S., Spector, T. D., & 6 othersNathan, P., Weersma, R. K., Hospers, G. A. P., Fehrmann, R. S. N., Bataille, V. & Falchi, M., Sept 2022, In: EBioMedicine. 83, p. 104235 104235.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein 100%
  • Association 100%
  • Immune Checkpoints 100%
  • Monocyte 36%
  • Interleukin 6 36%
  9 Citations (Scopus)

• Cutaneous Manifestations of SARS-CoV-2 infection during the Delta and Omicron waves in 348,691 UK users of the UK ZOE COVID Study App

  Visconti, A., Murray, B., Rossi, N., Wolf, J., Ourselin, S., Spector, T. D., Freeman, E. E., Bataille, V. & Falchi, M., Dec 2022, In: The British journal of dermatology. 187, 6, p. 900-908 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Symptom 100%
  • Infection 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Diagnostics 36%
  • COVID-19 27%
  11 Citations (Scopus)

• Metabolome Genome-Wide Association Study Identifies 74 Novel Genomic Regions Influencing Plasma Metabolites Levels

  Hysi, P. G., Mangino, M., Christofidou, P., Falchi, M., Karoly, E. D., NIHR Bioresource Investigators, NIHR. B. I., Mohney, R. P., Valdes, A. M., Spector, T. D. & Menni, C., Jan 2022, In: Metabolites. 12, 1, p. e61 61.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Metabolite 100%
  • Genome-Wide Association Study 100%
  • Metabolome 100%
  • Electric Potential 16%
  • Genetics 16%
  8 Citations (Scopus)

  81 Downloads (Pure)

• miRNAs as molecular biomarkers for prostate cancer

  Coradduzza, D., Solinas, T., Balzano, F., Culeddu, N., Rossi, N., Cruciani, S., Azara, E., Maioli, M., Zinellu, A., De Miglio, M. R., Madonia, M., Falchi, M. & Carru, C., 1 Nov 2022, In: JOURNAL OF MOLECULAR DIAGNOSTICS. 24, 11, p. 1171-1180 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Biological Marker 100%
  • Prostate Cancer 100%
  • microRNA 100%
  • MicroRNA 100%
  • Patient 57%
  4 Citations (Scopus)

  4 Downloads (Pure)

• PPI-induced changes in plasma metabolite levels influence total hip bone mineral density in a UK cohort

  Zhang, X., Adebayo, A., Wang, D., Raza, Y., Tomlinson, M., Dooley, H., Bowyer, R., Small, K., Steves, C., Spector, T., Duncan, E., Visconti, A. & Falchi, M., 26 Nov 2022, (Accepted/In press) In: Journal of Bone and Mineral Research.

  Research output: Contribution to journal › Article › peer-review

• Rare and common genetic determinants of metabolic individuality and their effects on human health

  Surendran, P., Stewart, I. D., Au Yeung, V. P. W., Pietzner, M., Raffler, J., Wörheide, M. A., Li, C., Smith, R. F., Wittemans, L. B. L., Bomba, L., Menni, C., Zierer, J., Rossi, N., Sheridan, P. A., Watkins, N. A., Mangino, M., Hysi, P. G., Di Angelantonio, E., Falchi, M., Spector, T. D., & 16 othersSoranzo, N., Michelotti, G. A., Arlt, W., Lotta, L. A., Denaxas, S., Hemingway, H., Gamazon, E. R., Howson, J. M. M., Wood, A. M., Danesh, J., Wareham, N. J., Kastenmüller, G., Fauman, E. B., Suhre, K., Butterworth, A. S. & Langenberg, C., Nov 2022, In: Nature Medicine. 28, 11, p. 2321-2332 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Genetics 100%
  • Metabolite 100%
  • Health 100%
  • Individuality 100%
  • Association 37%
  16 Citations (Scopus)

• Yoghurt consumption is associated with changes in the composition of the human gut microbiome and metabolome

  Le Roy, C. I., Kurilshikov, A., Leeming, E. R., Visconti, A., Bowyer, R. C. E., Menni, C., Falchi, M., Koutnikova, H., Veiga, P., Zhernakova, A., Derrien, M. & Spector, T. D., Dec 2022, In: BMC Microbiology. 22, 1, p. 39 1 p., 39.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Yogurt 100%
  • Food Product 18%
  • Diet 9%
  • Streptococcus 9%
  • Healthy Eating 9%
  28 Citations (Scopus)
• 2021

  Association Between Medication-Taking and Refractive Error in a Large General Population-Based Cohort

  Patasova, K., Khawaja, A. P., Tamraz, B., Williams, K. M., Mahroo, O. A., Freidin, M., Solebo, A. L., Vehof, J., Falchi, M., Rahi, J. S., Hammond, C. J. & Hysi, P. G., 1 Feb 2021, In: Investigative Ophthalmology & Visual Science. 62, 2, p. 15 1 p., 15.

  Research output: Contribution to journal › Article › peer-review

  • Drug Therapy 100%
  • Association 100%
  • Population 100%
  • Refractive Error 100%
  • Refraction Error 100%
  4 Citations (Scopus)

• Associations of Genetic Variants Contributing to Gut Microbiota Composition in Immunoglobin A Nephropathy

  He, J-W., Zhou, X-J., Li, Y-F., Wang, Y-N., Liu, L-J., Shi, S-F., Xin, X-H., Li, R-S., Falchi, M., Lv, J-C. & Zhang, H., 12 Jan 2021, In: mSystems. 6, 1, e00819.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• Current smoking and COVID-19 risk: results from a population symptom app in over 2.4 million people

  Hopkinson, N. S., Rossi, N., El-Sayed Moustafa, J., Laverty, A. A., Quint, J. K., Freidin, M., Visconti, A., Murray, B., Modat, M., Ourselin, S., Small, K., Davies, R., Wolf, J., Spector, T. D., Steves, C. J. & Falchi, M., 1 Jul 2021, In: Thorax. 76, 7, p. 714-722 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Symptom 100%
  • Smoking 100%
  • Diagnosis 8%
  • Diseases 8%
  • Electric Potential 8%
  90 Citations (Scopus)

• Diagnostic value of cutaneous manifestation of SARS-CoV-2 infection

  Visconti, A., Bataille, V., Rossi, N., Kluk, J., Murphy, R., Puig, S., Nambi, R., Bowyer, R. C. E., Murray, B., Bournot, A., Wolf, J., Ourselin, S., Steves, C. J., Spector, T. D. & Falchi, M., May 2021, In: The British journal of dermatology. 184, 5, p. 880-887 8 p.

  Research output: Contribution to journal › Article › peer-review

  File

  • Diagnostics 100%
  • Infection 100%
  • COVID-19 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Symptom 83%
  38 Citations (Scopus)

  62 Downloads (Pure)

• Ethnic-specific association of amylase gene copy number with adiposity traits in a large Middle Eastern biobank

  Rossi, N., Aliyev, E., Visconti, A., Akil, A. S. A., Syed, N., Aamer, W., Padmajeya, S. S., Falchi, M. & Fakhro, K. A., 9 Feb 2021, In: NPJ Genomic medicine. 6, 1, p. 8 8.

  Research output: Contribution to journal › Article › peer-review

  • Association 100%
  • Gene Dosage 100%
  • Amylase 100%
  • Fat 40%
  • Trunk 40%
  7 Citations (Scopus)

• Extensive weight loss reduces glycan age by altering IgG N-glycosylation

  Greto, V. L., Cvetko, A., Štambuk, T., Dempster, N. J., Kifer, D., Deriš, H., Cindrić, A., Vučković, F., Falchi, M., Gillies, R. S., Tomlinson, J. W., Gornik, O., Sgromo, B., Spector, T. D., Menni, C., Geremia, A., Arancibia-Cárcamo, C. V. & Lauc, G., Jul 2021, In: International Journal of Obesity. 45, 7, p. 1521-1531 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycosylation 100%
  • Age 100%
  • Weight 100%
  • Polysaccharides 100%
  • Aging 37%
  26 Citations (Scopus)

• Immune Trait Shifts in Association With Tobacco Smoking: A Study in Healthy Women

  Piaggeschi, G., Rolla, S., Rossi, N., Brusa, D., Naccarati, A., Couvreur, S., Spector, T. D., Roederer, M., Mangino, M., Cordero, F., Falchi, M. & Visconti, A., 9 Mar 2021, In: Frontiers in Immunology. 12, 637974.

  Research output: Contribution to journal › Article › peer-review

  • Smoking 100%
  • Association 100%
  • Immunity 100%
  • CD8 60%
  • T Cell 40%
  15 Citations (Scopus)

• O- and N-Glycosylation of Serum Immunoglobulin A is Associated with IgA Nephropathy and Glomerular Function

  Dotz, V., Visconti, A., Lomax-Browne, H., Florent, C., Hipgrave Ederveen, A., Medjeral-Thomas, N., Cook, H. T., Pickering, M., Wuhrer, M. & Falchi, M., Oct 2021, In: Journal of the American Society of Nephrology : JASN. 32, 10, p. 2455-2465 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glycosylation 100%
  • Immunoglobulin A 100%
  • Immunoglobulin Blood Level 100%
  • Polysaccharides 28%
  • Galactose 21%
  27 Citations (Scopus)

• Plasma N-glycome shows continuous deterioration as the diagnosis of insulin resistance approaches

  Cvetko, A., Mangino, M., Tijardović, M., Kifer, D., Falchi, M., Keser, T., Perola, M., Spector, T. D., Lauc, G., Menni, C. & Gornik, O., 13 Sept 2021, In: BMJ Open Diabetes Research and Care. 9, 1, e002263.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Diagnosis 100%
  • Deterioration 100%
  • Plasma 100%
  • Insulin Resistance 100%
  • Glycome 100%
  11 Citations (Scopus)

• Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4

  Australian Asthma Genetics Consortium (AAGC), 16 Nov 2021, In: Nature Communications. 12, 1, p. 6618 1 p., 6618.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DUSP1 100%
  • Nested Gene 33%
  • Cell Function 33%
  • Accuracy 33%
  • Heritability 33%
  12 Citations (Scopus)

• Self-Reported Symptoms of COVID-19, Including Symptoms Most Predictive of SARS-CoV-2 Infection, Are Heritable

  Williams, F. M. K., Freidin, M. B., Mangino, M., Couvreur, S., Visconti, A., Bowyer, R. C. E., Le Roy, C. I., Falchi, M., Mompeó, O., Sudre, C., Davies, R., Hammond, C., Menni, C., Steves, C. J. & Spector, T. D., 9 Feb 2021, (E-pub ahead of print) In: TWIN RESEARCH AND HUMAN GENETICS. 23, 6, p. 316-321 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Self Concept 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • COVID-19 100%
  • Symptom 100%
  • Infection 100%
  34 Citations (Scopus)

• Symptom clusters in COVID-19: A potential clinical prediction tool from the COVID Symptom Study app

  Sudre, C. H., Lee, K. A., Lochlainn, M. N., Varsavsky, T., Murray, B., Graham, M. S., Menni, C., Modat, M., Bowyer, R. C. E., Nguyen, L. H., Drew, D. A., Joshi, A. D., Ma, W., Guo, C-G., Lo, C-H., Ganesh, S., Buwe, A., Pujol, J. C., du Cadet, J. L., Visconti, A., & 13 othersFreidin, M. B., El-Sayed Moustafa, J. S., Falchi, M., Davies, R., Gomez, M. F., Fall, T., Cardoso, M. J., Wolf, J., Franks, P. W., Chan, A. T., Spector, T. D., Steves, C. J. & Ourselin, S., 19 Mar 2021, In: Science Advances. 7, 12, eabd4177.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Symptom 100%
  • COVID-19 100%
  • Electric Potential 100%
  • Time Series Analysis 25%
  • Time 25%
  78 Citations (Scopus)
• 2020

  A reference map of potential determinants for the human serum metabolome

  IMI DIRECT consortium, 3 Dec 2020, In: Nature. 588, 7836, p. 135-140 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Electric Potential 100%
  • Metabolite 100%
  • Metabolome 100%
  • Microbiome 30%
  • Lifestyle 20%
  180 Citations (Scopus)

  120 Downloads (Pure)

• Genetics plays a role in nevi distribution in women

  Visconti, A., Sanna, M., Bataille, V. & Falchi, M., 17 Mar 2020, In: Melanoma Management. 7, 1, p. MMT35

  Research output: Contribution to journal › Article
  2 Citations (Scopus)

• Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility

  AMFS Investigators, MelaNostrum Consortium, GenoMEL Consortium, Q-MEGA and QTWIN Investigators, ATHENS Melanoma Study Group, 23andMe, The SDH Study Group, IBD Investigators & Essen-Heidelberg Investigators, 1 May 2020, In: Nature Genetics. 52, 5, p. 494-504 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Phenotype 100%
  • Association 100%
  • Cutaneous Melanoma 100%
  • Introspection 100%
  • Genetic Architecture 100%
  103 Citations (Scopus)

• Looking for Sunshine: Genetic Predisposition to Sun-Seeking in 265,000 Individuals of European Ancestry

  Sanna, M., Li, X., Visconti, A., Freidin, M. B., Sacco, C., Ribero, S., Hysi, P., Bataille, V., Han, J. & Falchi, M., 10 Sept 2020, (E-pub ahead of print) In: Journal of Investigative Dermatology.

  Research output: Contribution to journal › Article › peer-review

  File
  4 Citations (Scopus)

  47 Downloads (Pure)

• Real-time tracking of self-reported symptoms to predict potential COVID-19

  Menni, C., Valdes, A. M., Freidin, M. B., Sudre, C. H., Nguyen, L. H., Drew, D. A., Ganesh, S., Varsavsky, T., Cardoso, M. J., El-Sayed Moustafa, J. S., Visconti, A., Hysi, P., Bowyer, R. C. E., Mangino, M., Falchi, M., Wolf, J., Ourselin, S., Chan, A. T., Steves, C. J. & Spector, T. D., 1 Jul 2020, In: Nature Medicine. 26, 7, p. 1037-1040 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Taste 100%
  • Smartphone 100%
  884 Citations (Scopus)

  43 Downloads (Pure)
• 2019

  Body site-specific genetic effects influence naevus count distribution in women

  Visconti, A., Ribero, S., Sanna, M., Spector, T. D., Bataille, V. & Falchi, M., 12 Aug 2019, (E-pub ahead of print) In: Pigment cell & melanoma research.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Woman 100%
  • Heredity 100%
  • Nevus Sebaceous 100%
  • Nodular Melanoma 44%
  • Lower Limb 33%
  15 Citations (Scopus)

  218 Downloads (Pure)

• Fine-Mapping of the Human Blood Plasma N-Glycome onto Its Proteome

  Suhre, K., Trbojević-Akmačić, I., Ugrina, I., Mook-Kanamori, D. O., Spector, T., Graumann, J., Lauc, G. & Falchi, M., 26 Jun 2019, In: Metabolites. 9, 7, 122.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Protein 100%
  • Proteome 100%
  • Blood Plasma 100%
  • Glycome 100%
  • Polysaccharides 50%
  7 Citations (Scopus)

  97 Downloads (Pure)

• Interplay between the human gut microbiome and host metabolism

  Visconti, A., Le Roy, C. I., Rosa, F., Martin, T. C., Mohney, R. P., Weizhong, L., de Rinaldis, E., Bell, J. T., Venter, J. C., Nelson, K. E., Spector, T. D. & Falchi, M., 3 Oct 2019, In: Nature Communications. 10, 1, 1 p., 4505.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Host 100%
  • Metabolite 100%
  • Metabolism 100%
  • Gut Microbiome 100%
  • Electric Potential 66%
  355 Citations (Scopus)

  126 Downloads (Pure)

• Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes

  Khamis, A., Canouil, M., Siddiq, A., Crouch, H., Falchi, M., Bulow, M. V., Ehehalt, F., Marselli, L., Distler, M., Richter, D., Weitz, J., Bokvist, K., Xenarios, I., Thorens, B., Schulte, A. M., Ibberson, M., Bonnefond, A., Marchetti, P., Solimena, M. & Froguel, P., Jun 2019, In: Molecular Metabolism. 24, p. 98-107 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Expression Quantitative Trait Loci 100%
  • Laser Capture Microdissection 100%
  • Nested Gene 55%
  • Sample 33%
  • Genetics 22%
  20 Citations (Scopus)

• TwinsUK: The UK Adult Twin Registry Update

  Verdi, S., Abbasian, G., Bowyer, R. C. E., Lachance, G., Yarand, D., Christofidou, P., Mangino, M., Menni, C., Bell, J. T., Falchi, M., Small, K. S., Williams, F. M. K., Hammond, C. J., Hart, D. J., Spector, T. D. & Steves, C. J., 17 Sept 2019, (E-pub ahead of print) In: TWIN RESEARCH AND HUMAN GENETICS. p. 1-7 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Adult 100%
  • Next Generation Sequencing 100%
  • Volunteer 66%
  • Biological Product 33%
  • Disease 33%
  79 Citations (Scopus)
• 2018

  Conducting metagenomic studies in microbiology and clinical research

  Martin, T. C., Visconti, A., Spector, T. D. & Falchi, M., 2018, In: APPLIED MICROBIOLOGY AND BIOTECHNOLOGY.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Clinical Research 100%
  • Metagenomics 100%
  • Microbiome 16%
  • Health 16%
  • Analytical Method 16%
  21 Citations (Scopus)

  102 Downloads (Pure)

• Deep molecular phenotypes link complex disorders and physiological insult to CpG methylation

  Zaghlool, S. B., Mook-Kanamori, D. O., Kader, S., Stephan, N., Halama, A., Engelke, R., Sarwath, H., Al-Dous, E. K., Mohamoud, Y. A., Roemisch-Margl, W., Adamski, J., Kastenmüller, G., Friedrich, N., Visconti, A., Tsai, P-C., Spector, T., Bell, J., Falchi, M., Wahl, A., Waldenberger, M., & 7 othersPeters, A., Gieger, C., Pezer, M., Lauc, G., Graumann, J., Malek, J. A. & Suhre, K., 8 Jan 2018, (E-pub ahead of print) In: Human Molecular Genetics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Phenotype 100%
  • Methylation 100%
  • CpG Site 100%
  • Metabolite 80%
  • Association 80%
  27 Citations (Scopus)

• Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure

  Visconti, A., Duffy, D., Liu, F., Zhu, G., Wu, W., Chen, Y., Hysi, P., Zeng, C., Sanna, M., Iles, M. M., Kanetsky, P. A., Demenais, F., Hamer, M. A., Uitterlinden, A. G., Ikram, M. A., Nijsten, T. E. C., Martin, N. G., Kayser, M., Spector, T. D., Han, J., & 2 othersBataille, V. & Falchi, M., 8 May 2018, In: Nature Communications. 1684.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genome Wide Association Study 100%
  • Sun Exposure 100%
  • Gene Locus 100%
  • Skin 100%
  • Genome-Wide Association Study 100%
  68 Citations (Scopus)

  157 Downloads (Pure)

• Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

  Duffy, D. L., Zhu, G., Li, X., Sanna, M., Iles, M. M., Jacobs, L. C., Evans, D. M., Yazar, S., Beesley, J., Law, M. H., Kraft, P., Visconti, A., Taylor, J. C., Lui, F., Henders, A. K., Bowdler, L., Glass, D., Ikram, A. M., Uitterlinden, A. G., Wright, M. J., & 25 othersMadden, P. A., Heath, A. C., Nelson, E. C., Green, A. C., Chanock, S., Barrett, J. H., Brown, M. A., Hayward, N. K., MacGregor, S., Sturm, R. A., Hewitt, A. W., Melanoma GWAS Consortium, Kayser, M., Hunter, D. J., Newton Bishop, J. A., Spector, T. D., Montgomery, G. W., Mackey, D. A., Smith, G. D., Nijsten, T. E., Bishop, D. T., Bataille, V., Falchi, M., Han, J. & Martin, N. G., 14 Nov 2018, In: Nature Communications. 9, 1, p. 4774

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Biological Product 100%
  • Nodular Melanoma 100%
  • Density 100%
  • Nevus Sebaceous 66%
  • Genome Wide Association Study 66%
  65 Citations (Scopus)

  89 Downloads (Pure)

• Omics studies for comprehensive understanding of immunoglobulin A nephropathy: state-of-the-art and future directions

  Schena, F. P., Serino, G., Sallustio, F., Falchi, M. & Cox, S. N., 13 Jun 2018, (E-pub ahead of print) In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

  Research output: Contribution to journal › Article › peer-review

  File

  • Immunoglobulin A Nephropathy 100%
  • Tamsulosin 100%
  • Comprehension 100%
  • Immunoglobulin A 100%
  • Disease 80%
  11 Citations (Scopus)

  133 Downloads (Pure)

• YAMP: a containerised workflow enabling reproducibility in metagenomics research

  Visconti, A., Martin, T. C. & Falchi, M., Jul 2018, In: Gigascience.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Research 100%
  • Workflow 100%
  • Reproducibility 100%
  • Metagenomics 100%
  • Job 50%
  16 Citations (Scopus)

  105 Downloads (Pure)
• 2017

  A statistical test for detecting parent-of-origin effects when parental information is missing

  Sacco, C., Viroli, C. & Falchi, M., 26 Sept 2017, In: Statistical applications in genetics and molecular biology. 16, 4, p. 275-289 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Statistical Test 100%
  • Epigenetic Mechanism 100%
  • Allele 66%
  • Nested Gene 33%
  • Gene Expression 33%
  205 Downloads (Pure)

• Circulating complement factor H-related proteins 1 and 5 correlate with disease activity in IgA nephropathy

  Medjeral-Thomas, N. R., Lomax-Browne, H. J., Beckwith, H., Willicombe, M., McLean, A. G., Brookes, P., Pusey, C. D., Falchi, M., Cook, H. T. & Pickering, M. C., 30 Jun 2017, (E-pub ahead of print) In: Kidney International.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Protein 100%
  • Disease Activity 100%
  • Immunoglobulin A Nephropathy 100%
  • Complement Factor H 100%
  • Factor H 100%
  84 Citations (Scopus)

  147 Downloads (Pure)

• Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice

  Carrat, G. R., Hu, M., Nguyen-Tu, M-S., Chabosseau, P., Gaulton, K. J., van de Bunt, M., Siddiq, A., Falchi, M., Thurner, M., Canouil, M., Pattou, F., Leclerc, I., Pullen, T. J., Cane, M. C., Prabhala, P., Greenwald, W., Schulte, A., Marchetti, P., Ibberson, M., MacDonald, P. E., & 6 othersManning Fox, J. E., Gloyn, A. L., Froguel, P., Solimena, M., McCarthy, M. I. & Rutter, G. A., 2 Feb 2017, In: American Journal of Human Genetics. 100, 2, p. 238-256 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mouse 100%
  • Insulin Release 100%
  • Proinsulin 100%
  • Glucose 75%
  • Allele 50%
  44 Citations (Scopus)

  310 Downloads (Pure)

• Genomic expression differences between cutaneous cells from red hair color individuals and black hair color individuals based on bioinformatic analysis

  Puig-Butille, J. A., Gimenez-Xavier, P., Visconti, A., Nsengimana, J., Garcia-García, F., Tell-Marti, G., Escamez, M. J., Newton-Bishop, J., Bataille, V., Río, M. D., Dopazo, J., Falchi, M. & Puig, S., 2017, In: Oncotarget. 8, 7, p. 11589-11599 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Analysis 100%
  • Cells 100%
  • Hair Color 100%
  • Bioinformatics 100%
  • Gene 66%
  5 Citations (Scopus)

  188 Downloads (Pure)