Mike Modo

The main interest of Dr Modo's research lies in the restorative neurobiology following brain damage, with a particular interest in cerebral ischaemia and neurodegeneration. An interdisciplinary approach encompassing in vivo and ex vivo methods probes the functional, immunological, and histological consequences of brain damage. Our aim is to stimulate and/or supplement the potential of endogenous repair mechanisms to promote improvements in behavioural impairments. To this end, we also study the neurobiology of brain development/degeneration and its relation to neoplastic formations. Recent research efforts are aimed to use non-invasive methods, such as neuroimaging (MRI and PET), to visualise brain damage and how restorative strategies (such as stem cell migration and integration) lead to functional improvements after insults to the brain. Especially the developments in molecular imaging currently under way promise new vistas to probe the repair of the central nervous system in vivo. These novel imaging methods will provide us with means to link anatomical, metabolic, immunological, and functional changes in damaged brains to behavioural impairment and recovery.

Restorative neurobiology following brain damage, with particular interest in cerebral ischaemia and neurodegeneration, as well as stem cell transplantation.