Mark Pfuhl

Mark Pfuhl


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Personal profile

Research interests

The group is interested in the study of protein structure, dynamics and interactions in solution by NMR spectroscopy and other biophysical techniques supported by bioinformatics. The main areas of interest are muscle proteins involved in the regulation of muscle contraction in the sarcomere (MyBP-C, Calponin) as well as proteins regulation protein expression as a response to work load on muscle (MS1/ABRA); the regulation of kinase activity by regulatory domains in kinases (Nek2) as well as associated scaffolding proteins (Pi3K/Cin85, AuroraA/MSPS/TACC3); the relationship of sequence to structure in multidomain proteins where we have been recenrly identifying a number of new domains (MS1/ABRA, PC1) and have identified the precise nature of domain boundaries for others (Cin85). We are also investigating the use of solid state NMR spectroscopy for the study of filamentous protein assemblies that are vital for the function of muscle.

Research interests (short)

Structure, dynamics and interactions of signalling, scaffolding and muscle proteins using NMR spectroscopy and other biophysical methods

Click here for the Pfuhl group webpage

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being


  • QP Physiology
  • NMR spectroscopy
  • Protein structure
  • Protein-Protein interactions
  • Biophysics
  • Protein dynamics
  • Cardiac muscle
  • Muscle regulation


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Collaborations and top research areas from the last five years

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