King's College London

Research portal

Professor Michael Heneghan

  1. Autoimmune hepatitis in pregnancy: Pearls and pitfalls

    Chung, Y. Y. & Heneghan, M. A., Aug 2022, In: Hepatology. 76, 2, p. 502-517 16 p.

    Research output: Contribution to journalReview articlepeer-review

  2. Systematic review with meta-analysis: outcomes of pregnancy in patients with autoimmune hepatitis

    Si, T., Huang, Z., Hegarty, R., Ma, Y. & Heneghan, M. A., Jun 2022, In: Alimentary Pharmacology and Therapeutics. 55, 11, p. 1368-1378 11 p.

    Research output: Contribution to journalArticlepeer-review

  3. Autoimmune hepatitis and pregnancy: considerations for the clinician

    Chung, Y. Y., Rahim, M. N. & Heneghan, M. A., 2 Mar 2022, In: Expert Review Of Clinical Immunology. 18, 4, p. 325-333 9 p.

    Research output: Contribution to journalArticlepeer-review

  4. Editorial: testing for Epstein Barr virus and treating autoimmune hepatitis—still a long way to go! Authors' reply

    Nayagam, J. S., Heneghan, M. A., Samyn, M. & Joshi, D., Feb 2022, In: Alimentary Pharmacology and Therapeutics. 55, 3, p. 366-367 2 p.

    Research output: Contribution to journalEditorialpeer-review

  5. Faecal calprotectin is a surrogate marker of biliary inflammation in primary sclerosing cholangitis associated inflammatory bowel disease

    Pavlidis, P., Joshi, D., El Sherif, Y., Warner, B., Gulati, S., Alexander, J., Cross, G., Dew, T., Arqoub, H. A., Devlin, J., Heneghan, M., Dubois, P., Bjarnason, I., Powell, N. & Hayee, BH., 2022, (Accepted/In press) In: Frontline Gastroenterology. 102053.

    Research output: Contribution to journalArticlepeer-review

  6. Aberrant hepatic trafficking of gut-derived T cells is not specific to primary sclerosing cholangitis

    Graham, J. J., Mukherjee, S., Yuksel, M., Mateos, R. S., Si, T., Huang, Z., Huang, X., Abu Arqoub, H., Patel, V., McPhail, M., Zen, Y., Heaton, N., Longhi, M. S., Heneghan, M. A., Liberal, R., Vergani, D., Mieli-Vergani, G., Ma, Y. & Hayee, BH., 7 Dec 2021, (E-pub ahead of print) In: Hepatology.

    Research output: Contribution to journalArticlepeer-review

  7. Epstein–Barr virus status and immunosuppression use in paediatric autoimmune liver disease

    Nayagam, J. S., Heneghan, M. A., Samyn, M. & Joshi, D., 18 Nov 2021, (E-pub ahead of print) In: Alimentary Pharmacology and Therapeutics.

    Research output: Contribution to journalArticlepeer-review

  8. Human Leukocyte Antigen Profile Predicts Severity of Autoimmune Liver Disease in Children of European Ancestry

    Ma, Y., Su, H., Yuksel, M., Serena Longhi, M., McPhail, M. J., Wang, P., Bansal, S., Wong, G. W., Graham, J., Yang, L., J Thompson, R., Doherty, D. G., Hadzic, N., Zen, Y., Quaglia, A., Heneghan, M. A., Samyn, M., Vergani, D. & Mieli-Vergani, G., Oct 2021, In: Hepatology. 74, 4, p. 2032-2046 15 p.

    Research output: Contribution to journalArticlepeer-review

  9. A novel microRNA-based prognostic model outperforms standard prognostic models in patients with acetaminophen-induced acute liver failure

    Tavabie, O. D., Karvellas, C. J., Salehi, S., Speiser, J. L., Rose, C. F., Menon, K., Prachalias, A., Heneghan, M. A., Agarwal, K., Lee, W. M., McPhail, M. J. W. & Aluvihare, V. R., Aug 2021, In: Journal of Hepatology. 75, 2, p. 424-434 11 p.

    Research output: Contribution to journalArticlepeer-review

  10. Dysregulation of the Lysophosphatidylcholine/Autotaxin/Lysophosphatidic Acid Axis in Acute-on-Chronic Liver Failure Is Associated With Mortality and Systemic Inflammation by Lysophosphatidic Acid–Dependent Monocyte Activation

    Trovato, F. M., Zia, R., Napoli, S., Wolfer, K., Huang, X., Morgan, P. E., Husbyn, H., Elgosbi, M., Lucangeli, M., Miquel, R., Wilson, I., Heaton, N. D., Heneghan, M. A., Auzinger, G., Antoniades, C. G., Wendon, J. A., Patel, V. C., Coen, M., Triantafyllou, E. & McPhail, M. J., Aug 2021, In: Hepatology. 74, 2, p. 907-925 19 p.

    Research output: Contribution to journalArticlepeer-review

  11. Towards personalised medicine in autoimmune hepatitis: Measurement of thiopurine metabolites results in higher biochemical response rates

    Candels, L. S., Rahim, M. N., Shah, S. & Heneghan, M. A., Aug 2021, In: Journal of Hepatology. 75, 2, p. 324-332 9 p.

    Research output: Contribution to journalArticlepeer-review

  12. Low baseline cortisol but not delta cortisol relates to 28-day transplant-free survival in acute liver failure syndromes

    Roth, S., Flint, E., Ghataore, L., Patel, V. C., Singanayagam, A., Vincent, R. P., Triantafyllou, E., Ma, Y., Bernal, W., Auzinger, G., Heneghan, M., McPhail, M., Antoniades, C., Christ-Crain, M., Taylor, D. R., Wendon, J. & Bernsmeier, C., Jul 2021, In: Journal of Hepatology. 75, p. S306-S306

    Research output: Contribution to journalMeeting Abstractpeer-review

  13. A 'real-world' analysis of risk factors for post liver transplant delirium and the effect on length of stay

    Tavabie, O. D., Colwill, M., Adamson, R., McPhail, M. J. W., Bernal, W., Jassem, W., Prachialias, A., Heneghan, M., Aluvihare, V. R. & Agarwal, K., 1 Oct 2020, In: European Journal of Gastroenterology and Hepatology. 32, 10, p. 1373-1380 8 p.

    Research output: Contribution to journalArticlepeer-review

  14. Assessing the Time-Dependent Impact of Performance Status on Outcomes After Liver Transplantation

    Wallace, D., Cowling, T., McPhail, M. J., Brown, S. E., Aluvihare, V., Suddle, A., Auzinger, G., Heneghan, M. A., Rowe, I. A., Walker, K., Heaton, N., van Der Meulen, J. & Bernal, W., 1 Oct 2020, In: Hepatology. 72, 4, p. 1341-1352 12 p.

    Research output: Contribution to journalArticlepeer-review

  15. REDEFINING POOR PROGNOSTIC CRITERIA FOR ACETAMINOPHEN-INDUCED ACUTE LIVER FAILURE USING REGENERATION AND CELL-DEATH LINKED MIRNA SIGNATURES

    Tavabie, O., Karvellas, C., Salehi, S., Speiser, J., Rose, C., Menon, K., Prachalias, A., Heneghan, M., Agarwal, K., Lee, W., McPhail, M. & Aluvihare, V., Sep 2020, In: Gut. 69, p. A5-A5

    Research output: Contribution to journalMeeting Abstractpeer-review

  16. Pregnancy in Liver Transplantation

    Rahim, M. N., Long, L., Penna, L., Williamson, C., Kametas, N. A., Nicolaides, K. H. & Heneghan, M. A., 1 Apr 2020, In: Liver Transplantation. 26, 4, p. 564-581 18 p.

    Research output: Contribution to journalReview articlepeer-review

  17. Seamless Management of Juvenile Autoimmune Liver Disease: Long-Term Medical and Social Outcome

    Di Giorgio, A., Hadzic, N., Dhawan, A., Deheragoda, M., Heneghan, M. A., Vergani, D., Mieli-Vergani, G. & Samyn, M., 1 Mar 2020, In: Journal of pediatrics. 218, p. 121-129.e3

    Research output: Contribution to journalArticlepeer-review

  18. Using pregnancy to assess risk and predict women's health

    Rahim, M. N., Williamson, C., Kametas, N. A. & Heneghan, M. A., Mar 2020, In: EClinicalMedicine. 20, 100292.

    Research output: Contribution to journalComment/debatepeer-review

  19. Sequential Cohort Analysis After Liver Transplantation Shows de Novo Extended Release Tacrolimus Is Safe, Efficacious, and Minimizes Renal Dysfunction

    Lim, T. Y., McPhail, M. J., Shah, A., Mahgoub, S., Nayagam, J., Cramp, M., Bernal, W., Menon, K., Jassem, W., Joshi, D., Heneghan, M. A., Agarwal, K., Heaton, N. D., Suddle, A., O'Grady, J. G. & Aluvihare, V. R., Feb 2020, In: Transplantation Direct. 6, 2, 00970.

    Research output: Contribution to journalArticlepeer-review

  20. Management of pregnancy in women with cirrhosis

    Rahim, M. N., Pirani, T., Williamson, C. & Heneghan, M. A., 2020, (Accepted/In press) In: United European Gastroenterology Journal.

    Research output: Contribution to journalReview articlepeer-review

  21. Challenges in the use of corticosteroids in the management of autoimmune hepatitis

    Chapman, R. W., Aspinall, R. J., Trivedi, P., Wright, G. & Heneghan, M., 2 Oct 2019, In: British Journal of Hospital Medicine. 80, 10, p. 594-599 6 p.

    Research output: Contribution to journalArticlepeer-review

  22. Intraductal deployment of two fully covered metallic stents for anastomotic strictures following living donor liver transplantation

    Warner, B., Joshi, D., Heneghan, M., Srinivasan, P., Prachalias, A. & Harrison, P., Aug 2019, In: Clinics and research in hepatology and gastroenterology. 43, 4, p. e45-e47

    Research output: Contribution to journalArticlepeer-review

  23. The effect of performance status at the time of transplantation on outcomes following liver transplantation: a national cohort study in the United Kingdom and Ireland

    Wallace, D., McPhail, M., Brown, S., Aluvihare, V., Suddle, A., Auzinger, G., Heneghan, M., Wendon, J., Heaton, N., van der Meulen, J. & Bernal, W., Aug 2019, In: Transplantation. 103, 8, p. 65-66

    Research output: Contribution to journalMeeting Abstractpeer-review

  24. Autotaxin mediates lipid dysregulation in acute-on-chronic liver failure, promoting persistence of systemic inflammation via lysophosphatidic acid-mediated monocyte activation

    McPhail, M. J. W., Trovato, F., Triantafyllou, E., Zia, R., Wolfer, K., Huang, X., Rabinowich, L., Patel, V. C., Holmes, E., Heaton, N., Heneghan, M., Bernal, W., Auzinger, G., Coen, M., Wendon, J. & Antoniades, H., Apr 2019, In: Journal of Hepatology. 70, p. E91-E92

    Research output: Contribution to journalMeeting Abstractpeer-review

  25. Immunometabolic profiling of ascites from patients with acute-on-chronic liver failure reveals increased MerTK plus immunosuppressive myeloid cells and cell death markers with preferential lipid metabolism compared to cirrhosis without organ failure

    Singanayagam, A., Erminelli, D., Triantafyllou, E., Bernsmeier, C., Tunc, E., Krasniqi, M., Patel, V., Lebosse, F., Nathwani, R., Atkinson, A., Dhar, A., Heneghan, M., Auzinger, G., Khamri, W., Adams, D., Wendon, J., Thursz, M., McPhail, M. J. W. & Antoniades, H., Apr 2019, In: Journal of Hepatology. 70, p. E183-E183

    Research output: Contribution to journalMeeting Abstractpeer-review

  26. Non-Invasive Markers (ALBI and APRI) Predict Pregnancy Outcomes in Women With Chronic Liver Disease

    Gonsalkorala, E. S., Cannon, M. D., Lim, T. Y., Penna, L., Willliamson, C. & Heneghan, M. A., Feb 2019, In: American Journal of Gastroenterology. 114, 2, p. 267-275

    Research output: Contribution to journalArticlepeer-review

  27. Therapeutic plasma exchange as a novel treatment for severe intrahepatic cholestasis of pregnancy: Case series and mechanism of action

    Ovadia, C., Lövgren-Sandblom, A., Edwards, L. A., Langedijk, J., Geenes, V., Chambers, J., Cheng, F., Clarke, L., Begum, S., Noori, M., Pusey, C., Padmagirison, R., Agarwal, S., Peerless, J., Cheesman, K., Heneghan, M., Oude Elferink, R., Patel, V. C., Marschall, H. U. & Williamson, C., Dec 2018, In: Journal of Clinical Apheresis. 33, 6, p. 638-644 7 p.

    Research output: Contribution to journalArticlepeer-review

  28. Grand Round: Autoimmune Hepatitis

    Trivedi, P. J., Hubscher, S. G., Heneghan, M., Gleeson, D. & Hirschfield, G. M., 20 Nov 2018, (E-pub ahead of print) In: Journal of Hepatology.

    Research output: Contribution to journalArticlepeer-review

  29. Inequity of care provision and outcome disparity in autoimmune hepatitis in the United Kingdom

    the UK-AIH Consortium, Nov 2018, In: Alimentary Pharmacology and Therapeutics. 48, 9, p. 951-960 10 p.

    Research output: Contribution to journalArticlepeer-review

  30. Outcomes of Pregnancy in Mothers With Cirrhosis: A National Population-Based Cohort Study of 1.3 Million Pregnancies

    Hagström, H., Höijer, J., Marschall, H., Williamson, C., Heneghan, M. A., Westbrook, R. H., Ludvigsson, J. F. & Stephansson, O., Nov 2018, In: Hepatology Communications. 2, 11, p. 1299-1305

    Research output: Contribution to journalArticlepeer-review

  31. Low Dose Interleukin-2 for Refractory Autoimmune Hepatitis

    Lim, T. Y., Martinez-Llordella, M., Kodela, E., Gray, E., Heneghan, M. A. & Sanchez-Fueyo, A., 5 Oct 2018, In: Hepatology. 68, 4, p. 1649-1652

    Research output: Contribution to journalArticlepeer-review

  32. Changes in Performance Status after Liver Transplantation; A National Cohort Study

    Bernal, W., Wallace, D., McPhail, M. J. W., Heneghan, M. A., Aluvihare, V., Wendon, J., Heaton, N. & Van der Meulen, J., Oct 2018, In: Hepatology. 68, p. 673A-673A

    Research output: Contribution to journalMeeting Abstractpeer-review

  33. Palliative care in end-stage liver disease: Time to do better?

    Mazzarelli, C., Prentice, W. M., Heneghan, M. A., Belli, L. S., Agarwal, K. & Cannon, M. D., Jul 2018, In: Liver Transplantation. 24, 7, p. 961-968 8 p.

    Research output: Contribution to journalReview articlepeer-review

  34. Hepatic diagnostics in pregnancy: Biopsy, biomarkers, and beyond

    Heneghan, M. A. & Cannon, M. D., 14 May 2018, (E-pub ahead of print) In: Hepatology.

    Research output: Contribution to journalArticlepeer-review

  35. Entecavir Or Tenofovir Monotherapy Prevents HBV Recurrence In Liver Transplant Recipients: A 5-Year Follow-Up Study After Hepatitis B Immunoglobulin Withdrawal

    Manini, M. A., Whitehouse, G., Bruce, M., Passerini, M., Lim, T. Y., Carey, I., Considine, A., Lampertico, P., Suddle, A., Heaton, N., Heneghan, M. & Agarwal, K., 13 Apr 2018, (E-pub ahead of print) In: DIGESTIVE AND LIVER DISEASE.

    Research output: Contribution to journalArticlepeer-review

  36. Liver transplantation in patients admitted to intensive care with acute-on-chronic liver failure

    Theocharidou, E., Pirani, T., Heneghan, M., Heaton, N., Bernal, W. & Mcphail, M., Apr 2018, In: Journal of Hepatology. 68, p. S241-S241

    Research output: Contribution to journalMeeting Abstractpeer-review

  37. Pre-treatment risk stratification in primary biliary cholangitis: 51st Annual Meeting of the Italian Association for the Study of the Liver – A.I.S.F.

    Carbone, M., Nardi, A., Carpino, G., Cardinale, V., Ainsworth, H., Heneghan, M., Thorburn, D., Bathgate, A., Jones, R., Neuberger, J. M., Battezzati, P. M., Zuin, M., Taylor-Robinson, S., Donato, M., Kirby, J., Mitchell-Thain, R., Floreani, A., Sampaziotis, F., Muratori, L., Alvaro, D. & 18 others, Marzioni, M., Miele, L., Marra, F., Giannini, E., Gaudio, E., Ronca, V., Bonato, G., Cristoferi, L., Malinverno, F., Gerussi, A., Cordell, H. J., Hirschfield, G. M., Stocken, D., Alexander, G. J., Sandford, R. N., Jones, D. E., Invernizzi, P. & Mells, G. F., Feb 2018, In: DIGESTIVE AND LIVER DISEASE. 50, 1, Supplement, p. 21-22 2 p.

    Research output: Contribution to journalMeeting abstractpeer-review

  38. Pretreatment prediction of response to ursodeoxycholic acid in primary biliary cholangitis: Development and validation of the UDCA Response Score

    Carbone, M., Nardi, A., Flack, S., Carpino, G., Varvaropoulou, N., Gavrila, C., Spicer, A., Badrock, J., Bernuzzi, F., Cardinale, V., Ainsworth, H. F., Heneghan, M. A., Thorburn, D., Bathgate, A., Jones, R., Neuberger, J. M., Battezzati, P. M., Zuin, M., Taylor-Robinson, S., Donato, M. F. & 30 others, Kirby, J., Mitchell-Thain, R., Floreani, A., Sampaziotis, F., Muratori, L., Alvaro, D., Marzioni, M., Miele, L., Marra, F., Giannini, E., Gaudio, E., Ronca, V., Bonato, G., Cristoferi, L., Malinverno, F., Gerussi, A., Jones, D. E., Jones, S., Prince, M., Wilkinson, M., Jones, S., Brown, A., Heneghan, M. A., Srirajaskanthan, R., Evans, C., Wright, A., Jones, D. E., Cox, M., Fraser, J. & Li, A., 2018, In: The Lancet Gastroenterology & Hepatology.

    Research output: Contribution to journalArticlepeer-review

  39. Pre-Transplant Performance Status and Outcome of Liver Transplantation.

    Bernal, W., McPhail, M., Brown, S. E., Aluvihare, V., Auzinger, G., Heaton, N., Heneghan, M. A. & Wendon, J., Oct 2017, In: Hepatology. 66, p. 14A-14A

    Research output: Contribution to journalMeeting Abstractpeer-review

  40. Efficacy and Safety of Mycophenolate Mofetil and Tacrolimus as Second-line Therapy for Patients with Autoimmune Hepatitis

    Efe, C., Hagström, H., Ytting, H., Bhanji, R. A., Müller, N. F., Wang, Q., Purnak, T., Muratori, L., Werner, M., Marschall, H-U., Muratori, P., Gunşar, F., Klintman, D., Parés, A., Heurgué–Berlot, A., Schiano, T. D., Cengiz, M., May-Sien Tana, M., Ma, X., Montano-Loza, A. J. & 7 others, Berg, T., Verma, S., Larsen, F. S., Ozaslan, E., Heneghan, M. A., Yoshida, E. M. & Wahlin, S., 8 Jun 2017, (E-pub ahead of print) In: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY.

    Research output: Contribution to journalArticlepeer-review

  41. Endoscopy in Pregnant Women with Liver Cirrhosis

    Cannon, M. D. & Heneghan, M. A., 1 Jun 2017, (E-pub ahead of print) In: Gastroenterology.

    Research output: Contribution to journalArticlepeer-review

  42. Liver transplantation and adolescence: the role of mental health

    Hames, A., Matcham, F. A. E., Joshi, D., Heneghan, M., Dhawan, A., Heaton, N. & Samyn, M., Nov 2016, In: Liver Transplantation. 22, 11, p. 1544–1553

    Research output: Contribution to journalArticlepeer-review

  43. Vedolizumab in Inflammatory Bowel Disease Associated with Autoimmune Liver Disease Pre- and Postliver Transplantation: A Case Series

    Lim, T. Y., Pavlidis, P., Gulati, S., Pirani, T., Samaan, M., Chung-Faye, G., Dubois, P., Irving, P., Heneghan, M. & Hayee, BH., Oct 2016, In: Inflammatory Bowel Diseases. 22, 10, p. E39-40

    Research output: Contribution to journalLetterpeer-review

  44. The inter-relationship of symptom severity and quality of life in 2055 patients with primary biliary cholangitis

    Dyson, J. K., Wilkinson, N., Jopson, L., Mells, G., Bathgate, A., Heneghan, M. A., Neuberger, J., Hirschfield, G. M., Ducker, S. J., Sandford, R., Alexander, G., Stocken, D. & Jones, D. E. J., 1 Sep 2016, In: Alimentary Pharmacology & Therapeutics.

    Research output: Contribution to journalArticlepeer-review

  45. CD39 mediated regulation of Th17-cell effector function is impaired in juvenile autoimmune liver disease

    Liberal, R., Grant, C. R., Ma, Y., Csizmadia, E., Jiang, Z. G., Heneghan, M. A., Yee, E. U., Mieli-Vergani, G., Vergani, D., Robson, S. C. & Longhi, M. S., 20 May 2016, In: Journal of Autoimmunity. 72, 0, p. 102-112

    Research output: Contribution to journalArticlepeer-review

  46. The UK-PBC risk scores: Derivation and validation of a scoring system for long-term prediction of end-stage liver disease in primary biliary cholangitis

    Carbone, M., Sharp, S. J., Flack, S., Paximadas, D., Spiess, K., Adgey, C., Griffiths, L., Lim, R., Trembling, P., Williamson, K., Wareham, N. J., Aldersley, M., Bathgate, A., Burroughs, A. K., Heneghan, M. A., Neuberger, J. M., Thorburn, D., Hirschfield, G. M., Cordell, H. J., Alexander, G. J. & 4 others, Jones, D. E. J., Sandford, R. N., Mells, G. F. & UK-PBC Consortium, Mar 2016, In: Hepatology. 63, 3, p. 930-50 21 p.

    Research output: Contribution to journalArticlepeer-review

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