Research output per year
Research output per year
- 35 results
Search results
-
2019
An Improved Adeno-Associated Virus Vector for Neurological Correction of the Mouse Model of Mucopolysaccharidosis IIIA
Gray, A. L., O'Leary, C., Liao, A., Agúndez, L., Youshani, A. S., Gleitz, H. F., Parker, H., Taylor, J. T., Danos, O., Hocquemiller, M., Palomar, N., Linden, R. M., Henckaerts, E., Holley, R. J. & Bigger, B. W., 1 Sept 2019, In: Human Gene Therapy. 30, 9, p. 1052-1066 15 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson's disease
Rosenblad, C., Li, Q., Pioli, E. Y., Dovero, S., Antunes, A. S., Agúndez, L., Bardelli, M., Linden, R. M., Henckaerts, E., Björklund, A., Bezard, E. & Björklund, T., 1 Aug 2019, In: Brain : a journal of neurology. 142, 8, p. 2402-2416 15 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Citations (Scopus) -
2018
Adeno-associated virus Rep proteins antagonize phosphatase PP1 to counteract KAP1 repression of the latent viral genome
Smith-Moore, S., Neil, S. J. D., Fraefel, C., Linden, R. M., Bollen, M., Rowe, H. M. & Henckaerts, E., 10 Apr 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 15, p. E3529-E3538Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)186 Downloads (Pure) -
A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency
Tordo, J., O'Leary, C., Antunes, A. S. L. M., Palomar, N., Aldrin-Kirk, P., Basche, M., Bennett, A., D'Souza, Z., Gleitz, H., Godwin, A., Holley, R. J., Parker, H., Liao, A. Y., Rouse, P., Youshani, A. S., Dridi, L., Martins, C., Levade, T., Stacey, K. B. & Davis, D. M. & 11 others, , 31 Jul 2018, In: Brain. 141, 7, p. 2014-2031 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile82 Citations (Scopus)188 Downloads (Pure) -
2017
Novel mutant AAV2 rep proteins support AAV2 replication without blocking HSV-1 helpervirus replication
Seyffert, M., Glauser, D. L., Schraner, E. M., De Oliveira, A. P., Mansilla-Soto, J., Vogt, B., Büning, H., Linden, R. M., Ackermann, M. & Fraefel, C., 26 Jan 2017, In: PLoS ONE. 12, 1, e0170908.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (Scopus) -
2015
AAV2 Rep68 can bind to consensus Rep-binding sites on the HSV-1 genome
Seyffert, M., Glauser, D. L., Tobler, K., Georgiev, O., Vogel, R., Vogt, B., Agúndez, L., Linden, M., Büning, H., Ackermann, M. & Fraefel, C., 19 Aug 2015, (E-pub ahead of print) In: Journal of Virology.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
Presence of a trs-Like Motif Promotes Rep-Mediated Wild-Type Adeno-Associated Virus Type 2 Integration
Petri, K., Gabriel, R., Agundez, L., Fronza, R., Afzal, S., Kaeppel, C., Linden, R. M., Henckaerts, E. & Schmidt, M., 15 Jul 2015, In: Journal of Virology. 89, 14, p. 7428-7432 5 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
Structural studies of AAV2 Rep68 reveal a partially structured linker and compact domain conformation
Musayev, F. N., Zarate-Perez, F., Bardelli, M. R., Bishop, C. M., Saniev, E. F., Linden, R. M., Henckaerts, E. & Escalante, C. R., 28 Aug 2015, (E-pub ahead of print) In: Biochemistry.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
2014
Adeno-Associated Virus Rep Represses the Human Integration Site Promoter by Two Pathways That Are Similar to Those Required for the Regulation of the Viral p5 Promoter
Dutheil, N., Smith, S. C., Agundez, L., Vincent-Mistiaen, Z. I., Escalante, C. R., Linden, R. M. & Henckaerts, E., Jul 2014, In: Journal of Virology. 88, 15, p. 8227-8241 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)102 Downloads (Pure) -
Comparative next-generation sequencing of adeno-associated virus inverted terminal repeats
Petri, K., Fronza, R., Gabriel, R., Kaeppel, C., Nowrouzi, A., Linden, R. M., Henckaerts, E. & Schmidt, M., May 2014, In: Biotechniques. 56, 5, p. 269-273 4 p.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
2013
The Oligomeric properties of the Adeno-Associated Virus Rep68 reflect its multifunctionality
Zarate-Perez, F., Mansilla-Soto, J., Bardelli, M., Burgner, J. W., Villamil-Jarauta, M., Kekilli, D., Samso, M., Linden, R. M. & Escalante, C. R., Jan 2013, In: Journal of Virology. 87, 2, p. 1232-1241 10 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
2012
Quantification of AAV particle titers by infrared fluorescence scanning of coomassie-stained sodium dodecyl sulfate-polyacrylamide gels
Kohlbrenner, E., Henckaerts, E., Rapti, K., Gordon, R. E., Linden, R. M., Hajjar, R. J. & Weber, T., 7 Aug 2012, In: Human gene therapy methods. 23, 3, p. 198-203 6 p.Research output: Contribution to journal › Article › peer-review
26 Citations (Scopus) -
The Interdomain Linker of AAV-2 Rep68 Is an Integral Part of Its Oligomerization Domain: Role of a Conserved SF3 Helicase Residue in Oligomerization
Zarate-Perez, F., Bardelli, M., Burgner, J. W., Villamil-Jarauta, M., Das, K., Kekilli, D., Mansilla-Soto, J., Linden, R. M. & Escalante, C. R., 14 Jun 2012, In: PL o S Pathogens. 8, 6, 12 p., e1002764.Research output: Contribution to journal › Article › peer-review
Open Access22 Citations (Scopus) -
2010
Adeno-associated virus: a key to the human genome?
Henckaerts, E. & Linden, R. M., Sept 2010, In: Future Virology. 5, 5, p. 555-574 20 p.Research output: Contribution to journal › Article › peer-review
43 Citations (Scopus) -
Near-perfect infectivity of wild-type AAV as benchmark for infectivity of recombinant AAV vectors
Zeltner, N., Kohlbrenner, E., Clement, N., Weber, T. & Linden, R. M., Jul 2010, In: Gene Therapy. 17, 7, p. 872 - 879 8 p.Research output: Contribution to journal › Article › peer-review
46 Citations (Scopus) -
The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment
Wang, X., Blanchard, J., Kohlbrenner, E., Clement, N., Linden, M., Radu, A., Grundke-Iqbal, I. & Iqbal, K., Nov 2010, In: Faseb Journal. 24, 11, p. 4420-4432 13 p.Research output: Contribution to journal › Article › peer-review
74 Citations (Scopus) -
2009
DNA Structure Modulates the Oligomerization Properties of the AAV Initiator Protein Rep68
Mansilla-Soto, J., Yoon-Robarts, M., Rice, W. J., Arya, S., Escalante, C. R. & Linden, R. M., Jul 2009, In: PL o S Pathogens. 5, 7, e1000513.Research output: Contribution to journal › Article › peer-review
29 Citations (Scopus) -
Site-specific integration of adeno-associated virus involves partial duplication of the target locus
Henckaerts, E., Dutheil, N., Zeltner, N., Kattman, S., Kohlbrenner, E., Ward, P., Clement, N., Rebollo, P., Kennedy, M., Keller, G. M. & Linden, R. M., 5 May 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 18, p. 7571 - 7576 6 p.Research output: Contribution to journal › Article › peer-review
59 Citations (Scopus) -
Transcriptional analysis of the adeno-associated virus integration site
Dutheil, N., Henckaerts, E., Kohlbrenner, E. & Linden, R. M., Dec 2009, In: Journal of Virology. 83, 23, p. 12512 - 12525 14 p.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
2008
Human cardiovascular progenitor cells develop from a KDR plus embryonic-stem-cell-derived population
Yang, L., Soonpaa, M. H., Adler, E. D., Roepke, T. K., Kattman, S. J., Kennedy, M., Henckaerts, E., Bonham, K., Abbott, G. W., Linden, R. M., Field, L. J. & Keller, G. M., 22 May 2008, In: NATURE. 453, 7194, p. 524-528 5 p.Research output: Contribution to journal › Article › peer-review
1199 Citations (Scopus) -
2007
Live covisualization of competing adeno-associated virus and herpes simplex virus type 1 DNA replication: molecular mechanisms of interaction.
Glauser, D., Strasser, R., Laimbacher, A., Saydam, O., Clement, N., Linden, R., Ackermann, M. & Fraefel, C., May 2007, In: Journal of Virology. 81, 9, p. 4732 - 4743 12 p.Research output: Contribution to journal › Article › peer-review
24 Citations (Scopus) -
2006
Homologous recombination is required for AAV-mediated gene targeting
Vasileva, A., Linden, R. M. & Jessberger, R., 2006, In: Nucleic Acids Research. 34, 11, p. 3345 - 3360 16 p.Research output: Contribution to journal › Article › peer-review
48 Citations (Scopus) -
2005
Altering AAV tropism with mosaic viral capsids
Gigout, L., Rebollo, P., Clement, N., Warrington, K. H., Muzyczka, N., Linden, R. M. & Weber, T., Jun 2005, In: Molecular Therapy. 11, 6, p. 856 - 865 10 p.Research output: Contribution to journal › Article › peer-review
58 Citations (Scopus) -
Four-dimensional visualization of the simultaneous activity of alternative adeno-associated virus replication origins
Glauser, D. L., Saydam, O., Balsiger, N. A., Heid, I., Linden, R. M., Ackermann, M. & Fraefel, C., Oct 2005, In: Journal of Virology. 79, 19, p. 12218 - 12230 13 p.Research output: Contribution to journal › Article › peer-review
19 Citations (Scopus) -
Transduction of pancreatic islets with pseudotyped adeno-associated virus: effect of viral capsid and genome conversion.
Zhang, N., Clement, N., Chen, D., S, F., Zhang, H., Rebello, P., Linden, R. & Bromberg, J., 15 Sept 2005, In: Transplantation. 15, 80, p. 683 - 690 8 p.Research output: Contribution to journal › Article › peer-review
12 Citations (Scopus) -
2004
Characterization of the mouse adeno-associated virus AAVS1 ortholog
Dutheil, N., Yoon-Robarts, M., Ward, P., Henckaerts, E., Skrabanek, L., Berns, K. I., Campagne, F. & Linden, R. M., Aug 2004, In: Journal of Virology. 78, 16, p. 8917 - 8921 5 p.Research output: Contribution to journal › Article › peer-review
26 Citations (Scopus) -
Residues within the B ' motif are critical for DNA binding by the superfamily 3 helicase Rep40 of adeno-associated virus type 2
Yoon-Robarts, M., Blouin, A. G., Bleker, S., Kleinschmidt, J. A., Aggarawal, A. K., Escalante, C. R. & Linden, R. M., 26 Nov 2004, In: Journal of Biological Chemistry. 279, 48, p. 50472 - 50481 10 p.Research output: Contribution to journal › Article › peer-review
44 Citations (Scopus) -
Structure of adeno-associated virus type 2 Rep40-ADP complex: Insight into nucleotide recognition and catalysis by superfamily 3 helicases
James, J. A., Aggarwal, A. K., Linden, R. M. & Escalante, C. R., 24 Aug 2004, In: Proceedings of the National Academy of Sciences of the United States of America. 101, 34, p. 12455 - 12460 6 p.Research output: Contribution to journal › Article › peer-review
42 Citations (Scopus) -
2003
Crystal structure of the SF3 helicase from adeno-associated virus type 2
James, J. A., Escalante, C. R., Yoon-Robarts, M., Edwards, T. A., Linden, R. M. & Aggarwal, A. K., 1 Aug 2003, In: Structure. 11, 8, p. 1025 - 1035 11 p.Research output: Contribution to journal › Article › peer-review
110 Citations (Scopus) -
Identification of active site residues of the adeno-associated virus type 2 Rep endonuclease
Yoon-Robarts, M. & Linden, R. M., 14 Feb 2003, In: Journal of Biological Chemistry. 278, 7, p. 4912 - 4918 7 p.Research output: Contribution to journal › Article › peer-review
23 Citations (Scopus) -
Rescue of the adeno-associated virus genome from a plasmid vector: Evidence for rescue by replication
Ward, P., Elias, P. & Linden, R. M., Nov 2003, In: Journal of Virology. 77, 21, p. 11480 - 11490 11 p.Research output: Contribution to journal › Article › peer-review
21 Citations (Scopus) -
2001
Amino-terminal domain exchange redirects origin-specific interactions of adeno-associated virus Rep78 in vitro
Yoon, M., Smith, D. H., Ward, P., Medrano, F. J., Aggarwal, A. K. & Linden, R. M., 2001, In: Journal of Virology. 75, 7, p. 3230 - 3239 10 p.Research output: Contribution to journal › Article › peer-review
30 Citations (Scopus) -
Novel cis-acting replication element in the adeno-associated virus type 2 genome is involved in amplification of integrated rep-cap sequences
Nony, P., Tessier, J., Chadeuf, G., Ward, P., Giraud, A., Dugast, M., Linden, R. M., Moullier, P. & Salvetti, A., 2001, In: Journal of Virology. 75, 20, p. 9991 - 9994 4 p.Research output: Contribution to journal › Article › peer-review
46 Citations (Scopus) -
Rep-dependent initiation of adeno-associated virus type 2 DNA replication by a herpes simplex virus type 1 replication complex in a reconstituted system
Ward, P., Falkenberg, M., Elias, P., Weitzman, M. & Linden, R. M., 2001, In: Journal of Virology. 75, 21, p. 10250 - 10258 9 p.Research output: Contribution to journal › Article › peer-review
38 Citations (Scopus) -
1999
Cross-cultural comparison of depressive symptoms in Europe does not support stereotypes of ageing
Copeland, J. R., Beekman, A. T., Dewey, M. E., Jordan, A., Lawlor, B. A., Linden, M., Lobo, A., Magnusson, H., Mann, A. H., Fichter, M., Prince, M. J., Saz, P., Turrina, C. & Wilson, K. C., 1999, In: British Journal of Psychiatry. 174, p. 322-9 8 p.Research output: Contribution to journal › Article › peer-review
26 Citations (Scopus)