Research output per year
Research output per year
- 1 - 50 out of 104 results
Search results
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2022
CureHeart wins Big Beat Challenge, a £30 million research award from the British Heart Foundation
Avkiran, M., 24 Sept 2022, (E-pub ahead of print) In: European Heart Journal. p. ehac510Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
2021
Phosphorylation at Serines 157 and 161 Is Necessary for Preserving Cardiac Expression Level and Functions of Sarcomeric Z-Disc Protein Telethonin
Lewis, H. R., Eminaga, S., Gautel, M. & Avkiran, M., 8 Sept 2021, In: Frontiers in Physiology. 12, 732020.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Quantitative analysis of the cardiac phosphoproteome in response to acute β‐adrenergic receptor stimulation in vivo
Güran, A., Ji, Y., Fang, P., Pan, K. T., Urlaub, H., Avkiran, M. & Lenz, C., 1 Nov 2021, In: International Journal of Molecular Sciences. 22, 22, 12584.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
2020
Cyclic AMP represses pathological MEF2 activation by myocyte-specific hypo-phosphorylation of HDAC5
He, T., Huang, J., Chen, L., Han, G., Stanmore, D., Krebs-Haupenthal, J., Avkiran, M., Hagenmüller, M. & Backs, J., Aug 2020, In: Journal of Molecular and Cellular Cardiology. 145, p. 88-98 11 p.Research output: Contribution to journal › Article › peer-review
21 Citations (Scopus) -
2019
Getting your research funded (and other tips for early career cardiovascular investigators)
Avkiran, M., 1 Sept 2019, In: Cardiovascular Research. 115, 11, p. e111-e112Research output: Contribution to journal › Comment/debate › peer-review
1 Citation (Scopus) -
Role of type 2A phosphatase regulatory subunit B56α in regulating cardiac responses to β-adrenergic stimulation in vivo
Puhl, S. L., Weeks, K., Guran, A., Ranieri, A., Boknik, P., Kirchhefer, U., Müller, F. U. & Avkiran, M., 2019, In: Cardiovascular Research. 115, 3, p. 519-529 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)183 Downloads (Pure) -
What Would You Do With a £30 Million Research Grant?
Avkiran, M. & Samani, N. J., 1 Jan 2019, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 39, 1, p. e26-e28Research output: Contribution to journal › Comment/debate › peer-review
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2018
Inflammation leads through PGE/EP signaling to HDAC5/MEF2-dependent transcription in cardiac myocytes
Tóth, A. D., Schell, R., Lévay, M., Vettel, C., Theis, P., Haslinger, C., Alban, F., Werhahn, S., Frischbier, L., Krebs-Haupenthal, J., Thomas, D., Gröne, H.-J., Avkiran, M., Katus, H. A., Wieland, T. & Backs, J., 15 Jun 2018, (E-pub ahead of print) In: EMBO Molecular Medicine.Research output: Contribution to journal › Article › peer-review
Open Access19 Citations (Scopus) -
Monophosphorylation of cardiac troponin-I at Ser23/24 is sufficient to regulate cardiac myofibrillar Ca2+ sensitivity and calpain-induced proteolysis
Martin-garrido, A., Biesiadecki, B. J., Salhi, H. E., Shaifta, Y., Dos Remedios, C. G., Ayaz-guner, S., Cai, W., Ge, Y., Avkiran, M. & Kentish, J. C., 1 Jun 2018, In: Journal of Biological Chemistry. 293, 22, p. 8588-8599Research output: Contribution to journal › Article › peer-review
Open AccessFile30 Citations (Scopus)235 Downloads (Pure) -
β-Adrenergic regulation of cardiac type 2A protein phosphatase through phosphorylation of regulatory subunit B56δ at S573
Ranieri, A., Kemp, E., Burgoyne, J. R. & Avkiran, M., Feb 2018, In: Journal of Molecular and Cellular Cardiology. 115, p. 20-31Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)212 Downloads (Pure) -
2017
Heterologous Expression of Fluorescent Fusion Proteins for Subcellular Localisation Studies: Insights from 3D Confocal Microscopy of GFP-Tagged HDAC5 in Adult Rat Ventricular Myocytes
Weeks, K. & Avkiran, M., 2 Aug 2017, (E-pub ahead of print) In: Heart, Lung & Circulation. 26 , Supplement 2, p. S106 1 p.Research output: Contribution to journal › Article › peer-review
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βAdrenergic stimulation induces histone deacetylase 5 (HDAC5) nuclear accumulation in cardiomyocytes by B55α-PP2A-mediated dephosphorylation
Weeks, K. L., Ranieri, A., Karaś, A., Bernardo, B. C., ASHCROFT, A., Molenaar, C., McMullen, J. R. & Avkiran, M., 5 Apr 2017, In: Journal of the American Heart Association. 6, 4, p. 1-14 e004861.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Citations (Scopus)201 Downloads (Pure) -
2016
Assessing structural and functional responses of murine hearts to acute and sustained β-adrenergic stimulation in vivo
Puhl, S.-L., Weeks, K. L., Ranieri, A. & Avkiran, M., May 2016, In: Journal of pharmacological and toxicological methods. 79, p. 60-71Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)199 Downloads (Pure) -
2015
Roles and post-translational regulation of cardiac class IIa histone deacetylase isoforms
Weeks, K. L. & Avkiran, M., 15 Apr 2015, In: The Journal of physiology. 593, 8, p. 1785-97 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Citations (Scopus)179 Downloads (Pure) -
2014
Exchanging cardiac phenotype: Is AKT-mediated NHE1 inhibition a permissive switch in physiological hypertrophy?
Weeks, K. & Avkiran, M., Dec 2014, In: Journal of Molecular and Cellular Cardiology. 77, p. 175-177 3 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Four-and-a-half LIM domains proteins are novel regulators of the protein kinase D pathway in cardiac myocytes
Stathopoulou, K., Cuello, F., Candasamy, A. J., Kemp, E. M., Ehler, E., Haworth, R. S. & Avkiran, M., 1 Feb 2014, In: Biochemical Journal. 457, 3, p. 451-461 11 p., N/A.Research output: Contribution to journal › Article › peer-review
Open Access16 Citations (Scopus) -
Phosphoregulation of the Titin-cap Protein Telethonin in Cardiac Myocytes
Candasamy, A. J., Haworth, R. S., Cuello, F., Ibrahim, M., Aravamudhan, S., Krueger, M., Holt, M. R., Terracciano, C. M. N., Mayr, M., Gautel, M. & Avkiran, M., 17 Jan 2014, In: Journal of Biological Chemistry. 289, 3, p. 1282-1293 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile36 Citations (Scopus)171 Downloads (Pure) -
Regulation of PP2A(C) Carboxylmethylation and Cellular Localisation by Inhibitory Class G-Protein Coupled Receptors in Cardiomyocytes
Longman, M. R., Ranieri, A., Avkiran, M. & Snabaitis, A. K., 27 Jan 2014, In: PL o S One . 9, 1, 10 p., e86234.Research output: Contribution to journal › Article › peer-review
Open Access11 Citations (Scopus) -
2013
The salt of the earth: Focus on Na+ regulation in the cardiac myocyte
Avkiran, M., Despa, S. & Shattock, M. J., Aug 2013, In: Journal of Molecular and Cellular Cardiology. 61, N/A, p. 1-1 1 p., N/A.Research output: Contribution to journal › Editorial › peer-review
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2012
cMyBP-C as a promiscuous substrate: phosphorylation by non-PKA kinases and its potential significance
Bardswell, S. C., Cuello, F., Kentish, J. C. & Avkiran, M., May 2012, In: Journal of Muscle Research and Cell Motility. 33, 1, p. 53-60 8 p.Research output: Contribution to journal › Literature review › peer-review
35 Citations (Scopus) -
Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice
Fraysse, B., Weinberger, F., Bardswell, S. C., Cuello, F., Vignier, N., Geertz, B., Starbatty, J., Kraemer, E., Coirault, C., Eschenhagen, T., Kentish, J. C., Avkiran, M. & Carrier, L., Jun 2012, In: Journal of Molecular and Cellular Cardiology. 52, 6, p. 1299-1307 9 p.Research output: Contribution to journal › Article › peer-review
112 Citations (Scopus) -
Neurohormonal regulation of cardiac histone deacetylase 5 nuclear localization by phosphorylation-dependent and phosphorylation-independent mechanisms
Haworth, R. S., Stathopoulou, K., Candasamy, A. J. & Avkiran, M., 8 Jun 2012, In: Circulation Research. 110, 12, p. 1585-1595 11 p.Research output: Contribution to journal › Article › peer-review
40 Citations (Scopus) -
Novel regulation of cardiac protein kinase D1 activation and histone deacetylase phosphorylation by four-and-a-half LIM-only (FHL) proteins
Stathopoulou, K., Cuello, F., Ehler, E., Haworth, R. S. & Avkiran, M., 2012, In: Cardiovascular Research. 93, p. S59 - S60Research output: Contribution to journal › Meeting abstract
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Phosphoregulation of the titin-cap protein telethonin in cardiac myocytes
Candasamy, A. J., Haworth, R. S., Boguslavsky, A., Cuello, F., Shattock, M. J., Mayr, M., Gautel, M. & Avkiran, M., 2012, In: Cardiovascular Research. 93, S1, p. S17 - S17Research output: Contribution to journal › Meeting abstract
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2011
A Critical Function for Ser-282 in Cardiac Myosin Binding Protein-C Phosphorylation and Cardiac Function
Sadayappan, S., Gulick, J., Osinska, H., Barefield, D., Cuello, F., Avkiran, M., Lasko, V. M., Lorenz, J. N., Maillet, M., Martin, J., Brown, J. H., Bers, D. M., Molkentin, J. D., James, J. & Robbins, J., 8 Jul 2011, In: Circulation Research. 109, 2, p. 141 - 150 10 p.Research output: Contribution to journal › Article › peer-review
111 Citations (Scopus) -
Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology
Eschenhagen, T., Force, T., Ewer, M. S., de Keulenaer, G. W., Suter, T. M., Anker, S. D., Avkiran, M., de Azambuja, E., Balligand, J.-L., Brutsaert, D. L., Condorelli, G., Hansen, A., Heymans, S., Hill, J. A., Hirsch, E., Hilfiker-Kleiner, D., Janssens, S., de Jong, S., Neubauer, G. & Pieske, B. & 8 others, , Jan 2011, In: EUROPEAN JOURNAL OF HEART FAILURE. 13, 1, p. 1 - 10 10 p.Research output: Contribution to journal › Article › peer-review
366 Citations (Scopus) -
Novel Role for p90 Ribosomal S6 Kinase in the Regulation of Cardiac Myofilament Phosphorylation
Cuello, F., Bardswell, S. C., Haworth, R. S., Ehler, E., Sadayappan, S., Kentish, J. C. & Avkiran, M., 18 Feb 2011, In: Journal of Biological Chemistry. 286, 7, p. 5300 - 5310 11 p.Research output: Contribution to journal › Article › peer-review
42 Citations (Scopus) -
Regulation by phosphodiesterase isoforms of protein kinase A-mediated attenuation of myocardial protein kinase D activation
Haworth, R. S., Cuello, F. & Avkiran, M., Jan 2011, In: Basic Research in Cardiology. 106, 1, p. 51 - 63 13 p.Research output: Contribution to journal › Article › peer-review
26 Citations (Scopus) -
2010
A Chemical Genetic Approach Reveals That p38 alpha MAPK Activation by Diphosphorylation Aggravates Myocardial Infarction and Is Prevented by the Direct Binding of SB203580
Kumphune, S., Bassi, R., Jacquet, S., Sicard, P., Clark, J. E., Verma, S., Avkiran, M., O'Keefe, S. J. & Marber, M. S., 2010, In: Journal of Biological Chemistry. 285, 5, p. 2968-2975 8 p.Research output: Contribution to journal › Article › peer-review
40 Citations (Scopus) -
Ca2+/calmodulin-dependent protein kinase II contributes to intracellular pH recovery from acidosis via Na+/H+ exchanger activation
Vila-Petroff, M., Mundina-Weilenmann, C., Lezcano, N., Snabaitis, A. K., Huergo, M. A., Valverde, C. A., Avkiran, M. & Mattiazzi, A., Jul 2010, In: Journal of Molecular and Cellular Cardiology. 49, 1, p. 106 - 112 7 p.Research output: Contribution to journal › Article › peer-review
49 Citations (Scopus) -
Distinct Sarcomeric Substrates Are Responsible for Protein Kinase D-mediated Regulation of Cardiac Myofilament Ca2+ Sensitivity and Cross-bridge Cycling
Bardswell, S. C., Cuello, F., Rowland, A. J., Sadayappan, S., Robbins, J., Gautel, M., Walker, J. W., Kentish, J. C. & Avkiran, M., 19 Feb 2010, In: Journal of Biological Chemistry. 285, 8, p. 5674 - 5682 9 p.Research output: Contribution to journal › Article › peer-review
94 Citations (Scopus) -
Feeling the stress: MAPKKK-MAPKK-MAPK signaling cascades in heart failure
Avkiran, M. & Marber, M. S., Feb 2010, In: Journal of Molecular and Cellular Cardiology. 48, 2, p. 283 - 285 3 p.Research output: Contribution to journal › Editorial › peer-review
3 Citations (Scopus) -
Legumain and cathepsin-L expression in human unstable carotid plaque.
Mattock, K., Gough, P., Humphries, J., Burnand, K., Patel, L., Suckling, K., Cuello, F., Watts, C., Gautel, M., Avkiran, M. & Smith, A., Jan 2010, In: Atherosclerosis. 208, 1, p. 83 - 89 7 p.Research output: Contribution to journal › Article › peer-review
49 Citations (Scopus) -
Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy
Hoskins, A. C., Jacques, A., Bardswell, S. C., McKenna, W. J., Tsang, V., dos Remedios, C. G., Ehler, E., Adams, K., Jalilzadeh, S., Avkiran, M., Watkins, H., Redwood, C., Marston, S. B. & Kentish, J. C., Nov 2010, In: Journal of Molecular and Cellular Cardiology. 49, 5, p. 737 - 745 9 p.Research output: Contribution to journal › Article › peer-review
61 Citations (Scopus) -
Proteomics Analysis of the Cardiac Myofilament Subproteome Reveals Dynamic Alterations in Phosphatase Subunit Distribution
Yin, X., Cuello, F., Mayr, U., Hao, Z., Hornshaw, M., Ehler, E., Avkiran, M. & Mayr, M., Mar 2010, In: MOLECULAR AND CELLULAR PROTEOMICS. 9, 3, p. 497 - 509 13 p.Research output: Contribution to journal › Article › peer-review
73 Citations (Scopus) -
Urotensin II Activates Sarcolemmal Na+/H+ Exchanger in Adult Rat Ventricular Myocytes
Kato, K., Yasutake, M., Jia, D., Snabaitis, A. K., Avkiran, M., Kusama, Y., Takano, T. & Mizuno, K., Feb 2010, In: Journal of Cardiovascular Pharmacology. 55, 2, p. 191 - 197 7 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
2009
Hierarchical and Critical Functions of Ser282 Phosphorylation in Cardiac Myosin Binding Protein-C Phosphorylation and Cardiac Function
Sadayappan, S., Gulick, J., Martin, L. A., Cuello, F., Avkiran, M., Lorenz, J. N. & Robbins, J., 2009, In: Circulation (Baltimore). 120, 18, p. S870 - S870Research output: Contribution to journal › Meeting abstract
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Paradoxical resistance to myocardial ischemia and age-related cardiomyopathy in NHE1 transgenic mice: A role for ER stress?
Cool, A. R., Bardswell, S. C., Pretheshan, S., Dighe, K., Kanaganayagam, G. S., Jabr, R. I., Merkle, S., Marber, M. S., Engelhardt, S. & Avkiran, M., Feb 2009, In: Journal of Molecular and Cellular Cardiology. 46, 2, p. 225 - 233 9 p.Research output: Contribution to journal › Article › peer-review
33 Citations (Scopus) -
2008
Blowing off acid: a new tool to study Na+/HCO3- co-transport
Avkiran, M., Mar 2008, In: British Journal of Pharmacology. 153, 5, p. 844 - 845 2 p.Research output: Contribution to journal › Editorial › peer-review
1 Citation (Scopus) -
Ca2+/Calmodulin-Dependent protein kinase II delta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure
Bossuyt, J., Helmstadter, K., Wu, X., Clements-Jewery, H., Haworth, R. S., Avkiran, M., Martin, J. L., Pogwizd, S. M. & Bers, D. M., Mar 2008, In: Circulation Research. 102, 6, p. 695 - 702 8 p.Research output: Contribution to journal › Article › peer-review
123 Citations (Scopus) -
Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse
Nishino, Y., Webb, I. G., Davidson, S. M., Ahmed, A. I., Clark, J. E., Jacquet, S., Shah, A. M., Miura, T., Yellon, D. M., Avkiran, M. & Marber, M. S., 1 Aug 2008, In: Circulation Research. 103, 3, p. 307 - 314 8 p.Research output: Contribution to journal › Article › peer-review
113 Citations (Scopus) -
Protein kinase B/Akt phosphorylates and inhibits the cardiac Na+/H+ exchanger NHE1
Snabaitis, A. K., Cuello, F. & Avkiran, M., 10 Oct 2008, In: Circulation Research. 103, 8, p. 881 - 890 10 p.Research output: Contribution to journal › Article › peer-review
104 Citations (Scopus) -
Protein kinase D in the cardiovascular system - Emerging roles in health and disease
Avkiran, M., Rowland, A. J., Cuello, F. & Haworth, R. S., Feb 2008, In: Circulation Research. 102, 2, p. 157 - 163 7 p.Research output: Contribution to journal › Literature review › peer-review
97 Citations (Scopus) -
Targeting Na+/H+ exchanger regulation for cardiac protection: a RSKy approach?
Avkiran, M., Cook, A. R. & Cuello, F., Apr 2008, In: Current Opinion in Pharmacology. 8, 2, p. 133 - 140 8 p.Research output: Contribution to journal › Literature review › peer-review
86 Citations (Scopus) -
Translating molecular target into drug therapy in cardiovascular disease
Bril, A. & Avkiran, M., Apr 2008, In: Current Opinion in Pharmacology. 8, 2, p. 111 - 113 3 p.Research output: Contribution to journal › Editorial › peer-review
2 Citations (Scopus) -
2007
Evidence for direct regulation of myocardial Na+/H+ exchanger isoform 1 phosphorylation and activity by 90-kDa ribosomal S6 kinase (RSK): Effects of the novel and specific RSK inhibitor fmk on responses to alpha(1)-adrenergic stimulation
Cuello, F., Snabaitis, A., Cohen, M., Taunton, J. & Avkiran, M., Mar 2007, In: Molecular Pharmacology. 71, 3, p. 799 - 806 8 p.Research output: Contribution to journal › Article › peer-review
59 Citations (Scopus) -
Protein kinase D selectively targets cardiac troponin I and regulates myofilament Ca2+ sensitivity in ventricular myocytes
Cuello, F., Bardswell, S., Haworth, R., Yin, X., Lutz, S., Wieland, T., Mayr, M., Kentish, J. & Avkiran, M., Mar 2007, In: Circulation Research. 100, 6, p. 864 - 873 10 p.Research output: Contribution to journal › Article › peer-review
90 Citations (Scopus) -
Regulation of protein kinase D activity in adult myocardium: Novel counter-regulatory roles for protein kinase CF, and protein kinase A
Haworth, R. S., Roberts, N. A., Cuello, F. & Avkiran, M., Dec 2007, In: Journal of Molecular and Cellular Cardiology. 43, 6, p. 686 - 695 10 p.Research output: Contribution to journal › Article › peer-review
40 Citations (Scopus) -
2006
Activation of p38 mitogen-activated protein kinase contributes to the early cardiodepressant action of tumor necrosis factor
Bellahcene, M., Jacquet, S., Cao, X. B., Tanno, M., Haworth, R. S., Layland, J., Kabir, A. M., Gaestel, M., Davis, R. J., Flavell, R. A., Shah, A. M., Avkiran, M. & Marber, M. S., 1 Aug 2006, In: Journal of the American College of Cardiology. 48, 3, p. 545 - 555 11 p.Research output: Contribution to journal › Article › peer-review
45 Citations (Scopus) -
A novel role for protein phosphatase 2A (PP2A) in GPCR-mediated regulation of the sarcolemmal Na+/H+ exchanger in adult myocardium
Snabaitis, A. K., D'Mello, R. & Avkiran, M., 2006, In: Heart. 92, 2, p. 020 1 p.Research output: Contribution to journal › Meeting abstract