King's College London

Research portal

Dr Michael Christie

Research interests

Autoimmunity in Type 1 diabetes: Type 1 diabetes is the result of the destruction of insulin-secreting pancreatic beta cells by a process in which autoimmune recognition of beta cell proteins is implicated. My research group has long-standing interests in the identification and characterisation of beta cell targets of the autoimmune response in Type 1 diabetes, with the view of developing strategies to identify individuals at risk for disease, and to apply antigen specific immune intervention to prevent disease progression in high-risk subjects. My group was the first to detect circulating autoantibodies to a tyrosine phosphatase-like protein, IA-2, in diabetic patients, and this antibody marker is now widely used for the prediction and diagnosis of disease. We have subsequently identified a region of the IA-2 molecule that is very commonly recognised by both ciirculating autoantibodies and T-cells in Type 1 diabetes. We are currently investigating the relationships between T- and B-cell responses to this and other regions of the IA-2 molecule, and the potential for this region to form the basis of antigen-specific vaccination protocols to prevent disease.

Development and function of pancreatic beta cells: IA-2 is a tyrosine phosphatase-like protein localised to secretory granules of pancreatic beta cells, as well as to secretory vesicles of a number of other neuroendocrine organs, including the pituitary. Our recent studies have shown that IA-2 is an important regulator of beta cell secretory granule content and insulin secretion. IA-2 is poorly expressed in fetal life, but is up-regulated after birth, in parallel with increases in islet insulin secretion in response to glucose. We are currently interested in understanding the changes in beta cell gene expression that occur during the functional maturation of pancreatic beta cells during their development, and the influences of hormones and environmental factors, particularly diet, on the development and function of the endocrine pancreas. These studies will aid our understanding of how early exposure to environmental factors can influence susceptibility to Type 1 and Type 2 diabetes later in life.

Participation in conference

Diabetes UK Annual Professional Conference, Birmingham,

Michael Christie (Speaker)

Mar 2006 → …

Activity: Participating in or organising an eventParticipation in conference

European Association for the Study of Diabetes, Athens,

Michael Christie (Speaker)

Sep 2005 → …

Activity: Participating in or organising an eventParticipation in conference

European Association for the Study of Diabetes, Munich,

Michael Christie (Speaker)

Sep 2004 → …

Activity: Participating in or organising an eventParticipation in conference

European Association for the Study of Diabetes, Munich, (invited session chair),

Michael Christie (Chair)

Sep 2004 → …

Activity: Participating in or organising an eventParticipation in conference

American Diabetes Association Annual Conference. San Francisco, USA

Michael Christie (Speaker)

Jun 2002 → …

Activity: Participating in or organising an eventParticipation in conference

Diabetes UK Annual Conference, Birmingham, (invited session chair),

Michael Christie (Chair)

Mar 2002 → …

Activity: Participating in or organising an eventParticipation in conference

all-day plenary Research Symposium at the Diabetes Professional Conference,

Michael Christie (Organiser)

2002 → …

Activity: Participating in or organising an eventParticipation in conference

European Association for the Study of Diabetes, Glasgow,

Michael Christie (Speaker)

Sep 2001 → …

Activity: Participating in or organising an eventParticipation in conference

11th International Congress in Immunology, Stockholm Sweden,

Michael Christie (Speaker)

Jul 2001 → …

Activity: Participating in or organising an eventParticipation in conference

Diabetes UK Annual Professional Conference, Birmingham

Michael Christie (Chair)

2001 → …

Activity: Participating in or organising an eventParticipation in conference

Types of External academic engagement - Contribution to the work of national or international committees and working groups

Expert witness during the consideration of a patent application from the University of San Francisco

Michael Christie (Member)

2001 → …

Activity: OtherTypes of External academic engagement - Contribution to the work of national or international committees and working groups

Research Programme Advisor - Genome Canada

Michael Christie (Advisor)

2001 → …

Activity: OtherTypes of External academic engagement - Contribution to the work of national or international committees and working groups

Publication peer-review

Molecular and Cellular Endocrinology (Journal)

Michael Christie (Editor)

2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Journal of Immunology (Journal)

Michael Christie (Editor)

2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Journal of Endocrinology (Journal)

Michael Christie (Editor)

2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Journal of Clinical Endocrinology and Metabolism (Journal)

Michael Christie (Editor)

2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Journal of Autoimmunity (Journal)

Michael Christie (Editor)

2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Hormone and Metabolic Research (Journal)

Michael Christie (Editor)

2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

FEBS Letters (Journal)

Michael Christie (Editor)

2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Diabetes/Metabolism Research and Reviews (Journal)

Michael Christie (Editor)

2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Diabetes Care (Journal)

Michael Christie (Editor)

2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Diabetologia (Journal)

Michael Christie (Editor)

2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Diabetes (Journal)

Michael Christie (Editor)

2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Clinical and Experimental Immunology (Journal)

Michael Christie (Editor)

2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Acta Paediatrica (Journal)

Michael Christie (Editor)

2001 → …

Activity: Publication peer-review and editorial workPublication peer-review

Types of Business and Community - Work on advisory panel to industry or government or non-government organisation

University of London Academic Trust Funds Committee

Michael Christie (Member)

2001 → …

Activity: OtherTypes of Business and Community - Work on advisory panel to industry or government or non-government organisation

Types of External academic engagement - Membership of external research organisation

Research Committee - Diabetes UK,

Michael Christie (Member)

2001 → …

Activity: OtherTypes of External academic engagement - Membership of external research organisation

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