Michael Curtis

2023

Study protocol: The effect of combined β-lactoglobulin supplementation and resistance exercise training prior to limb immobilisation on muscle protein synthesis rates in healthy young adults: study protocol for a randomised controlled trial

Hughes, A., Francis, T., Marjoram, L., Pollock, R., Curtis, M., Cape, A., Phillips, B. E., Smith, K. & Witard, O., 2023.

Research output: Working paper/Preprint › Preprint

2022

Mechanisms of torsades de pointes

Hancox, J. C. & Curtis, M. J., 1 Jan 2022, Torsades de Pointes. Elsevier, p. 51-77 27 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

OCT2013, AN ISCHAEMIA-ACTIVATED ANTIARRHYTHMIC PRODRUG, DEVOID OF THE SYSTEMIC SIDE EFFECTS OF LIDOCAINE

Hesketh, L. M., Sikkel, M. B., Mahoney-Sanchez, L., Mazzacuva, F., Chowdhury, R. A., Tzortzis, K. N., Firth, J., Winter, J., MacLeod, K. T., Ogrodzinski, S., Wilder, C. D. E., Patterson, L. H., Peters, N. S. & Curtis, M., May 2022, In: British Journal of Pharmacology. 179, 9, p. 2037-2053 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2 Citations (Scopus)

22 Downloads (Pure)

Planning experiments: Updated guidance on experimental design and analysis and their reporting III

Curtis, M. J., Alexander, S. P. H., Cirino, G., George, C. H., Kendall, D. A., Insel, P. A., Izzo, A. A., Ji, Y., Panettieri, R. A., Patel, H. H., Sobey, C. G., Stanford, S. C., Stanley, P., Stefanska, B., Stephens, G. J., Teixeira, M. M., Vergnolle, N. & Ahluwalia, A., Aug 2022, In: British Journal of Pharmacology. 179, 15, p. 3907-3913 7 p.

Research output: Contribution to journal › Editorial › peer-review

Open Access

127 Citations (Scopus)

Safety pharmacology in 2022: Taking one small step for cardiovascular safety assay development but one giant leap for regulatory drug safety assessment

Pugsley, M. K., Koshman, Y. E., de Korte, T., Authier, S., Winters, B. R. & Curtis, M. J., 18 Sept 2022, (E-pub ahead of print) In: Journal of pharmacological and toxicological methods. 117, p. 107206 1 p., 107206.

Research output: Contribution to journal › Editorial › peer-review

Open Access

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1 Citation (Scopus)

Similarity Maps for Ventricular Arrhythmia Classification

Lin, Q., Lam, H-K., Curtis, M. J. & Cvetkovic, Z., 1 Apr 2022, (Accepted/In press) Proceedings of 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC'22).

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review

Open Access

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79 Downloads (Pure)

2021

Safety pharmacology during the COVID pandemic

Pugsley, M. K., Koshman, Y., de Korte, T., Authier, S. & Curtis, M. J., 1 Sept 2021, In: Journal of pharmacological and toxicological methods. 111, 107089.

Research output: Contribution to journal › Editorial › peer-review

Open Access

2020

Characterisation of mexiletine’s translational therapeutic index for suppression of ischaemia-induced ventricular fibrillation in the rat isolated heart

Hesketh, L. M., Wilder, C. D. E., Ranadive, N. N., Lytra, G., Qazimi, P., Munro, J. S., Ahdi, N. & Curtis, M. J., 1 Dec 2020, In: Scientific Reports. 10, 1, 8397 .

Research output: Contribution to journal › Article › peer-review

Open Access

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1 Citation (Scopus)

91 Downloads (Pure)

Is there a role for the no observed adverse effect level in safety pharmacology?

Mow, T., Andersen, N. K., Dragsted, N., Lassen, A. B., Laursen, M., Bass, A. S., Valentin, J. P., Markgraf, C., Authier, S., Baird, T. J., Bhatt, S., Traebert, M., Leishman, D. J., Jones, D. & Curtis, M. J., Sept 2020, In: Journal of pharmacological and toxicological methods. 105, 106917.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

The application of electrophysiological methods to characterize AMPA receptors in dissociated adult rat and non-human primate cerebellar neurons for use in neuronal safety pharmacology assessments of the central nervous system

Miraucourt, L. S., Accardi, M. V., Asin, K. E., Pugsley, M. K., Curtis, M. J. & Authier, S., Sept 2020, In: Journal of pharmacological and toxicological methods. 105, 106883.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Twenty years of safety pharmacology model validation and the wider implications of this to drug discovery

Pugsley, M. K., Bekele, B., Griessel, H., de Korte, T., Authier, S., Grobler, A. F., Markgraf, C. G. & Curtis, M. J., Sept 2020, In: Journal of pharmacological and toxicological methods. 105, 106912.

Research output: Contribution to journal › Editorial › peer-review

1 Citation (Scopus)

2018

Clarification of the basis for the selection of requirements for publication in the British Journal of Pharmacology

Curtis, M. J., Ashton, J. C., Moon, L. D. F. & Ahluwalia, A., Sept 2018, In: British Journal of Pharmacology. 175, 18, p. 3633-3635 3 p.

Research output: Contribution to journal › Editorial › peer-review

Open Access

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16 Citations (Scopus)

96 Downloads (Pure)

Experimental design and analysis and their reporting II: Updated and simplified guidance for authors and peer reviewers

Curtis, M. J., Alexander, S., Cirino, G., Docherty, J. R., George, C. H., Giembycz, M. A., Hoyer, D., Insel, P. A., Izzo, A. A., Ji, Y., MacEwan, D. J., Sobey, C. G., Stanford, S. C., M Teixeira, M., Wonnacott, S. & Ahluwalia, A., Apr 2018, In: British Journal of Pharmacology. 175, 7, p. 987-993

Research output: Contribution to journal › Editorial › peer-review

Open Access

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1058 Citations (Scopus)

148 Downloads (Pure)

Facilitation of ischaemia-induced ventricular fibrillation by catecholamines is mediated by β1 and β2 agonism in the rat heart in vitro

Wilder, C. D. E., Pavlaki, N., Dursun, T., Gyimah, P., Caldwell-Dunn, E., Ranieri, A., Lewis, H. R. & Curtis, M. J., 1 May 2018, In: British Journal of Pharmacology. 175, 10, p. 1669-1690 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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4 Citations (Scopus)

145 Downloads (Pure)

Mechanism of doxorubicin cardiotoxicity evaluated by integrating multiple molecular effects into a biophysical model

Fernandez-Chas, M., Curtis, M. J. & Niederer, S. A., 14 Feb 2018, In: British Journal of Pharmacology. 175, 5, p. 763-781

Research output: Contribution to journal › Article › peer-review

Open Access

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30 Citations (Scopus)

160 Downloads (Pure)

Methods for Improved Discrimination between Ventricular Fibrillation and Tachycardia

Alwan, Y., Cvetkovic, Z. & Curtis, M. J., Oct 2018, In: IEEE Transactions on Biomedical Engineering. 65, 10, p. 2143-2151 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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8 Citations (Scopus)

273 Downloads (Pure)

2017

Addressing Reproducibility: Peer Review, Impact Factors, Checklists, Guidelines, and Reproducibility Initiatives

Williams, M., Mullane, K. & Curtis, M. J., 10 Oct 2017, Research in the Biomedical Sciences: Transparent and Reproducible. Elsevier, p. 197-306 110 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

4 Citations (Scopus)

A SPS Survey on Cardiovascular Safety Pharmacology Practices Assessing Proarrhythmia Risk in Drug Safety Testing: State of the Art Prior to Implementation of the Comprehensive In Vitro Proarrhythmia Assay (CiPA) Paradigm

Pugsley, M. K., Fermini, B., Koerner, J., Correll, K., Authier, S., Redfern, W. S., Valentin, J-P., Vargas, H., Leishman, D. J. & Curtis, M. J., Nov 2017, In: Journal of Pharmacological and Toxicological Methods. 88, Part 2, p. 245 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Biomedical Research in the 21st Century: Multiple Challenges in Resolving Reproducibility Issues

Mullane, K., Curtis, M. J. & Williams, M., 10 Oct 2017, Research in the Biomedical Sciences: Transparent and Reproducible. Elsevier, p. 307-353 47 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Citations (Scopus)

Cardiac voltage-gated ion channels in safety pharmacology: Review of the landscape leading to the CiPA initiative

Huang, H., Pugsley, M. K., Fermini, B., Curtis, M. J., Koerner, J., Accardi, M. & Authier, S., 11 Apr 2017, (E-pub ahead of print) In: Journal of Pharmacological and Toxicological Methods.

Research output: Contribution to journal › Article › peer-review

Open Access

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50 Citations (Scopus)

238 Downloads (Pure)

Experimental Planning and Execution

Mullane, K., Curtis, M. J. & Williams, M., 10 Oct 2017, Research in the Biomedical Sciences: Transparent and Reproducible. Elsevier, p. 67-106 40 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

3 Citations (Scopus)

Proarrhythmia liability assessment and the Comprehensive In Vitro Proarrhythmia Assay (CiPA): An Industry Survey on Current Practice

Authier, S., Pugsley, M. K., Koerner, J. E., Fermini, B., Redfern, W. S., Valentin, J-P., Vargas, H. M., Leishman, D. J., Correll, K. & Curtis, M. J., 20 Feb 2017, (E-pub ahead of print) In: Journal of Pharmacological and Toxicological Methods.

Research output: Contribution to journal › Article › peer-review

Open Access

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31 Citations (Scopus)

142 Downloads (Pure)

Research in the biomedical sciences: Transparent and reproducible

Williams, M., Curtis, M. J. & Mullane, K., 10 Oct 2017, Elsevier. 369 p.

Research output: Book/Report › Book › peer-review

1 Citation (Scopus)

The opportunities and challenges for biophysical modelling of adverse and beneficial drug actions on the heart

Niederer, S. A., de Oliveira, B. L. & Curtis, M. J., 1 Jun 2017, (E-pub ahead of print) In: Current Opinion in Systems Biology.

Research output: Contribution to journal › Article › peer-review

Open Access

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162 Downloads (Pure)

2016

Contractile function assessment by intraventricular balloon alters the ability of regional ischaemia to evoke ventricular fibrillation: Heart rhythm and function assay

Wilder, C. D. E., Masoud, R., Yazar, D., O'Brien, B. A., Eykyn, T. R. & Curtis, M. J., 1 Jan 2016, In: British Journal of Pharmacology. 173, 1, p. 39-52 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

Expression and function of Kv7.4 channels in rat cardiac mitochondria: Possible targets for cardioprotection

Testai, L., Barrese, V., Soldovieri, M. V., Ambrosino, P., Martelli, A., Vinciguerra, I., Miceli, F., Greenwood, I. A., Curtis, M. J., Breschi, M. C., Sisalli, M. J., Scorziello, A., Canduela, M. J., Grandes, P., Calderone, V. & Taglialatela, M., 1 May 2016, In: Cardiovascular Research. 110, 1, p. 40-50 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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68 Citations (Scopus)

201 Downloads (Pure)

Recalibration of nonclinical safety pharmacology assessment to anticipate evolving regulatory expectations

Pugsley, M. K., Authier, S., Hayes, E. S., Hamlin, R. L., Accardi, M. V. & Curtis, M. J., 22 Jun 2016, (E-pub ahead of print) In: Journal of Pharmacological and Toxicological Methods.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Safety pharmacology investigations on the nervous system: An industry survey

Authier, S., Arezzo, J., Delatte, M. S., Kallman, M-J., Markgraf, C., Paquette, D., Pugsley, M. K., Ratcliffe, S., Redfern, W. S., Stevens, J., Valentin, J-P., Vargas, H. M. & Curtis, M. J., 2 Jun 2016, (E-pub ahead of print) In: Journal of Pharmacological and Toxicological Methods.

Research output: Contribution to journal › Article › peer-review

Open Access

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54 Citations (Scopus)

654 Downloads (Pure)

Ventricular cycle length irregularity affects the correlation between ventricular rate and coronary flow in isolated, Langendorff perfused guinea pig hearts

Takács, H., Kui, P., Farkas, A. S., Sarusi, A., Forster, T., Papp, J. G., Varró, A., Curtis, M. J., Shattock, M. J. & Farkas, A., 2016, In: Journal of pharmacological and toxicological methods. 77, p. 45-52 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

2015

Biophysics and molecular biology of cardiac ion channels for the safety pharmacologist

Pugsley, M. K., Curtis, M. J. & Hayes, E. S., 2015, In: Handbook of Experimental Pharmacology. 229, p. 149-203 55 p.

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Charge is an important determinant of hemodynamic and adverse cardiovascular effects of cationic drugs

Pugsley, M. K., Authier, S. & Curtis, M. J., 1 Dec 2015, In: Pharmacological Research. 102, p. 46-52 7 p.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Experimental design and analysis and their reporting: new guidance for publication in BJP

Curtis, M. J., Bond, R. A., Spina, D., Ahluwalia, A., Alexander, S. P. A., Giembycz, M. A., Gilchrist, A., Hoyer, D., Insel, P. A., Izzo, A. A., Lawrence, A. J., MacEwan, D. J., Moon, L. D. F., Wonnacott, S., Weston, A. H. & McGrath, J. C., Jul 2015, In: British Journal of Pharmacology. 172, 14, p. 3461-3471 11 p.

Research output: Contribution to journal › Editorial › peer-review

Open Access

950 Citations (Scopus)

Haemodynamic Assessment in Safety Pharmacology

Authier, S., Pugsley, M. K. & Curtis, M., 2015, Principles of Safety Pharmacology. Springer, Vol. 229. p. 221-241 21 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

5 Citations (Scopus)

Potential role of cardiac chloride channels and transporters as novel therapeutic targets

Adkins, G. B. & Curtis, M. J., Jan 2015, In: Pharmacology and Therapeutics. 145, p. 67-75 9 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Replication – why we need to publish our findings

Curtis, M. J. & Abernethy, D. R., Aug 2015, In: Pharmacology Research and Perspectives. 3, 4, e00164.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

Structured prediction for differentiating between normal rhythms, ventricular tachycardia, and ventricular fibrillation in the ECG

Alwan, Y., Cvetkovic, Z. & Curtis, M., 4 Nov 2015, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Institute of Electrical and Electronics Engineers Inc., Vol. 2015-November. p. 310-314 5 p. 7318362

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review

5 Citations (Scopus)

The Diplomate in Safety Pharmacology (DSP) certification scheme

Authier, S., Curtis, M. J., Soloviev, M., Redfern, W. S., Kallman, M. J., Hamlin, R. L., Leishman, D. J., Valentin, J. P., Koerner, J. E., Vargas, H. M., Botchway, A., Correll, K. & Pugsley, M. K., 1 Sept 2015, In: Journal of pharmacological and toxicological methods. 75, p. 1-4 4 p.

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

2014

Absolute beat-to-beat variability and instability parameters of ECG intervals: biomarkers for predicting ischaemia-induced ventricular fibrillation

Sarusi, A., Rarosi, F., Szucs, M., Csik, N., Farkas, A. S., Papp, J. G., Varro, A., Forster, T., Curtis, M. J. & Farkas, A., Apr 2014, In: British Journal of Pharmacology. 171, 7, p. 1772-1782 11 p.

Research output: Contribution to journal › Article › peer-review