Mathias Gautel

Mathias Gautel


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Personal profile

Research interests

Our research is centred on the mechanisms that organise the smallest contractile unit of striated muscle, the sarcomere, and how sarcomeres cross-talk to signalling mechanisms controlling muscle growth and protein turnover. Many diseases of the heart and skeletal muscles, including the genetic diseases like familial hypertrophic cardiomyopathy result in disruptions of myofibril assembly and turnover. In most cases, the mechanisms that translate individual gene defects into a specific disease pattern are unclear. Identifying the basic biological functions of muscle disease genes is therefore a first step towards understanding, and eventually combating disease.

Research interests (short)

Molecular mechanisms of muscle disease, signal transduction in cardiac muscle sarcomeres.

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Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being


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Collaborations and top research areas from the last five years

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