Search results

• 2005

  Factors influencing PCR detection of viruses in cerebrospinal fluid of patients with suspected CNS infections

  Davies, N. W. S., Brown, L. J., Gonde, J., Irish, D., Robinson, R. O., Swan, A. V., Banatvala, J., Howard, R. S., Sharief, M. K. & Muir, P., Jan 2005, In: Journal of Neurology, Neurosurgery and Psychiatry. 76, 1, p. 82 - 87 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Patient 100%
  • Cerebrospinal Fluid 100%
  • Central Nervous System Infection 100%
  • Central Nervous System 100%
  • Epstein-Barr Virus 75%
  123 Citations (Scopus)
• 2004

  A multiplex assay for detection of microbe specific oligoclonal IGG in cerebrospinal fluid

  Davies, N. W. S., Morris, P., Howard, R., Keir, G. & Sharief, M. K., 2004, In: Journal of Neurology, Neurosurgery and Psychiatry. 75, 5, p. 061 1 p.

  Research output: Contribution to journal › Meeting abstract

• Evaluation of neuromuscular symptoms in UK Gulf War veterans - A controlled study

  Rose, M. R., Sharief, M. K., Priddin, J., Nikolaou, V., Hull, L., Unwin, C., Ajmal-Ali, R., Sherwood, R. A., Spellman, A., David, A. & Wessely, S., 9 Nov 2004, In: Neurology. 63, 9, p. 1681 - 1687 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Fatigue 100%
  • Veteran 100%
  • Symptom 100%
  • Neuromuscular 100%
  • Weakness 83%
  19 Citations (Scopus)

• Fatal fulminant acute disseminated encephalomyelitis presenting without brain MRI white matter lesions

  Davies, N. W. S., Cikurel, K., Sharief, M. K. & Howard, R. S., 2004, In: Journal of Neurology, Neurosurgery and Psychiatry. 75, 8, p. 052 1 p.

  Research output: Contribution to journal › Meeting abstract

• MS patient management: the Analog Model

  Sharief, M. K., Sept 2004, In: Journal of Neurology. 251, 5, p. 74 - 78 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Multiple Sclerosis 100%
  • Magnetism 100%
  • Patient 66%
  • Magnetic Resonance Imaging 33%
  • Nuclear Magnetic Resonance Imaging 33%

• Sativex (R) in the treatment of patients with chronic refractory pain due to MS or other defects of neurological function

  Sharief, M. K., Notcutt, W. G., Mutiboko, I., Hawkes, C., Bolt, J., Potts, R. L. & Smith, E. J., 2004, In: Journal of Neurology, Neurosurgery and Psychiatry. 75, 8, p. 035 1 p.

  Research output: Contribution to journal › Meeting abstract
• 2003

  CSF hypocretin (Orexin) in disorders of excessive daytime sleepiness

  Ebrahim, I. O., de Lacy, S., Howard, R. S., Sharief, M. K. & Williams, A. J., 2003, In: Sleep. 26, p. A282 - A282

  Research output: Contribution to journal › Meeting abstract

• CSF hypocretin (Orexin) in neurological and psychiatric conditions

  Ebrahim, I. O., Semra, Y. K., De Lacy, S., Howard, R. S., Kopelman, M. D., Williams, A. & Sharief, M. K., Mar 2003, In: Journal of Sleep Research. 12, 1, p. 83 - 84 2 p.

  Research output: Contribution to journal › Letter › peer-review

  12 Citations (Scopus)

• Disease modifying therapy for multiple sclerosis: Increasing availability in the UK

  Noori, M. A. & Sharief, M. K., 2003, In: Journal of Neurology, Neurosurgery and Psychiatry. 74, 10, p. 47 1 p.

  Research output: Contribution to journal › Meeting abstract

• Dose and frequency of administration of interferon-beta affect its efficacy in multiple sclerosis

  Sharief, M. K., 2003, In: CLINICAL DRUG INVESTIGATION. 23, 9, p. 551 - 559 9 p.

  Research output: Contribution to journal › Literature review › peer-review

  • Dose-Response Relationship 100%

• Double blind, crossover, randomised trial comparing low molecular weight heparin versus placebo in the treatment of chronic headache

  Cuadrado, M. J., Sanna, G., Sharief, M., Khamashta, M. A. & Hughes, G. R. V., 2003, In: Arthritis & Rheumatism. 48, 9, p. 883 1 p.

  Research output: Contribution to journal › Meeting abstract

• Evidence for cytokine dysregulation in multiple sclerosis: Peripheral blood mononuclear cell production of pro-inflammatory and anti-inflammatory cytokines during relapse and remission

  Hollifield, R. D., Harbige, L. S., Pham-Dinh, D. & Sharief, M. K., May 2003, In: Autoimmunity. 36, 3, p. 133 - 141 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Spontaneous Remission 100%
  • Multiple Sclerosis 100%
  • Anti-Inflammatory Drug 100%
  • Inflammatory Cytokine 100%
  • Anti-Inflammatory 100%
  49 Citations (Scopus)

• Expression ratios of the Bcl-2 family proteins and disease activity in multiple sclerosis

  Sharief, M. K., Matthews, H. & Noori, M. A., Jan 2003, In: Journal of Neuroimmunology. 134, 1-2, p. 158 - 165 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Apoptosis 100%
  • Peripheral Blood Lymphocyte 33%
  • Programmed Cell Death 16%
  • Gadolinium 16%
  • Magnetic Resonance Imaging 16%
  39 Citations (Scopus)

• Hypocretin (orexin) deficiency in narcolepsy and primary hypersomnia

  Ebrahim, I. O., Sharief, M. K., de Lacy, S., Semra, Y. K., Howard, R. S., Kopelman, M. D. & Williams, A. J., 1 Jan 2003, In: Journal of Neurology, Neurosurgery and Psychiatry. 74, 1, p. 127 - 130 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Narcolepsy 100%
  • Hypersomnia 100%
  • Orexin-A 80%
  • Central Nervous System 20%
  • Neuropeptide 20%
  61 Citations (Scopus)

• Hypocretin (orexin) in neurological, sleep and psychiatric disorders: A prospective study of CSF hypocretin

  Ebrahim, I. O., Howard, R. S., Williams, A. J., de Lacy, S., Semra, Y., Kopelman, M. D. & Sharief, M. K., 2003, In: Journal of Neurology, Neurosurgery and Psychiatry. 74, 3, p. 39 1 p.

  Research output: Contribution to journal › Meeting abstract

• Multiple sclerosis - Neurofilament light chain antibodies are correlated to cerebral atrophy

  Eikelenboom, M. J., Petzold, A., Lazeron, R. H. C., Silber, E., Sharief, M., Thompson, E. J., Barkhof, F., Giovannoni, G., Polman, C. H. & Uitdehaag, B. M. J., 28 Jan 2003, In: Neurology. 60, 2, p. 219 - 223 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Antibodies 100%
  • Magnetic Resonance Imaging 100%
  • Multiple Sclerosis 100%
  • Neurofilament Light Chain 100%
  • Immunoglobulin G 66%
  123 Citations (Scopus)

• Neurophysiologic analysis of neuromuscular symptoms in UK Gulf War veterans - Reply

  Sharief, M. K., Priddin, J., Delamont, R. S., Unwin, C., Rose, M. R., David, A. & Wessely, S., 23 Dec 2003, In: Neurology. 61, 12, p. 1827-1827 1 p.

  Research output: Contribution to journal › Letter › peer-review

• The effectiveness of Natalizumab on MRI outcome measures in patients with relapsing multiple sclerosis

  DALTON, C., BARKER, G., MACMANUS, D., MISZKIEL, K., BATES, D., BLUMHARDT, L., HAWKINS, C., PALACE, J., SHARIEF, M., SWINGLER, R., YOUNG, C. & MILLER, D., Mar 2003, In: Journal of Neurology, Neurosurgery and Psychiatry. 74, 3, p. 399-399 1 p.

  Research output: Contribution to journal › Meeting abstract › peer-review
• 2002

  An epidemiologically controlled study of weakness in UK Gulf War servicemen

  Rose, M., Pridden, J., Nikolaou, V., Unwin, C., Sharief, M., David, A. & Wessely, S., 15 Jul 2002, In: Journal of the Neurological Sciences. 199, p. S45-S45 1 p.

  Research output: Contribution to journal › Meeting abstract › peer-review

  6 Citations (Scopus)

• Cerebral embolism complicating Libman-Sacks endocarditis - Full recovery using recombinant tissue plasminogen activator

  Joven, B., Mellor-Pita, S., D'Cruz, D., Sharief, M., Khamashta, M. & Hughes, G. R. V., Sept 2002, In: Journal of Rheumatology. 29, 9, p. 2022 - 2024 3 p.

  Research output: Contribution to journal › Letter › peer-review

  7 Citations (Scopus)

• CSF hypocretin levels in neurologic and psychiatric conditions

  Ebrahim, I. O., Semra, Y. K., de Lacy, S., Howard, R. S., Williams, A. J. & Sharief, M. K., 2002, In: Sleep. 25, p. A378 - A378

  Research output: Contribution to journal › Meeting abstract

• Disease activity in multiple sclerosis correlates with T lymphocyte expression of the inhibitor of apoptosis proteins

  Semra, Y. K., Seidi, O. A. & Sharief, M. K., 2002, In: Journal of Neuroimmunology. 122, 1-2, p. 159 - 166 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Disease Activity 100%
  • Multiple Sclerosis 100%
  • T Lymphocyte 100%
  • Inhibitor of Apoptosis Protein 100%
  • Protein 100%
  35 Citations (Scopus)

• Down-regulation of survivin expression in T lymphocytes after interferon beta-1a treatment in patients with multiple sclerosis

  Sharief, M. K. & Semra, Y. K., 2002, In: Archives of neurology. 59, 7, p. 1115 - 1121 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Apoptosis 100%
  • Programmed Cell Death 24%
  36 Citations (Scopus)

• Encyclopaedia of Cognitive Science

  Smith, K. J. & Sharief, M., 2002, London: Nature Publishing Group.

  Research output: Book/Report › Book

• Expression of CD5 on B lymphocytes correlates with disease activity in patients with multiple sclerosis

  Seidi, O. A., Semra, Y. K. & Sharief, M. K., Dec 2002, In: Journal of Neuroimmunology. 133, 1-2, p. 205 - 210 6 p.

  Research output: Contribution to journal › Article › peer-review

  • B Cell 100%
  • CD5 100%
  • Autoantibodies 25%
  • Magnetic Resonance Imaging 12%
  • Relapsing Remitting Multiple Sclerosis 12%
  29 Citations (Scopus)

• Heightened intrathecal release of axonal cytoskeletal proteins in multiple sclerosis is associated with progressive disease and clinical disability

  Semra, Y. K., Seidi, O. A. & Sharief, M. K., 2002, In: Journal of Neuroimmunology. 122, 1-2, p. 132 - 139 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Intrathecal 100%
  • Multiple Sclerosis 100%
  • Primary Progressive Multiple Sclerosis 20%
  • Relapsing Remitting Multiple Sclerosis 20%
  • Nervous System Disorder 20%
  121 Citations (Scopus)

• Heightened intrathecal release of soluble CD137 in patients with multiple sclerosis

  Sharief, M. K., 2002, In: European Journal of Neurology. 9, 1, p. 49 - 54 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Immunoglobulin M 100%
  • Death Receptor 100%
  • Tumor Necrosis Factor 100%
  • Cell Death 100%
  32 Citations (Scopus)

• Intrathecal immune response against axonal cytoskeletal components in patients with multiple sclerosis: A prognostic study

  Seidi, O. A., Semera, Y. K., Gregson, N. A. & Sharief, M. K., 2002, In: Journal of Neurology, Neurosurgery and Psychiatry. 73, 2, p. 216 - 216 1 p.

  Research output: Contribution to journal › Meeting abstract

• Multiple Sclerosis

  Smith, K. J. & Sharief, M., 2002, Encyclopaedia of Cognitive Science. London: Nature Publishing Group

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Narcolepsy with cataplexy, monosymptomatic narcolepsy and primary hypersomnia: A prospective study in 24 patients including cerebrospinal fluid hypocretin levels

  Ebrahim, I. O., de Lacy, S., Sharief, M. K., Semra, Y. K., Howard, R. S. & Williams, A. J., 2002, In: Sleep. 25, p. A353 - A353

  Research output: Contribution to journal › Meeting abstract

• Neurophysiologic analysis of neuromuscular symptoms in UK Gulf War veterans. A controlled study.

  Sharief, M. K., Priddin, J., Delamont, R. S., Unwin, C., Rose, M. R., David, A. S. & Wessely, S., 26 Nov 2002, In: Neurology. 59, 10, p. 1518 - 1525 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuromuscular 100%
  • Electromyography 40%
  • Denervation 20%
  • Peripheral Nerve 20%
  • Neuromuscular Junction 20%
  57 Citations (Scopus)

• Overexpression of CD5 on B lymphocytes correlates with the disease activity in patients with relapsing-remitting multiple sclerosis

  Seidi, O. A., Semra, Y. K. & Sharief, M. K., 2002, In: Journal of Neurology, Neurosurgery and Psychiatry. 73, 2, p. 228 - 228 1 p.

  Research output: Contribution to journal › Meeting abstract

• Patients with progressive multiple sclerosis have elevated antibodies to neurofilament subunit

  Silber, E., Semra, Y. K., Gregson, N. A. & Sharief, M. K., 14 May 2002, In: Neurology. 58, 9, p. 1372 - 1381 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Brain 100%
  • Intrathecal 100%
  • Nervous System Disorder 100%
  • Lumbar Puncture 100%
  • Binding Antibody 100%
  145 Citations (Scopus)

• Reduced expression of the inhibitor of apoptosis proteins in T cells from patients with multiple sclerosis following interferon-beta therapy

  Sharief, M. K., Noori, M. A. & Zoukos, Y., 2002, In: Journal of Neuroimmunology. 129, 1-2, p. 224 - 231 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Apoptosis 100%
  • Death Receptor 12%
  • Programmed Cell Death 10%
  • Cell Death 10%
  • Pharmacotherapy 10%
  32 Citations (Scopus)

• Small sensory fibre dysfunction in selective cholinergic dysautonomia

  Warner, G., Sharief, M. K. & Anand, P., 2002, In: European Journal of Neurology. 9, 1, p. 109 - 109 1 p.

  Research output: Contribution to journal › Letter › peer-review

  5 Citations (Scopus)

• The expression of apoptosis-regulatory proteins in B lymphocytes from patients with multiple sclerosis

  Seidi, O. A. & Sharief, M. K., Sept 2002, In: Journal of Neuroimmunology. 130, 1-2, p. 202 - 210 9 p.

  Research output: Contribution to journal › Article › peer-review

  • B Cell 100%
  • Autoimmunity 25%
  • Cell Death 25%
  • Death Receptor 12%
  • Inflammatory Disorder 12%
  13 Citations (Scopus)

• The expression of pro- and anti-apoptosis Bcl-2 family proteins in lymphocytes from patients with multiple sclerosis

  Sharief, M. K., Douglas, M., Noori, M. & Semra, Y. K., 2002, In: Journal of Neuroimmunology. 125, 1-2, p. 155 - 162 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Apoptosis 100%
  • Multiple Sclerosis 100%
  • Bcl-2 100%
  • Antiapoptotic 22%
  • Central Nervous System 11%
  44 Citations (Scopus)

• The hypocretin/orexin system

  Ebrahim, I. O., Howard, R. S., Kopelman, M. D., Sharief, M. K. & Williams, A. J., 2002, In: Journal of the Royal Society of Medicine. 95, 5, p. 227 - 230 4 p.

  Research output: Contribution to journal › Literature review › peer-review

  65 Citations (Scopus)

• The prognostic value of intrathecal immune response against axonal components in patients with multiple sclerosis

  Seidi, O. A., Semera, Y. K., Gregson, N. A. & Sharief, M. K., 2002, In: Journal of Neurology, Neurosurgery and Psychiatry. 72, 1, p. 141 - 141 1 p.

  Research output: Contribution to journal › Meeting abstract

• Upregulated survivin expression in activated T lymphocytes correlates with disease activity in multiple sclerosis

  Sharief, M. K., Noori, M. A., Douglas, M. R. & Semra, Y. K., 2002, In: European Journal of Neurology. 9, 5, p. 503 - 510 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Multiple Sclerosis 100%
  • Apoptosis 85%
  • Bcl-2 14%
  • Magnetic Resonance Imaging of Head 14%
  • Programmed Cell Death 14%
  41 Citations (Scopus)
• 2001

  Heightened expression of survivin in activated T lymphocytes from patients with multiple sclerosis

  Sharief, M. K. & Semra, Y. K., 1 Oct 2001, In: Journal of Neuroimmunology. 119, 2, p. 358 - 364 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Patient 100%
  • Multiple Sclerosis 100%
  • T Lymphocyte 100%
  • Survivin 100%
  • Programmed Cell Death 37%
  40 Citations (Scopus)

• Interferon-beta therapy downregulates the anti-apoptosis protein FLIP in T cells from patients with multiple sclerosis

  Sharief, M. K., Semra, Y. K., Seidi, O. A. & Zoukos, Y., 2001, In: Journal of Neuroimmunology. 120, 1-2, p. 199 - 207 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Apoptosis 100%
  • Programmed Cell Death 12%
  • Pharmacotherapy 12%
  • Prospective Study 12%
  • Antiapoptotic 12%
  46 Citations (Scopus)

• Overexpression of the apoptosis inhibitor FLIP in T cells correlates with disease activity in multiple sclerosis

  Semra, Y. K., Seidi, O. A. & Sharief, M. K., 15 Feb 2001, In: Journal of Neuroimmunology. 113, 2, p. 268 - 274 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Cell Death 100%
  68 Citations (Scopus)

• The range of clinical and laboratory features in viral meningitis and encephalitis

  Davies, N., Brown, L., Irish, D., Muir, P., Sharief, M., Robinson, R. & Howard, R., 2001, In: Journal of Neurology, Neurosurgery and Psychiatry. 70, 2, p. 277 - 277 1 p.

  Research output: Contribution to journal › Meeting abstract

  38 Citations (Scopus)

• Upregulation of the inhibitor of apoptosis proteins in activated T lymphocytes from patients with multiple sclerosis

  Sharief, M. K. & Semra, Y. K., 1 Oct 2001, In: Journal of Neuroimmunology. 119, 2, p. 350 - 357 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Patient 100%
  • Upregulation 100%
  • Multiple Sclerosis 100%
  • T Lymphocyte 100%
  • Inhibitor of Apoptosis Protein 100%
  39 Citations (Scopus)
• 2000

  Impaired Fas-independent apoptosis of T lymphocytes in patients with multiple sclerosis

  Sharief, M. K., 22 Sept 2000, In: Journal of Neuroimmunology. 109, 2, p. 236 - 243 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Intrathecal 100%
  • Death Receptor 49%
  41 Citations (Scopus)

• Increased cellular expression of the caspase inhibitor FLIP in intrathecal lymphocytes from patients with multiple sclerosis

  Sharief, M. K., 1 Nov 2000, In: Journal of Neuroimmunology. 111, 1-2, p. 203 - 209 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Intrathecal 100%
  • Multiple Sclerosis 100%
  • Caspase 100%
  • Apoptosis 50%
  • Cell Signaling 25%
  34 Citations (Scopus)