King's College London

Research portal

Professor Miraz Rahman

  1. Isolation and In Silico Prediction of Potential Drug-like Compounds with a New Dimeric Prenylated Quinolone Alkaloid from Zanthoxylum rhetsa (Roxb.) Root Extracts Targeted against SARS-CoV-2 (Mpro)

    Tuz Zohra, F., Azam, ATM. Z., Ahmed, S., Halim, M., Rahman, M., Anwar, M. R., Sohrab, M. H., Tabassum, F., Hasan, C. M. & Ahsan, M., 24 Nov 2022, In: Molecules (Basel, Switzerland). 27, 23, p. 1 15 p., 8191.

    Research output: Contribution to journalArticlepeer-review

  2. Identification and characterisation of G-quadruplex DNA-forming sequences in the Pseudomonas aeruginosa genome

    Evans, L., Kotar, A., Valentini, M., Filloux, A., Jamshidi, S., Plavec, J., Rahman, M. & Vilar, R., 15 Nov 2022, In: RSC Chemical Biology. 18 p.

    Research output: Contribution to journalArticlepeer-review

  3. Mechanistic insight into the repair of C8-linked pyrrolobenzodiazepine monomer-mediated DNA damage

    Joseph, A. M., Nahar, K., Daw, S., Hasan, M., Lo, R., Le, T., Rahman, M. & Badrinarayanan, A., 18 Oct 2022, In: RSC Medicinal Chemistry. 32, 2, p. 1-13 13 p.

    Research output: Contribution to journalArticlepeer-review

  4. Development, Molecular Docking, and in Silico ADME Evaluation of Selective ALR2 Inhibitors for the Treatment of Diabetic Complications via Suppression of the Polyol Pathway

    Imran, A., Shehzad, M. T., Shah, S. J. A., Laws, M., Al-Adhami, T., Rahman, K. M., Khan, I. A., Shafiq, Z. & Iqbal, J., 2 Aug 2022, In: ACS Omega. 7, 30, p. 26425-26436 12 p.

    Research output: Contribution to journalArticlepeer-review

  5. DNA sequence-selective G-A cross-linking ADC payloads for use in solid tumour therapies

    Procopiou, G., Jackson, P. J. M., di Mascio, D., Auer, J. L., Pepper, C., Rahman, K. M., Fox, K. R. & Thurston, D. E., 29 Jul 2022, In: Communications Biology. 5, 1, p. 741 1 p., 741.

    Research output: Contribution to journalArticlepeer-review

  6. Development and exploration of novel substituted thiosemicarbazones as inhibitors of aldose reductase via in vitro analysis and computational study

    Imran, A., Shehzad, M. T., Shah, S. J. A., al Adhami, T., Laws, M., Rahman, K. M., Alharthy, R. D., Khan, I. A., Shafiq, Z. & Iqbal, J., Dec 2022, In: Scientific Reports. 12, 1, 5734.

    Research output: Contribution to journalArticlepeer-review

  7. Efflux pumps in Mycobacterium tuberculosis and their inhibition to tackle antimicrobial resistance

    Laws, M., Jin, P. & Rahman, K. M., Jan 2022, In: Trends in Microbiology. 30, 1, p. 57-68 12 p.

    Research output: Contribution to journalReview articlepeer-review

  8. Factors influencing the choice of monoclonal antibodies for antibody–drug conjugates

    Hasan, M., Jin, P., Laws, M. & Rahman, M., Jan 2022, In: DRUG DISCOVERY TODAY. 27, 1, p. 354-361 8 p.

    Research output: Contribution to journalReview articlepeer-review

  9. Strategies for drug repurposing against coronavirus targets

    Smith, P., Rahman, M. & Jin, P., 2022, In: Current Research in Pharmacology and Drug Discovery. 3, p. 1-14 14 p., 100072.

    Research output: Contribution to journalReview articlepeer-review

  10. Development of coumarin-thiosemicarbazone hybrids as aldose reductase inhibitors: Biological assays, molecular docking, simulation studies and ADME evaluation

    Imran, A., Tariq Shehzad, M., al Adhami, T., Miraz Rahman, K., Hussain, D., Alharthy, R. D., Shafiq, Z. & Iqbal, J., Oct 2021, In: BIOORGANIC CHEMISTRY. 115, 105164.

    Research output: Contribution to journalArticlepeer-review

  11. Synthesis, Microbiological Evaluation and Structure Activity Relationship Analysis of Linezolid Analogues with Different C5-acylamino Substituents.  

    Al-Adhami, T., Matsongos, C., Jamshidi, S., Hind, C. K., Clifford, M., Sutton, M. & Rahman, M., 2 Sep 2021, (Accepted/In press) In: Bioorganic and Medicinal Chemistry. 49, p. 1-13 13 p., 116397.

    Research output: Contribution to journalArticlepeer-review

  12. Schiff bases of sulphonamides as a new class of antifungal agent against multidrug-resistant Candida auris

    Chen, Y., Hamad, A., Khan, M., Jamshidi, S., Saeed, N., Clifford, M., Hind, C. K., Sutton, J. M. & Rahman, M., Aug 2021, In: MicrobiologyOpen. 10, 4, p. 1-8 8 p., e1218.

    Research output: Contribution to journalArticlepeer-review

  13. Indole alkaloids from the leaves of Ravenia spectabilis engl. with activity against pancreatic cancer cell line

    Tabassum, F., Hasan, C. M., Masud, M. M., Jamshidi, S., Rahman, K. M. & Ahsan, M., Jun 2021, In: PHYTOCHEMISTRY. 186, 112744.

    Research output: Contribution to journalArticlepeer-review

  14. A New Cyclohexanone Derivative from the Leaves of Bridelia stipularis

    Shahriar, K. R., Hossain, M. E., Rahman, K. M., Ahsan, M. & Hasan, C. M., May 2021, In: Chemistry of Natural Compounds. 57, 3, p. 455-458 4 p.

    Research output: Contribution to journalArticlepeer-review

  15. Antibody–drug conjugates—a tutorial review

    Baah, S., Laws, M. & Rahman, K. M., May 2021, In: Molecules. 26, 10, 2943.

    Research output: Contribution to journalReview articlepeer-review

  16. Development of photoactivable phenanthroline-based manganese(I) CO-Releasing molecules (PhotoCORMs) active against ESKAPE bacteria and bacterial biofilms

    Toscani, A., Hind, C., Clifford, M., Kim, S. H., Gucic, A., Woolley, C., Saeed, N., Rahman, K. M., Sutton, J. M. & Castagnolo, D., 5 Mar 2021, In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 213, 113172.

    Research output: Contribution to journalArticlepeer-review

  17. Therapeutic intervention of COVID-19 by natural products: A population-specific survey directed approach

    Gomez, C. R., Espinoza, I., Faruque, F. S., Hasan, M. M., Rahman, K. M., Walker, L. A. & Muhammad, I., Feb 2021, In: Molecules. 26, 4, 1191.

    Research output: Contribution to journalReview articlepeer-review

  18. Whole Genome Sequencing of Staphylococcus aureus SA-1199B Reveals Previously Unreported Mutations

    Laws, M., Rahman, M., Hind, C. K., Sutton, M. & Wand, M. E., Jan 2021, In: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. 57, 1, p. 1-2 2 p., 106225.

    Research output: Contribution to journalLetterpeer-review

  19. Antimicrobial Constituents from Machaerium Pers.: Inhibitory Activities and Synergism of Machaeriols and Machaeridiols against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus faecium, and Permeabilized Gram-Negative Pathogens

    Ilias, M., Jacob, M. R., Ibrahim, M. A., Raman, V., Kumarihamy, M., Wang, M., Al-Adhami, T., Hind, C., Clifford, M., Martin, B., Zhao, J., Sutton, J. M. & Rahman, M., 18 Dec 2020, In: Molecules (Basel, Switzerland). p. 1-14 14 p., 6000.

    Research output: Contribution to journalArticlepeer-review

  20. Integron gene cassettes harboring novel variants of d-alanine-d-alanine ligase confer high-level resistance to d-cycloserine

    Rahman, M. A., Kaiser, F., Jamshidi, S., Freitas Monteiro, M., Rahman, K. M., Mullany, P. & Roberts, A. P., Dec 2020, In: Scientific Reports. 10, 1, 20709.

    Research output: Contribution to journalArticlepeer-review

  21. Probing sulphamethazine and sulphamethoxazole based Schiff bases as urease inhibitors; synthesis, characterization, molecular docking and ADME evaluation

    Hamad, A., Abbas Khan, M., Ahmad, I., Imran, A., Khalil, R., Al-Adhami, T., Miraz Rahman, K., Quratulain, Zahra, N. & Shafiq, Z., Dec 2020, In: BIOORGANIC CHEMISTRY. 105, 104336.

    Research output: Contribution to journalArticlepeer-review

  22. A Cyclodextrin‐Stabilized Spermine‐Tagged Drug Triplex that Targets Theophylline to the Lungs Selectively in Respiratory Emergency

    Jones, S., Sofian, Z. M., Forbes, B., Al-Jamal, K., Benaouda, F., Royall, P., Wang, J., Luo, Y. M., Farag, D. & Rahman, M., 25 Sep 2020, (E-pub ahead of print) In: Advanced Therapeutics.

    Research output: Contribution to journalArticlepeer-review

  23. New broad-spectrum antibiotics containing a pyrrolobenzodiazepine ring with activity against multidrug resistant Gram-negative bacteria.

    Picconi, P., Hind, C. K., Nahar, K. S., Jamshidi, S., Di Maggio, L., Saeed, N., Evans, B., Solomons, J., Wand, M. E., Mark Sutton, J. & Rahman, K. M., 9 Jul 2020, In: Journal of Medicinal Chemistry. 63, 13, p. 6941–6958 18 p.

    Research output: Contribution to journalArticlepeer-review

  24. Antibiotic-in-cyclodextrin-in-liposomes: formulation development and interactions with model bacterial membranes

    Vandera, K-K. A., Picconi, P., Valero, M., González-Gaitano, G., Woods, A., Zain, N. M., Bruce, K., Clifton, L. A., Skoda, M. W. A., Rahman, K. M., Harvey, R. D. & Dreiss, C., 6 Jul 2020, In: Molecular Pharmaceutics. 17, 7, p. 2354-2369 16 p.

    Research output: Contribution to journalArticlepeer-review

  25. Development of sulfonamide-based Schiff bases targeting urease inhibition: Synthesis, characterization, inhibitory activity assessment, molecular docking and ADME studies

    Hamad, A., Khan, M., Rahman, M., Ahmad, I., ul-Huq, Z., Khan, S. & Shafiq, Z., 26 Jun 2020, In: BIOORGANIC CHEMISTRY. 102, p. 1-8 8 p., 104057.

    Research output: Contribution to journalArticlepeer-review

  26. N1-Benzofused Modification of Fluoroquinolones Reduces Activity Against Gram-Negative Bacteria

    Laws, M., Hind, C. K., Favoran, A., Jamshidi, S., Evans, B., Clifford, M., Mark Sutton, J. & Rahman, M., 2 Jun 2020, In: ACS Omega. 5, 21, p. 11923–11934 12 p., acsomega.9b03910.

    Research output: Contribution to journalArticlepeer-review

  27. SAR based in-vitro anticholinesterase and molecular docking studies of nitrogenous progesterone derivatives

    Amin, M. J., Miana, G. A., Rashid, U., Rahman, K. M., Khan, H. & Sadiq, A., Jun 2020, In: Steroids. 158, p. 1-11 108599.

    Research output: Contribution to journalArticlepeer-review

  28. Identifying the responses from the estrogen receptor expressed MCF7 cells treated in anticancer drugs of different modes of action using live-cell FTIR spectroscopy

    Altharawi, A., Rahman, M. & Chan, A., 22 May 2020, In: ACS Omega. 5, 22, p. 12698–12706 9 p., acsomega.9b04369.

    Research output: Contribution to journalArticlepeer-review

  29. Novel pyrrolobenzodiazepine (PBD) benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers

    Lewis, T., Corcoran, D. B., Thurston, D. E., J. Giles, P., Ashelford, K., Walsby, E. J., Fegan, C. D., Pepper, A. G. S., Rahman, K. M. & Pepper, C., 7 May 2020, In: Haematologica. Early view, 238584.

    Research output: Contribution to journalArticlepeer-review

  30. The Aurora B specificity switch is required to protect from non-disjunction at the metaphase/anaphase transition

    Kelly, J. R., Martini, S., Brownlow, N., Joshi, D., Federico, S., Jamshidi, S., Kjaer, S., Lockwood, N., Rahman, K. M., Fraternali, F., Parker, P. J. & Soliman, T. N., 13 Mar 2020, In: Nature Communications. 11, p. 1-14 1396.

    Research output: Contribution to journalArticlepeer-review

  31. Noncytotoxic Pyrrolobenzodiazepine-Ciprofloxacin Conjugate with Activity against Mycobacterium tuberculosis: Ciprofloxacin Conjugate with Activity against Mycobacterium tuberculosis

    Picconi, P., Jeeves, R., Jamshidi, S., Nahar, K. S., Laws, M. B., Moon, C., Bacon, J. & Rahman, K. M., 17 Dec 2019, In: ACS Omega. 4, 25, p. 20873-20881 9 p., acsomega.9b00834.

    Research output: Contribution to journalArticlepeer-review

  32. Effectiveness of efflux pump inhibitors as biofilm disruptors and resistance breakers in gram- negative (ESKAPEE) bacteria

    Reza, A., Mark Sutton, J. & Rahman, K. M., 1 Dec 2019, In: Antibiotics. 8, 4, 229.

    Research output: Contribution to journalReview articlepeer-review

  33. Evaluating the level of nitroreductase activity in clinical Klebsiella pneumoniae isolates to support strategies for nitro drug and prodrug development

    Wand, M. E., Taylor, H. V., Auer, J. L., Bock, L. J., Hind, C. K., Jamshidi, S., Rahman, K. M. & Sutton, J. M., 1 Nov 2019, In: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. 54, 5, p. 538-546 9 p.

    Research output: Contribution to journalArticlepeer-review

  34. Antibiotic Resistance Breakers: Current Approaches and Future Directions

    Laws, M. B., Shaaban, A. & Rahman, K. M., 1 Sep 2019, In: Fems Microbiology Reviews. 43, 5, p. 490-516 27 p.

    Research output: Contribution to journalReview articlepeer-review

  35. Towards identifying the mode of action of drugs using live-cell FTIR spectroscopy

    Altharawi, A., Rahman, K. M. & Chan, K. L. A., 21 Apr 2019, In: Analyst. 144, 8, p. 2725-2735 11 p.

    Research output: Contribution to journalArticlepeer-review

  36. Effects of Systematic Shortening of Noncovalent C8 Side Chain on the Cytotoxicity and NF-κB Inhibitory Capacity of Pyrrolobenzodiazepines (PBDs)

    Corcoran, D., Lewis, T., Nahar, K. S., Jamshidi, S., Fegan, C., Pepper, C., Thurston, D. E. & Rahman, K. M., 28 Feb 2019, In: Journal of Medicinal Chemistry. 62, 4, p. 2127-2139 13 p., 8b01849.

    Research output: Contribution to journalArticlepeer-review

  37. SmvA is an important efflux pump for cationic biocides in Klebsiella pneumoniae and other Enterobacteriaceae

    Wand, M. E., Jamshidi, S., Bock, L. J., Rahman, K. M. & Sutton, J. M., 4 Feb 2019, In: Scientific Reports. 9, 1, p. 1344 1344.

    Research output: Contribution to journalArticlepeer-review

  38. Chapter 4: Pyrrolobenzodiazepines as Transcription Factor Inhibitors: An Overview

    Corcoran, D. B., Thurston, D. E. & Rahman, K. M., 1 Jan 2019, Therapies for Retinal Degeneration: Targeting Common Processes. 65 ed. Royal Society of Chemistry, p. 81-124 44 p. (RSC Drug Discovery Series; vol. 2019-January, no. 65).

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

  39. Fusaproliferin, a fungal mycotoxin, shows cytotoxicity against pancreatic cancer cell lines

    Hoque, N., Hasan, C. M., Rana, S., Varsha, A., Sohrab, H. & Rahman, K. M., 11 Dec 2018, In: Molecules. 23, 12, 3288.

    Research output: Contribution to journalArticlepeer-review

  40. Role of bacterial efflux pumps in biofilm formation

    Alav, I., Sutton, J. M. & Rahman, K. M., 1 Aug 2018, In: Journal of Antimicrobial Chemotherapy. 73, 8, p. 2003-2020 18 p., dky042.

    Research output: Contribution to journalArticlepeer-review

  41. Synthesis, pharmacological evaluation and docking studies of progesterone and testosterone derivatives as anticancer agents

    Jabeen, M., Choudhry, M. I., Miana, G. A., Rahman, K. M., Rashid, U., Khan, H., Seddigh, A. & Sadiq, A., Aug 2018, In: Steroids. 136, p. 22-31

    Research output: Contribution to journalArticlepeer-review

  42. Topical delivery of anthramycin II: Influence of binary and ternary solvent systems

    Haque, T., Rahman, K. M., Thurston, D. E., Hadgraft, J. & Lane, M. E., Aug 2018, In: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 121, p. 59-64

    Research output: Contribution to journalArticlepeer-review

  43. Mapping the Dynamic Functions and Structural Features of AcrB Efflux Pump Transporter Using Accelerated Molecular Dynamics Simulations

    Jamshidi, S., Sutton, J. M. & Rahman, K. M., 11 Jul 2018, (E-pub ahead of print) In: Scientific Reports. 8, 1, p. 1-13 13 p., 10470.

    Research output: Contribution to journalArticlepeer-review

  44. Formation of a Novel C11-Acetone Adduct of a Pyrrolobenzodiazepine (PBD) with Loss of Cytotoxicity

    Corcoran, D., Picconi, P., Chui, C. K. F., Procopiou, G., Pysz, I., Rahman, K. M. & Thurston, D. E., 10 Apr 2018, (E-pub ahead of print) In: SYNLETT. 29, 8, p. 1112-1116 5 p.

    Research output: Contribution to journalLetterpeer-review

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