Research output per year
Research output per year
Personal profile
Research interests
My group's research focusses on developing and applying chemistry for molecular imaging and systemic targeted radiotherapy. We are particularly interested in incorporating radioactive metals into biomolecules that target cell-surface receptors of cancer cells. These radiolabelled biomolecules enable whole body diagnostic molecular imaging of cancer using PET or SPECT imaging, or alternatively, deliver a cytotoxic/radiotherapeutic dose of radiation to diseased cells.
Our research spans basic chemical research (chelator synthesis, inorganic chemistry, radiochemistry), application of new and existing chemistry to develop new radiolabelled agents, and preclinical research in which we test new radiolabelled agents in biological models of disease. We collaborate with a range of academic, industry and clinical partners.
For more information about myself, my research background and opportunities to work or collaborate with my group, see the following links:
http://soapboxscience.org/?p=1899
http://www.imagingcdt.com/research/supervisors/michelle-ma
https://wellcome.ac.uk/what-we-do/case-studies/michelle-ma
Alternatively, feel free to email me: michelle.ma@kcl.ac.uk
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Coordination of Transition Metals to Peptides, University of Melbourne
Award Date: 1 Jan 2010
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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All-optical multimode fibre photoacoustic endomicroscopy with scalable spatial resolution and field-of-view
Zhao, T., Pham, T., Baker, C., Ma, M., Ourselin, S., Vercauteren, T., Zhang, E. Z., Beard, P. & Xia, W., 11 Aug 2023, Proc. SPIE 12631. SPIE, 3 p. 126310MResearch output: Chapter in Book/Report/Conference proceeding › Conference paper › peer-review
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Diphosphine Bioconjugates via Pt(0)-Catalyzed Hydrophosphination. A Versatile Chelator Platform for Technetium-99m and Rhenium-188 Radiolabeling of Biomolecules
Nuttall, R. E., Pham, T. T., Chadwick, A. C., Hungnes, I. N., Firth, G., Heckenast, M. A., Sparkes, H. A., Galan, M. C., Ma, M. T. & Pringle, P. G., 2023, In: INORGANIC CHEMISTRY.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)3 Downloads (Pure) -
Probing Unexpected Reactivity in Radiometal Chemistry: Indium-111-Mediated Hydrolysis of Hybrid Cyclen-Hydroxypyridinone Ligands
Rivas, C., Jackson, J. A., Rigby, A., Jarvis, J. A., White, A. J. P., Blower, P. J., Phanopoulos, A. & Ma, M. T., 3 Apr 2023, In: INORGANIC CHEMISTRY. 62, 13, p. 5270-5281 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Downloads (Pure) -
Versatile Diphosphine Chelators for Radiolabeling Peptides with 99mTc and 64Cu
Hungnes, I. N., Pham, T. T., Rivas, C., Jarvis, J. A., Nuttall, R. E., Cooper, S. M., Young, J. D., Blower, P. J., Pringle, P. G. & Ma, M. T., 2023, In: INORGANIC CHEMISTRY.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Downloads (Pure) -
A General Design Strategy Enabling the Synthesis of Hydrolysis-Resistant, Water-Stable Titanium(IV) Complexes
Koller, A. J., Saini, S., Chaple, I. F., Joaqui-Joaqui, M. A., Paterson, B. M., Ma, M. T., Blower, P. J., Pierre, V. C., Robinson, J. R., Lapi, S. E. & Boros, E., 23 May 2022, In: Angewandte Chemie - International Edition. 61, 22, e202201211.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus)
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New chelators for diagnostic and therapeutic pairs of radioactive metal isotopes
National Nuclear Laboratory Ltd
1/10/2022 → 30/09/2026
Project: Research
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Next generation molecular imaging and therapy with radionuclides
Blower, P., Gee, T., Ng, T., Barrington, S., T. M. de Rosales, R., Ma, M., Fruhwirth, G., Southworth, R., Reader, A., Marsden, P. & Terry, S.
EPSRC Engineering and Physical Sciences Research Council
1/10/2019 → 30/09/2024
Project: Research
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A multiuser radioanalytical facility for molecular imaging and radiouclide therapy research
Blower, P., Ma, M., Gee, T., T. M. de Rosales, R., Ng, T. & Watt, F.
7/01/2019 → 6/01/2024
Project: Research
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A chemical toolbox for targeted radionuclide imaging and therapy of cancer cell receptors
Ma, M., Terry, S. & academic, A.
1/03/2018 → 30/04/2025
Project: Research