King's College London

Research portal

Dr Michael Christie

  1. Identification of tetraspanin-7 as a target of autoantibodies in type 1 diabetes

    McLaughlin, K. A., Richardson, C. C., Ravishankar, A., Brigatti, C., Liberati, D., Lampasona, V., Piemonti, L., Morgan, D., Feltbower, R. G. & Christie, M. R., 1 Jun 2016, In: Diabetes. 65, 6, p. 1690-1698 9 p.

    Research output: Contribution to journalArticlepeer-review

  2. Autoantibodies against cytochrome P450 side-chain cleavage enzyme in dogs (Canis lupus familiaris) affected with hypoadrenocorticism (Addison's Disease)

    Boag, A. M., Christie, M. R., McLaughlin, K. A., Syme, H. M., Graham, P. & Catchpole, B., 30 Nov 2015, In: PL o S One . 10, 11, e0143458.

    Research output: Contribution to journalArticlepeer-review

  3. Relationships between major epitopes of the IA-2 autoantigen in Type 1 diabetes: Implications for determinant spreading

    McLaughlin, K. A., Richardson, C. C., Williams, S., Bonifacio, E., Morgan, D., Feltbower, R. G., Powell, M., Rees Smith, B., Furmaniak, J. & Christie, M. R., 1 Oct 2015, In: CLINICAL IMMUNOLOGY. 160, 2, p. 226-236 11 p.

    Research output: Contribution to journalArticlepeer-review

  4. HLA-DR4-Associated T and B Cell Responses to Specific Determinants on the IA-2 Autoantigen in Type 1 Diabetes

    McLaughlin, K. A., Gulati, K., Richardson, C. C., Morgan, D., Bodansky, H. J., Feltbower, R. G. & Christie, M. R., 1 Nov 2014, In: Journal of Immunology. 193, 9, p. 4448-4456 9 p.

    Research output: Contribution to journalArticlepeer-review

  5. High frequency of autoantibodies in patients with long duration type 1 diabetes

    Richardson, C. C., Dromey, J. A., McLaughlin, K., Morgan, D., Bodansky, H. J., Feltbower, R. G., Barnett, A. H., Gill, G. V., Bain, S. C. & Christie, M. R., Nov 2013, In: Diabetologia. 56, 11, p. 2538-2540 3 p.

    Research output: Contribution to journalArticlepeer-review

  6. Failure to detect anti-idiotypic antibodies in the autoimmune response to IA-2 in Type 1 diabetes

    Richardson, C. C., McLaughlin, K., Brown, T. J., Morgan, D., Feltbower, R., Powell, M., Furmaniak, J., Smith, B. R. & Christie, M. R., Sep 2013, In: Autoimmunity. 46, 6, p. 375-381 7 p.

    Research output: Contribution to journalArticlepeer-review

  7. Relationships between major epitopes on the IA-2 autoantigen in type 1 diabetes

    Richardson, C. C., Christie, M. R. & McLaughlin, K., Sep 2013, Diabetologia. Vol. 56. p. S64-S64 1 p.

    Research output: Chapter in Book/Report/Conference proceedingMeeting abstract

  8. HLA- and autoantibody-associated T-cell responses to IA-2 determinants in type 1 diabetes

    McLaughlin, K., Gulati, K., Richardson, C. C., Morgan, D., Bodansky, H. J., McKinney, P. A., Feltbower, R. G. & Christie, M. R., Sep 2011, Diabetologia. Vol. 54. p. S171-S171 1 p.

    Research output: Chapter in Book/Report/Conference proceedingMeeting abstract

  9. Influence of HLA genes on antibody reactivity to the juxtamembrane and central region epitopes of the autoantigen IA-2

    Gulati, K., McLaughlin, K., Richardson, C. C. & Christie, M. R., Sep 2011, Diabetologia. Vol. 54. p. S169-S170 2 p.

    Research output: Chapter in Book/Report/Conference proceedingMeeting abstract

  10. Characterisation of IA-2 antibody epitopes by proteolysis of antibody-antigen complexes and mass spectrometry

    McLaughlin, K. A., Richardson, C. C., Homer, K. A. & Christie, M. R., 2010, In: Diabetologia. 53, p. S179 - S179

    Research output: Contribution to journalMeeting abstract

  11. Islets in Early Life are Resistant to Detrimental Effects of a High-fat Maternal Diet: A Study in Rats

    Foot, V. L., Richardson, C. C., Jefferson, W., Taylor, P. D. & Christie, M. R., 2010, In: Hormone and Metabolic Research. 42, 13, p. 923 - 929 7 p.

    Research output: Contribution to journalArticlepeer-review

  12. Autoantibodies and associated T-cell responses to determinants within the 831-860 region of the autoantigen IA-2 in Type 1 diabetes

    Weenink, S. M., Lo, J., Stephenson, C. R., McKinney, P. A., Ananieva-Jordanova, R., Smith, B. R., Furmaniak, J., Tremble, J. M., Bodansky, H. J. & Christie, M. R., Sep 2009, In: Journal of Autoimmunity. 33, 2, p. 147 - 154 8 p.

    Research output: Contribution to journalArticlepeer-review

  13. Somatostatin Secreted by Islet delta-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

    Hauge Evans, A. C., King, A. J., Carmignac, D., Richardson, C. C., Robinson, I. C. A. F., Low, M. J., Christie, M. R., Persaud, S. J. & Jones, P. M., Feb 2009, In: Diabetes. 58, 2, p. 403 - 411 9 p.

    Research output: Contribution to journalArticlepeer-review

  14. Regulation of beta cell mass during early life in somatostatin-deficient mice

    Richardson, C. C., To, K., Foot, V., Shamil, E., Jefferson, W., Carmignac, D., Robinson, I. C. A. & Christie, M. R., 2009, In: Diabetologia. 52, p. S22 - S23

    Research output: Contribution to journalMeeting abstract

  15. Autoantibodies to GAD65 and IA-2 in canine diabetes mellitus

    Davison, L. J., Weenink, S. M., Christie, M. R., Herrtage, M. E. & Catchpole, B., 15 Nov 2008, In: Veterinary Immunology and Immunopathology. 126, 1-2, p. 83 - 90 8 p.

    Research output: Contribution to journalArticlepeer-review

  16. Islets in neonatal life are resistant to detrimental effects of a high-fat maternal diet

    Richardson, C. C., Foot, V., Jefferson, W., Taylor, P., Christie, M. R. & CC Richardson, C., Jun 2008, Diabetes Supplement. Vol. 57. p. A440-A440 1 p.

    Research output: Chapter in Book/Report/Conference proceedingMeeting abstract

  17. The lack of anti-idiotypic antibodies, not the presence of the corresponding autoantibodies to glutamate decarboxylase, defines type 1 diabetes

    Oak, S., Gilliam, L. K., Landin-Olsson, M., Torn, C., Kockum, I., Pennington, C. R., Rowley, M. J., Christie, M. R., Banga, J. P. & Hampe, C. S., 8 Apr 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 14, p. 5471 - 5476 6 p.

    Research output: Contribution to journalArticlepeer-review

  18. Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming

    Samuelsson, A-M., Matthews, P. A., Argenton, M., Christie, M. R., McConnell, J. M., Jansen, E. H. J. M., Piersma, A. H., Ozanne, S. E., Twinn, D. F., Remacle, C., Rowlerson, A., Poston, L. & Taylor, P. D., Feb 2008, In: Hypertension. 51, 2, p. 383-392 10 p.

    Research output: Contribution to journalArticlepeer-review

  19. Evidence for the presence of stem cell-like progenitor cells in human adult pancreas

    Zhao, M., Amiel, S. A., Christie, M. R., Muiesan, P., Srinivasan, P., Littlejohn, W., Rela, M., Arno, M., Heaton, N. & Huang, G. C., Dec 2007, In: Journal of Endocrinology. 195, 3, p. 407 - 414 8 p.

    Research output: Contribution to journalArticlepeer-review

  20. GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77

    Desai, M., Cull, C. A., Horton, V. A., Christie, M. R., Bonifacio, E., Lampasona, V., Bingley, P. J., Levy, J. C., Mackay, I. R., Zimmet, P., Holman, R. R. & Clark, A., Oct 2007, In: Diabetologia. 50, 10, p. 2052 - 2060 9 p.

    Research output: Contribution to journalArticlepeer-review

  21. Low levels of glucose transporters and K+ATP channels in human pancreatic beta cells early in development

    Richardson, C. C., Hussain, K., Jones, P. M., Persaud, S., Löbner, K., Boehm, A., Clark, A. & Christie, M. R., May 2007, In: Diabetologia. 50, 5, p. 1000-1005 6 p.

    Research output: Contribution to journalArticlepeer-review

  22. Secretory characteristics of islets of Langerhans isolated from somatostatin-deficient mice

    Hauge-Evans, A. C., Carmignac, D., Robinson, I. C., Low, M. J., Christie, M. J., Jefferson, W., Persaud, S. J. & Jones, P. M., 2007, In: Diabetic Medicine. 24, p. 1 - 1 1 p.

    Research output: Contribution to journalMeeting abstract

  23. A role for kisspeptin in islet function

    Hauge-Evans, A. C., Richardson, C. C., Milne, H. M., Christie, M. R., Persaud, S. J. & Jones, P. M., Sep 2006, In: Diabetologia. 49, 9, p. 2131 - 2135 5 p.

    Research output: Contribution to journalArticlepeer-review

  24. Homotypic cell contact enhances insulin but not glucagon secretion

    Brereton, H. C., Carvell, M. J., Asare-Anane, H., Roberts, G., Christie, M. R., Persaud, S. J. & Jones, P. M., 9 Jun 2006, In: Biochemical and Biophysical Research Communications. 344, 3, p. 995-1000 6 p., 344.

    Research output: Contribution to journalArticlepeer-review

  25. Monoclonal antibody 76F distinguishes IA-2 from IA-2 beta and overlaps an autoantibody epitope

    Piquer, S., Valera, L., Lampasona, V., Jardin-Watelet, B., Roche, S., Granier, C., Roquet, F., Christie, M. R., Giordano, T., Malosio, M. L., Bonifacio, E. & Laune, D., May 2006, In: Journal of Autoimmunity. 26, 3, p. 215 - 222 8 p.

    Research output: Contribution to journalArticlepeer-review

  26. Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice

    Zhao, M., Amiel, S. A., Christie, M. R., Rela, M., Heaton, N. & Huang, G. C., Oct 2005, In: Diabetologia. 48, 10, p. 2051 - 2061 11 p.

    Research output: Contribution to journalArticlepeer-review

  27. The dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and insulin secretion

    Harashima, S. I., Clark, A., Christie, M. R. & Notkins, A. L., 14 Jun 2005, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 24, p. 8704 - 8709 6 p.

    Research output: Contribution to journalArticlepeer-review

  28. Autoantibodies to GAD and IA-2 in Saudi Arabian diabetic patients

    Damanhouri, L. H., Dromey, J. A., Christie, M. R., Nasrat, H. A., Ardawi, M. S., Robins, R. A. & Todd, I., Apr 2005, In: Diabetic Medicine. 22, 4, p. 448 - 452 5 p.

    Research output: Contribution to journalArticlepeer-review

  29. Enhanced insulin secretion from beta-cells in islet-like structures is caused by anatomical configuration rather than alterations in gene expression

    Luther, M. J., Muller, D., Brereton, H., Roberts, G., Christie, M., Souza, K., Jorns, A., Lenzen, S., Persaud, S. J. & Jones, P. M., 2005, In: Diabetologia. 48, p. 458 1 p.

    Research output: Contribution to journalMeeting abstract

  30. Reduced pancreatic insulin content in offspring of rats fed high saturated fat during pregnancy

    Richardson, C. C., Jensen, R., Aristodemou, S., Taylor, P. D., Poston, L. & Christie, M. R., 2005, In: Diabetologia. 48, p. 486 1 p.

    Research output: Contribution to journalMeeting abstract

  31. Relationship of autoantibodies to glutamic acid decarboxylase (GADA) to deterioration of glycamic control assessed by therapy progression in latent autoimmune diabetes in adults (LADA) in the UKPDS

    Clark, A., Desai, M., Cull, C. A., Horton, V. A., Christie, M. R., Bingley, P. J., Bonifacio, E., Levy, J. C. & Holman, R. R., 2005, In: Diabetologia. 48, p. 227 1 p.

    Research output: Contribution to journalMeeting abstract

  32. The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes

    Gillespie, K. M., Bain, S. C., Barnett, A. H., Bingley, P. J., Christie, M. R., Gill, G. V. & Gale, E. A. M., 6 Nov 2004, In: The Lancet. 364, 9446, p. 1699 - 1700 2 p.

    Research output: Contribution to journalArticlepeer-review

  33. Mapping of epitopes for autoantibodies to the type 1 diabetes autoantigen IA-2 by peptide phage display and molecular modeling: Overlap of antibody and T cell determinants

    Dromey, J. A., Weenink, S. M., Peters, G. H., Endl, J., Tighe, P. J., Todd, I. & Christie, M. R., 1 Apr 2004, In: Journal of Immunology. 172, 7, p. 4084 - 4090 7 p.

    Research output: Contribution to journalArticlepeer-review

  34. The development of new density gradient media for purifying human islets and islet-quality assessments

    Huang, G. C., Zhao, M., Jones, P., Persaud, S., Ramracheya, R., Lobner, K., Christie, M. R., Banga, J. P., Peakman, M., Sirinivsan, P., Rela, M., Heaton, N. & Amiel, S., 15 Jan 2004, In: Transplantation. 77, 1, p. 143 - 145 3 p.

    Research output: Contribution to journalArticlepeer-review

  35. GAD65 autoantibody titres at diagnosis in Latent Autoimmune Diabetes in Adults (LADA) differ from Type 1 diabetes (T1D) and together with epitope specificity predict insulin requirement

    Desai, M., Williams, A. J. K., Horton, V. A., Bingley, P. J., Levy, J. C., Cull, C. A., Holman, R. R., Bonifacio, E., Christie, M. R. & Clark, A., 2004, In: Diabetologia. 47, p. 509 1 p.

    Research output: Contribution to journalMeeting abstract

  36. Sequential expression of elements of beta cell stimulus-secretion coupling follows islet hormone expression in human fetal life

    Richardson, C. C., Jones, P., Persaud, S., Hussain, K., Clark, A. & Christie, M. R., 2004, In: Diabetologia. 47, p. 133 1 p.

    Research output: Contribution to journalMeeting abstract

  37. Different regulated expression of the tyrosine phosphatase-like proteins IA-2 and phogrin by glucose and insulin in pancreatic islets - Relationship to development of insulin secretory responses in early life

    Lobner, K., Steinbrenner, H., Roberts, G. A., Ling, Z. D., Huang, G. C., Piquer, S., Pipeleers, D. G., Seissler, J. & Christie, M. R., 1 Oct 2002, In: Diabetes. 51, 10, p. 2982 - 2988 7 p.

    Research output: Contribution to journalArticlepeer-review

  38. IA-2 antibody-negative status predicts remission and recovery of C-peptide levels in type 1 diabetic patients treated with cyclosporinl

    Christie, M. R., Molvig, J., Hawkes, C. J., Carstensen, B., Mandrup-Poulsen, T. & Canadian-European Randomised Control Trial Group, Jul 2002, In: Diabetes Care. 25, 7, p. 1192 - 1197 6 p.

    Research output: Contribution to journalArticlepeer-review

  39. Amelioration of streptozotocin-induced diabetes in mice using human islet cells derived from long-term culture in vitro

    Zhao, M., Christie, M. R., Heaton, N., George, S., Amiel, S. & Huang, G. C., 15 May 2002, In: Transplantation. 73, 9, p. 1454-1460 7 p.

    Research output: Contribution to journalArticlepeer-review

  40. Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens

    Bearzatto, M., Naserke, H., Piquer, S., Koczwara, K., Lampasona, V., Williams, A., Christie, M. R., Bingley, P. J., Ziegler, A. G. & Bonifacio, E., 15 Apr 2002, In: Journal of Immunology. 168, 8, p. 4202 - 4208 7 p.

    Research output: Contribution to journalArticlepeer-review

  41. Proliferation and apoptosis in human islet development: apoptosis is associated with islet amyldoidosis in Type 2 diabetes

    Clark, A., Roberts, C., Osborn, J., Case, L. & Christie, M. R., 2002, In: Diabetologia. 45, p. 88 1 p.

    Research output: Contribution to journalMeeting abstract

  42. Autoantibodies to a 38-kDa glycosylated islet cell membrane-associated antigen in (pre)type 1 diabetes - Association with IA-2 and islet cell autoantibodies

    Winnock, F., Christie, M. R., Batstra, M. R., Aanstoot, H. J., Weets, I., Decochez, K., Jopart, P., Nicolaij, D., Gorus, F. K. & Belgian Diabetes Registry, 2001, In: Diabetes Care. 24, 7, p. 1181 - 1186 6 p.

    Research output: Contribution to journalArticlepeer-review

  43. Expression of the protein tyrosine phosphatase-like protein IA-2 during pancreatic islet development

    Roberts, C., Roberts, G. A., Lobner, K., Bearzatto, M., Clark, A., Bonifacio, E. & Christie, M. R., 2001, In: Journal of Histochemistry and Cytochemistry. 49, 6, p. 767 - 775 9 p.

    Research output: Contribution to journalArticlepeer-review

  44. Restoration of glucose-responsive insulin secretion following formation of cell clusters in the poorly responsive betaTC-3 cell line.

    Roberts, G. A., Lobner, K., Hauge-Evans, A., Bearzatto, M., Persaud, S., Jones, P. & Christie, M. R., 2001, In: Diabetologia. 44, p. A118 - A118

    Research output: Contribution to journalMeeting abstract

  45. The protein tyrosine phosphatase like molecule IA-2 as a model for paracrine regulation by insulin

    Lobner, K., Steinbrenner, H., Roberts, G. A., Bonifacio, E., Seissler, J. & Christie, M. R., 2001, In: Diabetologia. 44, p. A30 - A30

    Research output: Contribution to journalMeeting abstract

  46. Human monoclonal antibodies isolated from type I diabetes patients define multiple epitopes in the protein tyrosine phosphatase-like IA-2 antigen

    Kolm-Litty, V., Berlo, S., Bonifacio, E., Bearzatto, M., Engel, A. M., Christie, M., Ziegler, A. G., Wild, T. & Endl, J., 15 Oct 2000, In: Journal of Immunology. 165, 8, p. 4676 - 4684 9 p.

    Research output: Contribution to journalArticlepeer-review

  47. T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes

    Hawkes, C. J., Schloot, N. C., Marks, J., Willemen, S. J. M., Drijfhout, J. W., Mayer, E. K., Christie, M. R. & Roep, B. O., Mar 2000, In: Diabetes. 49, 3, p. 356 - 366 11 p.

    Research output: Contribution to journalArticlepeer-review

Previous 1 2 Next

Export:RIS BibTex Word PDF - will at most contain 500 items

Search within the list

Refine results

Type

Type

Language

Language

Publication year

Publication year

Meeting and poster abstracts

Meeting and poster abstracts

Open Access Status

Open Access Status

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454