Research output per year
Research output per year
Personal profile
Research interests (short)
Mark McPhail is a Senior Lecturer and Consultant in Liver Critical Care and Hepatology in the Institute of Liver Studies, King's College London and Department of Hepatology at Imperial College. His main research interests are in outcome prediction, metabolism and immunity in liver failure syndromes. He is also working on novel methods to diagnose and monitor hepatic encephalopathy and sepsis.
He also holds a PhD in Molecular Physics from the University of Strathclyde. During his doctorate he collaborated with the NASA Jet Propulsion Laboratory, Pasadena and the University of Bologna on modelling rotation and vibration of atmospheric molecules involved in ozone depletion and global warming.
While retraining in medicine following his PhD he maintained an interest in teaching physics as an Associate Lecturer with the Open University. He continues to develop an interest in statistics and has published widely using multivariate methods.
His present focus is on using metabolic profiling to improve prognostication and find novel pathways for metabolic modulation of innate immune responses through the action of lipids on CD14+ monocytes in patients with acute and acute-on-chronic liver failure.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, Bachelor of Medicine and Bachelor of Surgery, Medicine & Surgery, University of Glasgow
Award Date: 7 Jun 2004
Molecular Quantum Physics, Doctor of Philosophy, Rovibrational interactions in atmospheric molecules, University of Strathclyde
Award Date: 3 Nov 1997
Physics, Bachelor of Science, Physics, University of Strathclyde
Award Date: 4 Jul 1994
External positions
Honorary Senior Lecturer, Imperial College London
1 Apr 1800 → …
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Collaborations and top research areas from the last five years
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Autotaxin upregulation in liver failure and the effect on monocyte phenotype and function is a pan-aetiology phenomenon
Trovato, F. M. & McPhail, M., Jan 2024, In: Journal of Hepatology. 80, 1, p. e16-e18Research output: Contribution to journal › Article › peer-review
Open Access -
Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of oesophageal varices: study protocol for a randomised controlled trial
BOPPP study group, Patel, V., McPhail, M., Uddin, R., Jafari, H., Lawrence, V., Le Boutillier, C., Shearer, J., Yaziji, N., Cape, A., Ahmed, H., Ward, C., Walsh, P., Besly, K., Zamalloa, A., Kelly, J. & Carter, B., 16 Apr 2024, In: Trials. 25, 1, 265.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Immunopathogenesis of acute on chronic liver failure
Artru, F. & McPhail, M. J., May 2024, In: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 24, 5, p. 724-732 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Liver Elastography in Acute Liver Failure: A Pilot Study
Trovato, F. M., Artru, F., Miquel, R., Pirani, T. & McPhail, M. J. W., 8 Feb 2024, In: Critical Care Explorations. 6, 2, p. e1048Research output: Contribution to journal › Article › peer-review
Open Access -
Liver transplantation for acute-on-chronic liver failure
Artru, F., Trovato, F., Morrison, M., Bernal, W. & McPhail, M., Jun 2024, In: The Lancet Gastroenterology and Hepatology. 9, 6, p. 564-576 13 p.Research output: Contribution to journal › Review article › peer-review
7 Citations (Scopus)
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POPIMP: Checkpoint Inhibitors to Restore Monocyte/Macrophage Function in Liver Failure
1/04/2022 → 31/05/2025
Project: Research
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MICROB-PREDICT: MICROBiome-based biomarkers to PREDICT decompensation of liver cirrhosis and treatment response
Shawcross, D., Moyes, D., McPhail, M. & Shoaie, S.
1/01/2019 → 31/03/2025
Project: Research