Research output per year
Research output per year
Personal profile
Research interests (short)
Current work utilises CRISPR/CAS9 generated knock-in models of TDP-43 to understand the pathological mechanisms underlying ALS/FTD, with a view to identifying therapeutic targets.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Developmental Neuroscience, Doctor of Philosophy, The role of APRIL in the development of the peripheral nervous system, Cardiff University
1 Oct 2009 → 30 Sept 2013
Award Date: 1 Apr 2013
Biomedical Science, Bachelor of Science, Biomedical Science Degree, Cardiff University
1 Oct 2006 → 31 Jul 2009
Award Date: 30 Jul 2009
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Collaborations and top research areas from the last five years
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Research output
- 11 Article
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MRI-guided histology of TDP-43 knock-in mice implicates parvalbumin interneuron loss, impaired neurogenesis and aberrant neurodevelopment in amyotrophic lateral sclerosis-frontotemporal dementia
Lin, Z., Kim, E., Ahmed, M., Han, G., Simmons, C., Redhead, Y., Bartlett, J., Pena Altamira, E., Callaghan, I., White, M., Singh, N., Sawiak, S., Spires-Jones, T., Vernon, A., Coleman, M. P., Green, J., Henstridge, C. M., Davies, J., Cash, D. & Sreedharan, J., 5 Apr 2021, In: Brain Communications. 3, 2, p. FCAB114 20 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus) -
Protection against oxaliplatin-induced mechanical and thermal hypersensitivity in Sarm1−/− mice
Gould, S. A., White, M., Wilbrey, A. L., Pór, E., Coleman, M. P. & Adalbert, R., Apr 2021, In: Experimental Neurology. 338, 113607.Research output: Contribution to journal › Article › peer-review
Open Access21 Citations (Scopus) -
Coexistence of perseveration and apathy in the TDP-43Q331K knock-in mouse model of ALS–FTD
Kim, E., White, M. A., Phillips, B. U., Lopez-Cruz, L., Kim, H., Heath, C. J., Lee, J. E., Saksida, L. M., Sreedharan, J. & Bussey, T. J., 1 Dec 2020, In: Translational psychiatry. 10, 1, 377.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (Scopus) -
Distinct effects on mRNA export factor GANP underlie neurological disease phenotypes and alter gene expression depending on intron content
Woldegebriel, R., Kvist, J., Andersson, N., Õunap, K., Reinson, K., Wojcik, M. H., Bijlsma, E. K., Hoffer, M. J. V., Ryan, M. M., Stark, Z., Walsh, M., Cuppen, I., van den Boogaard, M-J. H., Bharucha-Goebel, D., Donkervoort, S., Winchester, S., Zori, R., Bönnemann, C. G., Maroofian, R., O'Connor, E., & 8 others, 3 Jun 2020, In: Human Molecular Genetics. 29, 9, p. 1426-1439 14 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
Shortened TDP43 isoforms upregulated by neuronal hyperactivity drive TDP43 pathology in ALS
Weskamp, K., Tank, E. M., Miguez, R., McBride, J. P., Gómez, N. B., White, M., Lin, Z., Moreno Gonzalez, C., Serio, A., Sreedharan, J. & Barmada, S. J., 2 Mar 2020, In: Journal of Clinical Investigation. 130, 3, p. 1139-1155 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile69 Citations (Scopus)263 Downloads (Pure)
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Developing a genetic screen to identify modifiers of TDP-43 misregulation in FTD
1/05/2024 → 31/10/2024
Project: Research
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ARUK-RF2020A: Targeting TDP-43-mediated neurodegeneration for therapeutic benefit in frontotemporal dementia
White, M., Shaw, C. & Sreedharan, J.
1/05/2021 → 30/12/2024
Project: Research
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Alzheimer’s Research UK London Network Centre Grant Sub-project: Dr Matthew White
1/01/2022 → 30/06/2024
Project: Research
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Alzheimer’s Research UK London Network Centre Grant sub-project: Frank Hirth
1/01/2022 → 30/06/2024
Project: Research
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Targeting TDP-43 autoregulation for therapeutic benefit in ALS-FTD
Takeda Pharmaceutical Company Limited
1/10/2021 → 31/12/2022
Project: Research
Prizes
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Sir Michael Berridge Prize
White, Matthew (Recipient), 29 Jun 2018
Prize: Prize (including medals and awards)